Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WT61_LEIDO

TriTrypDb:

LdBPK_141200.1 , LdCL_140017900 , LDHU3_14.1530

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7WT61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT61

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.542
CLV_C14_Caspase3-7	59	63	PF00656	0.574
CLV_C14_Caspase3-7	683	687	PF00656	0.683
CLV_C14_Caspase3-7	880	884	PF00656	0.605
CLV_NRD_NRD_1	220	222	PF00675	0.548
CLV_NRD_NRD_1	261	263	PF00675	0.478
CLV_NRD_NRD_1	436	438	PF00675	0.585
CLV_NRD_NRD_1	517	519	PF00675	0.536
CLV_NRD_NRD_1	6	8	PF00675	0.481
CLV_NRD_NRD_1	734	736	PF00675	0.752
CLV_PCSK_KEX2_1	260	262	PF00082	0.513
CLV_PCSK_KEX2_1	517	519	PF00082	0.530
CLV_PCSK_KEX2_1	6	8	PF00082	0.477
CLV_PCSK_KEX2_1	734	736	PF00082	0.679
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.477
CLV_PCSK_SKI1_1	17	21	PF00082	0.473
CLV_PCSK_SKI1_1	229	233	PF00082	0.601
CLV_PCSK_SKI1_1	262	266	PF00082	0.464
CLV_PCSK_SKI1_1	369	373	PF00082	0.626
CLV_PCSK_SKI1_1	413	417	PF00082	0.495
CLV_PCSK_SKI1_1	517	521	PF00082	0.476
CLV_PCSK_SKI1_1	638	642	PF00082	0.523
DEG_APCC_DBOX_1	6	14	PF00400	0.477
DEG_Nend_UBRbox_2	1	3	PF02207	0.520
DEG_SCF_FBW7_1	824	830	PF00400	0.421
DEG_SPOP_SBC_1	39	43	PF00917	0.669
DEG_SPOP_SBC_1	404	408	PF00917	0.537
DEG_SPOP_SBC_1	655	659	PF00917	0.549
DOC_CKS1_1	119	124	PF01111	0.681
DOC_CKS1_1	129	134	PF01111	0.605
DOC_CKS1_1	824	829	PF01111	0.422
DOC_CYCLIN_yCln2_LP_2	484	490	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	534	537	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	700	706	PF00134	0.617
DOC_MAPK_gen_1	413	423	PF00069	0.407
DOC_MAPK_gen_1	745	753	PF00069	0.515
DOC_MAPK_MEF2A_6	416	423	PF00069	0.414
DOC_PP1_RVXF_1	499	506	PF00149	0.370
DOC_PP2B_LxvP_1	52	55	PF13499	0.649
DOC_PP2B_LxvP_1	533	536	PF13499	0.452
DOC_PP2B_LxvP_1	77	80	PF13499	0.555
DOC_PP4_FxxP_1	426	429	PF00568	0.408
DOC_PP4_FxxP_1	545	548	PF00568	0.477
DOC_USP7_MATH_1	105	109	PF00917	0.693
DOC_USP7_MATH_1	113	117	PF00917	0.621
DOC_USP7_MATH_1	196	200	PF00917	0.585
DOC_USP7_MATH_1	302	306	PF00917	0.504
DOC_USP7_MATH_1	39	43	PF00917	0.618
DOC_USP7_MATH_1	392	396	PF00917	0.618
DOC_USP7_MATH_1	398	402	PF00917	0.580
DOC_USP7_MATH_1	540	544	PF00917	0.439
DOC_USP7_MATH_1	56	60	PF00917	0.612
DOC_USP7_MATH_1	589	593	PF00917	0.390
DOC_USP7_MATH_1	655	659	PF00917	0.560
DOC_USP7_MATH_1	677	681	PF00917	0.682
DOC_USP7_MATH_1	690	694	PF00917	0.610
DOC_USP7_MATH_1	706	710	PF00917	0.663
DOC_USP7_MATH_1	712	716	PF00917	0.564
DOC_USP7_MATH_1	792	796	PF00917	0.386
DOC_USP7_MATH_1	80	84	PF00917	0.636
DOC_USP7_MATH_1	854	858	PF00917	0.580
DOC_USP7_MATH_1	903	907	PF00917	0.464
DOC_USP7_MATH_2	785	791	PF00917	0.419
DOC_WW_Pin1_4	109	114	PF00397	0.618
DOC_WW_Pin1_4	115	120	PF00397	0.632
DOC_WW_Pin1_4	128	133	PF00397	0.554
DOC_WW_Pin1_4	176	181	PF00397	0.633
DOC_WW_Pin1_4	288	293	PF00397	0.549
DOC_WW_Pin1_4	305	310	PF00397	0.518
DOC_WW_Pin1_4	348	353	PF00397	0.557
DOC_WW_Pin1_4	35	40	PF00397	0.663
DOC_WW_Pin1_4	415	420	PF00397	0.432
DOC_WW_Pin1_4	461	466	PF00397	0.486
DOC_WW_Pin1_4	544	549	PF00397	0.462
DOC_WW_Pin1_4	69	74	PF00397	0.623
DOC_WW_Pin1_4	721	726	PF00397	0.762
DOC_WW_Pin1_4	796	801	PF00397	0.390
DOC_WW_Pin1_4	823	828	PF00397	0.422
LIG_14-3-3_CanoR_1	134	138	PF00244	0.646
LIG_14-3-3_CanoR_1	338	348	PF00244	0.685
LIG_14-3-3_CanoR_1	382	388	PF00244	0.567
LIG_14-3-3_CanoR_1	47	51	PF00244	0.626
LIG_14-3-3_CanoR_1	539	548	PF00244	0.458
LIG_14-3-3_CanoR_1	747	752	PF00244	0.401
LIG_14-3-3_CanoR_1	89	93	PF00244	0.666
LIG_APCC_ABBA_1	558	563	PF00400	0.387
LIG_APCC_ABBAyCdc20_2	557	563	PF00400	0.388
LIG_BIR_III_4	230	234	PF00653	0.596
LIG_BIR_III_4	810	814	PF00653	0.465
LIG_BRCT_BRCA1_1	904	908	PF00533	0.375
LIG_deltaCOP1_diTrp_1	912	917	PF00928	0.403
LIG_FHA_1	230	236	PF00498	0.567
LIG_FHA_1	266	272	PF00498	0.468
LIG_FHA_1	47	53	PF00498	0.584
LIG_FHA_1	479	485	PF00498	0.373
LIG_FHA_1	528	534	PF00498	0.466
LIG_FHA_1	661	667	PF00498	0.537
LIG_FHA_1	695	701	PF00498	0.666
LIG_FHA_1	755	761	PF00498	0.501
LIG_FHA_1	820	826	PF00498	0.480
LIG_FHA_1	828	834	PF00498	0.378
LIG_FHA_1	925	931	PF00498	0.490
LIG_FHA_2	404	410	PF00498	0.575
LIG_FHA_2	461	467	PF00498	0.517
LIG_LIR_Apic_2	543	548	PF02991	0.457
LIG_LIR_Apic_2	644	650	PF02991	0.417
LIG_LIR_Nem_3	595	599	PF02991	0.403
LIG_MLH1_MIPbox_1	905	909	PF16413	0.376
LIG_PCNA_yPIPBox_3	14	28	PF02747	0.485
LIG_PDZ_Class_1	930	935	PF00595	0.470
LIG_REV1ctd_RIR_1	906	915	PF16727	0.380
LIG_RPA_C_Fungi	730	742	PF08784	0.575
LIG_SH2_CRK	648	652	PF00017	0.444
LIG_SH2_STAT5	27	30	PF00017	0.592
LIG_SH2_STAT5	596	599	PF00017	0.414
LIG_SH2_STAT5	924	927	PF00017	0.444
LIG_SH3_1	126	132	PF00018	0.677
LIG_SH3_2	129	134	PF14604	0.672
LIG_SH3_3	116	122	PF00018	0.639
LIG_SH3_3	126	132	PF00018	0.586
LIG_SH3_3	233	239	PF00018	0.527
LIG_SH3_3	425	431	PF00018	0.437
LIG_SH3_3	484	490	PF00018	0.575
LIG_SH3_3	534	540	PF00018	0.452
LIG_SH3_3	583	589	PF00018	0.408
LIG_SUMO_SIM_anti_2	466	472	PF11976	0.424
LIG_SUMO_SIM_par_1	662	667	PF11976	0.541
LIG_SUMO_SIM_par_1	826	832	PF11976	0.424
LIG_TRAF2_1	206	209	PF00917	0.643
LIG_TRAF2_2	138	143	PF00917	0.584
LIG_TRFH_1	348	352	PF08558	0.536
LIG_TYR_ITIM	594	599	PF00017	0.405
LIG_WRC_WIRS_1	158	163	PF05994	0.557
LIG_WW_3	649	653	PF00397	0.474
MOD_CDC14_SPxK_1	799	802	PF00782	0.427
MOD_CDK_SPxK_1	128	134	PF00069	0.677
MOD_CDK_SPxK_1	796	802	PF00069	0.405
MOD_CK1_1	108	114	PF00069	0.636
MOD_CK1_1	118	124	PF00069	0.722
MOD_CK1_1	133	139	PF00069	0.587
MOD_CK1_1	176	182	PF00069	0.596
MOD_CK1_1	255	261	PF00069	0.524
MOD_CK1_1	29	35	PF00069	0.595
MOD_CK1_1	305	311	PF00069	0.606
MOD_CK1_1	321	327	PF00069	0.530
MOD_CK1_1	38	44	PF00069	0.600
MOD_CK1_1	46	52	PF00069	0.563
MOD_CK1_1	478	484	PF00069	0.370
MOD_CK1_1	544	550	PF00069	0.454
MOD_CK1_1	592	598	PF00069	0.414
MOD_CK1_1	680	686	PF00069	0.675
MOD_CK1_1	72	78	PF00069	0.689
MOD_CK1_1	723	729	PF00069	0.708
MOD_CK1_1	768	774	PF00069	0.529
MOD_CK1_1	791	797	PF00069	0.390
MOD_CK1_1	823	829	PF00069	0.425
MOD_CK1_1	902	908	PF00069	0.350
MOD_CK1_1	91	97	PF00069	0.733
MOD_CK2_1	403	409	PF00069	0.581
MOD_CK2_1	460	466	PF00069	0.534
MOD_CK2_1	829	835	PF00069	0.419
MOD_CK2_1	890	896	PF00069	0.717
MOD_DYRK1A_RPxSP_1	128	132	PF00069	0.673
MOD_GlcNHglycan	107	110	PF01048	0.685
MOD_GlcNHglycan	115	118	PF01048	0.636
MOD_GlcNHglycan	135	138	PF01048	0.706
MOD_GlcNHglycan	166	169	PF01048	0.728
MOD_GlcNHglycan	175	178	PF01048	0.609
MOD_GlcNHglycan	191	194	PF01048	0.623
MOD_GlcNHglycan	226	229	PF01048	0.549
MOD_GlcNHglycan	28	31	PF01048	0.607
MOD_GlcNHglycan	341	344	PF01048	0.758
MOD_GlcNHglycan	394	397	PF01048	0.637
MOD_GlcNHglycan	400	403	PF01048	0.580
MOD_GlcNHglycan	409	412	PF01048	0.549
MOD_GlcNHglycan	457	460	PF01048	0.608
MOD_GlcNHglycan	58	61	PF01048	0.634
MOD_GlcNHglycan	62	65	PF01048	0.744
MOD_GlcNHglycan	628	631	PF01048	0.400
MOD_GlcNHglycan	669	672	PF01048	0.572
MOD_GlcNHglycan	707	711	PF01048	0.751
MOD_GlcNHglycan	713	717	PF01048	0.739
MOD_GlcNHglycan	74	77	PF01048	0.802
MOD_GlcNHglycan	767	770	PF01048	0.373
MOD_GlcNHglycan	790	793	PF01048	0.464
MOD_GlcNHglycan	810	814	PF01048	0.384
MOD_GlcNHglycan	84	87	PF01048	0.674
MOD_GlcNHglycan	901	904	PF01048	0.364
MOD_GSK3_1	105	112	PF00069	0.639
MOD_GSK3_1	113	120	PF00069	0.664
MOD_GSK3_1	185	192	PF00069	0.654
MOD_GSK3_1	252	259	PF00069	0.560
MOD_GSK3_1	26	33	PF00069	0.549
MOD_GSK3_1	305	312	PF00069	0.691
MOD_GSK3_1	348	355	PF00069	0.598
MOD_GSK3_1	35	42	PF00069	0.620
MOD_GSK3_1	357	364	PF00069	0.631
MOD_GSK3_1	394	401	PF00069	0.607
MOD_GSK3_1	403	410	PF00069	0.572
MOD_GSK3_1	455	462	PF00069	0.613
MOD_GSK3_1	475	482	PF00069	0.381
MOD_GSK3_1	523	530	PF00069	0.483
MOD_GSK3_1	540	547	PF00069	0.507
MOD_GSK3_1	56	63	PF00069	0.591
MOD_GSK3_1	577	584	PF00069	0.424
MOD_GSK3_1	614	621	PF00069	0.445
MOD_GSK3_1	64	71	PF00069	0.696
MOD_GSK3_1	656	663	PF00069	0.547
MOD_GSK3_1	690	697	PF00069	0.658
MOD_GSK3_1	717	724	PF00069	0.761
MOD_GSK3_1	787	794	PF00069	0.417
MOD_GSK3_1	809	816	PF00069	0.376
MOD_GSK3_1	819	826	PF00069	0.420
MOD_GSK3_1	88	95	PF00069	0.709
MOD_GSK3_1	899	906	PF00069	0.446
MOD_N-GLC_1	336	341	PF02516	0.621
MOD_N-GLC_1	459	464	PF02516	0.495
MOD_N-GLC_1	820	825	PF02516	0.397
MOD_N-GLC_1	842	847	PF02516	0.676
MOD_NEK2_1	189	194	PF00069	0.686
MOD_NEK2_1	224	229	PF00069	0.513
MOD_NEK2_1	265	270	PF00069	0.454
MOD_NEK2_1	45	50	PF00069	0.681
MOD_NEK2_1	494	499	PF00069	0.387
MOD_NEK2_1	524	529	PF00069	0.486
MOD_NEK2_1	624	629	PF00069	0.380
MOD_NEK2_1	664	669	PF00069	0.546
MOD_NEK2_1	779	784	PF00069	0.409
MOD_NEK2_1	90	95	PF00069	0.702
MOD_NEK2_1	916	921	PF00069	0.392
MOD_NEK2_1	930	935	PF00069	0.470
MOD_NEK2_2	562	567	PF00069	0.424
MOD_NEK2_2	903	908	PF00069	0.471
MOD_NEK2_2	924	929	PF00069	0.413
MOD_PIKK_1	136	142	PF00454	0.632
MOD_PIKK_1	234	240	PF00454	0.604
MOD_PIKK_1	357	363	PF00454	0.658
MOD_PIKK_1	570	576	PF00454	0.365
MOD_PIKK_1	581	587	PF00454	0.412
MOD_PKA_2	127	133	PF00069	0.727
MOD_PKA_2	224	230	PF00069	0.627
MOD_PKA_2	30	36	PF00069	0.668
MOD_PKA_2	383	389	PF00069	0.558
MOD_PKA_2	46	52	PF00069	0.540
MOD_PKA_2	88	94	PF00069	0.665
MOD_PKA_2	95	101	PF00069	0.609
MOD_PKB_1	745	753	PF00069	0.490
MOD_Plk_1	318	324	PF00069	0.697
MOD_Plk_1	478	484	PF00069	0.314
MOD_Plk_1	779	785	PF00069	0.491
MOD_Plk_1	820	826	PF00069	0.398
MOD_Plk_2-3	639	645	PF00069	0.419
MOD_Plk_4	185	191	PF00069	0.547
MOD_Plk_4	243	249	PF00069	0.521
MOD_Plk_4	290	296	PF00069	0.533
MOD_Plk_4	479	485	PF00069	0.383
MOD_Plk_4	489	495	PF00069	0.408
MOD_Plk_4	529	535	PF00069	0.454
MOD_Plk_4	592	598	PF00069	0.387
MOD_Plk_4	656	662	PF00069	0.547
MOD_Plk_4	813	819	PF00069	0.384
MOD_Plk_4	820	826	PF00069	0.440
MOD_Plk_4	903	909	PF00069	0.397
MOD_ProDKin_1	109	115	PF00069	0.619
MOD_ProDKin_1	118	124	PF00069	0.628
MOD_ProDKin_1	128	134	PF00069	0.672
MOD_ProDKin_1	176	182	PF00069	0.631
MOD_ProDKin_1	288	294	PF00069	0.544
MOD_ProDKin_1	305	311	PF00069	0.521
MOD_ProDKin_1	348	354	PF00069	0.558
MOD_ProDKin_1	35	41	PF00069	0.665
MOD_ProDKin_1	415	421	PF00069	0.424
MOD_ProDKin_1	461	467	PF00069	0.479
MOD_ProDKin_1	544	550	PF00069	0.452
MOD_ProDKin_1	69	75	PF00069	0.624
MOD_ProDKin_1	721	727	PF00069	0.759
MOD_ProDKin_1	796	802	PF00069	0.390
MOD_ProDKin_1	823	829	PF00069	0.420
MOD_SUMO_rev_2	571	578	PF00179	0.360
TRG_DiLeu_BaEn_1	417	422	PF01217	0.410
TRG_DiLeu_BaEn_1	479	484	PF01217	0.381
TRG_DiLeu_BaEn_1	515	520	PF01217	0.444
TRG_DiLeu_LyEn_5	515	520	PF01217	0.444
TRG_ENDOCYTIC_2	596	599	PF00928	0.417
TRG_ER_diArg_1	260	262	PF00400	0.511
TRG_ER_diArg_1	516	518	PF00400	0.543
TRG_ER_diArg_1	734	736	PF00400	0.679
TRG_ER_diArg_1	745	748	PF00400	0.387
TRG_ER_diArg_1	760	763	PF00400	0.400
TRG_ER_diArg_1	81	84	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHJ0	Leptomonas seymouri	57%	92%
A4H7R6	Leishmania braziliensis	76%	99%
A4HW59	Leishmania infantum	100%	100%
E9APV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QFM1	Leishmania major	91%	99%