Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WT04_LEIDO

TriTrypDb:

LdBPK_140830.1 , LdCL_140013800 , LDHU3_14.1070

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WT04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WT04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.489
CLV_NRD_NRD_1	167	169	PF00675	0.782
CLV_NRD_NRD_1	227	229	PF00675	0.732
CLV_NRD_NRD_1	234	236	PF00675	0.727
CLV_NRD_NRD_1	253	255	PF00675	0.633
CLV_NRD_NRD_1	300	302	PF00675	0.682
CLV_NRD_NRD_1	330	332	PF00675	0.628
CLV_NRD_NRD_1	58	60	PF00675	0.696
CLV_NRD_NRD_1	92	94	PF00675	0.685
CLV_PCSK_FUR_1	225	229	PF00082	0.666
CLV_PCSK_FUR_1	90	94	PF00082	0.677
CLV_PCSK_KEX2_1	149	151	PF00082	0.716
CLV_PCSK_KEX2_1	167	169	PF00082	0.732
CLV_PCSK_KEX2_1	227	229	PF00082	0.732
CLV_PCSK_KEX2_1	234	236	PF00082	0.727
CLV_PCSK_KEX2_1	252	254	PF00082	0.640
CLV_PCSK_KEX2_1	300	302	PF00082	0.682
CLV_PCSK_KEX2_1	329	331	PF00082	0.633
CLV_PCSK_KEX2_1	58	60	PF00082	0.666
CLV_PCSK_KEX2_1	92	94	PF00082	0.684
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.697
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.635
CLV_PCSK_SKI1_1	316	320	PF00082	0.675
CLV_PCSK_SKI1_1	341	345	PF00082	0.637
CLV_PCSK_SKI1_1	44	48	PF00082	0.663
CLV_Separin_Metazoa	187	191	PF03568	0.473
DEG_APCC_DBOX_1	189	197	PF00400	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SPOP_SBC_1	160	164	PF00917	0.521
DEG_SPOP_SBC_1	318	322	PF00917	0.465
DOC_MAPK_gen_1	352	360	PF00069	0.405
DOC_MAPK_MEF2A_6	262	270	PF00069	0.450
DOC_MAPK_RevD_3	136	150	PF00069	0.474
DOC_PP2B_LxvP_1	4	7	PF13499	0.565
DOC_PP2B_PxIxI_1	285	291	PF00149	0.497
DOC_USP7_MATH_1	192	196	PF00917	0.426
DOC_USP7_MATH_1	255	259	PF00917	0.532
DOC_USP7_MATH_1	380	384	PF00917	0.391
DOC_USP7_MATH_1	8	12	PF00917	0.551
DOC_WW_Pin1_4	108	113	PF00397	0.538
DOC_WW_Pin1_4	123	128	PF00397	0.516
DOC_WW_Pin1_4	155	160	PF00397	0.526
DOC_WW_Pin1_4	161	166	PF00397	0.467
LIG_14-3-3_CanoR_1	133	139	PF00244	0.490
LIG_14-3-3_CanoR_1	150	159	PF00244	0.465
LIG_BRCT_BRCA1_1	386	390	PF00533	0.342
LIG_DCNL_PONY_1	1	4	PF03556	0.494
LIG_FHA_2	24	30	PF00498	0.512
LIG_FHA_2	320	326	PF00498	0.504
LIG_LIR_Nem_3	387	393	PF02991	0.296
LIG_LIR_Nem_3	67	73	PF02991	0.441
LIG_NRBOX	265	271	PF00104	0.452
LIG_PDZ_Class_2	392	397	PF00595	0.301
LIG_Pex14_2	393	397	PF04695	0.282
LIG_SH2_STAT5	71	74	PF00017	0.492
LIG_SH3_3	135	141	PF00018	0.467
LIG_SH3_3	186	192	PF00018	0.486
LIG_Sin3_3	306	313	PF02671	0.426
LIG_SUMO_SIM_par_1	286	292	PF11976	0.533
LIG_TRAF2_1	100	103	PF00917	0.515
LIG_TRAF2_1	347	350	PF00917	0.426
LIG_WW_3	187	191	PF00397	0.600
MOD_CDC14_SPxK_1	164	167	PF00782	0.579
MOD_CDK_SPK_2	108	113	PF00069	0.622
MOD_CDK_SPxK_1	161	167	PF00069	0.583
MOD_CDK_SPxxK_3	161	168	PF00069	0.585
MOD_CK1_1	11	17	PF00069	0.570
MOD_CK1_1	233	239	PF00069	0.657
MOD_CK1_1	317	323	PF00069	0.682
MOD_CK1_1	337	343	PF00069	0.467
MOD_CK2_1	23	29	PF00069	0.570
MOD_CK2_1	319	325	PF00069	0.616
MOD_Cter_Amidation	250	253	PF01082	0.585
MOD_Cter_Amidation	82	85	PF01082	0.628
MOD_GlcNHglycan	11	14	PF01048	0.568
MOD_GlcNHglycan	238	242	PF01048	0.668
MOD_GlcNHglycan	311	314	PF01048	0.688
MOD_GlcNHglycan	34	37	PF01048	0.710
MOD_GlcNHglycan	372	376	PF01048	0.681
MOD_GlcNHglycan	39	42	PF01048	0.635
MOD_GSK3_1	151	158	PF00069	0.561
MOD_GSK3_1	233	240	PF00069	0.615
MOD_GSK3_1	28	35	PF00069	0.538
MOD_GSK3_1	314	321	PF00069	0.597
MOD_GSK3_1	367	374	PF00069	0.700
MOD_GSK3_1	380	387	PF00069	0.355
MOD_N-GLC_1	123	128	PF02516	0.584
MOD_NEK2_1	384	389	PF00069	0.357
MOD_NEK2_2	134	139	PF00069	0.605
MOD_NEK2_2	192	197	PF00069	0.551
MOD_NEK2_2	380	385	PF00069	0.363
MOD_PKA_2	233	239	PF00069	0.622
MOD_PKA_2	299	305	PF00069	0.600
MOD_PKA_2	337	343	PF00069	0.702
MOD_PKB_1	235	243	PF00069	0.621
MOD_Plk_1	101	107	PF00069	0.649
MOD_Plk_1	28	34	PF00069	0.516
MOD_Plk_4	264	270	PF00069	0.651
MOD_Plk_4	380	386	PF00069	0.315
MOD_ProDKin_1	108	114	PF00069	0.680
MOD_ProDKin_1	123	129	PF00069	0.650
MOD_ProDKin_1	155	161	PF00069	0.664
MOD_SUMO_rev_2	203	212	PF00179	0.563
MOD_SUMO_rev_2	312	318	PF00179	0.584
MOD_SUMO_rev_2	337	343	PF00179	0.630
MOD_SUMO_rev_2	76	86	PF00179	0.661
TRG_ER_diArg_1	225	228	PF00400	0.627
TRG_ER_diArg_1	234	237	PF00400	0.623
TRG_ER_diArg_1	252	254	PF00400	0.574
TRG_ER_diArg_1	328	331	PF00400	0.523
TRG_ER_diArg_1	57	59	PF00400	0.642
TRG_ER_diArg_1	89	92	PF00400	0.633
TRG_NLS_Bipartite_1	149	171	PF00514	0.647
TRG_NLS_MonoExtN_4	165	171	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I683	Leptomonas seymouri	30%	100%
A4H7N2	Leishmania braziliensis	53%	100%
A4HW21	Leishmania infantum	99%	100%
E9APS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFQ6	Leishmania major	86%	100%