NADP oxidoreductase coenzyme F420-dependent, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADP oxidoreductase coenzyme F420-dependent, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WT63_LEIDO

TriTrypDb:

LdBPK_141360.1 , LdCL_140019500 , LDHU3_14.1700

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WT63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT63

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006520	amino acid metabolic process	3	7
GO:0006560	proline metabolic process	6	7
GO:0006561	proline biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008652	amino acid biosynthetic process	4	7
GO:0009058	biosynthetic process	2	7
GO:0009064	glutamine family amino acid metabolic process	5	7
GO:0009084	glutamine family amino acid biosynthetic process	6	7
GO:0009987	cellular process	1	7
GO:0016053	organic acid biosynthetic process	4	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044283	small molecule biosynthetic process	3	7
GO:0046394	carboxylic acid biosynthetic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1901605	alpha-amino acid metabolic process	4	7
GO:1901607	alpha-amino acid biosynthetic process	5	7
GO:0018130	heterocycle biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055129	L-proline biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004735	pyrroline-5-carboxylate reductase activity	5	7
GO:0016491	oxidoreductase activity	2	7
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	7
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	531	535	PF00656	0.551
CLV_NRD_NRD_1	259	261	PF00675	0.447
CLV_NRD_NRD_1	463	465	PF00675	0.662
CLV_PCSK_FUR_1	461	465	PF00082	0.566
CLV_PCSK_KEX2_1	461	463	PF00082	0.660
CLV_PCSK_KEX2_1	487	489	PF00082	0.647
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.647
CLV_PCSK_SKI1_1	204	208	PF00082	0.329
CLV_PCSK_SKI1_1	384	388	PF00082	0.582
CLV_PCSK_SKI1_1	432	436	PF00082	0.571
CLV_PCSK_SKI1_1	52	56	PF00082	0.459
CLV_PCSK_SKI1_1	570	574	PF00082	0.550
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DEG_ODPH_VHL_1	98	110	PF01847	0.443
DEG_SPOP_SBC_1	482	486	PF00917	0.618
DOC_CKS1_1	274	279	PF01111	0.543
DOC_CKS1_1	80	85	PF01111	0.645
DOC_CYCLIN_RxL_1	49	59	PF00134	0.452
DOC_CYCLIN_RxL_1	567	577	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	501	507	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.595
DOC_MAPK_FxFP_2	89	92	PF00069	0.535
DOC_MAPK_gen_1	163	172	PF00069	0.495
DOC_PP1_RVXF_1	512	518	PF00149	0.579
DOC_PP4_FxxP_1	363	366	PF00568	0.634
DOC_PP4_FxxP_1	89	92	PF00568	0.600
DOC_USP7_MATH_1	100	104	PF00917	0.521
DOC_USP7_MATH_1	218	222	PF00917	0.587
DOC_USP7_MATH_1	227	231	PF00917	0.594
DOC_USP7_MATH_1	289	293	PF00917	0.598
DOC_USP7_MATH_1	302	306	PF00917	0.709
DOC_USP7_MATH_1	320	324	PF00917	0.571
DOC_USP7_MATH_1	348	352	PF00917	0.636
DOC_USP7_MATH_1	372	376	PF00917	0.619
DOC_USP7_MATH_1	38	42	PF00917	0.508
DOC_USP7_MATH_1	386	390	PF00917	0.495
DOC_USP7_MATH_1	452	456	PF00917	0.636
DOC_USP7_UBL2_3	435	439	PF12436	0.440
DOC_USP7_UBL2_3	487	491	PF12436	0.563
DOC_WW_Pin1_4	228	233	PF00397	0.647
DOC_WW_Pin1_4	238	243	PF00397	0.416
DOC_WW_Pin1_4	273	278	PF00397	0.547
DOC_WW_Pin1_4	305	310	PF00397	0.636
DOC_WW_Pin1_4	79	84	PF00397	0.592
DOC_WW_Pin1_4	90	95	PF00397	0.622
LIG_14-3-3_CanoR_1	416	422	PF00244	0.708
LIG_14-3-3_CanoR_1	488	494	PF00244	0.661
LIG_14-3-3_CanoR_1	553	561	PF00244	0.581
LIG_14-3-3_CanoR_1	72	80	PF00244	0.554
LIG_Actin_WH2_2	547	564	PF00022	0.580
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.537
LIG_BIR_III_2	534	538	PF00653	0.607
LIG_BRCT_BRCA1_1	282	286	PF00533	0.591
LIG_BRCT_BRCA1_1	359	363	PF00533	0.542
LIG_eIF4E_1	2	8	PF01652	0.540
LIG_eIF4E_1	349	355	PF01652	0.453
LIG_EVH1_2	85	89	PF00568	0.519
LIG_FHA_1	239	245	PF00498	0.513
LIG_FHA_1	27	33	PF00498	0.563
LIG_FHA_1	274	280	PF00498	0.551
LIG_FHA_1	359	365	PF00498	0.636
LIG_FHA_1	511	517	PF00498	0.579
LIG_FHA_2	113	119	PF00498	0.376
LIG_FHA_2	141	147	PF00498	0.478
LIG_FHA_2	320	326	PF00498	0.606
LIG_FHA_2	34	40	PF00498	0.496
LIG_FHA_2	421	427	PF00498	0.712
LIG_FHA_2	439	445	PF00498	0.389
LIG_FHA_2	73	79	PF00498	0.500
LIG_HCF-1_HBM_1	39	42	PF13415	0.483
LIG_LIR_Apic_2	360	366	PF02991	0.627
LIG_LIR_Gen_1	39	50	PF02991	0.419
LIG_LIR_Gen_1	426	434	PF02991	0.509
LIG_LIR_Gen_1	59	70	PF02991	0.506
LIG_LIR_Nem_3	39	45	PF02991	0.410
LIG_LIR_Nem_3	426	430	PF02991	0.510
LIG_LIR_Nem_3	471	476	PF02991	0.626
LIG_LIR_Nem_3	566	572	PF02991	0.490
LIG_LIR_Nem_3	59	65	PF02991	0.502
LIG_MYND_1	537	541	PF01753	0.615
LIG_MYND_1	96	100	PF01753	0.591
LIG_SH2_CRK	34	38	PF00017	0.497
LIG_SH2_CRK	42	46	PF00017	0.413
LIG_SH2_CRK	473	477	PF00017	0.634
LIG_SH2_NCK_1	555	559	PF00017	0.587
LIG_SH2_STAP1	2	6	PF00017	0.585
LIG_SH2_STAP1	555	559	PF00017	0.587
LIG_SH2_STAT5	2	5	PF00017	0.553
LIG_SH2_STAT5	42	45	PF00017	0.414
LIG_SH2_STAT5	427	430	PF00017	0.568
LIG_SH2_STAT5	437	440	PF00017	0.459
LIG_SH2_STAT5	46	49	PF00017	0.419
LIG_SH2_STAT5	555	558	PF00017	0.705
LIG_SH3_3	229	235	PF00018	0.797
LIG_SH3_3	303	309	PF00018	0.688
LIG_SH3_3	310	316	PF00018	0.589
LIG_SH3_3	389	395	PF00018	0.672
LIG_SH3_3	476	482	PF00018	0.596
LIG_SH3_3	534	540	PF00018	0.624
LIG_SH3_3	80	86	PF00018	0.581
LIG_SH3_3	91	97	PF00018	0.770
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.475
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.475
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.530
LIG_SUMO_SIM_par_1	187	193	PF11976	0.434
LIG_TRAF2_1	322	325	PF00917	0.559
LIG_TRAF2_1	329	332	PF00917	0.649
LIG_TRAF2_1	334	337	PF00917	0.584
LIG_TYR_ITIM	32	37	PF00017	0.522
LIG_WW_2	313	316	PF00397	0.649
LIG_WW_2	392	395	PF00397	0.618
LIG_WW_2	537	540	PF00397	0.618
LIG_WW_3	405	409	PF00397	0.677
MOD_CDC14_SPxK_1	308	311	PF00782	0.613
MOD_CDK_SPxK_1	305	311	PF00069	0.637
MOD_CDK_SPxxK_3	238	245	PF00069	0.526
MOD_CK1_1	152	158	PF00069	0.492
MOD_CK1_1	16	22	PF00069	0.575
MOD_CK1_1	211	217	PF00069	0.609
MOD_CK1_1	230	236	PF00069	0.606
MOD_CK1_1	278	284	PF00069	0.636
MOD_CK1_1	305	311	PF00069	0.629
MOD_CK1_1	359	365	PF00069	0.737
MOD_CK1_1	375	381	PF00069	0.555
MOD_CK1_1	557	563	PF00069	0.479
MOD_CK2_1	112	118	PF00069	0.372
MOD_CK2_1	319	325	PF00069	0.665
MOD_CK2_1	326	332	PF00069	0.624
MOD_CK2_1	33	39	PF00069	0.500
MOD_CK2_1	420	426	PF00069	0.716
MOD_CK2_1	438	444	PF00069	0.459
MOD_CK2_1	72	78	PF00069	0.499
MOD_CMANNOS	517	520	PF00535	0.521
MOD_GlcNHglycan	15	18	PF01048	0.574
MOD_GlcNHglycan	208	211	PF01048	0.438
MOD_GlcNHglycan	216	219	PF01048	0.547
MOD_GlcNHglycan	236	239	PF01048	0.677
MOD_GlcNHglycan	350	353	PF01048	0.653
MOD_GlcNHglycan	374	377	PF01048	0.621
MOD_GlcNHglycan	454	457	PF01048	0.616
MOD_GlcNHglycan	523	526	PF01048	0.613
MOD_GlcNHglycan	556	559	PF01048	0.598
MOD_GSK3_1	19	26	PF00069	0.523
MOD_GSK3_1	214	221	PF00069	0.634
MOD_GSK3_1	230	237	PF00069	0.623
MOD_GSK3_1	298	305	PF00069	0.736
MOD_GSK3_1	416	423	PF00069	0.732
MOD_GSK3_1	553	560	PF00069	0.505
MOD_GSK3_1	72	79	PF00069	0.592
MOD_NEK2_1	106	111	PF00069	0.393
MOD_NEK2_1	139	144	PF00069	0.598
MOD_NEK2_1	206	211	PF00069	0.529
MOD_NEK2_1	243	248	PF00069	0.471
MOD_NEK2_1	266	271	PF00069	0.539
MOD_NEK2_1	357	362	PF00069	0.538
MOD_NEK2_1	8	13	PF00069	0.484
MOD_NEK2_2	302	307	PF00069	0.557
MOD_PIKK_1	218	224	PF00454	0.690
MOD_PIKK_1	320	326	PF00454	0.617
MOD_PKA_2	407	413	PF00069	0.672
MOD_PKA_2	452	458	PF00069	0.713
MOD_Plk_1	19	25	PF00069	0.577
MOD_Plk_1	326	332	PF00069	0.620
MOD_Plk_1	38	44	PF00069	0.420
MOD_Plk_2-3	331	337	PF00069	0.589
MOD_Plk_4	106	112	PF00069	0.388
MOD_Plk_4	302	308	PF00069	0.656
MOD_Plk_4	359	365	PF00069	0.622
MOD_Plk_4	475	481	PF00069	0.673
MOD_Plk_4	8	14	PF00069	0.510
MOD_ProDKin_1	228	234	PF00069	0.644
MOD_ProDKin_1	238	244	PF00069	0.399
MOD_ProDKin_1	273	279	PF00069	0.547
MOD_ProDKin_1	305	311	PF00069	0.637
MOD_ProDKin_1	79	85	PF00069	0.591
MOD_ProDKin_1	90	96	PF00069	0.621
TRG_DiLeu_BaEn_4	444	450	PF01217	0.587
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.380
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.471
TRG_ENDOCYTIC_2	167	170	PF00928	0.529
TRG_ENDOCYTIC_2	34	37	PF00928	0.430
TRG_ENDOCYTIC_2	42	45	PF00928	0.487
TRG_ENDOCYTIC_2	427	430	PF00928	0.585
TRG_ENDOCYTIC_2	473	476	PF00928	0.634
TRG_ER_diArg_1	461	464	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F8	Leptomonas seymouri	40%	100%
A4H7U8	Leishmania braziliensis	70%	98%
A4HW74	Leishmania infantum	100%	100%
E9APX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QFK6	Leishmania major	90%	100%