Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSZ1_LEIDO

TriTrypDb:

LdBPK_140710.1 , LdCL_140012500 , LDHU3_14.0950

Length:

299

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 50
NetGPI	no	yes: 0, no: 50

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	45
GO:0110165	cellular anatomical entity	1	47
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

A0A3S7WSZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSZ1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	51
GO:0006629	lipid metabolic process	3	51
GO:0006631	fatty acid metabolic process	4	51
GO:0006633	fatty acid biosynthetic process	5	51
GO:0008152	metabolic process	1	51
GO:0008610	lipid biosynthetic process	4	51
GO:0009058	biosynthetic process	2	51
GO:0009987	cellular process	1	51
GO:0016053	organic acid biosynthetic process	4	51
GO:0019752	carboxylic acid metabolic process	5	51
GO:0032787	monocarboxylic acid metabolic process	6	51
GO:0043436	oxoacid metabolic process	4	51
GO:0044237	cellular metabolic process	2	51
GO:0044238	primary metabolic process	2	51
GO:0044249	cellular biosynthetic process	3	51
GO:0044255	cellular lipid metabolic process	3	51
GO:0044281	small molecule metabolic process	2	51
GO:0044283	small molecule biosynthetic process	3	51
GO:0046394	carboxylic acid biosynthetic process	5	51
GO:0071704	organic substance metabolic process	2	51
GO:0072330	monocarboxylic acid biosynthetic process	6	51
GO:1901576	organic substance biosynthetic process	3	51
GO:0000038	very long-chain fatty acid metabolic process	5	6
GO:0006643	membrane lipid metabolic process	4	6
GO:0006665	sphingolipid metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0019367	fatty acid elongation, saturated fatty acid	7	6
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	6
GO:0030148	sphingolipid biosynthetic process	5	6
GO:0030497	fatty acid elongation	6	6
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	6
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	6
GO:0042761	very long-chain fatty acid biosynthetic process	6	6
GO:0046467	membrane lipid biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	51
GO:0004312	fatty acid synthase activity	5	51
GO:0009922	fatty acid elongase activity	6	51
GO:0016740	transferase activity	2	51
GO:0016746	acyltransferase activity	3	51
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	51
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.268
CLV_NRD_NRD_1	237	239	PF00675	0.543
CLV_PCSK_KEX2_1	146	148	PF00082	0.344
CLV_PCSK_KEX2_1	237	239	PF00082	0.554
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.344
CLV_PCSK_SKI1_1	112	116	PF00082	0.456
CLV_PCSK_SKI1_1	79	83	PF00082	0.507
DOC_CDC14_PxL_1	71	79	PF14671	0.267
DOC_MAPK_MEF2A_6	204	212	PF00069	0.447
DOC_PP1_RVXF_1	144	151	PF00149	0.458
DOC_PP1_RVXF_1	245	251	PF00149	0.373
DOC_PP2B_LxvP_1	36	39	PF13499	0.269
DOC_USP7_MATH_1	183	187	PF00917	0.387
LIG_Actin_WH2_2	256	272	PF00022	0.428
LIG_BRCT_BRCA1_1	260	264	PF00533	0.312
LIG_EH1_1	154	162	PF00400	0.316
LIG_EH1_1	181	189	PF00400	0.304
LIG_eIF4E_1	182	188	PF01652	0.272
LIG_FHA_1	136	142	PF00498	0.289
LIG_FHA_1	156	162	PF00498	0.279
LIG_FHA_1	226	232	PF00498	0.321
LIG_FHA_1	78	84	PF00498	0.268
LIG_FHA_2	85	91	PF00498	0.327
LIG_Integrin_RGD_1	9	11	PF01839	0.582
LIG_LIR_Apic_2	266	271	PF02991	0.419
LIG_LIR_Apic_2	70	75	PF02991	0.232
LIG_LIR_Gen_1	137	148	PF02991	0.295
LIG_LIR_Gen_1	211	220	PF02991	0.375
LIG_LIR_Gen_1	255	265	PF02991	0.302
LIG_LIR_Nem_3	137	143	PF02991	0.304
LIG_LIR_Nem_3	186	192	PF02991	0.321
LIG_LIR_Nem_3	196	202	PF02991	0.464
LIG_LIR_Nem_3	211	215	PF02991	0.318
LIG_LIR_Nem_3	255	260	PF02991	0.285
LIG_LIR_Nem_3	70	74	PF02991	0.343
LIG_Pex14_2	123	127	PF04695	0.395
LIG_Pex14_2	150	154	PF04695	0.354
LIG_Pex14_2	260	264	PF04695	0.311
LIG_Pex14_2	82	86	PF04695	0.322
LIG_PTAP_UEV_1	204	209	PF05743	0.344
LIG_SH2_CRK	116	120	PF00017	0.260
LIG_SH2_CRK	72	76	PF00017	0.313
LIG_SH2_CRK	78	82	PF00017	0.262
LIG_SH2_GRB2like	109	112	PF00017	0.253
LIG_SH2_GRB2like	91	94	PF00017	0.173
LIG_SH2_PTP2	202	205	PF00017	0.523
LIG_SH2_STAP1	167	171	PF00017	0.303
LIG_SH2_STAP1	265	269	PF00017	0.483
LIG_SH2_STAT5	162	165	PF00017	0.315
LIG_SH2_STAT5	189	192	PF00017	0.323
LIG_SH2_STAT5	202	205	PF00017	0.459
LIG_SH2_STAT5	230	233	PF00017	0.266
LIG_SH2_STAT5	253	256	PF00017	0.299
LIG_SH2_STAT5	268	271	PF00017	0.451
LIG_SH2_STAT5	37	40	PF00017	0.302
LIG_SH2_STAT5	72	75	PF00017	0.316
LIG_SH2_STAT5	91	94	PF00017	0.233
LIG_SH3_1	202	208	PF00018	0.536
LIG_SH3_1	268	274	PF00018	0.469
LIG_SH3_3	202	208	PF00018	0.434
LIG_SH3_3	268	274	PF00018	0.448
LIG_SUMO_SIM_par_1	60	66	PF11976	0.291
LIG_TYR_ITIM	254	259	PF00017	0.313
LIG_UBA3_1	126	131	PF00899	0.335
LIG_WRC_WIRS_1	209	214	PF05994	0.387
LIG_WRC_WIRS_1	5	10	PF05994	0.411
MOD_GlcNHglycan	171	174	PF01048	0.457
MOD_GlcNHglycan	205	208	PF01048	0.270
MOD_GlcNHglycan	275	278	PF01048	0.504
MOD_GSK3_1	63	70	PF00069	0.309
MOD_N-GLC_1	169	174	PF02516	0.432
MOD_N-GLC_2	12	14	PF02516	0.572
MOD_NEK2_1	127	132	PF00069	0.314
MOD_NEK2_1	135	140	PF00069	0.326
MOD_NEK2_1	169	174	PF00069	0.262
MOD_NEK2_1	193	198	PF00069	0.365
MOD_NEK2_1	232	237	PF00069	0.280
MOD_NEK2_1	252	257	PF00069	0.299
MOD_NEK2_1	264	269	PF00069	0.281
MOD_NEK2_1	4	9	PF00069	0.354
MOD_NEK2_1	60	65	PF00069	0.316
MOD_NEK2_1	77	82	PF00069	0.233
MOD_NEK2_2	84	89	PF00069	0.336
MOD_PKA_2	203	209	PF00069	0.365
MOD_Plk_1	282	288	PF00069	0.741
MOD_Plk_1	84	90	PF00069	0.314
MOD_Plk_4	156	162	PF00069	0.309
MOD_Plk_4	183	189	PF00069	0.283
MOD_Plk_4	225	231	PF00069	0.279
MOD_Plk_4	252	258	PF00069	0.287
MOD_Plk_4	264	270	PF00069	0.289
MOD_Plk_4	60	66	PF00069	0.314
MOD_Plk_4	67	73	PF00069	0.318
TRG_AP2beta_CARGO_1	137	147	PF09066	0.171
TRG_DiLeu_BaEn_1	22	27	PF01217	0.415
TRG_ENDOCYTIC_2	104	107	PF00928	0.276
TRG_ENDOCYTIC_2	191	194	PF00928	0.310
TRG_ENDOCYTIC_2	256	259	PF00928	0.288
TRG_ENDOCYTIC_2	31	34	PF00928	0.295
TRG_ENDOCYTIC_2	71	74	PF00928	0.325
TRG_ENDOCYTIC_2	78	81	PF00928	0.270
TRG_ER_diArg_1	147	150	PF00400	0.342
TRG_ER_diLys_1	296	299	PF00400	0.692
TRG_NLS_MonoExtC_3	144	149	PF00514	0.367
TRG_NLS_MonoExtN_4	145	150	PF00514	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	24%	100%
A0A0N0P5E5	Leptomonas seymouri	42%	100%
A0A0N0P7D1	Leptomonas seymouri	61%	90%
A0A0N0P7D6	Leptomonas seymouri	32%	100%
A0A0N0P7R2	Leptomonas seymouri	71%	98%
A0A0N1HZJ8	Leptomonas seymouri	40%	92%
A0A0N1I9H5	Leptomonas seymouri	32%	100%
A0A0N1ILQ4	Leptomonas seymouri	35%	100%
A0A0N1IM10	Leptomonas seymouri	29%	100%
A0A0N1PDR8	Leptomonas seymouri	37%	100%
A0A0S4IS29	Bodo saltans	48%	100%
A0A0S4IVJ6	Bodo saltans	34%	94%
A0A0S4IVS6	Bodo saltans	41%	100%
A0A0S4IW98	Bodo saltans	45%	94%
A0A0S4KMP5	Bodo saltans	24%	91%
A0A1X0NNK7	Trypanosomatidae	39%	100%
A0A1X0NNL0	Trypanosomatidae	33%	99%
A0A1X0NNM4	Trypanosomatidae	35%	100%
A0A1X0NNM5	Trypanosomatidae	49%	97%
A0A1X0NP89	Trypanosomatidae	39%	94%
A0A3Q8I8T7	Leishmania donovani	32%	100%
A0A3Q8I9T2	Leishmania donovani	30%	100%
A0A3Q8I9U9	Leishmania donovani	40%	100%
A0A3Q8I9X8	Leishmania donovani	59%	100%
A0A3Q8IC05	Leishmania donovani	40%	99%
A0A3Q8ID51	Leishmania donovani	31%	100%
A0A3Q8IIA9	Leishmania donovani	33%	97%
A0A3R7KG78	Trypanosoma rangeli	43%	100%
A0A3R7MJR2	Trypanosoma rangeli	37%	100%
A0A3R7NSQ3	Trypanosoma rangeli	36%	100%
A0A3S5H6R7	Leishmania donovani	31%	99%
A0A3S5H6R8	Leishmania donovani	34%	96%
A0A3S7WSY8	Leishmania donovani	34%	96%
A0A3S7WT03	Leishmania donovani	91%	100%
A0A3S7WT16	Leishmania donovani	44%	93%
A0A422NNP1	Trypanosoma rangeli	51%	100%
A0JNC4	Bos taurus	28%	100%
A1L3X0	Homo sapiens	29%	100%
A4H7M2	Leishmania braziliensis	32%	96%
A4H7M3	Leishmania braziliensis	31%	100%
A4H7M4	Leishmania braziliensis	32%	95%
A4H7M5	Leishmania braziliensis	35%	96%
A4H7M6	Leishmania braziliensis	77%	100%
A4H7M7	Leishmania braziliensis	43%	100%
A4H7M8	Leishmania braziliensis	27%	100%
A4H7M9	Leishmania braziliensis	30%	100%
A4H7N0	Leishmania braziliensis	39%	98%
A4HW06	Leishmania infantum	24%	100%
A4HW07	Leishmania infantum	34%	96%
A4HW08	Leishmania infantum	31%	99%
A4HW09	Leishmania infantum	33%	97%
A4HW10	Leishmania infantum	35%	96%
A4HW12	Leishmania infantum	59%	100%
A4HW13	Leishmania infantum	40%	100%
A4HW14	Leishmania infantum	44%	100%
A4HW15	Leishmania infantum	30%	100%
A4HW16	Leishmania infantum	31%	100%
A4HW17	Leishmania infantum	32%	100%
A4HW18	Leishmania infantum	39%	99%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
D4A612	Rattus norvegicus	26%	100%
D4ADY9	Rattus norvegicus	29%	100%
E8NHR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AGL0	Leishmania infantum	90%	100%
E9AGL2	Leishmania infantum	99%	100%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	97%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	96%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
G5EEE5	Caenorhabditis elegans	33%	100%
O35949	Mus musculus	31%	100%
P39540	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	96%
P49191	Caenorhabditis elegans	32%	93%
Q03574	Caenorhabditis elegans	31%	100%
Q20300	Caenorhabditis elegans	30%	100%
Q20303	Caenorhabditis elegans	31%	100%
Q2KJD9	Bos taurus	23%	100%
Q32NI8	Xenopus laevis	24%	100%
Q3S8M4	Macaca mulatta	24%	95%
Q4QFQ9	Leishmania major	41%	100%
Q4QFR0	Leishmania major	33%	100%
Q4QFR1	Leishmania major	30%	100%
Q4QFR2	Leishmania major	30%	100%
Q4QFR3	Leishmania major	42%	100%
Q4QFR4	Leishmania major	40%	100%
Q4QFR5	Leishmania major	59%	100%
Q4QFR6	Leishmania major	88%	100%
Q4QFR7	Leishmania major	34%	95%
Q4QFR8	Leishmania major	32%	95%
Q4QFR9	Leishmania major	30%	100%
Q4QFS0	Leishmania major	34%	100%
Q4R516	Macaca fascicularis	24%	100%
Q5M8U1	Xenopus tropicalis	23%	100%
Q5RFL5	Pongo abelii	24%	100%
Q5ZJR8	Gallus gallus	32%	100%
Q6PC64	Danio rerio	35%	100%
Q7LKX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	82%
Q8BHI7	Mus musculus	24%	100%
Q920L5	Mus musculus	31%	100%
Q920L6	Rattus norvegicus	31%	100%
Q920L7	Rattus norvegicus	23%	100%
Q95K73	Macaca fascicularis	24%	95%
Q9BW60	Homo sapiens	25%	100%
Q9D2Y9	Mus musculus	29%	100%
Q9EQC4	Mus musculus	24%	96%
Q9GZR5	Homo sapiens	23%	95%
Q9H5J4	Homo sapiens	33%	100%
Q9HB03	Homo sapiens	29%	100%
Q9JLJ5	Mus musculus	25%	100%
Q9NYP7	Homo sapiens	24%	100%
Q9UTF7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%
Q9VV87	Drosophila melanogaster	35%	95%
Q9XVQ9	Caenorhabditis elegans	28%	100%
V5BE99	Trypanosoma cruzi	40%	100%
V5BIX9	Trypanosoma cruzi	36%	100%
V5BND3	Trypanosoma cruzi	52%	100%
V5DF68	Trypanosoma cruzi	36%	100%