PX domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PX domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSS9_LEIDO

TriTrypDb:

LdBPK_140220.1 , LdCL_140007100 , LDHU3_14.0290

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSS9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005543	phospholipid binding	3	12
GO:0008289	lipid binding	2	12
GO:0035091	phosphatidylinositol binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.586
CLV_C14_Caspase3-7	311	315	PF00656	0.435
CLV_C14_Caspase3-7	94	98	PF00656	0.389
CLV_NRD_NRD_1	253	255	PF00675	0.532
CLV_NRD_NRD_1	325	327	PF00675	0.496
CLV_NRD_NRD_1	42	44	PF00675	0.521
CLV_NRD_NRD_1	56	58	PF00675	0.265
CLV_NRD_NRD_1	81	83	PF00675	0.410
CLV_PCSK_KEX2_1	164	166	PF00082	0.461
CLV_PCSK_KEX2_1	253	255	PF00082	0.532
CLV_PCSK_KEX2_1	400	402	PF00082	0.494
CLV_PCSK_KEX2_1	42	44	PF00082	0.469
CLV_PCSK_KEX2_1	56	58	PF00082	0.265
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.517
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.480
CLV_PCSK_PC7_1	160	166	PF00082	0.461
CLV_PCSK_SKI1_1	146	150	PF00082	0.374
CLV_PCSK_SKI1_1	153	157	PF00082	0.389
CLV_PCSK_SKI1_1	167	171	PF00082	0.565
CLV_PCSK_SKI1_1	3	7	PF00082	0.463
CLV_PCSK_SKI1_1	384	388	PF00082	0.404
CLV_PCSK_SKI1_1	65	69	PF00082	0.311
DEG_APCC_DBOX_1	145	153	PF00400	0.486
DEG_COP1_1	19	27	PF00400	0.461
DEG_MDM2_SWIB_1	226	233	PF02201	0.455
DEG_SPOP_SBC_1	179	183	PF00917	0.635
DEG_SPOP_SBC_1	219	223	PF00917	0.737
DOC_CYCLIN_RxL_1	381	389	PF00134	0.458
DOC_CYCLIN_yClb5_NLxxxL_5	103	110	PF00134	0.410
DOC_MAPK_gen_1	326	333	PF00069	0.411
DOC_MAPK_gen_1	56	64	PF00069	0.305
DOC_MAPK_MEF2A_6	326	335	PF00069	0.490
DOC_PP1_RVXF_1	332	338	PF00149	0.334
DOC_PP4_FxxP_1	130	133	PF00568	0.326
DOC_PP4_FxxP_1	22	25	PF00568	0.558
DOC_USP7_MATH_1	178	182	PF00917	0.594
DOC_USP7_MATH_1	220	224	PF00917	0.656
DOC_USP7_MATH_1	444	448	PF00917	0.590
DOC_USP7_MATH_1	81	85	PF00917	0.392
DOC_USP7_UBL2_3	176	180	PF12436	0.627
DOC_WW_Pin1_4	293	298	PF00397	0.483
DOC_WW_Pin1_4	445	450	PF00397	0.611
DOC_WW_Pin1_4	75	80	PF00397	0.327
LIG_14-3-3_CanoR_1	153	158	PF00244	0.543
LIG_14-3-3_CanoR_1	165	170	PF00244	0.549
LIG_14-3-3_CanoR_1	3	8	PF00244	0.448
LIG_14-3-3_CanoR_1	56	64	PF00244	0.265
LIG_14-3-3_CanoR_1	82	87	PF00244	0.410
LIG_Actin_WH2_2	138	155	PF00022	0.515
LIG_Actin_WH2_2	244	261	PF00022	0.435
LIG_Actin_WH2_2	265	283	PF00022	0.535
LIG_Actin_WH2_2	417	434	PF00022	0.439
LIG_BIR_III_4	300	304	PF00653	0.554
LIG_BRCT_BRCA1_1	222	226	PF00533	0.554
LIG_BRCT_BRCA1_1	95	99	PF00533	0.410
LIG_CaM_IQ_9	418	434	PF13499	0.389
LIG_deltaCOP1_diTrp_1	124	130	PF00928	0.410
LIG_eIF4E_1	70	76	PF01652	0.327
LIG_FHA_1	137	143	PF00498	0.488
LIG_FHA_1	377	383	PF00498	0.385
LIG_FHA_1	9	15	PF00498	0.453
LIG_FHA_2	21	27	PF00498	0.507
LIG_FHA_2	315	321	PF00498	0.513
LIG_FHA_2	369	375	PF00498	0.545
LIG_LIR_Apic_2	123	128	PF02991	0.409
LIG_LIR_Apic_2	19	25	PF02991	0.458
LIG_LIR_Apic_2	229	235	PF02991	0.505
LIG_LIR_Apic_2	69	73	PF02991	0.327
LIG_LIR_Gen_1	227	237	PF02991	0.517
LIG_LIR_Gen_1	325	335	PF02991	0.381
LIG_LIR_Gen_1	436	446	PF02991	0.531
LIG_LIR_Gen_1	55	64	PF02991	0.289
LIG_LIR_Nem_3	168	172	PF02991	0.659
LIG_LIR_Nem_3	227	233	PF02991	0.530
LIG_LIR_Nem_3	264	268	PF02991	0.503
LIG_LIR_Nem_3	285	289	PF02991	0.531
LIG_LIR_Nem_3	392	397	PF02991	0.402
LIG_LIR_Nem_3	436	442	PF02991	0.593
LIG_LIR_Nem_3	55	61	PF02991	0.289
LIG_LIR_Nem_3	6	10	PF02991	0.375
LIG_LIR_Nem_3	69	75	PF02991	0.265
LIG_NRBOX	63	69	PF00104	0.358
LIG_Pex14_1	125	129	PF04695	0.410
LIG_Pex14_2	121	125	PF04695	0.398
LIG_Pex14_2	226	230	PF04695	0.468
LIG_REV1ctd_RIR_1	190	200	PF16727	0.602
LIG_REV1ctd_RIR_1	394	405	PF16727	0.358
LIG_SH2_CRK	356	360	PF00017	0.432
LIG_SH2_CRK	70	74	PF00017	0.323
LIG_SH2_GRB2like	328	331	PF00017	0.489
LIG_SH2_SRC	232	235	PF00017	0.508
LIG_SH2_STAP1	228	232	PF00017	0.528
LIG_SH2_STAP1	289	293	PF00017	0.406
LIG_SH2_STAP1	378	382	PF00017	0.326
LIG_SH2_STAP1	398	402	PF00017	0.466
LIG_SH2_STAP1	58	62	PF00017	0.313
LIG_SH2_STAT5	172	175	PF00017	0.659
LIG_SH2_STAT5	232	235	PF00017	0.508
LIG_SH2_STAT5	268	271	PF00017	0.418
LIG_SH2_STAT5	323	326	PF00017	0.558
LIG_SH2_STAT5	328	331	PF00017	0.295
LIG_SH2_STAT5	378	381	PF00017	0.332
LIG_SH2_STAT5	7	10	PF00017	0.502
LIG_SH2_STAT5	92	95	PF00017	0.410
LIG_SH3_3	214	220	PF00018	0.752
LIG_SH3_3	22	28	PF00018	0.402
LIG_SH3_3	407	413	PF00018	0.424
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.372
LIG_SUMO_SIM_par_1	59	66	PF11976	0.327
LIG_TRAF2_1	371	374	PF00917	0.450
LIG_TRFH_1	129	133	PF08558	0.412
LIG_TYR_ITIM	5	10	PF00017	0.480
LIG_UBA3_1	76	83	PF00899	0.358
MOD_CDK_SPxxK_3	75	82	PF00069	0.327
MOD_CK1_1	222	228	PF00069	0.589
MOD_CK1_1	236	242	PF00069	0.510
MOD_CK1_1	261	267	PF00069	0.561
MOD_CK1_1	84	90	PF00069	0.392
MOD_CK2_1	165	171	PF00069	0.670
MOD_CK2_1	314	320	PF00069	0.586
MOD_CK2_1	368	374	PF00069	0.476
MOD_CK2_1	84	90	PF00069	0.333
MOD_GlcNHglycan	198	202	PF01048	0.632
MOD_GlcNHglycan	235	238	PF01048	0.514
MOD_GlcNHglycan	260	263	PF01048	0.481
MOD_GlcNHglycan	360	363	PF01048	0.540
MOD_GlcNHglycan	427	430	PF01048	0.432
MOD_GlcNHglycan	50	53	PF01048	0.302
MOD_GlcNHglycan	93	96	PF01048	0.432
MOD_GSK3_1	180	187	PF00069	0.516
MOD_GSK3_1	218	225	PF00069	0.614
MOD_GSK3_1	289	296	PF00069	0.529
MOD_GSK3_1	364	371	PF00069	0.572
MOD_GSK3_1	376	383	PF00069	0.307
MOD_GSK3_1	44	51	PF00069	0.388
MOD_GSK3_1	71	78	PF00069	0.460
MOD_GSK3_1	84	91	PF00069	0.263
MOD_N-GLC_2	330	332	PF02516	0.470
MOD_NEK2_1	184	189	PF00069	0.465
MOD_NEK2_1	191	196	PF00069	0.420
MOD_NEK2_1	258	263	PF00069	0.487
MOD_NEK2_1	308	313	PF00069	0.548
MOD_NEK2_1	358	363	PF00069	0.497
MOD_NEK2_1	376	381	PF00069	0.536
MOD_NEK2_1	425	430	PF00069	0.341
MOD_NEK2_2	289	294	PF00069	0.481
MOD_PIKK_1	314	320	PF00454	0.540
MOD_PIKK_1	376	382	PF00454	0.438
MOD_PK_1	82	88	PF00069	0.410
MOD_PKA_1	56	62	PF00069	0.265
MOD_PKA_1	82	88	PF00069	0.410
MOD_PKA_2	133	139	PF00069	0.437
MOD_PKA_2	56	62	PF00069	0.313
MOD_PKA_2	81	87	PF00069	0.392
MOD_PKB_1	165	173	PF00069	0.551
MOD_Plk_1	18	24	PF00069	0.492
MOD_Plk_1	228	234	PF00069	0.514
MOD_Plk_1	289	295	PF00069	0.507
MOD_Plk_4	138	144	PF00069	0.521
MOD_Plk_4	180	186	PF00069	0.511
MOD_Plk_4	308	314	PF00069	0.424
MOD_Plk_4	71	77	PF00069	0.279
MOD_Plk_4	88	94	PF00069	0.145
MOD_ProDKin_1	293	299	PF00069	0.483
MOD_ProDKin_1	445	451	PF00069	0.617
MOD_ProDKin_1	75	81	PF00069	0.327
MOD_SUMO_rev_2	320	329	PF00179	0.521
TRG_DiLeu_BaEn_1	138	143	PF01217	0.495
TRG_ENDOCYTIC_2	328	331	PF00928	0.373
TRG_ENDOCYTIC_2	356	359	PF00928	0.457
TRG_ENDOCYTIC_2	394	397	PF00928	0.540
TRG_ENDOCYTIC_2	58	61	PF00928	0.289
TRG_ENDOCYTIC_2	7	10	PF00928	0.456
TRG_ER_diArg_1	143	146	PF00400	0.423
TRG_ER_diArg_1	41	43	PF00400	0.529
TRG_ER_diArg_1	56	58	PF00400	0.265
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW83	Leptomonas seymouri	73%	78%
A0A0S4IZJ1	Bodo saltans	26%	81%
A0A1X0NNT5	Trypanosomatidae	31%	80%
A0A3R7LA20	Trypanosoma rangeli	29%	92%
A4H7I2	Leishmania braziliensis	91%	100%
A4HVW4	Leishmania infantum	100%	100%
C9ZT62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	86%
E9APL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QFW3	Leishmania major	98%	100%
V5BMA1	Trypanosoma cruzi	30%	91%