Ion transport protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ion transport protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WSZ6_LEIDO

TriTrypDb:

LdBPK_140550.1 , LdCL_140010900 , LDHU3_14.0750

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3S7WSZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0005216	monoatomic ion channel activity	4	11
GO:0005227	calcium activated cation channel activity	6	11
GO:0005261	monoatomic cation channel activity	5	11
GO:0005267	potassium channel activity	6	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015079	potassium ion transmembrane transporter activity	6	11
GO:0015267	channel activity	4	11
GO:0015269	calcium-activated potassium channel activity	7	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0016286	small conductance calcium-activated potassium channel activity	8	11
GO:0022803	passive transmembrane transporter activity	3	11
GO:0022836	gated channel activity	5	11
GO:0022839	monoatomic ion gated channel activity	6	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0046873	metal ion transmembrane transporter activity	5	11
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.362
CLV_NRD_NRD_1	14	16	PF00675	0.485
CLV_NRD_NRD_1	319	321	PF00675	0.442
CLV_NRD_NRD_1	322	324	PF00675	0.456
CLV_NRD_NRD_1	353	355	PF00675	0.377
CLV_NRD_NRD_1	421	423	PF00675	0.471
CLV_PCSK_KEX2_1	14	16	PF00082	0.489
CLV_PCSK_KEX2_1	2	4	PF00082	0.519
CLV_PCSK_KEX2_1	353	355	PF00082	0.359
CLV_PCSK_KEX2_1	421	423	PF00082	0.471
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.546
CLV_PCSK_PC7_1	10	16	PF00082	0.473
CLV_PCSK_SKI1_1	117	121	PF00082	0.290
CLV_PCSK_SKI1_1	14	18	PF00082	0.419
CLV_PCSK_SKI1_1	147	151	PF00082	0.563
CLV_PCSK_SKI1_1	3	7	PF00082	0.467
CLV_PCSK_SKI1_1	412	416	PF00082	0.530
DEG_Nend_UBRbox_1	1	4	PF02207	0.657
DEG_SPOP_SBC_1	189	193	PF00917	0.575
DEG_SPOP_SBC_1	445	449	PF00917	0.760
DOC_CKS1_1	137	142	PF01111	0.353
DOC_MAPK_gen_1	204	213	PF00069	0.515
DOC_MAPK_gen_1	306	315	PF00069	0.631
DOC_MAPK_gen_1	333	341	PF00069	0.595
DOC_MAPK_gen_1	398	407	PF00069	0.658
DOC_MAPK_gen_1	421	429	PF00069	0.663
DOC_MAPK_HePTP_8	201	213	PF00069	0.564
DOC_MAPK_MEF2A_6	160	168	PF00069	0.378
DOC_MAPK_MEF2A_6	204	213	PF00069	0.545
DOC_MAPK_MEF2A_6	21	28	PF00069	0.587
DOC_MAPK_MEF2A_6	400	409	PF00069	0.655
DOC_PP1_RVXF_1	256	263	PF00149	0.290
DOC_PP4_FxxP_1	120	123	PF00568	0.358
DOC_USP7_MATH_1	362	366	PF00917	0.611
DOC_USP7_MATH_1	431	435	PF00917	0.712
DOC_USP7_MATH_1	445	449	PF00917	0.664
DOC_USP7_UBL2_3	17	21	PF12436	0.650
DOC_WW_Pin1_4	119	124	PF00397	0.334
DOC_WW_Pin1_4	136	141	PF00397	0.267
DOC_WW_Pin1_4	248	253	PF00397	0.279
LIG_14-3-3_CanoR_1	117	123	PF00244	0.481
LIG_14-3-3_CanoR_1	160	165	PF00244	0.447
LIG_14-3-3_CanoR_1	180	189	PF00244	0.425
LIG_14-3-3_CanoR_1	206	212	PF00244	0.468
LIG_14-3-3_CanoR_1	306	315	PF00244	0.588
LIG_14-3-3_CanoR_1	364	373	PF00244	0.689
LIG_14-3-3_CanoR_1	475	483	PF00244	0.628
LIG_Actin_WH2_2	41	58	PF00022	0.555
LIG_APCC_ABBAyCdc20_2	21	27	PF00400	0.553
LIG_BRCT_BRCA1_1	121	125	PF00533	0.408
LIG_BRCT_BRCA1_1	190	194	PF00533	0.567
LIG_BRCT_BRCA1_1	75	79	PF00533	0.355
LIG_CaM_IQ_9	310	326	PF13499	0.607
LIG_CtBP_PxDLS_1	491	495	PF00389	0.684
LIG_deltaCOP1_diTrp_1	233	239	PF00928	0.283
LIG_EH1_1	126	134	PF00400	0.481
LIG_EH1_1	289	297	PF00400	0.662
LIG_EVH1_2	140	144	PF00568	0.413
LIG_FHA_1	108	114	PF00498	0.568
LIG_FHA_1	190	196	PF00498	0.550
LIG_FHA_1	203	209	PF00498	0.460
LIG_FHA_1	224	230	PF00498	0.325
LIG_FHA_1	336	342	PF00498	0.596
LIG_FHA_1	344	350	PF00498	0.528
LIG_FHA_1	424	430	PF00498	0.672
LIG_FHA_1	475	481	PF00498	0.681
LIG_FHA_1	82	88	PF00498	0.408
LIG_FHA_1	97	103	PF00498	0.487
LIG_FHA_2	292	298	PF00498	0.625
LIG_FHA_2	465	471	PF00498	0.693
LIG_GBD_Chelix_1	259	267	PF00786	0.396
LIG_KLC1_Yacidic_2	22	27	PF13176	0.572
LIG_LIR_Gen_1	122	133	PF02991	0.481
LIG_LIR_Gen_1	139	150	PF02991	0.411
LIG_LIR_Gen_1	22	33	PF02991	0.616
LIG_LIR_Gen_1	238	247	PF02991	0.317
LIG_LIR_Gen_1	268	277	PF02991	0.340
LIG_LIR_Gen_1	278	285	PF02991	0.422
LIG_LIR_Nem_3	139	145	PF02991	0.443
LIG_LIR_Nem_3	22	28	PF02991	0.597
LIG_LIR_Nem_3	233	239	PF02991	0.383
LIG_LIR_Nem_3	244	250	PF02991	0.283
LIG_LIR_Nem_3	278	283	PF02991	0.485
LIG_MLH1_MIPbox_1	121	125	PF16413	0.378
LIG_NRBOX	340	346	PF00104	0.581
LIG_Pex14_1	265	269	PF04695	0.355
LIG_PTB_Apo_2	108	115	PF02174	0.572
LIG_PTB_Apo_2	167	174	PF02174	0.391
LIG_PTB_Phospho_1	167	173	PF10480	0.422
LIG_SH2_CRK	162	166	PF00017	0.378
LIG_SH2_CRK	280	284	PF00017	0.593
LIG_SH2_GRB2like	167	170	PF00017	0.467
LIG_SH2_PTP2	25	28	PF00017	0.631
LIG_SH2_SRC	25	28	PF00017	0.616
LIG_SH2_SRC	30	33	PF00017	0.626
LIG_SH2_STAP1	162	166	PF00017	0.378
LIG_SH2_STAP1	337	341	PF00017	0.623
LIG_SH2_STAT5	124	127	PF00017	0.388
LIG_SH2_STAT5	155	158	PF00017	0.330
LIG_SH2_STAT5	167	170	PF00017	0.407
LIG_SH2_STAT5	173	176	PF00017	0.566
LIG_SH2_STAT5	25	28	PF00017	0.609
LIG_SH2_STAT5	269	272	PF00017	0.400
LIG_SH2_STAT5	337	340	PF00017	0.650
LIG_SH2_STAT5	385	388	PF00017	0.608
LIG_SH3_1	324	330	PF00018	0.669
LIG_SH3_3	324	330	PF00018	0.669
LIG_SUMO_SIM_anti_2	425	431	PF11976	0.680
LIG_SUMO_SIM_par_1	337	342	PF11976	0.615
LIG_SUMO_SIM_par_1	442	450	PF11976	0.625
LIG_SUMO_SIM_par_1	67	73	PF11976	0.422
LIG_TRAF2_1	29	32	PF00917	0.645
LIG_TYR_ITIM	245	250	PF00017	0.355
MOD_CK1_1	107	113	PF00069	0.511
MOD_CK1_1	183	189	PF00069	0.554
MOD_CK1_1	238	244	PF00069	0.397
MOD_CK1_1	253	259	PF00069	0.402
MOD_CK1_1	286	292	PF00069	0.507
MOD_CK1_1	417	423	PF00069	0.561
MOD_CK1_1	449	455	PF00069	0.602
MOD_CK1_1	70	76	PF00069	0.447
MOD_CK2_1	26	32	PF00069	0.670
MOD_CK2_1	291	297	PF00069	0.530
MOD_CK2_1	362	368	PF00069	0.574
MOD_CK2_1	452	458	PF00069	0.693
MOD_CK2_1	464	470	PF00069	0.558
MOD_Cter_Amidation	12	15	PF01082	0.597
MOD_GlcNHglycan	106	109	PF01048	0.498
MOD_GlcNHglycan	182	185	PF01048	0.509
MOD_GlcNHglycan	255	258	PF01048	0.408
MOD_GlcNHglycan	308	311	PF01048	0.425
MOD_GlcNHglycan	349	352	PF01048	0.462
MOD_GlcNHglycan	377	380	PF01048	0.533
MOD_GlcNHglycan	449	452	PF01048	0.634
MOD_GlcNHglycan	483	486	PF01048	0.657
MOD_GlcNHglycan	76	79	PF01048	0.516
MOD_GSK3_1	223	230	PF00069	0.481
MOD_GSK3_1	335	342	PF00069	0.471
MOD_GSK3_1	343	350	PF00069	0.419
MOD_GSK3_1	362	369	PF00069	0.542
MOD_GSK3_1	445	452	PF00069	0.687
MOD_GSK3_1	486	493	PF00069	0.632
MOD_GSK3_1	70	77	PF00069	0.467
MOD_N-GLC_1	227	232	PF02516	0.407
MOD_N-GLC_1	81	86	PF02516	0.408
MOD_NEK2_1	1	6	PF00069	0.644
MOD_NEK2_1	190	195	PF00069	0.407
MOD_NEK2_1	223	228	PF00069	0.422
MOD_NEK2_1	235	240	PF00069	0.360
MOD_NEK2_1	275	280	PF00069	0.394
MOD_NEK2_1	301	306	PF00069	0.516
MOD_NEK2_1	339	344	PF00069	0.438
MOD_NEK2_1	366	371	PF00069	0.521
MOD_NEK2_1	415	420	PF00069	0.631
MOD_NEK2_1	446	451	PF00069	0.700
MOD_NEK2_1	494	499	PF00069	0.716
MOD_NEK2_1	67	72	PF00069	0.321
MOD_NEK2_1	86	91	PF00069	0.422
MOD_PIKK_1	223	229	PF00454	0.407
MOD_PIKK_1	464	470	PF00454	0.570
MOD_PIKK_1	86	92	PF00454	0.435
MOD_PK_1	160	166	PF00069	0.447
MOD_PKA_2	352	358	PF00069	0.505
MOD_PKA_2	464	470	PF00069	0.527
MOD_PKA_2	474	480	PF00069	0.519
MOD_Plk_1	227	233	PF00069	0.407
MOD_Plk_1	26	32	PF00069	0.562
MOD_Plk_1	81	87	PF00069	0.340
MOD_Plk_4	160	166	PF00069	0.408
MOD_Plk_4	190	196	PF00069	0.472
MOD_Plk_4	207	213	PF00069	0.228
MOD_Plk_4	265	271	PF00069	0.388
MOD_Plk_4	278	284	PF00069	0.430
MOD_Plk_4	291	297	PF00069	0.475
MOD_Plk_4	339	345	PF00069	0.458
MOD_Plk_4	423	429	PF00069	0.564
MOD_Plk_4	46	52	PF00069	0.502
MOD_Plk_4	67	73	PF00069	0.331
MOD_Plk_4	81	87	PF00069	0.290
MOD_ProDKin_1	119	125	PF00069	0.334
MOD_ProDKin_1	136	142	PF00069	0.324
MOD_ProDKin_1	248	254	PF00069	0.331
MOD_SUMO_rev_2	464	474	PF00179	0.608
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.555
TRG_ENDOCYTIC_2	155	158	PF00928	0.331
TRG_ENDOCYTIC_2	162	165	PF00928	0.333
TRG_ENDOCYTIC_2	247	250	PF00928	0.355
TRG_ENDOCYTIC_2	25	28	PF00928	0.504
TRG_ENDOCYTIC_2	269	272	PF00928	0.355
TRG_ENDOCYTIC_2	280	283	PF00928	0.396
TRG_ENDOCYTIC_2	385	388	PF00928	0.605
TRG_ER_diArg_1	14	16	PF00400	0.659
TRG_ER_diArg_1	305	308	PF00400	0.522
TRG_ER_diArg_1	317	320	PF00400	0.518
TRG_ER_diArg_1	352	354	PF00400	0.448
TRG_NLS_MonoExtC_3	319	324	PF00514	0.370
TRG_NLS_MonoExtN_4	318	324	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A8	Leptomonas seymouri	71%	90%
A0A0S4IWT9	Bodo saltans	34%	94%
A0A1X0NNP7	Trypanosomatidae	44%	93%
A0A422NNK5	Trypanosoma rangeli	42%	97%
A4H7L2	Leishmania braziliensis	80%	100%
A4HVZ6	Leishmania infantum	100%	100%
E9APP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFT1	Leishmania major	95%	100%
V5BNC5	Trypanosoma cruzi	42%	97%