Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WSW7_LEIDO

TriTrypDb:

LdBPK_140510.1 , LdCL_140010500 , LDHU3_14.0690

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.565
CLV_C14_Caspase3-7	349	353	PF00656	0.603
CLV_NRD_NRD_1	130	132	PF00675	0.686
CLV_NRD_NRD_1	275	277	PF00675	0.629
CLV_NRD_NRD_1	390	392	PF00675	0.497
CLV_NRD_NRD_1	451	453	PF00675	0.652
CLV_NRD_NRD_1	527	529	PF00675	0.551
CLV_NRD_NRD_1	73	75	PF00675	0.581
CLV_PCSK_KEX2_1	129	131	PF00082	0.709
CLV_PCSK_KEX2_1	275	277	PF00082	0.629
CLV_PCSK_KEX2_1	390	392	PF00082	0.481
CLV_PCSK_KEX2_1	451	453	PF00082	0.652
CLV_PCSK_KEX2_1	73	75	PF00082	0.588
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.575
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.481
CLV_PCSK_SKI1_1	131	135	PF00082	0.592
CLV_PCSK_SKI1_1	316	320	PF00082	0.612
CLV_PCSK_SKI1_1	480	484	PF00082	0.563
CLV_Separin_Metazoa	38	42	PF03568	0.676
DEG_APCC_DBOX_1	139	147	PF00400	0.671
DEG_Nend_UBRbox_1	1	4	PF02207	0.595
DEG_SCF_FBW7_1	12	18	PF00400	0.615
DOC_CKS1_1	12	17	PF01111	0.615
DOC_CYCLIN_RxL_1	388	397	PF00134	0.585
DOC_MAPK_gen_1	388	395	PF00069	0.473
DOC_MAPK_MEF2A_6	354	362	PF00069	0.646
DOC_PP4_FxxP_1	362	365	PF00568	0.720
DOC_USP7_MATH_1	177	181	PF00917	0.621
DOC_USP7_MATH_1	230	234	PF00917	0.707
DOC_USP7_MATH_1	243	247	PF00917	0.625
DOC_USP7_MATH_1	274	278	PF00917	0.780
DOC_USP7_MATH_1	409	413	PF00917	0.703
DOC_USP7_MATH_1	419	423	PF00917	0.620
DOC_USP7_MATH_1	424	428	PF00917	0.529
DOC_USP7_MATH_1	537	541	PF00917	0.672
DOC_USP7_MATH_1	543	547	PF00917	0.668
DOC_USP7_UBL2_3	388	392	PF12436	0.486
DOC_WW_Pin1_4	105	110	PF00397	0.719
DOC_WW_Pin1_4	11	16	PF00397	0.825
DOC_WW_Pin1_4	184	189	PF00397	0.674
DOC_WW_Pin1_4	445	450	PF00397	0.812
LIG_14-3-3_CanoR_1	260	269	PF00244	0.609
LIG_14-3-3_CanoR_1	354	358	PF00244	0.617
LIG_14-3-3_CanoR_1	73	79	PF00244	0.644
LIG_Actin_WH2_2	22	37	PF00022	0.533
LIG_Actin_WH2_2	326	343	PF00022	0.557
LIG_BIR_III_2	265	269	PF00653	0.780
LIG_BIR_III_4	225	229	PF00653	0.701
LIG_Dynein_DLC8_1	39	45	PF01221	0.789
LIG_FHA_1	145	151	PF00498	0.570
LIG_FHA_1	282	288	PF00498	0.703
LIG_FHA_1	395	401	PF00498	0.559
LIG_FHA_2	115	121	PF00498	0.764
LIG_FHA_2	214	220	PF00498	0.539
LIG_FHA_2	262	268	PF00498	0.632
LIG_FHA_2	370	376	PF00498	0.550
LIG_FHA_2	442	448	PF00498	0.601
LIG_FHA_2	93	99	PF00498	0.751
LIG_GBD_Chelix_1	510	518	PF00786	0.632
LIG_LIR_Apic_2	361	365	PF02991	0.725
LIG_LIR_Nem_3	240	244	PF02991	0.593
LIG_LIR_Nem_3	505	510	PF02991	0.634
LIG_NRBOX	346	352	PF00104	0.668
LIG_PDZ_Class_1	543	548	PF00595	0.634
LIG_SH2_CRK	507	511	PF00017	0.624
LIG_SH2_STAT3	312	315	PF00017	0.539
LIG_SH2_STAT5	503	506	PF00017	0.625
LIG_SH2_STAT5	531	534	PF00017	0.535
LIG_SH3_2	271	276	PF14604	0.702
LIG_SH3_3	185	191	PF00018	0.735
LIG_SH3_3	224	230	PF00018	0.765
LIG_SH3_3	265	271	PF00018	0.828
LIG_SH3_3	36	42	PF00018	0.630
LIG_TRAF2_1	334	337	PF00917	0.516
LIG_TRAF2_1	372	375	PF00917	0.555
LIG_TRAF2_1	499	502	PF00917	0.496
LIG_TRAF2_1	77	80	PF00917	0.613
LIG_WW_3	267	271	PF00397	0.678
MOD_CDK_SPK_2	105	110	PF00069	0.619
MOD_CDK_SPxK_1	445	451	PF00069	0.634
MOD_CDK_SPxxK_3	445	452	PF00069	0.640
MOD_CK1_1	11	17	PF00069	0.763
MOD_CK1_1	180	186	PF00069	0.636
MOD_CK1_1	187	193	PF00069	0.628
MOD_CK1_1	233	239	PF00069	0.767
MOD_CK1_1	311	317	PF00069	0.652
MOD_CK1_1	426	432	PF00069	0.704
MOD_CK1_1	438	444	PF00069	0.578
MOD_CK1_1	47	53	PF00069	0.796
MOD_CK2_1	213	219	PF00069	0.690
MOD_CK2_1	243	249	PF00069	0.673
MOD_CK2_1	369	375	PF00069	0.558
MOD_CK2_1	441	447	PF00069	0.601
MOD_CK2_1	471	477	PF00069	0.631
MOD_CK2_1	74	80	PF00069	0.618
MOD_CK2_1	92	98	PF00069	0.746
MOD_Cter_Amidation	71	74	PF01082	0.640
MOD_GlcNHglycan	221	225	PF01048	0.728
MOD_GlcNHglycan	252	256	PF01048	0.548
MOD_GlcNHglycan	379	382	PF01048	0.512
MOD_GlcNHglycan	411	414	PF01048	0.675
MOD_GlcNHglycan	420	424	PF01048	0.569
MOD_GlcNHglycan	426	429	PF01048	0.496
MOD_GlcNHglycan	436	440	PF01048	0.539
MOD_GlcNHglycan	46	49	PF01048	0.719
MOD_GlcNHglycan	464	468	PF01048	0.597
MOD_GlcNHglycan	539	542	PF01048	0.612
MOD_GlcNHglycan	82	85	PF01048	0.604
MOD_GlcNHglycan	89	92	PF01048	0.637
MOD_GSK3_1	101	108	PF00069	0.678
MOD_GSK3_1	112	119	PF00069	0.772
MOD_GSK3_1	177	184	PF00069	0.648
MOD_GSK3_1	239	246	PF00069	0.764
MOD_GSK3_1	336	343	PF00069	0.572
MOD_GSK3_1	40	47	PF00069	0.711
MOD_GSK3_1	409	416	PF00069	0.678
MOD_GSK3_1	419	426	PF00069	0.573
MOD_GSK3_1	435	442	PF00069	0.774
MOD_GSK3_1	463	470	PF00069	0.599
MOD_GSK3_1	7	14	PF00069	0.653
MOD_GSK3_1	87	94	PF00069	0.667
MOD_N-GLC_1	121	126	PF02516	0.645
MOD_N-GLC_1	409	414	PF02516	0.652
MOD_N-GLC_2	456	458	PF02516	0.579
MOD_NEK2_1	250	255	PF00069	0.595
MOD_NEK2_1	379	384	PF00069	0.541
MOD_NEK2_1	418	423	PF00069	0.796
MOD_NEK2_1	440	445	PF00069	0.771
MOD_NEK2_1	6	11	PF00069	0.639
MOD_NEK2_2	181	186	PF00069	0.563
MOD_NEK2_2	8	13	PF00069	0.610
MOD_PIKK_1	230	236	PF00454	0.746
MOD_PIKK_1	281	287	PF00454	0.645
MOD_PIKK_1	311	317	PF00454	0.642
MOD_PIKK_1	40	46	PF00454	0.792
MOD_PKA_1	275	281	PF00069	0.613
MOD_PKA_1	73	79	PF00069	0.693
MOD_PKA_2	112	118	PF00069	0.733
MOD_PKA_2	261	267	PF00069	0.647
MOD_PKA_2	274	280	PF00069	0.655
MOD_PKA_2	321	327	PF00069	0.483
MOD_PKA_2	353	359	PF00069	0.614
MOD_PKA_2	40	46	PF00069	0.792
MOD_PKA_2	450	456	PF00069	0.754
MOD_PKA_2	73	79	PF00069	0.693
MOD_PKA_2	80	86	PF00069	0.520
MOD_Plk_1	239	245	PF00069	0.595
MOD_Plk_1	336	342	PF00069	0.641
MOD_Plk_1	413	419	PF00069	0.720
MOD_Plk_2-3	305	311	PF00069	0.560
MOD_Plk_4	413	419	PF00069	0.684
MOD_ProDKin_1	105	111	PF00069	0.718
MOD_ProDKin_1	11	17	PF00069	0.826
MOD_ProDKin_1	184	190	PF00069	0.672
MOD_ProDKin_1	445	451	PF00069	0.812
MOD_SUMO_for_1	133	136	PF00179	0.650
TRG_DiLeu_BaEn_1	128	133	PF01217	0.548
TRG_DiLeu_BaEn_1	296	301	PF01217	0.623
TRG_DiLeu_BaEn_4	374	380	PF01217	0.544
TRG_DiLeu_LyEn_5	296	301	PF01217	0.623
TRG_ENDOCYTIC_2	507	510	PF00928	0.624
TRG_ER_diArg_1	130	132	PF00400	0.670
TRG_ER_diArg_1	259	262	PF00400	0.685
TRG_ER_diArg_1	274	276	PF00400	0.569
TRG_ER_diArg_1	52	55	PF00400	0.660
TRG_NES_CRM1_1	291	304	PF08389	0.522
TRG_NLS_MonoExtN_4	388	394	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9D0	Leptomonas seymouri	37%	81%
A4H6I2	Leishmania braziliensis	61%	100%
A4HVZ2	Leishmania infantum	99%	100%
E9APP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QFT5	Leishmania major	86%	100%