Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSS0_LEIDO

TriTrypDb:

LdBPK_131560.1 , LdCL_130018700 , LDHU3_13.1610

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.446
CLV_NRD_NRD_1	54	56	PF00675	0.538
CLV_PCSK_KEX2_1	112	114	PF00082	0.446
CLV_PCSK_KEX2_1	238	240	PF00082	0.645
CLV_PCSK_KEX2_1	54	56	PF00082	0.538
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.734
CLV_PCSK_SKI1_1	164	168	PF00082	0.533
CLV_PCSK_SKI1_1	2	6	PF00082	0.608
CLV_PCSK_SKI1_1	203	207	PF00082	0.426
DEG_Nend_UBRbox_1	1	4	PF02207	0.571
DOC_CKS1_1	44	49	PF01111	0.523
DOC_MAPK_gen_1	197	206	PF00069	0.448
DOC_MAPK_RevD_3	98	113	PF00069	0.455
DOC_PP4_FxxP_1	149	152	PF00568	0.602
DOC_USP7_MATH_1	30	34	PF00917	0.703
DOC_USP7_MATH_1	77	81	PF00917	0.620
DOC_USP7_MATH_1	84	88	PF00917	0.521
DOC_WW_Pin1_4	135	140	PF00397	0.647
DOC_WW_Pin1_4	26	31	PF00397	0.732
DOC_WW_Pin1_4	43	48	PF00397	0.285
LIG_14-3-3_CanoR_1	147	152	PF00244	0.781
LIG_14-3-3_CanoR_1	54	58	PF00244	0.574
LIG_BRCT_BRCA1_1	77	81	PF00533	0.545
LIG_FHA_1	120	126	PF00498	0.477
LIG_FHA_1	5	11	PF00498	0.507
LIG_FHA_1	69	75	PF00498	0.697
LIG_FHA_2	125	131	PF00498	0.522
LIG_FHA_2	44	50	PF00498	0.564
LIG_LIR_Gen_1	111	118	PF02991	0.485
LIG_LIR_Gen_1	48	57	PF02991	0.536
LIG_LIR_Nem_3	111	117	PF02991	0.438
LIG_LIR_Nem_3	48	53	PF02991	0.519
LIG_MYND_1	140	144	PF01753	0.608
LIG_NRBOX	40	46	PF00104	0.445
LIG_SH2_STAP1	114	118	PF00017	0.509
LIG_SH2_STAT5	92	95	PF00017	0.545
LIG_SH3_3	33	39	PF00018	0.614
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.536
LIG_SUMO_SIM_par_1	124	130	PF11976	0.439
LIG_SUMO_SIM_par_1	203	209	PF11976	0.485
LIG_SUMO_SIM_par_1	40	46	PF11976	0.633
LIG_TRAF2_1	168	171	PF00917	0.614
LIG_UBA3_1	5	12	PF00899	0.551
MOD_CK1_1	43	49	PF00069	0.525
MOD_CK2_1	124	130	PF00069	0.514
MOD_CK2_1	5	11	PF00069	0.468
MOD_CK2_1	53	59	PF00069	0.595
MOD_GlcNHglycan	2	5	PF01048	0.542
MOD_GlcNHglycan	33	36	PF01048	0.733
MOD_GlcNHglycan	48	53	PF01048	0.532
MOD_GlcNHglycan	68	71	PF01048	0.720
MOD_GlcNHglycan	75	78	PF01048	0.678
MOD_GSK3_1	26	33	PF00069	0.650
MOD_GSK3_1	73	80	PF00069	0.681
MOD_NEK2_1	5	10	PF00069	0.475
MOD_PKA_2	53	59	PF00069	0.573
MOD_Plk_1	48	54	PF00069	0.595
MOD_Plk_1	59	65	PF00069	0.569
MOD_Plk_2-3	124	130	PF00069	0.539
MOD_Plk_4	37	43	PF00069	0.639
MOD_Plk_4	5	11	PF00069	0.450
MOD_ProDKin_1	135	141	PF00069	0.654
MOD_ProDKin_1	26	32	PF00069	0.735
MOD_ProDKin_1	43	49	PF00069	0.277
MOD_SUMO_for_1	223	226	PF00179	0.583
MOD_SUMO_rev_2	193	198	PF00179	0.512
MOD_SUMO_rev_2	226	231	PF00179	0.757
TRG_DiLeu_BaEn_1	130	135	PF01217	0.574
TRG_ENDOCYTIC_2	114	117	PF00928	0.512
TRG_ENDOCYTIC_2	92	95	PF00928	0.511
TRG_ER_diArg_1	112	114	PF00400	0.482
TRG_ER_diArg_1	17	20	PF00400	0.505
TRG_ER_diArg_1	53	55	PF00400	0.524
TRG_NLS_MonoCore_2	237	242	PF00514	0.804
TRG_NLS_MonoExtC_3	237	243	PF00514	0.729
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Q3	Leptomonas seymouri	50%	100%
A0A422P490	Trypanosoma rangeli	31%	100%
A4H7C4	Leishmania braziliensis	76%	100%
A4HVS9	Leishmania infantum	98%	100%
E9APG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QG12	Leishmania major	88%	98%