Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSY8_LEIDO

TriTrypDb:

LdBPK_140660.1 , LdCL_140012100 , LDHU3_14.0890

Length:

280

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 26
NetGPI	no	yes: 0, no: 27

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	25
GO:0110165	cellular anatomical entity	1	26

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Expansion

Sequence features

A0A3S7WSY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSY8

Function

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Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	3
GO:0001676	long-chain fatty acid metabolic process	5	3
GO:0006082	organic acid metabolic process	3	28
GO:0006629	lipid metabolic process	3	28
GO:0006631	fatty acid metabolic process	4	28
GO:0006633	fatty acid biosynthetic process	5	28
GO:0006643	membrane lipid metabolic process	4	3
GO:0006665	sphingolipid metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	28

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	28
GO:0004312	fatty acid synthase activity	5	28
GO:0009922	fatty acid elongase activity	6	28
GO:0016740	transferase activity	2	28
GO:0016746	acyltransferase activity	3	28
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	28
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	28

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	264	266	PF00675	0.296
CLV_NRD_NRD_1	272	274	PF00675	0.496
CLV_PCSK_KEX2_1	272	274	PF00082	0.481
CLV_PCSK_KEX2_1	278	280	PF00082	0.534
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.546
CLV_PCSK_SKI1_1	191	195	PF00082	0.313
DEG_Nend_UBRbox_3	1	3	PF02207	0.356
DOC_AGCK_PIF_1	152	157	PF00069	0.390
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.542
DOC_MAPK_gen_1	190	200	PF00069	0.421

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	25%	95%
A0A0N0P5E5	Leptomonas seymouri	34%	94%
A0A0N0P7D1	Leptomonas seymouri	32%	84%
A0A0N0P7D6	Leptomonas seymouri	44%	97%
A0A0N0P7R2	Leptomonas seymouri	36%	92%
A0A0N1HZJ8	Leptomonas seymouri	28%	86%
A0A0N1I9H5	Leptomonas seymouri	73%	100%
A0A0N1IIZ8	Leptomonas seymouri	24%	91%
A0A0N1ILQ4	Leptomonas seymouri	39%	96%
A0A0N1IM10	Leptomonas seymouri	50%	98%

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