Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WT47_LEIDO

TriTrypDb:

LdBPK_141150.1 , LdCL_140017200 , LDHU3_14.1450

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WT47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.551
CLV_NRD_NRD_1	138	140	PF00675	0.555
CLV_NRD_NRD_1	181	183	PF00675	0.545
CLV_NRD_NRD_1	260	262	PF00675	0.638
CLV_NRD_NRD_1	3	5	PF00675	0.724
CLV_NRD_NRD_1	304	306	PF00675	0.661
CLV_PCSK_KEX2_1	118	120	PF00082	0.769
CLV_PCSK_KEX2_1	138	140	PF00082	0.332
CLV_PCSK_KEX2_1	260	262	PF00082	0.560
CLV_PCSK_KEX2_1	3	5	PF00082	0.724
CLV_PCSK_KEX2_1	304	306	PF00082	0.661
CLV_PCSK_KEX2_1	327	329	PF00082	0.613
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.769
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.613
CLV_PCSK_SKI1_1	10	14	PF00082	0.681
CLV_PCSK_SKI1_1	118	122	PF00082	0.552
CLV_PCSK_SKI1_1	138	142	PF00082	0.553
CLV_PCSK_SKI1_1	306	310	PF00082	0.630
CLV_PCSK_SKI1_1	324	328	PF00082	0.437
CLV_PCSK_SKI1_1	339	343	PF00082	0.456
CLV_PCSK_SKI1_1	91	95	PF00082	0.682
CLV_Separin_Metazoa	232	236	PF03568	0.725
DEG_APCC_DBOX_1	181	189	PF00400	0.623
DEG_Nend_UBRbox_3	1	3	PF02207	0.607
DEG_SCF_FBW7_2	129	136	PF00400	0.687
DEG_SPOP_SBC_1	171	175	PF00917	0.706
DEG_SPOP_SBC_1	273	277	PF00917	0.622
DOC_CKS1_1	130	135	PF01111	0.581
DOC_CYCLIN_RxL_1	180	189	PF00134	0.628
DOC_MAPK_DCC_7	80	89	PF00069	0.749
DOC_MAPK_FxFP_2	29	32	PF00069	0.590
DOC_MAPK_FxFP_2	342	345	PF00069	0.551
DOC_MAPK_HePTP_8	77	89	PF00069	0.667
DOC_MAPK_MEF2A_6	80	89	PF00069	0.749
DOC_PP1_RVXF_1	337	343	PF00149	0.497
DOC_PP2B_LxvP_1	150	153	PF13499	0.723
DOC_PP2B_LxvP_1	155	158	PF13499	0.694
DOC_PP4_FxxP_1	130	133	PF00568	0.694
DOC_PP4_FxxP_1	29	32	PF00568	0.590
DOC_PP4_FxxP_1	342	345	PF00568	0.551
DOC_USP7_MATH_1	171	175	PF00917	0.748
DOC_USP7_MATH_1	196	200	PF00917	0.624
DOC_USP7_MATH_1	268	272	PF00917	0.796
DOC_USP7_MATH_1	331	335	PF00917	0.572
DOC_USP7_MATH_1	76	80	PF00917	0.718
DOC_USP7_MATH_1	95	99	PF00917	0.689
DOC_WW_Pin1_4	12	17	PF00397	0.622
DOC_WW_Pin1_4	129	134	PF00397	0.586
DOC_WW_Pin1_4	160	165	PF00397	0.749
DOC_WW_Pin1_4	167	172	PF00397	0.748
DOC_WW_Pin1_4	310	315	PF00397	0.650
LIG_14-3-3_CanoR_1	10	15	PF00244	0.602
LIG_14-3-3_CanoR_1	154	158	PF00244	0.776
LIG_14-3-3_CanoR_1	217	223	PF00244	0.643
LIG_14-3-3_CanoR_1	50	57	PF00244	0.682
LIG_14-3-3_CanoR_1	80	88	PF00244	0.740
LIG_BIR_III_4	110	114	PF00653	0.609
LIG_deltaCOP1_diTrp_1	8	11	PF00928	0.652
LIG_FHA_1	147	153	PF00498	0.608
LIG_FHA_1	228	234	PF00498	0.703
LIG_FHA_2	219	225	PF00498	0.545
LIG_HP1_1	184	188	PF01393	0.610
LIG_IBAR_NPY_1	236	238	PF08397	0.735
LIG_LIR_Gen_1	212	220	PF02991	0.636
LIG_LIR_Gen_1	294	303	PF02991	0.601
LIG_LIR_Gen_1	319	330	PF02991	0.621
LIG_LIR_Gen_1	367	375	PF02991	0.593
LIG_LIR_Gen_1	8	19	PF02991	0.625
LIG_LIR_Nem_3	109	115	PF02991	0.789
LIG_LIR_Nem_3	212	216	PF02991	0.529
LIG_LIR_Nem_3	294	299	PF02991	0.621
LIG_LIR_Nem_3	319	325	PF02991	0.636
LIG_LIR_Nem_3	367	371	PF02991	0.532
LIG_LIR_Nem_3	8	14	PF02991	0.721
LIG_MYND_1	16	20	PF01753	0.663
LIG_Pex14_1	391	395	PF04695	0.534
LIG_Pex14_2	130	134	PF04695	0.684
LIG_REV1ctd_RIR_1	369	376	PF16727	0.629
LIG_RPA_C_Fungi	300	312	PF08784	0.606
LIG_SH2_NCK_1	242	246	PF00017	0.662
LIG_SH2_SRC	242	245	PF00017	0.620
LIG_SH2_STAT5	215	218	PF00017	0.616
LIG_SH2_STAT5	296	299	PF00017	0.612
LIG_SH2_STAT5	336	339	PF00017	0.542
LIG_SH2_STAT5	368	371	PF00017	0.611
LIG_SH3_3	231	237	PF00018	0.729
LIG_SUMO_SIM_par_1	183	189	PF11976	0.565
LIG_TRAF2_1	102	105	PF00917	0.699
LIG_UBA3_1	298	306	PF00899	0.600
MOD_CDK_SPK_2	160	165	PF00069	0.723
MOD_CDK_SPxK_1	129	135	PF00069	0.587
MOD_CK1_1	170	176	PF00069	0.686
MOD_CK1_1	197	203	PF00069	0.586
MOD_CK1_1	271	277	PF00069	0.804
MOD_CK1_1	34	40	PF00069	0.587
MOD_CK1_1	79	85	PF00069	0.704
MOD_CK2_1	288	294	PF00069	0.637
MOD_CK2_1	99	105	PF00069	0.689
MOD_GlcNHglycan	124	127	PF01048	0.708
MOD_GlcNHglycan	188	191	PF01048	0.549
MOD_GlcNHglycan	270	273	PF01048	0.685
MOD_GlcNHglycan	276	279	PF01048	0.713
MOD_GlcNHglycan	59	62	PF01048	0.535
MOD_GlcNHglycan	96	100	PF01048	0.664
MOD_GSK3_1	156	163	PF00069	0.721
MOD_GSK3_1	167	174	PF00069	0.572
MOD_GSK3_1	196	203	PF00069	0.656
MOD_GSK3_1	268	275	PF00069	0.702
MOD_GSK3_1	284	291	PF00069	0.675
MOD_GSK3_1	31	38	PF00069	0.591
MOD_GSK3_1	312	319	PF00069	0.747
MOD_GSK3_1	357	364	PF00069	0.637
MOD_GSK3_1	91	98	PF00069	0.745
MOD_N-GLC_1	346	351	PF02516	0.509
MOD_N-GLC_2	73	75	PF02516	0.650
MOD_NEK2_1	251	256	PF00069	0.663
MOD_NEK2_1	57	62	PF00069	0.625
MOD_PIKK_1	361	367	PF00454	0.731
MOD_PKA_2	153	159	PF00069	0.668
MOD_PKA_2	43	49	PF00069	0.692
MOD_PKA_2	79	85	PF00069	0.746
MOD_Plk_1	294	300	PF00069	0.664
MOD_Plk_1	34	40	PF00069	0.598
MOD_Plk_1	357	363	PF00069	0.648
MOD_Plk_2-3	227	233	PF00069	0.705
MOD_Plk_4	218	224	PF00069	0.529
MOD_Plk_4	294	300	PF00069	0.521
MOD_Plk_4	346	352	PF00069	0.522
MOD_ProDKin_1	12	18	PF00069	0.620
MOD_ProDKin_1	129	135	PF00069	0.583
MOD_ProDKin_1	160	166	PF00069	0.750
MOD_ProDKin_1	167	173	PF00069	0.747
MOD_ProDKin_1	310	316	PF00069	0.650
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.622
TRG_ENDOCYTIC_2	296	299	PF00928	0.553
TRG_ENDOCYTIC_2	368	371	PF00928	0.512
TRG_ER_diArg_1	259	261	PF00400	0.560
TRG_ER_diArg_1	3	6	PF00400	0.723
TRG_ER_diArg_1	303	305	PF00400	0.641
TRG_ER_diArg_1	41	44	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	119	124	PF00026	0.734
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P428	Leptomonas seymouri	50%	100%
A4H7R2	Leishmania braziliensis	71%	100%
A4HW50	Leishmania infantum	99%	100%
E9APV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QFM7	Leishmania major	92%	100%