Flavin-binding monooxygenase-like/Pyridine nucleotide-disulfide oxidoreductase/NAD(P)-binding Rossmann-like domain/L-lysine 6-monooxygenase (NADPH-requiring), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flavin-binding monooxygenase-like, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTA1_LEIDO

TriTrypDb:

LdBPK_150100.1 , LdCL_150005900 , LDHU3_15.0130

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTA1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004497	monooxygenase activity	3	11
GO:0004499	N,N-dimethylaniline monooxygenase activity	5	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	11
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0050661	NADP binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.329
CLV_C14_Caspase3-7	408	412	PF00656	0.696
CLV_NRD_NRD_1	296	298	PF00675	0.514
CLV_NRD_NRD_1	333	335	PF00675	0.538
CLV_NRD_NRD_1	377	379	PF00675	0.356
CLV_NRD_NRD_1	387	389	PF00675	0.378
CLV_NRD_NRD_1	552	554	PF00675	0.489
CLV_PCSK_KEX2_1	190	192	PF00082	0.248
CLV_PCSK_KEX2_1	209	211	PF00082	0.248
CLV_PCSK_KEX2_1	333	335	PF00082	0.565
CLV_PCSK_KEX2_1	377	379	PF00082	0.356
CLV_PCSK_KEX2_1	387	389	PF00082	0.378
CLV_PCSK_KEX2_1	552	554	PF00082	0.489
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.248
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.248
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.489
CLV_PCSK_SKI1_1	104	108	PF00082	0.320
CLV_PCSK_SKI1_1	387	391	PF00082	0.377
CLV_PCSK_SKI1_1	443	447	PF00082	0.332
CLV_PCSK_SKI1_1	45	49	PF00082	0.320
CLV_PCSK_SKI1_1	531	535	PF00082	0.473
CLV_PCSK_SKI1_1	62	66	PF00082	0.162
DEG_Nend_UBRbox_3	1	3	PF02207	0.404
DEG_SPOP_SBC_1	405	409	PF00917	0.600
DOC_CYCLIN_RxL_1	525	537	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	445	448	PF00134	0.319
DOC_MAPK_DCC_7	306	315	PF00069	0.530
DOC_MAPK_DCC_7	443	452	PF00069	0.351
DOC_MAPK_gen_1	123	132	PF00069	0.363
DOC_MAPK_gen_1	189	195	PF00069	0.245
DOC_MAPK_gen_1	301	309	PF00069	0.549
DOC_MAPK_gen_1	344	352	PF00069	0.520
DOC_MAPK_gen_1	552	560	PF00069	0.485
DOC_MAPK_MEF2A_6	123	132	PF00069	0.359
DOC_MAPK_MEF2A_6	306	315	PF00069	0.528
DOC_MAPK_MEF2A_6	443	452	PF00069	0.351
DOC_PP1_RVXF_1	320	327	PF00149	0.401
DOC_PP2B_LxvP_1	445	448	PF13499	0.333
DOC_PP4_FxxP_1	381	384	PF00568	0.459
DOC_USP7_MATH_1	222	226	PF00917	0.661
DOC_USP7_MATH_1	236	240	PF00917	0.706
DOC_USP7_MATH_1	328	332	PF00917	0.577
DOC_USP7_MATH_1	355	359	PF00917	0.538
DOC_USP7_MATH_1	417	421	PF00917	0.659
DOC_USP7_MATH_1	432	436	PF00917	0.317
DOC_WW_Pin1_4	401	406	PF00397	0.579
DOC_WW_Pin1_4	52	57	PF00397	0.256
LIG_14-3-3_CanoR_1	333	340	PF00244	0.562
LIG_BIR_III_4	411	415	PF00653	0.580
LIG_BRCT_BRCA1_1	114	118	PF00533	0.355
LIG_BRCT_BRCA1_1	402	406	PF00533	0.487
LIG_deltaCOP1_diTrp_1	139	142	PF00928	0.248
LIG_FHA_1	150	156	PF00498	0.381
LIG_FHA_1	239	245	PF00498	0.542
LIG_FHA_1	257	263	PF00498	0.615
LIG_FHA_1	334	340	PF00498	0.563
LIG_FHA_1	521	527	PF00498	0.422
LIG_FHA_2	109	115	PF00498	0.327
LIG_FHA_2	26	32	PF00498	0.248
LIG_FHA_2	303	309	PF00498	0.561
LIG_FHA_2	406	412	PF00498	0.686
LIG_LIR_Gen_1	115	124	PF02991	0.374
LIG_LIR_Gen_1	139	147	PF02991	0.264
LIG_LIR_Gen_1	214	224	PF02991	0.313
LIG_LIR_Nem_3	115	121	PF02991	0.279
LIG_LIR_Nem_3	122	128	PF02991	0.252
LIG_LIR_Nem_3	139	145	PF02991	0.256
LIG_LIR_Nem_3	183	187	PF02991	0.267
LIG_LIR_Nem_3	214	219	PF02991	0.426
LIG_LIR_Nem_3	503	509	PF02991	0.315
LIG_LYPXL_S_1	57	61	PF13949	0.381
LIG_LYPXL_yS_3	379	382	PF13949	0.350
LIG_LYPXL_yS_3	58	61	PF13949	0.381
LIG_MYND_1	380	384	PF01753	0.446
LIG_PCNA_yPIPBox_3	156	169	PF02747	0.236
LIG_PCNA_yPIPBox_3	485	494	PF02747	0.416
LIG_Rb_LxCxE_1	428	444	PF01857	0.311
LIG_SH2_CRK	216	220	PF00017	0.396
LIG_SH2_GRB2like	506	509	PF00017	0.304
LIG_SH2_NCK_1	79	83	PF00017	0.327
LIG_SH2_STAP1	202	206	PF00017	0.381
LIG_SH2_STAP1	522	526	PF00017	0.475
LIG_SH2_STAT3	93	96	PF00017	0.287
LIG_SH2_STAT3	97	100	PF00017	0.296
LIG_SH2_STAT5	168	171	PF00017	0.259
LIG_SH2_STAT5	204	207	PF00017	0.267
LIG_SH2_STAT5	425	428	PF00017	0.281
LIG_SH2_STAT5	506	509	PF00017	0.304
LIG_SH2_STAT5	522	525	PF00017	0.403
LIG_SH2_STAT5	93	96	PF00017	0.220
LIG_SH3_3	152	158	PF00018	0.267
LIG_SH3_3	246	252	PF00018	0.567
LIG_SH3_3	310	316	PF00018	0.441
LIG_SH3_3	53	59	PF00018	0.280
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.424
LIG_SUMO_SIM_anti_2	435	440	PF11976	0.391
LIG_TRFH_1	30	34	PF08558	0.362
LIG_WRC_WIRS_1	184	189	PF05994	0.269
MOD_CK1_1	225	231	PF00069	0.632
MOD_CK1_1	238	244	PF00069	0.637
MOD_CK1_1	399	405	PF00069	0.702
MOD_CK1_1	407	413	PF00069	0.657
MOD_CK1_1	518	524	PF00069	0.474
MOD_CK2_1	108	114	PF00069	0.327
MOD_CK2_1	302	308	PF00069	0.510
MOD_GlcNHglycan	114	117	PF01048	0.400
MOD_GlcNHglycan	133	136	PF01048	0.145
MOD_GlcNHglycan	199	202	PF01048	0.327
MOD_GlcNHglycan	22	25	PF01048	0.280
MOD_GlcNHglycan	225	228	PF01048	0.672
MOD_GlcNHglycan	353	356	PF01048	0.695
MOD_GlcNHglycan	357	360	PF01048	0.448
MOD_GlcNHglycan	494	497	PF01048	0.409
MOD_GlcNHglycan	502	505	PF01048	0.304
MOD_GSK3_1	104	111	PF00069	0.259
MOD_GSK3_1	222	229	PF00069	0.610
MOD_GSK3_1	256	263	PF00069	0.658
MOD_GSK3_1	328	335	PF00069	0.539
MOD_GSK3_1	351	358	PF00069	0.698
MOD_GSK3_1	395	402	PF00069	0.623
MOD_GSK3_1	514	521	PF00069	0.546
MOD_N-GLC_1	400	405	PF02516	0.659
MOD_NEK2_1	14	19	PF00069	0.270
MOD_NEK2_1	20	25	PF00069	0.235
MOD_NEK2_1	235	240	PF00069	0.529
MOD_NEK2_1	350	355	PF00069	0.629
MOD_NEK2_1	395	400	PF00069	0.603
MOD_NEK2_1	514	519	PF00069	0.543
MOD_NEK2_1	533	538	PF00069	0.305
MOD_NEK2_1	558	563	PF00069	0.569
MOD_PIKK_1	149	155	PF00454	0.327
MOD_PIKK_1	461	467	PF00454	0.447
MOD_PK_1	117	123	PF00069	0.244
MOD_PK_1	126	132	PF00069	0.336
MOD_PKA_1	333	339	PF00069	0.534
MOD_PKA_2	20	26	PF00069	0.267
MOD_PKA_2	302	308	PF00069	0.522
MOD_PKA_2	332	338	PF00069	0.614
MOD_PKA_2	518	524	PF00069	0.474
MOD_Plk_1	138	144	PF00069	0.327
MOD_Plk_4	15	21	PF00069	0.313
MOD_Plk_4	425	431	PF00069	0.279
MOD_Plk_4	534	540	PF00069	0.475
MOD_ProDKin_1	401	407	PF00069	0.582
MOD_ProDKin_1	52	58	PF00069	0.256
MOD_SUMO_rev_2	203	211	PF00179	0.381
TRG_DiLeu_BaEn_1	391	396	PF01217	0.545
TRG_ENDOCYTIC_2	216	219	PF00928	0.441
TRG_ENDOCYTIC_2	379	382	PF00928	0.362
TRG_ENDOCYTIC_2	506	509	PF00928	0.376
TRG_ENDOCYTIC_2	58	61	PF00928	0.327
TRG_ER_diArg_1	332	334	PF00400	0.701
TRG_ER_diArg_1	377	379	PF00400	0.355
TRG_ER_diArg_1	386	388	PF00400	0.373
TRG_NES_CRM1_1	122	136	PF08389	0.274
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM8	Leptomonas seymouri	69%	99%
A0A0S4KJK2	Bodo saltans	42%	93%
A0A1X0NTN1	Trypanosomatidae	51%	100%
A4H7Y0	Leishmania braziliensis	86%	100%
A4HWA7	Leishmania infantum	99%	100%
C9ZNU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	90%
E9AQ07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O60774	Homo sapiens	23%	100%
P17635	Oryctolagus cuniculus	24%	100%
P17636	Oryctolagus cuniculus	24%	100%
P31513	Homo sapiens	25%	100%
P32417	Oryctolagus cuniculus	24%	100%
P36366	Cavia porcellus	23%	100%
P36367	Oryctolagus cuniculus	24%	100%
P49326	Homo sapiens	24%	100%
P97501	Mus musculus	23%	100%
P97872	Mus musculus	23%	100%
Q01740	Homo sapiens	23%	100%
Q28505	Macaca mulatta	23%	100%
Q4QFH4	Leishmania major	94%	100%
Q5REK0	Pongo abelii	24%	100%
Q6IRI9	Rattus norvegicus	24%	100%
Q7YS44	Pan troglodytes	25%	100%
Q8HYJ9	Bos taurus	22%	100%
Q8HZ69	Gorilla gorilla gorilla	24%	100%
Q8HZ70	Pan troglodytes	24%	100%
Q8K2I3	Mus musculus	23%	100%
Q8K4C0	Rattus norvegicus	23%	100%
Q8SPQ7	Macaca mulatta	25%	100%
Q94K43	Arabidopsis thaliana	24%	100%
Q95LA1	Canis lupus familiaris	26%	100%
Q99518	Homo sapiens	24%	100%
Q9EQ76	Rattus norvegicus	25%	100%
Q9FWW9	Arabidopsis thaliana	25%	100%
V5BBZ3	Trypanosoma cruzi	51%	100%