Hypothetical_protein_conserved

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WT08_LEIDO

TriTrypDb:

LdBPK_140860.1 , LdCL_140014100 , LDHU3_14.1100

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 176, 193, 197, 275
Promastigote/Amastigote: 187

Expansion

Sequence features

A0A3S7WT08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.509
CLV_NRD_NRD_1	201	203	PF00675	0.764
CLV_PCSK_KEX2_1	105	107	PF00082	0.551
CLV_PCSK_KEX2_1	426	428	PF00082	0.640
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.551
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.640
CLV_PCSK_SKI1_1	148	152	PF00082	0.672
CLV_PCSK_SKI1_1	158	162	PF00082	0.665
CLV_PCSK_SKI1_1	17	21	PF00082	0.579
CLV_PCSK_SKI1_1	45	49	PF00082	0.646
CLV_PCSK_SKI1_1	90	94	PF00082	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.505
DEG_SCF_FBW7_1	232	239	PF00400	0.627
DOC_CDC14_PxL_1	188	196	PF14671	0.670
DOC_CKS1_1	337	342	PF01111	0.581
DOC_MAPK_MEF2A_6	72	81	PF00069	0.638
DOC_PP2B_LxvP_1	67	70	PF13499	0.650
DOC_USP7_MATH_1	173	177	PF00917	0.686
DOC_USP7_MATH_1	19	23	PF00917	0.635
DOC_USP7_MATH_1	220	224	PF00917	0.660
DOC_USP7_MATH_1	236	240	PF00917	0.540
DOC_USP7_MATH_1	259	263	PF00917	0.614
DOC_USP7_MATH_1	265	269	PF00917	0.584
DOC_USP7_MATH_1	271	275	PF00917	0.512
DOC_USP7_MATH_1	283	287	PF00917	0.582
DOC_USP7_MATH_1	294	298	PF00917	0.490
DOC_USP7_MATH_1	312	316	PF00917	0.691
DOC_USP7_MATH_1	323	327	PF00917	0.637
DOC_USP7_MATH_1	37	41	PF00917	0.655
DOC_USP7_MATH_1	374	378	PF00917	0.587
DOC_USP7_MATH_1	381	385	PF00917	0.538
DOC_USP7_MATH_1	414	418	PF00917	0.716
DOC_USP7_UBL2_3	16	20	PF12436	0.575
DOC_USP7_UBL2_3	422	426	PF12436	0.616
DOC_USP7_UBL2_3	9	13	PF12436	0.529
DOC_WW_Pin1_4	136	141	PF00397	0.662
DOC_WW_Pin1_4	232	237	PF00397	0.659
DOC_WW_Pin1_4	240	245	PF00397	0.604
DOC_WW_Pin1_4	272	277	PF00397	0.698
DOC_WW_Pin1_4	336	341	PF00397	0.575
DOC_WW_Pin1_4	62	67	PF00397	0.665
LIG_14-3-3_CanoR_1	349	358	PF00244	0.751
LIG_14-3-3_CanoR_1	38	47	PF00244	0.597
LIG_14-3-3_CanoR_1	90	96	PF00244	0.597
LIG_BRCT_BRCA1_1	175	179	PF00533	0.625
LIG_FHA_1	159	165	PF00498	0.588
LIG_FHA_1	181	187	PF00498	0.629
LIG_FHA_2	191	197	PF00498	0.611
LIG_LIR_Apic_2	253	259	PF02991	0.583
LIG_LIR_Apic_2	298	304	PF02991	0.667
LIG_LIR_Apic_2	306	312	PF02991	0.593
LIG_LIR_Apic_2	318	323	PF02991	0.615
LIG_LIR_Apic_2	356	361	PF02991	0.635
LIG_LIR_Apic_2	393	398	PF02991	0.561
LIG_LIR_Gen_1	94	100	PF02991	0.543
LIG_LIR_Nem_3	94	98	PF02991	0.547
LIG_MYND_3	191	195	PF01753	0.611
LIG_PTAP_UEV_1	324	329	PF05743	0.585
LIG_SH2_CRK	291	295	PF00017	0.626
LIG_SH2_CRK	301	305	PF00017	0.535
LIG_SH2_CRK	309	313	PF00017	0.554
LIG_SH2_CRK	320	324	PF00017	0.577
LIG_SH2_CRK	335	339	PF00017	0.649
LIG_SH2_CRK	348	352	PF00017	0.581
LIG_SH2_CRK	358	362	PF00017	0.576
LIG_SH2_CRK	369	373	PF00017	0.631
LIG_SH2_CRK	395	399	PF00017	0.551
LIG_SH2_CRK	409	413	PF00017	0.651
LIG_SH2_CRK	421	425	PF00017	0.568
LIG_SH2_PTP2	256	259	PF00017	0.642
LIG_SH2_SRC	256	259	PF00017	0.642
LIG_SH2_STAT5	256	259	PF00017	0.642
LIG_SH3_3	270	276	PF00018	0.646
LIG_SH3_3	297	303	PF00018	0.612
LIG_SH3_3	319	325	PF00018	0.630
LIG_SH3_3	334	340	PF00018	0.609
LIG_SH3_3	365	371	PF00018	0.633
LIG_SH3_3	417	423	PF00018	0.619
LIG_SH3_3	71	77	PF00018	0.620
LIG_SH3_4	422	429	PF00018	0.627
LIG_TRAF2_1	117	120	PF00917	0.587
LIG_TRAF2_1	193	196	PF00917	0.615
LIG_TRAF2_1	222	225	PF00917	0.643
MOD_CDK_SPK_2	140	145	PF00069	0.668
MOD_CK1_1	101	107	PF00069	0.607
MOD_CK1_1	139	145	PF00069	0.674
MOD_CK1_1	205	211	PF00069	0.811
MOD_CK1_1	239	245	PF00069	0.696
MOD_CK1_1	260	266	PF00069	0.718
MOD_CK1_1	295	301	PF00069	0.624
MOD_CK1_1	326	332	PF00069	0.646
MOD_CK1_1	373	379	PF00069	0.526
MOD_CK1_1	391	397	PF00069	0.623
MOD_CK1_1	402	408	PF00069	0.611
MOD_CK1_1	55	61	PF00069	0.668
MOD_CK1_1	91	97	PF00069	0.615
MOD_CK2_1	140	146	PF00069	0.681
MOD_CK2_1	190	196	PF00069	0.577
MOD_CK2_1	261	267	PF00069	0.677
MOD_CK2_1	312	318	PF00069	0.741
MOD_CK2_1	350	356	PF00069	0.635
MOD_CK2_1	422	428	PF00069	0.573
MOD_GlcNHglycan	128	131	PF01048	0.715
MOD_GlcNHglycan	175	178	PF01048	0.714
MOD_GlcNHglycan	21	24	PF01048	0.700
MOD_GlcNHglycan	229	232	PF01048	0.725
MOD_GlcNHglycan	245	248	PF01048	0.623
MOD_GlcNHglycan	263	266	PF01048	0.477
MOD_GlcNHglycan	281	284	PF01048	0.717
MOD_GlcNHglycan	286	289	PF01048	0.668
MOD_GlcNHglycan	294	297	PF01048	0.733
MOD_GlcNHglycan	314	317	PF01048	0.629
MOD_GlcNHglycan	325	328	PF01048	0.572
MOD_GlcNHglycan	329	332	PF01048	0.582
MOD_GlcNHglycan	343	346	PF01048	0.561
MOD_GlcNHglycan	362	365	PF01048	0.668
MOD_GlcNHglycan	372	375	PF01048	0.563
MOD_GlcNHglycan	390	393	PF01048	0.612
MOD_GlcNHglycan	401	404	PF01048	0.547
MOD_GlcNHglycan	412	415	PF01048	0.764
MOD_GlcNHglycan	416	419	PF01048	0.648
MOD_GlcNHglycan	56	60	PF01048	0.639
MOD_GlcNHglycan	90	93	PF01048	0.580
MOD_GSK3_1	136	143	PF00069	0.710
MOD_GSK3_1	180	187	PF00069	0.659
MOD_GSK3_1	190	197	PF00069	0.558
MOD_GSK3_1	202	209	PF00069	0.608
MOD_GSK3_1	232	239	PF00069	0.750
MOD_GSK3_1	257	264	PF00069	0.644
MOD_GSK3_1	267	274	PF00069	0.611
MOD_GSK3_1	279	286	PF00069	0.561
MOD_GSK3_1	323	330	PF00069	0.665
MOD_GSK3_1	370	377	PF00069	0.608
MOD_GSK3_1	382	389	PF00069	0.594
MOD_GSK3_1	410	417	PF00069	0.662
MOD_GSK3_1	45	52	PF00069	0.693
MOD_N-GLC_1	158	163	PF02516	0.675
MOD_N-GLC_1	312	317	PF02516	0.628
MOD_NEK2_1	194	199	PF00069	0.673
MOD_NEK2_1	266	271	PF00069	0.598
MOD_NEK2_1	382	387	PF00069	0.528
MOD_NEK2_1	85	90	PF00069	0.613
MOD_PIKK_1	180	186	PF00454	0.675
MOD_PIKK_1	202	208	PF00454	0.695
MOD_PIKK_1	209	215	PF00454	0.623
MOD_PIKK_1	220	226	PF00454	0.519
MOD_PIKK_1	98	104	PF00454	0.485
MOD_PKA_1	12	18	PF00069	0.669
MOD_PKA_1	126	132	PF00069	0.474
MOD_PKA_1	202	208	PF00069	0.695
MOD_PKA_2	279	285	PF00069	0.622
MOD_PKA_2	37	43	PF00069	0.644
MOD_Plk_1	194	200	PF00069	0.676
MOD_Plk_1	70	76	PF00069	0.636
MOD_ProDKin_1	136	142	PF00069	0.661
MOD_ProDKin_1	232	238	PF00069	0.660
MOD_ProDKin_1	240	246	PF00069	0.603
MOD_ProDKin_1	272	278	PF00069	0.699
MOD_ProDKin_1	336	342	PF00069	0.579
MOD_ProDKin_1	62	68	PF00069	0.660
MOD_SUMO_for_1	117	120	PF00179	0.565
MOD_SUMO_rev_2	103	113	PF00179	0.536
MOD_SUMO_rev_2	119	129	PF00179	0.612
MOD_SUMO_rev_2	141	150	PF00179	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE22	Leptomonas seymouri	43%	100%
A0A1X0NNK6	Trypanosomatidae	32%	90%
A4H7N5	Leishmania braziliensis	68%	96%
A4HW24	Leishmania infantum	100%	100%
C9ZT09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	85%
E9APS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QFQ3	Leishmania major	92%	100%