Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WT76_LEIDO

TriTrypDb:

LdBPK_141490.1 , LdCL_140020700 , LDHU3_14.1850

Length:

148

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7WT76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.406
CLV_PCSK_KEX2_1	3	5	PF00082	0.406
CLV_PCSK_SKI1_1	3	7	PF00082	0.401
CLV_PCSK_SKI1_1	47	51	PF00082	0.401
DEG_Nend_Nbox_1	1	3	PF02207	0.606
DEG_ODPH_VHL_1	133	145	PF01847	0.330
DOC_MAPK_gen_1	3	9	PF00069	0.682
DOC_USP7_MATH_1	74	78	PF00917	0.549
LIG_14-3-3_CanoR_1	3	8	PF00244	0.662
LIG_14-3-3_CanoR_1	56	63	PF00244	0.593
LIG_FHA_1	4	10	PF00498	0.651
LIG_FHA_1	76	82	PF00498	0.525
LIG_FHA_2	28	34	PF00498	0.586
LIG_LIR_Gen_1	31	42	PF02991	0.640
LIG_LIR_Nem_3	31	37	PF02991	0.648
LIG_Pex14_1	97	101	PF04695	0.268
LIG_Pex14_2	119	123	PF04695	0.268
LIG_Pex14_2	67	71	PF04695	0.542
LIG_Pex14_2	93	97	PF04695	0.434
LIG_SH2_CRK	101	105	PF00017	0.311
LIG_SH3_3	2	8	PF00018	0.676
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.526
LIG_SUMO_SIM_par_1	87	94	PF11976	0.402
LIG_TYR_ITIM	120	125	PF00017	0.346
MOD_CK1_1	54	60	PF00069	0.686
MOD_CK1_1	77	83	PF00069	0.532
MOD_GlcNHglycan	11	14	PF01048	0.459
MOD_GlcNHglycan	110	113	PF01048	0.599
MOD_GlcNHglycan	15	18	PF01048	0.425
MOD_GlcNHglycan	58	61	PF01048	0.402
MOD_GlcNHglycan	86	89	PF01048	0.268
MOD_GSK3_1	23	30	PF00069	0.717
MOD_GSK3_1	9	16	PF00069	0.651
MOD_PKA_1	3	9	PF00069	0.682
MOD_PKA_2	3	9	PF00069	0.700
MOD_Plk_1	74	80	PF00069	0.538
MOD_Plk_4	133	139	PF00069	0.363
MOD_Plk_4	77	83	PF00069	0.513
TRG_ENDOCYTIC_2	101	104	PF00928	0.286
TRG_ENDOCYTIC_2	122	125	PF00928	0.311
TRG_ER_diArg_1	2	4	PF00400	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B8	Leptomonas seymouri	78%	100%
A0A1X0NP05	Trypanosomatidae	61%	97%
A0A3R7KDD1	Trypanosoma rangeli	55%	98%
A4H7W0	Leishmania braziliensis	92%	100%
A4HW86	Leishmania infantum	100%	100%
C9ZSS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9APY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFJ4	Leishmania major	96%	100%
V5BG05	Trypanosoma cruzi	58%	98%