SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSX9_LEIDO

TriTrypDb:

LdBPK_140610.1 , LdCL_140011600 , LDHU3_14.0840

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WSX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSX9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0001510	RNA methylation	4	1
GO:0002128	tRNA nucleoside ribose methylation	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0030488	tRNA methylation	5	1
GO:0032259	methylation	2	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0008168	methyltransferase activity	4	8
GO:0008173	RNA methyltransferase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0008171	O-methyltransferase activity	5	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016300	tRNA (uracil) methyltransferase activity	6	1
GO:0016427	tRNA (cytosine) methyltransferase activity	6	1
GO:0052665	tRNA (uracil-2'-O-)-methyltransferase activity	7	1
GO:0052666	tRNA (cytosine-2'-O-)-methyltransferase activity	7	1
GO:0062105	RNA 2'-O-methyltransferase activity	5	1
GO:0106050	tRNA 2'-O-methyltransferase activity	6	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.536
CLV_MEL_PAP_1	283	289	PF00089	0.464
CLV_NRD_NRD_1	191	193	PF00675	0.473
CLV_NRD_NRD_1	61	63	PF00675	0.693
CLV_NRD_NRD_1	76	78	PF00675	0.695
CLV_PCSK_FUR_1	74	78	PF00082	0.572
CLV_PCSK_KEX2_1	145	147	PF00082	0.716
CLV_PCSK_KEX2_1	191	193	PF00082	0.473
CLV_PCSK_KEX2_1	76	78	PF00082	0.596
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.716
CLV_PCSK_PC7_1	72	78	PF00082	0.555
CLV_PCSK_SKI1_1	113	117	PF00082	0.485
CLV_PCSK_SKI1_1	191	195	PF00082	0.495
CLV_PCSK_SKI1_1	390	394	PF00082	0.620
CLV_PCSK_SKI1_1	470	474	PF00082	0.508
DEG_SPOP_SBC_1	20	24	PF00917	0.648
DEG_SPOP_SBC_1	47	51	PF00917	0.665
DOC_CKS1_1	222	227	PF01111	0.402
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.552
DOC_MAPK_gen_1	74	82	PF00069	0.576
DOC_MAPK_MEF2A_6	319	326	PF00069	0.450
DOC_PP1_SILK_1	229	234	PF00149	0.382
DOC_PP2B_LxvP_1	324	327	PF13499	0.425
DOC_PP2B_LxvP_1	82	85	PF13499	0.473
DOC_PP4_FxxP_1	376	379	PF00568	0.507
DOC_USP7_MATH_1	141	145	PF00917	0.589
DOC_USP7_MATH_1	19	23	PF00917	0.764
DOC_USP7_MATH_1	279	283	PF00917	0.530
DOC_USP7_MATH_1	350	354	PF00917	0.571
DOC_USP7_MATH_1	47	51	PF00917	0.661
DOC_WW_Pin1_4	207	212	PF00397	0.606
DOC_WW_Pin1_4	221	226	PF00397	0.361
DOC_WW_Pin1_4	23	28	PF00397	0.682
DOC_WW_Pin1_4	30	35	PF00397	0.596
DOC_WW_Pin1_4	346	351	PF00397	0.719
DOC_WW_Pin1_4	43	48	PF00397	0.671
DOC_WW_Pin1_4	484	489	PF00397	0.536
LIG_14-3-3_CanoR_1	157	167	PF00244	0.782
LIG_FHA_1	109	115	PF00498	0.472
LIG_FHA_1	252	258	PF00498	0.660
LIG_FHA_1	305	311	PF00498	0.522
LIG_FHA_1	38	44	PF00498	0.690
LIG_FHA_1	391	397	PF00498	0.668
LIG_FHA_1	437	443	PF00498	0.419
LIG_FHA_1	49	55	PF00498	0.651
LIG_FHA_1	98	104	PF00498	0.578
LIG_FHA_2	159	165	PF00498	0.699
LIG_FHA_2	183	189	PF00498	0.444
LIG_FHA_2	268	274	PF00498	0.753
LIG_LIR_Apic_2	373	379	PF02991	0.407
LIG_LIR_Gen_1	125	132	PF02991	0.577
LIG_LIR_Gen_1	330	340	PF02991	0.388
LIG_LIR_Nem_3	125	131	PF02991	0.573
LIG_LIR_Nem_3	330	336	PF02991	0.362
LIG_LIR_Nem_3	467	472	PF02991	0.479
LIG_Pex14_1	469	473	PF04695	0.495
LIG_Rb_pABgroove_1	327	335	PF01858	0.377
LIG_SH2_CRK	445	449	PF00017	0.426
LIG_SH2_NCK_1	372	376	PF00017	0.468
LIG_SH2_SRC	372	375	PF00017	0.462
LIG_SH2_STAP1	128	132	PF00017	0.569
LIG_SH2_STAP1	306	310	PF00017	0.545
LIG_SH2_STAT3	340	343	PF00017	0.474
LIG_SH2_STAT5	306	309	PF00017	0.428
LIG_SH2_STAT5	404	407	PF00017	0.334
LIG_SH3_3	216	222	PF00018	0.405
LIG_SH3_3	344	350	PF00018	0.598
LIG_SH3_3	423	429	PF00018	0.372
LIG_SH3_3	78	84	PF00018	0.562
LIG_SUMO_SIM_par_1	356	361	PF11976	0.349
LIG_TRAF2_1	160	163	PF00917	0.634
LIG_TRAF2_1	253	256	PF00917	0.626
LIG_TYR_ITIM	443	448	PF00017	0.411
LIG_WRC_WIRS_1	287	292	PF05994	0.430
MOD_CK1_1	108	114	PF00069	0.564
MOD_CK1_1	23	29	PF00069	0.716
MOD_CK1_1	260	266	PF00069	0.649
MOD_CK1_1	267	273	PF00069	0.642
MOD_CK1_1	304	310	PF00069	0.523
MOD_CK1_1	351	357	PF00069	0.522
MOD_CK1_1	377	383	PF00069	0.559
MOD_CK1_1	46	52	PF00069	0.806
MOD_CK1_1	464	470	PF00069	0.492
MOD_CK2_1	182	188	PF00069	0.455
MOD_CK2_1	250	256	PF00069	0.707
MOD_CK2_1	267	273	PF00069	0.751
MOD_DYRK1A_RPxSP_1	348	352	PF00069	0.540
MOD_GlcNHglycan	107	110	PF01048	0.567
MOD_GlcNHglycan	11	14	PF01048	0.611
MOD_GlcNHglycan	122	125	PF01048	0.590
MOD_GlcNHglycan	264	267	PF01048	0.631
MOD_GlcNHglycan	277	280	PF01048	0.642
MOD_GlcNHglycan	292	295	PF01048	0.315
MOD_GlcNHglycan	413	416	PF01048	0.433
MOD_GSK3_1	104	111	PF00069	0.565
MOD_GSK3_1	158	165	PF00069	0.720
MOD_GSK3_1	19	26	PF00069	0.637
MOD_GSK3_1	246	253	PF00069	0.632
MOD_GSK3_1	260	267	PF00069	0.648
MOD_GSK3_1	275	282	PF00069	0.751
MOD_GSK3_1	286	293	PF00069	0.397
MOD_GSK3_1	346	353	PF00069	0.579
MOD_GSK3_1	43	50	PF00069	0.611
MOD_N-GLC_1	207	212	PF02516	0.663
MOD_NEK2_1	262	267	PF00069	0.626
MOD_NEK2_1	290	295	PF00069	0.369
MOD_NEK2_1	436	441	PF00069	0.418
MOD_NEK2_1	482	487	PF00069	0.500
MOD_NEK2_2	122	127	PF00069	0.555
MOD_NEK2_2	279	284	PF00069	0.524
MOD_PIKK_1	170	176	PF00454	0.618
MOD_PIKK_1	377	383	PF00454	0.608
MOD_PKA_2	158	164	PF00069	0.744
MOD_PKA_2	170	176	PF00069	0.611
MOD_PKA_2	446	452	PF00069	0.360
MOD_PKA_2	482	488	PF00069	0.561
MOD_PKB_1	284	292	PF00069	0.454
MOD_Plk_1	162	168	PF00069	0.637
MOD_Plk_4	162	168	PF00069	0.709
MOD_Plk_4	286	292	PF00069	0.541
MOD_ProDKin_1	207	213	PF00069	0.589
MOD_ProDKin_1	221	227	PF00069	0.357
MOD_ProDKin_1	23	29	PF00069	0.682
MOD_ProDKin_1	30	36	PF00069	0.598
MOD_ProDKin_1	346	352	PF00069	0.714
MOD_ProDKin_1	43	49	PF00069	0.672
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.460
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.487
TRG_ENDOCYTIC_2	128	131	PF00928	0.588
TRG_ENDOCYTIC_2	445	448	PF00928	0.422
TRG_ENDOCYTIC_2	95	98	PF00928	0.545
TRG_ER_diArg_1	190	192	PF00400	0.469
TRG_ER_diArg_1	283	286	PF00400	0.515
TRG_ER_diArg_1	481	484	PF00400	0.486
TRG_ER_diArg_1	73	76	PF00400	0.654
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIC5	Leptomonas seymouri	49%	94%
A4H7L7	Leishmania braziliensis	69%	100%
A4HW02	Leishmania infantum	100%	100%
E9APQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QFS5	Leishmania major	93%	100%
V5BIX5	Trypanosoma cruzi	30%	100%