Ras family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ras family protein

Gene product:

guanine nucleotide-binding protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WT13_LEIDO

TriTrypDb:

LdBPK_140820.1 , LdCL_140013700 , LDHU3_14.1060

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0005769	early endosome	8	1
GO:0016020	membrane	2	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S7WT13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT13

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	1
GO:0007165	signal transduction	2	2
GO:0007264	small GTPase mediated signal transduction	4	2
GO:0007265	Ras protein signal transduction	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0032482	Rab protein signal transduction	6	2
GO:0033036	macromolecule localization	2	2
GO:0035556	intracellular signal transduction	3	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	1
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	1
GO:0065007	biological regulation	1	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0016192	vesicle-mediated transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0003924	GTPase activity	7	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.325
CLV_C14_Caspase3-7	335	339	PF00656	0.599
CLV_C14_Caspase3-7	6	10	PF00656	0.626
CLV_NRD_NRD_1	343	345	PF00675	0.692
CLV_PCSK_KEX2_1	343	345	PF00082	0.692
DEG_Nend_UBRbox_2	1	3	PF02207	0.645
DEG_SCF_FBW7_1	359	366	PF00400	0.621
DEG_SPOP_SBC_1	237	241	PF00917	0.340
DEG_SPOP_SBC_1	30	34	PF00917	0.604
DEG_SPOP_SBC_1	64	68	PF00917	0.649
DOC_ANK_TNKS_1	23	30	PF00023	0.604
DOC_ANK_TNKS_1	343	350	PF00023	0.631
DOC_CKS1_1	360	365	PF01111	0.573
DOC_MAPK_MEF2A_6	217	225	PF00069	0.341
DOC_PP2B_LxvP_1	203	206	PF13499	0.334
DOC_PP2B_LxvP_1	92	95	PF13499	0.580
DOC_USP7_MATH_1	135	139	PF00917	0.450
DOC_USP7_MATH_1	237	241	PF00917	0.361
DOC_USP7_MATH_1	31	35	PF00917	0.604
DOC_USP7_MATH_1	327	331	PF00917	0.689
DOC_USP7_MATH_1	363	367	PF00917	0.627
DOC_USP7_MATH_1	371	375	PF00917	0.576
DOC_USP7_MATH_1	409	413	PF00917	0.640
DOC_USP7_MATH_1	41	45	PF00917	0.546
DOC_USP7_MATH_1	52	56	PF00917	0.546
DOC_USP7_MATH_1	64	68	PF00917	0.534
DOC_WW_Pin1_4	359	364	PF00397	0.612
DOC_WW_Pin1_4	369	374	PF00397	0.637
DOC_WW_Pin1_4	405	410	PF00397	0.681
DOC_WW_Pin1_4	69	74	PF00397	0.627
LIG_14-3-3_CanoR_1	24	28	PF00244	0.605
LIG_14-3-3_CanoR_1	255	262	PF00244	0.367
LIG_14-3-3_CanoR_1	358	363	PF00244	0.731
LIG_14-3-3_CanoR_1	380	390	PF00244	0.688
LIG_BRCT_BRCA1_1	179	183	PF00533	0.364
LIG_BRCT_BRCA1_1	52	56	PF00533	0.509
LIG_BRCT_BRCA1_1	81	85	PF00533	0.560
LIG_FHA_1	105	111	PF00498	0.444
LIG_FHA_1	137	143	PF00498	0.371
LIG_FHA_1	157	163	PF00498	0.364
LIG_FHA_1	265	271	PF00498	0.374
LIG_FHA_1	278	284	PF00498	0.296
LIG_FHA_1	360	366	PF00498	0.575
LIG_FHA_1	387	393	PF00498	0.615
LIG_FHA_2	195	201	PF00498	0.387
LIG_FHA_2	52	58	PF00498	0.590
LIG_IRF3_LxIS_1	73	79	PF10401	0.526
LIG_LIR_Gen_1	277	286	PF02991	0.415
LIG_LIR_Nem_3	107	111	PF02991	0.381
LIG_LIR_Nem_3	277	282	PF02991	0.378
LIG_PTB_Apo_2	178	185	PF02174	0.364
LIG_PTB_Phospho_1	178	184	PF10480	0.364
LIG_SH2_CRK	108	112	PF00017	0.301
LIG_SH2_SRC	132	135	PF00017	0.349
LIG_SH2_STAT5	127	130	PF00017	0.415
LIG_SH2_STAT5	368	371	PF00017	0.615
LIG_SH3_3	131	137	PF00018	0.364
LIG_SH3_3	146	152	PF00018	0.364
LIG_SH3_3	357	363	PF00018	0.597
LIG_SH3_3	46	52	PF00018	0.587
LIG_SH3_3	67	73	PF00018	0.635
LIG_SUMO_SIM_par_1	109	115	PF11976	0.415
LIG_SUMO_SIM_par_1	282	287	PF11976	0.364
LIG_SUMO_SIM_par_1	74	79	PF11976	0.525
LIG_TRAF2_1	170	173	PF00917	0.415
MOD_CDK_SPK_2	69	74	PF00069	0.608
MOD_CK1_1	18	24	PF00069	0.617
MOD_CK1_1	201	207	PF00069	0.355
MOD_CK1_1	268	274	PF00069	0.390
MOD_CK1_1	310	316	PF00069	0.690
MOD_CK1_1	330	336	PF00069	0.575
MOD_CK1_1	34	40	PF00069	0.507
MOD_CK1_1	366	372	PF00069	0.620
MOD_CK1_1	45	51	PF00069	0.564
MOD_CK1_1	79	85	PF00069	0.542
MOD_CK2_1	194	200	PF00069	0.272
MOD_CK2_1	313	319	PF00069	0.702
MOD_Cter_Amidation	341	344	PF01082	0.569
MOD_GlcNHglycan	152	155	PF01048	0.388
MOD_GlcNHglycan	267	270	PF01048	0.415
MOD_GlcNHglycan	300	303	PF01048	0.694
MOD_GlcNHglycan	312	315	PF01048	0.653
MOD_GlcNHglycan	329	332	PF01048	0.509
MOD_GlcNHglycan	365	368	PF01048	0.659
MOD_GlcNHglycan	373	376	PF01048	0.719
MOD_GlcNHglycan	401	404	PF01048	0.665
MOD_GlcNHglycan	411	414	PF01048	0.529
MOD_GlcNHglycan	95	98	PF01048	0.518
MOD_GSK3_1	194	201	PF00069	0.329
MOD_GSK3_1	238	245	PF00069	0.385
MOD_GSK3_1	264	271	PF00069	0.471
MOD_GSK3_1	30	37	PF00069	0.570
MOD_GSK3_1	303	310	PF00069	0.579
MOD_GSK3_1	330	337	PF00069	0.645
MOD_GSK3_1	350	357	PF00069	0.686
MOD_GSK3_1	359	366	PF00069	0.551
MOD_GSK3_1	395	402	PF00069	0.686
MOD_GSK3_1	405	412	PF00069	0.575
MOD_GSK3_1	41	48	PF00069	0.697
MOD_GSK3_1	65	72	PF00069	0.642
MOD_NEK2_1	104	109	PF00069	0.413
MOD_NEK2_1	166	171	PF00069	0.516
MOD_NEK2_1	265	270	PF00069	0.408
MOD_NEK2_1	354	359	PF00069	0.489
MOD_NEK2_1	76	81	PF00069	0.638
MOD_PIKK_1	210	216	PF00454	0.434
MOD_PIKK_1	381	387	PF00454	0.547
MOD_PK_1	74	80	PF00069	0.525
MOD_PKA_2	23	29	PF00069	0.604
MOD_PKA_2	254	260	PF00069	0.367
MOD_PKA_2	306	312	PF00069	0.574
MOD_Plk_4	158	164	PF00069	0.364
MOD_Plk_4	198	204	PF00069	0.364
MOD_Plk_4	23	29	PF00069	0.574
MOD_Plk_4	31	37	PF00069	0.554
MOD_Plk_4	42	48	PF00069	0.494
MOD_ProDKin_1	359	365	PF00069	0.612
MOD_ProDKin_1	369	375	PF00069	0.640
MOD_ProDKin_1	405	411	PF00069	0.681
MOD_ProDKin_1	69	75	PF00069	0.626
TRG_ENDOCYTIC_2	108	111	PF00928	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKL4	Leptomonas seymouri	52%	100%
A4HW20	Leishmania infantum	99%	100%
E9AI46	Leishmania braziliensis	66%	99%
E9APS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AV47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q4QCD4	Leishmania major	32%	100%
Q4QFQ7	Leishmania major	89%	100%