Ras-like small GTPase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WT46_LEIDO

TriTrypDb:

LdBPK_141250.1 , LdCL_140018400 , LDHU3_14.1590

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WT46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0003924	GTPase activity	7	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	6
GO:0019001	guanyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032561	guanyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.348
CLV_NRD_NRD_1	219	221	PF00675	0.577
CLV_NRD_NRD_1	358	360	PF00675	0.525
CLV_NRD_NRD_1	420	422	PF00675	0.293
CLV_NRD_NRD_1	452	454	PF00675	0.293
CLV_NRD_NRD_1	469	471	PF00675	0.293
CLV_NRD_NRD_1	52	54	PF00675	0.293
CLV_NRD_NRD_1	734	736	PF00675	0.584
CLV_NRD_NRD_1	761	763	PF00675	0.534
CLV_PCSK_KEX2_1	130	132	PF00082	0.348
CLV_PCSK_KEX2_1	218	220	PF00082	0.588
CLV_PCSK_KEX2_1	339	341	PF00082	0.501
CLV_PCSK_KEX2_1	358	360	PF00082	0.470
CLV_PCSK_KEX2_1	420	422	PF00082	0.293
CLV_PCSK_KEX2_1	452	454	PF00082	0.293
CLV_PCSK_KEX2_1	733	735	PF00082	0.586
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.501
CLV_PCSK_SKI1_1	14	18	PF00082	0.491
CLV_PCSK_SKI1_1	230	234	PF00082	0.472
CLV_PCSK_SKI1_1	376	380	PF00082	0.423
CLV_PCSK_SKI1_1	384	388	PF00082	0.293
CLV_PCSK_SKI1_1	421	425	PF00082	0.266
CLV_PCSK_SKI1_1	429	433	PF00082	0.268
CLV_PCSK_SKI1_1	470	474	PF00082	0.336
CLV_Separin_Metazoa	278	282	PF03568	0.580
DEG_APCC_DBOX_1	221	229	PF00400	0.598
DEG_SCF_FBW7_2	662	669	PF00400	0.433
DEG_SPOP_SBC_1	684	688	PF00917	0.483
DEG_SPOP_SBC_1	7	11	PF00917	0.539
DEG_SPOP_SBC_1	83	87	PF00917	0.348
DOC_CKS1_1	106	111	PF01111	0.276
DOC_CYCLIN_RxL_1	426	434	PF00134	0.216
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.379
DOC_MAPK_gen_1	420	427	PF00069	0.293
DOC_MAPK_MEF2A_6	420	427	PF00069	0.348
DOC_PP2B_LxvP_1	535	538	PF13499	0.573
DOC_PP4_FxxP_1	152	155	PF00568	0.240
DOC_USP7_MATH_1	145	149	PF00917	0.319
DOC_USP7_MATH_1	157	161	PF00917	0.237
DOC_USP7_MATH_1	179	183	PF00917	0.304
DOC_USP7_MATH_1	198	202	PF00917	0.245
DOC_USP7_MATH_1	246	250	PF00917	0.477
DOC_USP7_MATH_1	289	293	PF00917	0.538
DOC_USP7_MATH_1	311	315	PF00917	0.582
DOC_USP7_MATH_1	42	46	PF00917	0.300
DOC_USP7_MATH_1	525	529	PF00917	0.563
DOC_USP7_MATH_1	563	567	PF00917	0.555
DOC_USP7_MATH_1	583	587	PF00917	0.622
DOC_USP7_MATH_1	6	10	PF00917	0.562
DOC_USP7_MATH_1	634	638	PF00917	0.519
DOC_USP7_MATH_1	685	689	PF00917	0.572
DOC_USP7_MATH_1	736	740	PF00917	0.536
DOC_USP7_MATH_1	83	87	PF00917	0.348
DOC_USP7_MATH_1	91	95	PF00917	0.272
DOC_USP7_MATH_1	99	103	PF00917	0.205
DOC_WW_Pin1_4	105	110	PF00397	0.281
DOC_WW_Pin1_4	122	127	PF00397	0.224
DOC_WW_Pin1_4	141	146	PF00397	0.238
DOC_WW_Pin1_4	170	175	PF00397	0.361
DOC_WW_Pin1_4	182	187	PF00397	0.267
DOC_WW_Pin1_4	378	383	PF00397	0.400
DOC_WW_Pin1_4	578	583	PF00397	0.636
DOC_WW_Pin1_4	585	590	PF00397	0.550
DOC_WW_Pin1_4	616	621	PF00397	0.641
DOC_WW_Pin1_4	622	627	PF00397	0.596
DOC_WW_Pin1_4	630	635	PF00397	0.532
DOC_WW_Pin1_4	662	667	PF00397	0.436
LIG_14-3-3_CanoR_1	195	204	PF00244	0.293
LIG_14-3-3_CanoR_1	281	286	PF00244	0.633
LIG_14-3-3_CanoR_1	312	316	PF00244	0.644
LIG_14-3-3_CanoR_1	340	345	PF00244	0.520
LIG_14-3-3_CanoR_1	347	356	PF00244	0.508
LIG_14-3-3_CanoR_1	376	382	PF00244	0.418
LIG_14-3-3_CanoR_1	420	426	PF00244	0.280
LIG_14-3-3_CanoR_1	470	475	PF00244	0.336
LIG_14-3-3_CanoR_1	62	72	PF00244	0.288
LIG_14-3-3_CanoR_1	652	661	PF00244	0.412
LIG_14-3-3_CanoR_1	728	736	PF00244	0.598
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_4	645	649	PF00653	0.442
LIG_BRCT_BRCA1_1	251	255	PF00533	0.495
LIG_BRCT_BRCA1_1	44	48	PF00533	0.300
LIG_FHA_1	269	275	PF00498	0.423
LIG_FHA_1	349	355	PF00498	0.498
LIG_FHA_1	422	428	PF00498	0.332
LIG_FHA_1	685	691	PF00498	0.499
LIG_FHA_2	208	214	PF00498	0.556
LIG_FHA_2	239	245	PF00498	0.481
LIG_FHA_2	329	335	PF00498	0.440
LIG_FHA_2	687	693	PF00498	0.519
LIG_LIR_Apic_2	150	155	PF02991	0.238
LIG_LIR_Gen_1	238	246	PF02991	0.417
LIG_LIR_Gen_1	351	357	PF02991	0.448
LIG_LIR_Gen_1	665	676	PF02991	0.420
LIG_LIR_LC3C_4	203	208	PF02991	0.538
LIG_LIR_Nem_3	238	242	PF02991	0.418
LIG_LIR_Nem_3	301	305	PF02991	0.583
LIG_LIR_Nem_3	351	356	PF02991	0.448
LIG_LIR_Nem_3	446	451	PF02991	0.293
LIG_LIR_Nem_3	45	51	PF02991	0.291
LIG_LIR_Nem_3	665	671	PF02991	0.419
LIG_MYND_1	660	664	PF01753	0.440
LIG_NRBOX	755	761	PF00104	0.486
LIG_PCNA_yPIPBox_3	260	274	PF02747	0.398
LIG_SH2_SRC	466	469	PF00017	0.293
LIG_SH2_SRC	74	77	PF00017	0.348
LIG_SH2_STAP1	202	206	PF00017	0.293
LIG_SH2_STAP1	350	354	PF00017	0.494
LIG_SH2_STAP1	95	99	PF00017	0.216
LIG_SH2_STAT3	202	205	PF00017	0.293
LIG_SH2_STAT5	256	259	PF00017	0.393
LIG_SH2_STAT5	303	306	PF00017	0.522
LIG_SH2_STAT5	350	353	PF00017	0.501
LIG_SH2_STAT5	504	507	PF00017	0.491
LIG_SH2_STAT5	74	77	PF00017	0.293
LIG_SH3_1	130	136	PF00018	0.276
LIG_SH3_3	103	109	PF00018	0.276
LIG_SH3_3	130	136	PF00018	0.276
LIG_SH3_3	408	414	PF00018	0.348
LIG_SH3_3	591	597	PF00018	0.655
LIG_SH3_3	621	627	PF00018	0.602
LIG_SH3_3	70	76	PF00018	0.348
LIG_SUMO_SIM_anti_2	674	681	PF11976	0.420
LIG_SUMO_SIM_par_1	15	20	PF11976	0.524
LIG_SUMO_SIM_par_1	636	642	PF11976	0.397
LIG_TRAF2_1	210	213	PF00917	0.559
LIG_WRC_WIRS_1	236	241	PF05994	0.464
LIG_WRC_WIRS_1	368	373	PF05994	0.481
MOD_CDC14_SPxK_1	381	384	PF00782	0.372
MOD_CDK_SPxK_1	378	384	PF00069	0.391
MOD_CK1_1	102	108	PF00069	0.349
MOD_CK1_1	144	150	PF00069	0.326
MOD_CK1_1	175	181	PF00069	0.322
MOD_CK1_1	182	188	PF00069	0.286
MOD_CK1_1	238	244	PF00069	0.448
MOD_CK1_1	249	255	PF00069	0.498
MOD_CK1_1	284	290	PF00069	0.516
MOD_CK1_1	301	307	PF00069	0.625
MOD_CK1_1	369	375	PF00069	0.473
MOD_CK1_1	506	512	PF00069	0.640
MOD_CK1_1	528	534	PF00069	0.571
MOD_CK1_1	633	639	PF00069	0.660
MOD_CK1_1	686	692	PF00069	0.533
MOD_CK1_1	708	714	PF00069	0.721
MOD_CK1_1	715	721	PF00069	0.615
MOD_CK2_1	207	213	PF00069	0.547
MOD_CK2_1	218	224	PF00069	0.574
MOD_CK2_1	328	334	PF00069	0.507
MOD_CK2_1	634	640	PF00069	0.475
MOD_CK2_1	686	692	PF00069	0.498
MOD_CK2_1	82	88	PF00069	0.300
MOD_GlcNHglycan	1	4	PF01048	0.550
MOD_GlcNHglycan	121	125	PF01048	0.382
MOD_GlcNHglycan	147	150	PF01048	0.314
MOD_GlcNHglycan	174	177	PF01048	0.310
MOD_GlcNHglycan	251	254	PF01048	0.463
MOD_GlcNHglycan	306	309	PF01048	0.706
MOD_GlcNHglycan	321	324	PF01048	0.517
MOD_GlcNHglycan	397	400	PF01048	0.299
MOD_GlcNHglycan	441	445	PF01048	0.312
MOD_GlcNHglycan	485	488	PF01048	0.300
MOD_GlcNHglycan	509	512	PF01048	0.645
MOD_GlcNHglycan	527	530	PF01048	0.731
MOD_GlcNHglycan	535	538	PF01048	0.554
MOD_GlcNHglycan	552	555	PF01048	0.505
MOD_GlcNHglycan	692	696	PF01048	0.534
MOD_GlcNHglycan	703	706	PF01048	0.568
MOD_GlcNHglycan	717	720	PF01048	0.509
MOD_GlcNHglycan	724	727	PF01048	0.707
MOD_GlcNHglycan	95	98	PF01048	0.277
MOD_GSK3_1	101	108	PF00069	0.320
MOD_GSK3_1	141	148	PF00069	0.370
MOD_GSK3_1	165	172	PF00069	0.327
MOD_GSK3_1	175	182	PF00069	0.259
MOD_GSK3_1	280	287	PF00069	0.547
MOD_GSK3_1	306	313	PF00069	0.565
MOD_GSK3_1	328	335	PF00069	0.442
MOD_GSK3_1	42	49	PF00069	0.269
MOD_GSK3_1	466	473	PF00069	0.293
MOD_GSK3_1	502	509	PF00069	0.612
MOD_GSK3_1	585	592	PF00069	0.625
MOD_GSK3_1	616	623	PF00069	0.612
MOD_GSK3_1	630	637	PF00069	0.535
MOD_GSK3_1	680	687	PF00069	0.467
MOD_GSK3_1	691	698	PF00069	0.541
MOD_GSK3_1	701	708	PF00069	0.536
MOD_GSK3_1	718	725	PF00069	0.593
MOD_GSK3_1	83	90	PF00069	0.290
MOD_GSK3_1	91	98	PF00069	0.274
MOD_N-GLC_1	246	251	PF02516	0.496
MOD_N-GLC_1	268	273	PF02516	0.441
MOD_N-GLC_1	348	353	PF02516	0.432
MOD_N-GLC_1	533	538	PF02516	0.516
MOD_N-GLC_1	747	752	PF02516	0.462
MOD_N-GLC_1	83	88	PF02516	0.353
MOD_N-GLC_1	99	104	PF02516	0.200
MOD_N-GLC_2	577	579	PF02516	0.608
MOD_NEK2_1	1	6	PF00069	0.558
MOD_NEK2_1	17	22	PF00069	0.528
MOD_NEK2_1	206	211	PF00069	0.542
MOD_NEK2_1	319	324	PF00069	0.569
MOD_NEK2_1	377	382	PF00069	0.396
MOD_NEK2_1	533	538	PF00069	0.607
MOD_NEK2_1	64	69	PF00069	0.293
MOD_NEK2_1	671	676	PF00069	0.401
MOD_NEK2_1	747	752	PF00069	0.429
MOD_NEK2_2	653	658	PF00069	0.432
MOD_OFUCOSY	194	200	PF10250	0.293
MOD_PIKK_1	17	23	PF00454	0.442
MOD_PIKK_1	185	191	PF00454	0.348
MOD_PIKK_1	348	354	PF00454	0.500
MOD_PIKK_1	405	411	PF00454	0.293
MOD_PKA_1	218	224	PF00069	0.574
MOD_PKA_1	470	476	PF00069	0.336
MOD_PKA_2	218	224	PF00069	0.574
MOD_PKA_2	280	286	PF00069	0.663
MOD_PKA_2	311	317	PF00069	0.647
MOD_PKA_2	412	418	PF00069	0.293
MOD_Plk_1	17	23	PF00069	0.442
MOD_Plk_1	246	252	PF00069	0.489
MOD_Plk_1	268	274	PF00069	0.442
MOD_Plk_1	327	333	PF00069	0.501
MOD_Plk_1	348	354	PF00069	0.426
MOD_Plk_1	639	645	PF00069	0.413
MOD_Plk_1	680	686	PF00069	0.461
MOD_Plk_1	747	753	PF00069	0.465
MOD_Plk_1	99	105	PF00069	0.300
MOD_Plk_2-3	328	334	PF00069	0.447
MOD_Plk_4	102	108	PF00069	0.328
MOD_Plk_4	147	153	PF00069	0.276
MOD_Plk_4	235	241	PF00069	0.464
MOD_Plk_4	246	252	PF00069	0.336
MOD_Plk_4	298	304	PF00069	0.613
MOD_Plk_4	311	317	PF00069	0.625
MOD_Plk_4	470	476	PF00069	0.293
MOD_Plk_4	545	551	PF00069	0.548
MOD_Plk_4	634	640	PF00069	0.450
MOD_Plk_4	671	677	PF00069	0.423
MOD_ProDKin_1	105	111	PF00069	0.281
MOD_ProDKin_1	122	128	PF00069	0.224
MOD_ProDKin_1	141	147	PF00069	0.238
MOD_ProDKin_1	170	176	PF00069	0.361
MOD_ProDKin_1	182	188	PF00069	0.267
MOD_ProDKin_1	378	384	PF00069	0.391
MOD_ProDKin_1	578	584	PF00069	0.640
MOD_ProDKin_1	585	591	PF00069	0.550
MOD_ProDKin_1	616	622	PF00069	0.638
MOD_ProDKin_1	630	636	PF00069	0.526
MOD_ProDKin_1	662	668	PF00069	0.429
MOD_SUMO_for_1	539	542	PF00179	0.571
MOD_SUMO_rev_2	221	228	PF00179	0.550
TRG_DiLeu_BaEn_2	449	455	PF01217	0.348
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.416
TRG_DiLeu_BaLyEn_6	657	662	PF01217	0.432
TRG_ENDOCYTIC_2	350	353	PF00928	0.451
TRG_ENDOCYTIC_2	448	451	PF00928	0.293
TRG_ER_diArg_1	129	131	PF00400	0.348
TRG_ER_diArg_1	217	220	PF00400	0.582
TRG_ER_diArg_1	451	453	PF00400	0.293
TRG_ER_diArg_1	733	735	PF00400	0.589
TRG_NES_CRM1_1	669	681	PF08389	0.407
TRG_Pf-PMV_PEXEL_1	429	434	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I177	Leptomonas seymouri	63%	87%
A4H7T7	Leishmania braziliensis	73%	100%
E9APW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFL7	Leishmania major	90%	100%