Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WSX8_LEIDO

TriTrypDb:

LdBPK_140570.1 , LdCL_140011100 , LDHU3_14.0790

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WSX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.791
CLV_NRD_NRD_1	226	228	PF00675	0.727
CLV_NRD_NRD_1	331	333	PF00675	0.511
CLV_NRD_NRD_1	407	409	PF00675	0.481
CLV_NRD_NRD_1	41	43	PF00675	0.689
CLV_NRD_NRD_1	416	418	PF00675	0.527
CLV_NRD_NRD_1	422	424	PF00675	0.528
CLV_NRD_NRD_1	433	435	PF00675	0.519
CLV_PCSK_KEX2_1	226	228	PF00082	0.761
CLV_PCSK_KEX2_1	329	331	PF00082	0.483
CLV_PCSK_KEX2_1	407	409	PF00082	0.481
CLV_PCSK_KEX2_1	41	43	PF00082	0.714
CLV_PCSK_KEX2_1	416	418	PF00082	0.516
CLV_PCSK_KEX2_1	422	424	PF00082	0.496
CLV_PCSK_KEX2_1	456	458	PF00082	0.629
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.546
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.649
CLV_PCSK_SKI1_1	126	130	PF00082	0.704
CLV_PCSK_SKI1_1	167	171	PF00082	0.700
CLV_PCSK_SKI1_1	299	303	PF00082	0.402
CLV_PCSK_SKI1_1	318	322	PF00082	0.375
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DEG_SCF_FBW7_1	340	347	PF00400	0.691
DOC_CDC14_PxL_1	267	275	PF14671	0.437
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.513
DOC_MAPK_gen_1	223	231	PF00069	0.551
DOC_MAPK_MEF2A_6	51	58	PF00069	0.553
DOC_MAPK_MEF2A_6	9	18	PF00069	0.530
DOC_PP1_RVXF_1	165	172	PF00149	0.503
DOC_PP1_SILK_1	452	457	PF00149	0.848
DOC_PP2B_LxvP_1	108	111	PF13499	0.582
DOC_PP2B_LxvP_1	20	23	PF13499	0.553
DOC_PP2B_LxvP_1	272	275	PF13499	0.513
DOC_PP2B_PxIxI_1	53	59	PF00149	0.527
DOC_PP4_FxxP_1	476	479	PF00568	0.759
DOC_USP7_MATH_1	202	206	PF00917	0.574
DOC_USP7_MATH_1	344	348	PF00917	0.759
DOC_USP7_MATH_1	391	395	PF00917	0.809
DOC_USP7_MATH_1	63	67	PF00917	0.562
DOC_USP7_UBL2_3	299	303	PF12436	0.723
DOC_USP7_UBL2_3	321	325	PF12436	0.738
DOC_WW_Pin1_4	238	243	PF00397	0.470
DOC_WW_Pin1_4	255	260	PF00397	0.477
DOC_WW_Pin1_4	30	35	PF00397	0.489
DOC_WW_Pin1_4	340	345	PF00397	0.725
DOC_WW_Pin1_4	354	359	PF00397	0.736
DOC_WW_Pin1_4	367	372	PF00397	0.708
DOC_WW_Pin1_4	434	439	PF00397	0.851
DOC_WW_Pin1_4	469	474	PF00397	0.786
LIG_14-3-3_CanoR_1	150	156	PF00244	0.503
LIG_14-3-3_CanoR_1	332	340	PF00244	0.730
LIG_14-3-3_CanoR_1	362	371	PF00244	0.713
LIG_14-3-3_CanoR_1	407	411	PF00244	0.658
LIG_14-3-3_CanoR_1	434	438	PF00244	0.800
LIG_14-3-3_CanoR_1	457	464	PF00244	0.757
LIG_14-3-3_CanoR_1	483	487	PF00244	0.786
LIG_BIR_III_2	31	35	PF00653	0.488
LIG_BIR_III_4	217	221	PF00653	0.539
LIG_BRCT_BRCA1_1	121	125	PF00533	0.573
LIG_BRCT_BRCA1_1	65	69	PF00533	0.560
LIG_FHA_1	116	122	PF00498	0.522
LIG_FHA_1	15	21	PF00498	0.586
LIG_FHA_1	172	178	PF00498	0.480
LIG_FHA_1	211	217	PF00498	0.510
LIG_FHA_1	24	30	PF00498	0.676
LIG_FHA_2	231	237	PF00498	0.547
LIG_FHA_2	249	255	PF00498	0.354
LIG_FHA_2	443	449	PF00498	0.755
LIG_FHA_2	93	99	PF00498	0.533
LIG_GBD_Chelix_1	282	290	PF00786	0.474
LIG_IRF3_LxIS_1	282	289	PF10401	0.436
LIG_LIR_Apic_2	475	479	PF02991	0.756
LIG_LIR_Gen_1	258	267	PF02991	0.514
LIG_LIR_LC3C_4	279	284	PF02991	0.299
LIG_LIR_Nem_3	122	128	PF02991	0.568
LIG_LIR_Nem_3	225	231	PF02991	0.462
LIG_LIR_Nem_3	258	264	PF02991	0.514
LIG_MYND_1	271	275	PF01753	0.294
LIG_NRBOX	14	20	PF00104	0.672
LIG_NRBOX	286	292	PF00104	0.323
LIG_PCNA_yPIPBox_3	9	19	PF02747	0.463
LIG_PDZ_Class_2	483	488	PF00595	0.821
LIG_Pex14_1	115	119	PF04695	0.585
LIG_Pex14_2	180	184	PF04695	0.472
LIG_Pex14_2	69	73	PF04695	0.539
LIG_RPA_C_Fungi	411	423	PF08784	0.684
LIG_SH2_GRB2like	181	184	PF00017	0.590
LIG_SH2_GRB2like	192	195	PF00017	0.570
LIG_SH2_SRC	234	237	PF00017	0.693
LIG_SH2_STAP1	224	228	PF00017	0.698
LIG_SH2_STAT3	188	191	PF00017	0.507
LIG_SH2_STAT5	119	122	PF00017	0.652
LIG_SH2_STAT5	181	184	PF00017	0.590
LIG_SH2_STAT5	224	227	PF00017	0.600
LIG_SH2_STAT5	234	237	PF00017	0.576
LIG_SH2_STAT5	294	297	PF00017	0.544
LIG_SH2_STAT5	36	39	PF00017	0.592
LIG_SH3_3	1	7	PF00018	0.646
LIG_SH3_3	236	242	PF00018	0.622
LIG_SH3_3	443	449	PF00018	0.742
LIG_SH3_4	299	306	PF00018	0.666
LIG_Sin3_3	25	32	PF02671	0.551
LIG_SUMO_SIM_anti_2	289	294	PF11976	0.436
LIG_SUMO_SIM_par_1	212	217	PF11976	0.571
LIG_SUMO_SIM_par_1	274	279	PF11976	0.416
LIG_SUMO_SIM_par_1	283	289	PF11976	0.311
LIG_SUMO_SIM_par_1	52	59	PF11976	0.704
LIG_UBA3_1	291	299	PF00899	0.648
LIG_WRPW_2	198	201	PF00400	0.627
MOD_CDK_SPK_2	340	345	PF00069	0.652
MOD_CDK_SPK_2	367	372	PF00069	0.682
MOD_CDK_SPxxK_3	238	245	PF00069	0.640
MOD_CK1_1	336	342	PF00069	0.711
MOD_CK1_1	365	371	PF00069	0.714
MOD_CK1_1	394	400	PF00069	0.789
MOD_CK1_1	430	436	PF00069	0.802
MOD_CK1_1	437	443	PF00069	0.716
MOD_CK1_1	460	466	PF00069	0.853
MOD_CK1_1	469	475	PF00069	0.689
MOD_CK2_1	230	236	PF00069	0.590
MOD_CK2_1	92	98	PF00069	0.722
MOD_DYRK1A_RPxSP_1	238	242	PF00069	0.625
MOD_GlcNHglycan	121	124	PF01048	0.719
MOD_GlcNHglycan	278	281	PF01048	0.416
MOD_GlcNHglycan	335	338	PF01048	0.691
MOD_GlcNHglycan	351	354	PF01048	0.491
MOD_GlcNHglycan	372	375	PF01048	0.679
MOD_GlcNHglycan	379	382	PF01048	0.712
MOD_GlcNHglycan	465	468	PF01048	0.849
MOD_GSK3_1	115	122	PF00069	0.661
MOD_GSK3_1	248	255	PF00069	0.608
MOD_GSK3_1	336	343	PF00069	0.682
MOD_GSK3_1	344	351	PF00069	0.672
MOD_GSK3_1	361	368	PF00069	0.548
MOD_GSK3_1	399	406	PF00069	0.791
MOD_GSK3_1	423	430	PF00069	0.822
MOD_GSK3_1	433	440	PF00069	0.705
MOD_GSK3_1	456	463	PF00069	0.844
MOD_LATS_1	421	427	PF00433	0.817
MOD_N-GLC_1	115	120	PF02516	0.666
MOD_N-GLC_1	182	187	PF02516	0.595
MOD_N-GLC_1	193	198	PF02516	0.578
MOD_N-GLC_1	210	215	PF02516	0.636
MOD_N-GLC_1	63	68	PF02516	0.716
MOD_NEK2_1	14	19	PF00069	0.611
MOD_NEK2_1	252	257	PF00069	0.711
MOD_NEK2_1	286	291	PF00069	0.430
MOD_NEK2_1	348	353	PF00069	0.576
MOD_NEK2_1	450	455	PF00069	0.673
MOD_NEK2_1	84	89	PF00069	0.706
MOD_PIKK_1	394	400	PF00454	0.828
MOD_PKA_1	422	428	PF00069	0.679
MOD_PKA_1	456	462	PF00069	0.739
MOD_PKA_2	222	228	PF00069	0.572
MOD_PKA_2	344	350	PF00069	0.769
MOD_PKA_2	361	367	PF00069	0.478
MOD_PKA_2	406	412	PF00069	0.854
MOD_PKA_2	422	428	PF00069	0.620
MOD_PKA_2	433	439	PF00069	0.689
MOD_PKA_2	456	462	PF00069	0.843
MOD_PKA_2	482	488	PF00069	0.691
MOD_Plk_1	115	121	PF00069	0.665
MOD_Plk_1	193	199	PF00069	0.555
MOD_Plk_1	210	216	PF00069	0.594
MOD_Plk_4	124	130	PF00069	0.678
MOD_Plk_4	14	20	PF00069	0.563
MOD_Plk_4	230	236	PF00069	0.602
MOD_Plk_4	248	254	PF00069	0.457
MOD_Plk_4	344	350	PF00069	0.663
MOD_Plk_4	450	456	PF00069	0.812
MOD_Plk_4	65	71	PF00069	0.607
MOD_Plk_4	85	91	PF00069	0.629
MOD_ProDKin_1	238	244	PF00069	0.587
MOD_ProDKin_1	255	261	PF00069	0.598
MOD_ProDKin_1	30	36	PF00069	0.610
MOD_ProDKin_1	340	346	PF00069	0.663
MOD_ProDKin_1	354	360	PF00069	0.677
MOD_ProDKin_1	367	373	PF00069	0.638
MOD_ProDKin_1	434	440	PF00069	0.839
MOD_ProDKin_1	469	475	PF00069	0.741
MOD_SUMO_for_1	302	305	PF00179	0.668
MOD_SUMO_for_1	310	313	PF00179	0.587
MOD_SUMO_for_1	320	323	PF00179	0.409
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.542
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.707
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.535
TRG_ENDOCYTIC_2	181	184	PF00928	0.590
TRG_ENDOCYTIC_2	228	231	PF00928	0.607
TRG_ER_diArg_1	226	228	PF00400	0.712
TRG_ER_diArg_1	330	332	PF00400	0.641
TRG_ER_diArg_1	422	424	PF00400	0.719
TRG_NLS_MonoCore_2	328	333	PF00514	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W9	Leptomonas seymouri	35%	100%
A4H7L3	Leishmania braziliensis	71%	100%
A4HVZ8	Leishmania infantum	99%	100%
E9APQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFS9	Leishmania major	87%	94%