Bifunctional NAD(P)H-hydrate repair enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bifunctional NAD(P)H-hydrate repair enzyme

Species:

Leishmania donovani

UniProt:

A0A3S7WT52_LEIDO

TriTrypDb:

LdBPK_141270.1 , LdCL_140018600 , LDHU3_14.1610

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WT52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT52

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006753	nucleoside phosphate metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009117	nucleotide metabolic process	5	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	2
GO:0019362	pyridine nucleotide metabolic process	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044281	small molecule metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046496	nicotinamide nucleotide metabolic process	6	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0072524	pyridine-containing compound metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0110051	metabolite repair	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016829	lyase activity	2	7
GO:0016835	carbon-oxygen lyase activity	3	7
GO:0016836	hydro-lyase activity	4	7
GO:0016853	isomerase activity	2	7
GO:0016854	racemase and epimerase activity	3	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0047453	ATP-dependent NAD(P)H-hydrate dehydratase activity	5	7
GO:0052855	ADP-dependent NAD(P)H-hydrate dehydratase activity	5	7
GO:0052856	NADHX epimerase activity	4	7
GO:0052857	NADPHX epimerase activity	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.348
CLV_NRD_NRD_1	245	247	PF00675	0.413
CLV_NRD_NRD_1	259	261	PF00675	0.490
CLV_NRD_NRD_1	441	443	PF00675	0.321
CLV_PCSK_KEX2_1	20	22	PF00082	0.377
CLV_PCSK_KEX2_1	245	247	PF00082	0.413
CLV_PCSK_KEX2_1	259	261	PF00082	0.490
CLV_PCSK_KEX2_1	441	443	PF00082	0.321
CLV_PCSK_SKI1_1	240	244	PF00082	0.540
CLV_PCSK_SKI1_1	246	250	PF00082	0.457
CLV_PCSK_SKI1_1	260	264	PF00082	0.340
CLV_PCSK_SKI1_1	271	275	PF00082	0.340
CLV_PCSK_SKI1_1	301	305	PF00082	0.321
CLV_PCSK_SKI1_1	94	98	PF00082	0.386
DEG_APCC_DBOX_1	245	253	PF00400	0.534
DEG_Kelch_Keap1_1	184	189	PF01344	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.720
DOC_CKS1_1	413	418	PF01111	0.521
DOC_CYCLIN_RxL_1	222	231	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.410
DOC_MAPK_gen_1	266	275	PF00069	0.329
DOC_PP2B_LxvP_1	134	137	PF13499	0.488
DOC_PP2B_LxvP_1	170	173	PF13499	0.386
DOC_PP2B_LxvP_1	99	102	PF13499	0.386
DOC_USP7_MATH_1	36	40	PF00917	0.465
DOC_USP7_MATH_2	108	114	PF00917	0.371
DOC_WW_Pin1_4	412	417	PF00397	0.521
DOC_WW_Pin1_4	547	552	PF00397	0.663
LIG_14-3-3_CanoR_1	21	29	PF00244	0.334
LIG_14-3-3_CanoR_1	4	11	PF00244	0.587
LIG_14-3-3_CanoR_1	532	540	PF00244	0.574
LIG_Actin_WH2_2	16	32	PF00022	0.450
LIG_BIR_III_2	31	35	PF00653	0.583
LIG_FHA_1	185	191	PF00498	0.274
LIG_FHA_1	298	304	PF00498	0.521
LIG_FHA_1	343	349	PF00498	0.493
LIG_FHA_1	361	367	PF00498	0.417
LIG_FHA_1	448	454	PF00498	0.521
LIG_FHA_1	466	472	PF00498	0.521
LIG_FHA_1	486	492	PF00498	0.521
LIG_FHA_1	526	532	PF00498	0.521
LIG_FHA_2	11	17	PF00498	0.533
LIG_FHA_2	232	238	PF00498	0.415
LIG_FHA_2	302	308	PF00498	0.521
LIG_FHA_2	320	326	PF00498	0.521
LIG_GBD_Chelix_1	11	19	PF00786	0.492
LIG_LIR_Apic_2	307	311	PF02991	0.521
LIG_LIR_Gen_1	158	167	PF02991	0.386
LIG_LIR_Gen_1	200	211	PF02991	0.386
LIG_LIR_Gen_1	250	258	PF02991	0.475
LIG_LIR_Gen_1	57	63	PF02991	0.386
LIG_LIR_Nem_3	158	163	PF02991	0.362
LIG_LIR_Nem_3	200	206	PF02991	0.386
LIG_LIR_Nem_3	250	256	PF02991	0.539
LIG_LIR_Nem_3	57	62	PF02991	0.334
LIG_MAD2	94	102	PF02301	0.371
LIG_NRBOX	486	492	PF00104	0.521
LIG_PCNA_yPIPBox_3	41	53	PF02747	0.350
LIG_SH2_CRK	224	228	PF00017	0.445
LIG_SH2_CRK	308	312	PF00017	0.495
LIG_SH2_SRC	160	163	PF00017	0.386
LIG_SH2_SRC	83	86	PF00017	0.386
LIG_SH2_STAP1	160	164	PF00017	0.386
LIG_SH2_STAT3	218	221	PF00017	0.450
LIG_SH2_STAT3	63	66	PF00017	0.342
LIG_SH2_STAT5	218	221	PF00017	0.450
LIG_SH2_STAT5	255	258	PF00017	0.551
LIG_SH2_STAT5	63	66	PF00017	0.393
LIG_SH2_STAT5	83	86	PF00017	0.246
LIG_SH3_1	404	410	PF00018	0.593
LIG_SH3_3	127	133	PF00018	0.383
LIG_SH3_3	404	410	PF00018	0.593
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.385
LIG_SUMO_SIM_par_1	374	380	PF11976	0.521
LIG_SUMO_SIM_par_1	69	75	PF11976	0.449
LIG_TYR_ITIM	222	227	PF00017	0.430
LIG_WW_3	154	158	PF00397	0.488
MOD_CDK_SPxxK_3	547	554	PF00069	0.675
MOD_CK1_1	10	16	PF00069	0.530
MOD_CK1_1	3	9	PF00069	0.685
MOD_CK1_1	412	418	PF00069	0.386
MOD_CK1_1	465	471	PF00069	0.488
MOD_CK1_1	547	553	PF00069	0.746
MOD_CK2_1	10	16	PF00069	0.544
MOD_CK2_1	231	237	PF00069	0.423
MOD_CK2_1	301	307	PF00069	0.386
MOD_CK2_1	319	325	PF00069	0.386
MOD_GlcNHglycan	112	115	PF01048	0.371
MOD_GlcNHglycan	180	183	PF01048	0.386
MOD_GlcNHglycan	24	27	PF01048	0.421
MOD_GlcNHglycan	260	263	PF01048	0.506
MOD_GlcNHglycan	287	290	PF01048	0.449
MOD_GlcNHglycan	464	467	PF01048	0.394
MOD_GlcNHglycan	479	482	PF01048	0.386
MOD_GlcNHglycan	546	549	PF01048	0.670
MOD_GlcNHglycan	557	560	PF01048	0.652
MOD_GlcNHglycan	74	77	PF01048	0.449
MOD_GSK3_1	297	304	PF00069	0.379
MOD_GSK3_1	3	10	PF00069	0.683
MOD_GSK3_1	319	326	PF00069	0.488
MOD_GSK3_1	461	468	PF00069	0.449
MOD_GSK3_1	499	506	PF00069	0.467
MOD_GSK3_1	550	557	PF00069	0.635
MOD_GSK3_1	57	64	PF00069	0.280
MOD_N-GLC_1	503	508	PF02516	0.274
MOD_N-GLC_1	544	549	PF02516	0.557
MOD_NEK2_1	147	152	PF00069	0.339
MOD_NEK2_1	447	452	PF00069	0.386
MOD_NEK2_1	499	504	PF00069	0.445
MOD_NEK2_1	62	67	PF00069	0.403
MOD_NEK2_1	72	77	PF00069	0.423
MOD_PIKK_1	36	42	PF00454	0.446
MOD_PIKK_1	62	68	PF00454	0.488
MOD_PKA_2	258	264	PF00069	0.561
MOD_PKA_2	3	9	PF00069	0.685
MOD_PKA_2	525	531	PF00069	0.386
MOD_Plk_1	124	130	PF00069	0.364
MOD_Plk_1	42	48	PF00069	0.428
MOD_Plk_4	199	205	PF00069	0.386
MOD_Plk_4	282	288	PF00069	0.313
MOD_Plk_4	409	415	PF00069	0.386
MOD_Plk_4	455	461	PF00069	0.386
MOD_Plk_4	94	100	PF00069	0.386
MOD_ProDKin_1	412	418	PF00069	0.386
MOD_ProDKin_1	547	553	PF00069	0.668
TRG_DiLeu_BaEn_1	420	425	PF01217	0.386
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.386
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.462
TRG_DiLeu_LyEn_5	420	425	PF01217	0.386
TRG_ENDOCYTIC_2	160	163	PF00928	0.362
TRG_ENDOCYTIC_2	224	227	PF00928	0.435
TRG_ENDOCYTIC_2	253	256	PF00928	0.547
TRG_ENDOCYTIC_2	56	59	PF00928	0.386
TRG_ER_diArg_1	19	21	PF00400	0.367
TRG_ER_diArg_1	245	247	PF00400	0.405
TRG_ER_diArg_1	258	260	PF00400	0.476
TRG_ER_diArg_1	441	443	PF00400	0.386
TRG_NES_CRM1_1	237	251	PF08389	0.548
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B5	Leptomonas seymouri	68%	97%
A0A1X0NNH9	Trypanosomatidae	45%	91%
A0A3R7M9Q9	Trypanosoma rangeli	45%	96%
A1S0R2	Thermofilum pendens (strain DSM 2475 / Hrk 5)	30%	100%
A2BLC0	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	32%	100%
A4H7T9	Leishmania braziliensis	87%	100%
A4HW65	Leishmania infantum	100%	100%
B1L3W1	Korarchaeum cryptofilum (strain OPF8)	28%	100%
B5YIM0	Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)	30%	100%
B8E2P6	Dictyoglomus turgidum (strain DSM 6724 / Z-1310)	27%	100%
C9ZSV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
D1BAA5	Thermanaerovibrio acidaminovorans (strain ATCC 49978 / DSM 6589 / Su883)	32%	100%
E9APW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O27324	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	100%
O29407	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O67377	Aquifex aeolicus (strain VF5)	28%	100%
P31806	Escherichia coli (strain K12)	47%	100%
P37391	Mycobacterium leprae (strain TN)	29%	100%
P56176	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	100%
P74217	Synechocystis sp. (strain PCC 6803 / Kazusa)	30%	100%
P9WF10	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WF11	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q2RGI2	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	32%	100%
Q2S580	Salinibacter ruber (strain DSM 13855 / M31)	32%	100%
Q4QFL5	Leishmania major	95%	100%
Q58981	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	100%
Q7NIE6	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	32%	100%
Q83CM5	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	37%	100%
Q8DGC3	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	33%	100%
Q8NSS3	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	26%	98%
Q8TX67	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	28%	100%
Q8ZV04	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	33%	100%
Q9KMX5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	39%	100%
Q9X024	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	30%	100%
Q9ZJM4	Helicobacter pylori (strain J99 / ATCC 700824)	26%	100%
V5BG46	Trypanosoma cruzi	47%	95%