Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSY4_LEIDO

TriTrypDb:

LdBPK_140630.1 , LdCL_140011800 , LDHU3_14.0860

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.585
CLV_C14_Caspase3-7	221	225	PF00656	0.614
CLV_C14_Caspase3-7	430	434	PF00656	0.530
CLV_C14_Caspase3-7	444	448	PF00656	0.436
CLV_NRD_NRD_1	313	315	PF00675	0.521
CLV_NRD_NRD_1	320	322	PF00675	0.429
CLV_NRD_NRD_1	369	371	PF00675	0.611
CLV_NRD_NRD_1	379	381	PF00675	0.562
CLV_NRD_NRD_1	440	442	PF00675	0.527
CLV_NRD_NRD_1	467	469	PF00675	0.592
CLV_NRD_NRD_1	484	486	PF00675	0.499
CLV_NRD_NRD_1	578	580	PF00675	0.560
CLV_NRD_NRD_1	585	587	PF00675	0.503
CLV_NRD_NRD_1	588	590	PF00675	0.498
CLV_NRD_NRD_1	84	86	PF00675	0.494
CLV_PCSK_FUR_1	438	442	PF00082	0.532
CLV_PCSK_FUR_1	482	486	PF00082	0.650
CLV_PCSK_FUR_1	586	590	PF00082	0.490
CLV_PCSK_KEX2_1	239	241	PF00082	0.475
CLV_PCSK_KEX2_1	313	315	PF00082	0.521
CLV_PCSK_KEX2_1	325	327	PF00082	0.389
CLV_PCSK_KEX2_1	369	371	PF00082	0.611
CLV_PCSK_KEX2_1	379	381	PF00082	0.562
CLV_PCSK_KEX2_1	440	442	PF00082	0.527
CLV_PCSK_KEX2_1	456	458	PF00082	0.393
CLV_PCSK_KEX2_1	467	469	PF00082	0.489
CLV_PCSK_KEX2_1	484	486	PF00082	0.499
CLV_PCSK_KEX2_1	548	550	PF00082	0.574
CLV_PCSK_KEX2_1	578	580	PF00082	0.560
CLV_PCSK_KEX2_1	585	587	PF00082	0.503
CLV_PCSK_KEX2_1	588	590	PF00082	0.498
CLV_PCSK_KEX2_1	84	86	PF00082	0.494
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.475
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.501
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.541
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.574
CLV_PCSK_PC7_1	321	327	PF00082	0.494
CLV_PCSK_PC7_1	365	371	PF00082	0.602
CLV_PCSK_SKI1_1	117	121	PF00082	0.459
CLV_PCSK_SKI1_1	239	243	PF00082	0.479
CLV_PCSK_SKI1_1	281	285	PF00082	0.671
CLV_PCSK_SKI1_1	313	317	PF00082	0.520
CLV_PCSK_SKI1_1	322	326	PF00082	0.412
CLV_PCSK_SKI1_1	468	472	PF00082	0.580
CLV_PCSK_SKI1_1	519	523	PF00082	0.498
CLV_PCSK_SKI1_1	548	552	PF00082	0.577
CLV_PCSK_SKI1_1	578	582	PF00082	0.556
CLV_PCSK_SKI1_1	84	88	PF00082	0.494
CLV_TASPASE1	136	142	PF01112	0.451
DEG_APCC_DBOX_1	116	124	PF00400	0.475
DEG_Nend_Nbox_1	1	3	PF02207	0.503
DEG_SCF_FBW7_1	550	555	PF00400	0.553
DEG_SPOP_SBC_1	251	255	PF00917	0.667
DOC_CYCLIN_RxL_1	307	320	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	470	476	PF00134	0.533
DOC_MAPK_gen_1	346	354	PF00069	0.567
DOC_MAPK_gen_1	467	474	PF00069	0.591
DOC_MAPK_gen_1	84	91	PF00069	0.495
DOC_MAPK_MEF2A_6	346	354	PF00069	0.567
DOC_MAPK_MEF2A_6	467	476	PF00069	0.553
DOC_MAPK_MEF2A_6	84	93	PF00069	0.494
DOC_MAPK_NFAT4_5	84	92	PF00069	0.495
DOC_PP2B_LxvP_1	422	425	PF13499	0.592
DOC_PP2B_LxvP_1	470	473	PF13499	0.538
DOC_PP2B_LxvP_1	98	101	PF13499	0.469
DOC_USP7_MATH_1	102	106	PF00917	0.519
DOC_USP7_MATH_1	188	192	PF00917	0.662
DOC_USP7_MATH_1	208	212	PF00917	0.490
DOC_USP7_MATH_1	251	255	PF00917	0.625
DOC_USP7_MATH_1	381	385	PF00917	0.631
DOC_USP7_MATH_1	580	584	PF00917	0.515
DOC_WW_Pin1_4	100	105	PF00397	0.488
DOC_WW_Pin1_4	13	18	PF00397	0.504
DOC_WW_Pin1_4	160	165	PF00397	0.699
DOC_WW_Pin1_4	184	189	PF00397	0.656
DOC_WW_Pin1_4	255	260	PF00397	0.699
DOC_WW_Pin1_4	300	305	PF00397	0.546
DOC_WW_Pin1_4	34	39	PF00397	0.546
DOC_WW_Pin1_4	40	45	PF00397	0.525
DOC_WW_Pin1_4	409	414	PF00397	0.606
DOC_WW_Pin1_4	494	499	PF00397	0.719
DOC_WW_Pin1_4	530	535	PF00397	0.668
DOC_WW_Pin1_4	548	553	PF00397	0.444
DOC_WW_Pin1_4	91	96	PF00397	0.498
LIG_14-3-3_CanoR_1	214	223	PF00244	0.650
LIG_14-3-3_CanoR_1	250	259	PF00244	0.650
LIG_14-3-3_CanoR_1	260	268	PF00244	0.639
LIG_14-3-3_CanoR_1	30	34	PF00244	0.539
LIG_14-3-3_CanoR_1	313	318	PF00244	0.462
LIG_14-3-3_CanoR_1	394	402	PF00244	0.665
LIG_14-3-3_CanoR_1	519	524	PF00244	0.498
LIG_14-3-3_CanoR_1	564	568	PF00244	0.505
LIG_14-3-3_CanoR_1	578	587	PF00244	0.469
LIG_BRCT_BRCA1_1	257	261	PF00533	0.698
LIG_BRCT_BRCA1_1	293	297	PF00533	0.597
LIG_CtBP_PxDLS_1	95	99	PF00389	0.503
LIG_deltaCOP1_diTrp_1	114	121	PF00928	0.456
LIG_FHA_1	156	162	PF00498	0.646
LIG_FHA_1	275	281	PF00498	0.602
LIG_FHA_1	397	403	PF00498	0.679
LIG_FHA_1	469	475	PF00498	0.558
LIG_FHA_1	579	585	PF00498	0.560
LIG_FHA_2	216	222	PF00498	0.674
LIG_FHA_2	428	434	PF00498	0.519
LIG_LIR_Gen_1	258	269	PF02991	0.682
LIG_LIR_Gen_1	553	563	PF02991	0.532
LIG_LIR_Gen_1	67	75	PF02991	0.453
LIG_LIR_Nem_3	114	119	PF02991	0.454
LIG_LIR_Nem_3	258	264	PF02991	0.694
LIG_LIR_Nem_3	538	544	PF02991	0.684
LIG_LIR_Nem_3	553	559	PF02991	0.431
LIG_LIR_Nem_3	67	71	PF02991	0.448
LIG_MYND_1	420	424	PF01753	0.597
LIG_SH2_NCK_1	461	465	PF00017	0.461
LIG_SH2_PTP2	68	71	PF00017	0.447
LIG_SH2_SRC	418	421	PF00017	0.596
LIG_SH2_SRC	461	464	PF00017	0.462
LIG_SH2_STAT5	122	125	PF00017	0.498
LIG_SH2_STAT5	268	271	PF00017	0.552
LIG_SH2_STAT5	418	421	PF00017	0.596
LIG_SH2_STAT5	68	71	PF00017	0.457
LIG_SH2_STAT5	88	91	PF00017	0.494
LIG_SH3_3	261	267	PF00018	0.634
LIG_SH3_3	35	41	PF00018	0.552
LIG_SH3_3	375	381	PF00018	0.586
LIG_SH3_3	422	428	PF00018	0.589
LIG_SH3_3	469	475	PF00018	0.600
LIG_SH3_3	508	514	PF00018	0.672
LIG_SH3_3	98	104	PF00018	0.511
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.450
LIG_SUMO_SIM_par_1	94	99	PF11976	0.500
LIG_TRFH_1	121	125	PF08558	0.483
LIG_TYR_ITIM	66	71	PF00017	0.451
LIG_TYR_ITIM	86	91	PF00017	0.494
LIG_WW_1	265	268	PF00397	0.545
MOD_CDC14_SPxK_1	497	500	PF00782	0.635
MOD_CDK_SPK_2	255	260	PF00069	0.655
MOD_CDK_SPK_2	530	535	PF00069	0.554
MOD_CDK_SPxK_1	494	500	PF00069	0.640
MOD_CDK_SPxxK_3	160	167	PF00069	0.604
MOD_CDK_SPxxK_3	300	307	PF00069	0.535
MOD_CK1_1	103	109	PF00069	0.482
MOD_CK1_1	15	21	PF00069	0.504
MOD_CK1_1	171	177	PF00069	0.647
MOD_CK1_1	189	195	PF00069	0.498
MOD_CK1_1	213	219	PF00069	0.664
MOD_CK1_1	252	258	PF00069	0.692
MOD_CK1_1	291	297	PF00069	0.521
MOD_CK1_1	382	388	PF00069	0.686
MOD_CK1_1	390	396	PF00069	0.608
MOD_CK1_1	403	409	PF00069	0.571
MOD_CK1_1	42	48	PF00069	0.547
MOD_CK1_1	94	100	PF00069	0.508
MOD_Cter_Amidation	82	85	PF01082	0.486
MOD_GlcNHglycan	130	133	PF01048	0.583
MOD_GlcNHglycan	152	155	PF01048	0.536
MOD_GlcNHglycan	188	191	PF01048	0.513
MOD_GlcNHglycan	244	247	PF01048	0.585
MOD_GlcNHglycan	381	384	PF01048	0.607
MOD_GlcNHglycan	390	393	PF01048	0.547
MOD_GlcNHglycan	516	519	PF01048	0.622
MOD_GlcNHglycan	81	84	PF01048	0.479
MOD_GSK3_1	124	131	PF00069	0.536
MOD_GSK3_1	140	147	PF00069	0.519
MOD_GSK3_1	167	174	PF00069	0.679
MOD_GSK3_1	182	189	PF00069	0.546
MOD_GSK3_1	209	216	PF00069	0.640
MOD_GSK3_1	249	256	PF00069	0.690
MOD_GSK3_1	287	294	PF00069	0.567
MOD_GSK3_1	384	391	PF00069	0.651
MOD_GSK3_1	394	401	PF00069	0.591
MOD_GSK3_1	402	409	PF00069	0.548
MOD_GSK3_1	423	430	PF00069	0.541
MOD_GSK3_1	548	555	PF00069	0.566
MOD_GSK3_1	96	103	PF00069	0.507
MOD_N-GLC_1	274	279	PF02516	0.547
MOD_NEK2_1	112	117	PF00069	0.416
MOD_NEK2_1	128	133	PF00069	0.561
MOD_NEK2_1	140	145	PF00069	0.482
MOD_NEK2_1	209	214	PF00069	0.559
MOD_NEK2_1	242	247	PF00069	0.562
MOD_NEK2_1	293	298	PF00069	0.618
MOD_NEK2_1	404	409	PF00069	0.610
MOD_NEK2_1	478	483	PF00069	0.629
MOD_NEK2_1	89	94	PF00069	0.492
MOD_NEK2_1	96	101	PF00069	0.483
MOD_NEK2_2	580	585	PF00069	0.516
MOD_PIKK_1	155	161	PF00454	0.692
MOD_PIKK_1	259	265	PF00454	0.690
MOD_PIKK_1	423	429	PF00454	0.579
MOD_PKA_1	313	319	PF00069	0.467
MOD_PKA_1	379	385	PF00069	0.621
MOD_PKA_1	578	584	PF00069	0.559
MOD_PKA_2	213	219	PF00069	0.644
MOD_PKA_2	249	255	PF00069	0.646
MOD_PKA_2	259	265	PF00069	0.646
MOD_PKA_2	29	35	PF00069	0.537
MOD_PKA_2	313	319	PF00069	0.462
MOD_PKA_2	379	385	PF00069	0.632
MOD_PKA_2	387	393	PF00069	0.595
MOD_PKA_2	509	515	PF00069	0.591
MOD_PKA_2	563	569	PF00069	0.542
MOD_PKA_2	578	584	PF00069	0.419
MOD_PKB_1	248	256	PF00069	0.624
MOD_Plk_1	232	238	PF00069	0.554
MOD_Plk_1	274	280	PF00069	0.546
MOD_Plk_1	339	345	PF00069	0.559
MOD_Plk_1	468	474	PF00069	0.556
MOD_Plk_1	552	558	PF00069	0.548
MOD_Plk_4	140	146	PF00069	0.559
MOD_Plk_4	233	239	PF00069	0.492
MOD_Plk_4	275	281	PF00069	0.547
MOD_Plk_4	313	319	PF00069	0.462
MOD_Plk_4	354	360	PF00069	0.591
MOD_Plk_4	552	558	PF00069	0.581
MOD_Plk_4	563	569	PF00069	0.440
MOD_Plk_4	64	70	PF00069	0.467
MOD_ProDKin_1	100	106	PF00069	0.491
MOD_ProDKin_1	13	19	PF00069	0.504
MOD_ProDKin_1	160	166	PF00069	0.701
MOD_ProDKin_1	184	190	PF00069	0.654
MOD_ProDKin_1	255	261	PF00069	0.700
MOD_ProDKin_1	300	306	PF00069	0.538
MOD_ProDKin_1	34	40	PF00069	0.546
MOD_ProDKin_1	409	415	PF00069	0.606
MOD_ProDKin_1	494	500	PF00069	0.718
MOD_ProDKin_1	530	536	PF00069	0.668
MOD_ProDKin_1	548	554	PF00069	0.439
MOD_ProDKin_1	91	97	PF00069	0.500
MOD_SUMO_rev_2	320	327	PF00179	0.495
MOD_SUMO_rev_2	451	458	PF00179	0.541
MOD_SUMO_rev_2	543	550	PF00179	0.614
TRG_DiLeu_BaEn_4	229	235	PF01217	0.590
TRG_DiLeu_BaEn_4	362	368	PF01217	0.582
TRG_DiLeu_BaEn_4	453	459	PF01217	0.545
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.480
TRG_ENDOCYTIC_2	331	334	PF00928	0.508
TRG_ENDOCYTIC_2	68	71	PF00928	0.447
TRG_ENDOCYTIC_2	88	91	PF00928	0.494
TRG_ER_diArg_1	247	250	PF00400	0.611
TRG_ER_diArg_1	312	314	PF00400	0.521
TRG_ER_diArg_1	378	380	PF00400	0.616
TRG_ER_diArg_1	438	441	PF00400	0.540
TRG_ER_diArg_1	466	468	PF00400	0.586
TRG_ER_diArg_1	482	485	PF00400	0.499
TRG_ER_diArg_1	577	579	PF00400	0.559
TRG_ER_diArg_1	584	586	PF00400	0.502
TRG_ER_diArg_1	587	589	PF00400	0.497
TRG_ER_diArg_1	84	86	PF00400	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7L9	Leishmania braziliensis	59%	100%
A4HW04	Leishmania infantum	99%	100%
E9APQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QFS3	Leishmania major	86%	100%