Transmembrane amino acid transporter protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane amino acid transporter protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WST2_LEIDO

TriTrypDb:

LdBPK_140330.1 , LdCL_140008300 , LDHU3_14.0420

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7WST2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WST2

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	706	710	PF00656	0.433
CLV_NRD_NRD_1	593	595	PF00675	0.293
CLV_NRD_NRD_1	657	659	PF00675	0.311
CLV_NRD_NRD_1	663	665	PF00675	0.304
CLV_PCSK_KEX2_1	593	595	PF00082	0.293
CLV_PCSK_KEX2_1	657	659	PF00082	0.308
CLV_PCSK_SKI1_1	239	243	PF00082	0.653
CLV_PCSK_SKI1_1	312	316	PF00082	0.615
CLV_PCSK_SKI1_1	323	327	PF00082	0.520
CLV_PCSK_SKI1_1	375	379	PF00082	0.352
CLV_PCSK_SKI1_1	520	524	PF00082	0.321
CLV_PCSK_SKI1_1	593	597	PF00082	0.301
CLV_PCSK_SKI1_1	660	664	PF00082	0.338
DEG_COP1_1	260	269	PF00400	0.479
DEG_Nend_UBRbox_1	1	4	PF02207	0.576
DEG_SCF_FBW7_1	24	31	PF00400	0.554
DEG_SPOP_SBC_1	258	262	PF00917	0.534
DEG_SPOP_SBC_1	408	412	PF00917	0.491
DOC_CDC14_PxL_1	291	299	PF14671	0.530
DOC_CKS1_1	110	115	PF01111	0.622
DOC_CKS1_1	25	30	PF01111	0.591
DOC_CKS1_1	33	38	PF01111	0.558
DOC_CYCLIN_RxL_1	514	528	PF00134	0.560
DOC_CYCLIN_RxL_1	664	673	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.301
DOC_CYCLIN_yCln2_LP_2	647	653	PF00134	0.367
DOC_MAPK_gen_1	447	457	PF00069	0.546
DOC_MAPK_gen_1	520	529	PF00069	0.510
DOC_MAPK_gen_1	664	671	PF00069	0.552
DOC_MAPK_JIP1_4	608	614	PF00069	0.538
DOC_MAPK_MEF2A_6	389	396	PF00069	0.546
DOC_MAPK_MEF2A_6	520	529	PF00069	0.490
DOC_PIKK_1	177	185	PF02985	0.538
DOC_PP1_RVXF_1	665	672	PF00149	0.538
DOC_PP2B_LxvP_1	26	29	PF13499	0.524
DOC_PP2B_LxvP_1	331	334	PF13499	0.283
DOC_PP2B_LxvP_1	433	436	PF13499	0.391
DOC_PP2B_LxvP_1	647	650	PF13499	0.367
DOC_PP4_FxxP_1	22	25	PF00568	0.557
DOC_PP4_FxxP_1	625	628	PF00568	0.420
DOC_USP7_MATH_1	155	159	PF00917	0.564
DOC_USP7_MATH_1	214	218	PF00917	0.501
DOC_USP7_MATH_1	227	231	PF00917	0.536
DOC_USP7_MATH_1	258	262	PF00917	0.491
DOC_USP7_MATH_1	301	305	PF00917	0.464
DOC_USP7_MATH_1	353	357	PF00917	0.438
DOC_USP7_MATH_1	408	412	PF00917	0.396
DOC_USP7_MATH_1	456	460	PF00917	0.435
DOC_USP7_MATH_1	79	83	PF00917	0.481
DOC_USP7_UBL2_3	367	371	PF12436	0.518
DOC_WW_Pin1_4	109	114	PF00397	0.576
DOC_WW_Pin1_4	15	20	PF00397	0.629
DOC_WW_Pin1_4	24	29	PF00397	0.542
DOC_WW_Pin1_4	32	37	PF00397	0.538
DOC_WW_Pin1_4	485	490	PF00397	0.362
DOC_WW_Pin1_4	56	61	PF00397	0.595
DOC_WW_Pin1_4	704	709	PF00397	0.393
LIG_14-3-3_CanoR_1	14	19	PF00244	0.588
LIG_14-3-3_CanoR_1	526	530	PF00244	0.386
LIG_14-3-3_CanoR_1	565	574	PF00244	0.349
LIG_14-3-3_CanoR_1	600	607	PF00244	0.549
LIG_14-3-3_CanoR_1	613	617	PF00244	0.430
LIG_14-3-3_CanoR_1	664	670	PF00244	0.537
LIG_Actin_WH2_2	550	567	PF00022	0.358
LIG_Actin_WH2_2	649	666	PF00022	0.409
LIG_APCC_ABBA_1	376	381	PF00400	0.483
LIG_APCC_ABBAyCdc20_2	375	381	PF00400	0.508
LIG_BRCT_BRCA1_1	229	233	PF00533	0.528
LIG_BRCT_BRCA1_1	318	322	PF00533	0.420
LIG_BRCT_BRCA1_1	331	335	PF00533	0.360
LIG_BRCT_BRCA1_1	489	493	PF00533	0.397
LIG_BRCT_BRCA1_1	621	625	PF00533	0.403
LIG_Clathr_ClatBox_1	469	473	PF01394	0.438
LIG_EH1_1	397	405	PF00400	0.391
LIG_eIF4E_1	379	385	PF01652	0.600
LIG_eIF4E_1	391	397	PF01652	0.327
LIG_eIF4E_1	398	404	PF01652	0.255
LIG_FHA_1	220	226	PF00498	0.428
LIG_FHA_1	277	283	PF00498	0.572
LIG_FHA_1	326	332	PF00498	0.339
LIG_FHA_1	459	465	PF00498	0.431
LIG_FHA_1	507	513	PF00498	0.394
LIG_FHA_1	549	555	PF00498	0.316
LIG_FHA_1	582	588	PF00498	0.420
LIG_FHA_1	88	94	PF00498	0.593
LIG_FHA_2	192	198	PF00498	0.516
LIG_FHA_2	7	13	PF00498	0.559
LIG_FHA_2	94	100	PF00498	0.614
LIG_GBD_Chelix_1	632	640	PF00786	0.552
LIG_HP1_1	442	446	PF01393	0.438
LIG_IRF3_LxIS_1	609	615	PF10401	0.480
LIG_IRF3_LxIS_1	632	637	PF10401	0.338
LIG_LIR_Apic_2	622	628	PF02991	0.399
LIG_LIR_Gen_1	350	359	PF02991	0.430
LIG_LIR_Gen_1	490	501	PF02991	0.326
LIG_LIR_Gen_1	532	541	PF02991	0.379
LIG_LIR_Gen_1	615	624	PF02991	0.433
LIG_LIR_Gen_1	673	682	PF02991	0.508
LIG_LIR_LC3C_4	296	299	PF02991	0.470
LIG_LIR_Nem_3	319	325	PF02991	0.390
LIG_LIR_Nem_3	350	354	PF02991	0.424
LIG_LIR_Nem_3	490	496	PF02991	0.362
LIG_LIR_Nem_3	532	536	PF02991	0.382
LIG_LIR_Nem_3	542	547	PF02991	0.357
LIG_LIR_Nem_3	602	607	PF02991	0.554
LIG_LIR_Nem_3	615	619	PF02991	0.349
LIG_LIR_Nem_3	626	632	PF02991	0.346
LIG_LIR_Nem_3	668	674	PF02991	0.495
LIG_LYPXL_yS_3	391	394	PF13949	0.391
LIG_MAD2	375	383	PF02301	0.560
LIG_MLH1_MIPbox_1	489	493	PF16413	0.397
LIG_MYND_1	24	28	PF01753	0.551
LIG_PDZ_Class_3	706	711	PF00595	0.472
LIG_Pex14_1	387	391	PF04695	0.530
LIG_Pex14_2	105	109	PF04695	0.543
LIG_Pex14_2	318	322	PF04695	0.420
LIG_Pex14_2	678	682	PF04695	0.412
LIG_PTB_Apo_2	392	399	PF02174	0.438
LIG_PTB_Phospho_1	392	398	PF10480	0.438
LIG_SH2_CRK	398	402	PF00017	0.396
LIG_SH2_CRK	53	57	PF00017	0.548
LIG_SH2_CRK	630	634	PF00017	0.283
LIG_SH2_CRK	683	687	PF00017	0.420
LIG_SH2_NCK_1	53	57	PF00017	0.489
LIG_SH2_PTP2	674	677	PF00017	0.391
LIG_SH2_STAP1	358	362	PF00017	0.392
LIG_SH2_STAT3	476	479	PF00017	0.338
LIG_SH2_STAT5	363	366	PF00017	0.505
LIG_SH2_STAT5	521	524	PF00017	0.508
LIG_SH2_STAT5	616	619	PF00017	0.363
LIG_SH2_STAT5	655	658	PF00017	0.483
LIG_SH2_STAT5	674	677	PF00017	0.307
LIG_SH2_STAT5	87	90	PF00017	0.572
LIG_SH3_1	483	489	PF00018	0.279
LIG_SH3_2	478	483	PF14604	0.347
LIG_SH3_3	22	28	PF00018	0.608
LIG_SH3_3	30	36	PF00018	0.573
LIG_SH3_3	475	481	PF00018	0.362
LIG_SH3_3	483	489	PF00018	0.279
LIG_SH3_3	512	518	PF00018	0.560
LIG_SH3_3	54	60	PF00018	0.598
LIG_Sin3_3	568	575	PF02671	0.491
LIG_SUMO_SIM_anti_2	466	471	PF11976	0.460
LIG_SUMO_SIM_anti_2	576	581	PF11976	0.391
LIG_SUMO_SIM_par_1	345	350	PF11976	0.434
LIG_SUMO_SIM_par_1	453	459	PF11976	0.525
LIG_SUMO_SIM_par_1	460	466	PF11976	0.409
LIG_SUMO_SIM_par_1	508	513	PF11976	0.491
LIG_SUMO_SIM_par_1	555	561	PF11976	0.320
LIG_SUMO_SIM_par_1	632	637	PF11976	0.347
LIG_TRAF2_1	194	197	PF00917	0.521
LIG_TRAF2_1	45	48	PF00917	0.567
LIG_TRAF2_1	9	12	PF00917	0.579
LIG_TRFH_1	53	57	PF08558	0.577
LIG_TYR_ITIM	377	382	PF00017	0.490
LIG_TYR_ITIM	396	401	PF00017	0.202
LIG_TYR_ITIM	614	619	PF00017	0.420
LIG_TYR_ITIM	627	632	PF00017	0.162
LIG_TYR_ITSM	600	607	PF00017	0.538
LIG_UBA3_1	417	424	PF00899	0.397
LIG_ULM_U2AF65_1	657	662	PF00076	0.538
LIG_WRC_WIRS_1	322	327	PF05994	0.314
LIG_WRC_WIRS_1	348	353	PF05994	0.380
MOD_CDK_SPK_2	15	20	PF00069	0.541
MOD_CDK_SPxxK_3	109	116	PF00069	0.614
MOD_CK1_1	244	250	PF00069	0.502
MOD_CK1_1	271	277	PF00069	0.576
MOD_CK1_1	508	514	PF00069	0.467
MOD_CK1_1	553	559	PF00069	0.336
MOD_CK2_1	114	120	PF00069	0.594
MOD_CK2_1	160	166	PF00069	0.593
MOD_CK2_1	191	197	PF00069	0.495
MOD_CK2_1	485	491	PF00069	0.325
MOD_CK2_1	6	12	PF00069	0.527
MOD_CK2_1	89	95	PF00069	0.511
MOD_CMANNOS	387	390	PF00535	0.360
MOD_GlcNHglycan	116	119	PF01048	0.817
MOD_GlcNHglycan	140	143	PF01048	0.789
MOD_GlcNHglycan	177	182	PF01048	0.792
MOD_GlcNHglycan	243	246	PF01048	0.735
MOD_GlcNHglycan	270	273	PF01048	0.732
MOD_GlcNHglycan	39	42	PF01048	0.832
MOD_GlcNHglycan	426	429	PF01048	0.424
MOD_GlcNHglycan	541	544	PF01048	0.420
MOD_GlcNHglycan	560	563	PF01048	0.396
MOD_GlcNHglycan	568	571	PF01048	0.311
MOD_GlcNHglycan	6	9	PF01048	0.817
MOD_GlcNHglycan	619	622	PF01048	0.334
MOD_GlcNHglycan	636	639	PF01048	0.420
MOD_GlcNHglycan	693	696	PF01048	0.452
MOD_GlcNHglycan	81	84	PF01048	0.717
MOD_GSK3_1	108	115	PF00069	0.549
MOD_GSK3_1	123	130	PF00069	0.488
MOD_GSK3_1	20	27	PF00069	0.580
MOD_GSK3_1	237	244	PF00069	0.459
MOD_GSK3_1	268	275	PF00069	0.514
MOD_GSK3_1	28	35	PF00069	0.419
MOD_GSK3_1	321	328	PF00069	0.307
MOD_GSK3_1	353	360	PF00069	0.425
MOD_GSK3_1	501	508	PF00069	0.315
MOD_GSK3_1	51	58	PF00069	0.569
MOD_GSK3_1	525	532	PF00069	0.548
MOD_GSK3_1	619	626	PF00069	0.399
MOD_GSK3_1	632	639	PF00069	0.344
MOD_GSK3_1	69	76	PF00069	0.607
MOD_GSK3_1	703	710	PF00069	0.423
MOD_GSK3_1	89	96	PF00069	0.393
MOD_N-GLC_1	123	128	PF02516	0.779
MOD_N-GLC_1	155	160	PF02516	0.715
MOD_N-GLC_1	548	553	PF02516	0.568
MOD_N-GLC_1	63	68	PF02516	0.686
MOD_NEK2_1	318	323	PF00069	0.368
MOD_NEK2_1	325	330	PF00069	0.295
MOD_NEK2_1	409	414	PF00069	0.405
MOD_NEK2_1	423	428	PF00069	0.252
MOD_NEK2_1	458	463	PF00069	0.378
MOD_NEK2_1	496	501	PF00069	0.414
MOD_NEK2_1	525	530	PF00069	0.487
MOD_NEK2_1	539	544	PF00069	0.315
MOD_NEK2_1	555	560	PF00069	0.258
MOD_NEK2_1	573	578	PF00069	0.162
MOD_NEK2_1	596	601	PF00069	0.597
MOD_NEK2_1	612	617	PF00069	0.279
MOD_NEK2_1	619	624	PF00069	0.371
MOD_NEK2_1	63	68	PF00069	0.545
MOD_NEK2_1	632	637	PF00069	0.292
MOD_NEK2_1	88	93	PF00069	0.584
MOD_PIKK_1	244	250	PF00454	0.431
MOD_PIKK_1	448	454	PF00454	0.525
MOD_PKA_2	13	19	PF00069	0.544
MOD_PKA_2	138	144	PF00069	0.618
MOD_PKA_2	191	197	PF00069	0.582
MOD_PKA_2	525	531	PF00069	0.525
MOD_PKA_2	599	605	PF00069	0.538
MOD_PKA_2	612	618	PF00069	0.248
MOD_PKA_2	73	79	PF00069	0.621
MOD_Plk_1	472	478	PF00069	0.491
MOD_Plk_4	260	266	PF00069	0.562
MOD_Plk_4	302	308	PF00069	0.464
MOD_Plk_4	347	353	PF00069	0.380
MOD_Plk_4	434	440	PF00069	0.367
MOD_Plk_4	458	464	PF00069	0.434
MOD_Plk_4	496	502	PF00069	0.491
MOD_Plk_4	550	556	PF00069	0.325
MOD_Plk_4	575	581	PF00069	0.388
MOD_ProDKin_1	109	115	PF00069	0.575
MOD_ProDKin_1	15	21	PF00069	0.629
MOD_ProDKin_1	24	30	PF00069	0.546
MOD_ProDKin_1	32	38	PF00069	0.540
MOD_ProDKin_1	485	491	PF00069	0.362
MOD_ProDKin_1	56	62	PF00069	0.597
MOD_ProDKin_1	704	710	PF00069	0.393
MOD_SUMO_rev_2	304	314	PF00179	0.390
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.536
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.497
TRG_ENDOCYTIC_2	206	209	PF00928	0.471
TRG_ENDOCYTIC_2	379	382	PF00928	0.525
TRG_ENDOCYTIC_2	391	394	PF00928	0.406
TRG_ENDOCYTIC_2	398	401	PF00928	0.454
TRG_ENDOCYTIC_2	521	524	PF00928	0.483
TRG_ENDOCYTIC_2	604	607	PF00928	0.525
TRG_ENDOCYTIC_2	616	619	PF00928	0.391
TRG_ENDOCYTIC_2	629	632	PF00928	0.162
TRG_ENDOCYTIC_2	674	677	PF00928	0.371
TRG_ENDOCYTIC_2	683	686	PF00928	0.375
TRG_ER_diArg_1	593	595	PF00400	0.493
TRG_ER_diArg_1	656	658	PF00400	0.489
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.822

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C5	Leptomonas seymouri	69%	97%
A0A0N1PBG3	Leptomonas seymouri	32%	84%
A0A0S4ISI1	Bodo saltans	44%	100%
A4H7J2	Leishmania braziliensis	74%	100%
A4HVX5	Leishmania infantum	100%	100%
E9APM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4QFV2	Leishmania major	87%	100%