Squalene monooxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

squalene monooxygenase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WSP8_LEIDO

TriTrypDb:

LdBPK_131360.1 , LdCL_130020900 , LDHU3_13.1870

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WSP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSP8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006694	steroid biosynthetic process	5	12
GO:0008152	metabolic process	1	12
GO:0008202	steroid metabolic process	4	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0016125	sterol metabolic process	4	12
GO:0016126	sterol biosynthetic process	5	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901617	organic hydroxy compound biosynthetic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004497	monooxygenase activity	3	12
GO:0004506	squalene monooxygenase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0071949	FAD binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.480
CLV_NRD_NRD_1	204	206	PF00675	0.440
CLV_NRD_NRD_1	563	565	PF00675	0.462
CLV_NRD_NRD_1	58	60	PF00675	0.306
CLV_PCSK_SKI1_1	206	210	PF00082	0.305
CLV_PCSK_SKI1_1	520	524	PF00082	0.430
CLV_PCSK_SKI1_1	548	552	PF00082	0.366
CLV_PCSK_SKI1_1	59	63	PF00082	0.275
CLV_PCSK_SKI1_1	66	70	PF00082	0.305
DEG_MDM2_SWIB_1	501	508	PF02201	0.254
DEG_MDM2_SWIB_1	530	537	PF02201	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.420
DOC_CYCLIN_RxL_1	60	73	PF00134	0.332
DOC_MAPK_gen_1	122	130	PF00069	0.458
DOC_MAPK_gen_1	252	260	PF00069	0.386
DOC_MAPK_gen_1	517	525	PF00069	0.468
DOC_MAPK_gen_1	562	569	PF00069	0.478
DOC_MAPK_MEF2A_6	206	215	PF00069	0.256
DOC_MAPK_MEF2A_6	517	525	PF00069	0.353
DOC_PP1_RVXF_1	22	28	PF00149	0.330
DOC_PP4_FxxP_1	536	539	PF00568	0.393
DOC_PP4_FxxP_1	69	72	PF00568	0.313
DOC_USP7_MATH_1	30	34	PF00917	0.361
DOC_USP7_MATH_1	334	338	PF00917	0.361
DOC_WW_Pin1_4	228	233	PF00397	0.303
DOC_WW_Pin1_4	25	30	PF00397	0.470
DOC_WW_Pin1_4	422	427	PF00397	0.324
DOC_WW_Pin1_4	538	543	PF00397	0.426
LIG_14-3-3_CanoR_1	205	211	PF00244	0.354
LIG_14-3-3_CanoR_1	31	35	PF00244	0.474
LIG_14-3-3_CanoR_1	368	374	PF00244	0.343
LIG_14-3-3_CanoR_1	403	412	PF00244	0.309
LIG_Actin_WH2_2	11	28	PF00022	0.435
LIG_Actin_WH2_2	366	382	PF00022	0.338
LIG_Actin_WH2_2	415	431	PF00022	0.256
LIG_Actin_WH2_2	73	91	PF00022	0.390
LIG_BRCT_BRCA1_1	128	132	PF00533	0.273
LIG_BRCT_BRCA1_1	140	144	PF00533	0.279
LIG_BRCT_BRCA1_2	140	146	PF00533	0.435
LIG_CtBP_PxDLS_1	306	310	PF00389	0.355
LIG_EH_1	187	191	PF12763	0.362
LIG_FHA_1	161	167	PF00498	0.330
LIG_FHA_1	207	213	PF00498	0.272
LIG_FHA_1	245	251	PF00498	0.436
LIG_FHA_1	261	267	PF00498	0.167
LIG_FHA_1	318	324	PF00498	0.284
LIG_FHA_1	538	544	PF00498	0.306
LIG_FHA_2	150	156	PF00498	0.299
LIG_FHA_2	176	182	PF00498	0.409
LIG_FHA_2	30	36	PF00498	0.329
LIG_FHA_2	68	74	PF00498	0.369
LIG_G3BP_FGDF_1	130	135	PF02136	0.313
LIG_HP1_1	211	215	PF01393	0.377
LIG_LIR_Apic_2	181	186	PF02991	0.399
LIG_LIR_Apic_2	281	285	PF02991	0.256
LIG_LIR_Apic_2	67	72	PF02991	0.312
LIG_LIR_Gen_1	311	319	PF02991	0.393
LIG_LIR_Gen_1	33	41	PF02991	0.294
LIG_LIR_Gen_1	430	437	PF02991	0.324
LIG_LIR_Gen_1	504	513	PF02991	0.392
LIG_LIR_LC3C_4	209	214	PF02991	0.386
LIG_LIR_Nem_3	129	135	PF02991	0.282
LIG_LIR_Nem_3	225	230	PF02991	0.309
LIG_LIR_Nem_3	238	243	PF02991	0.270
LIG_LIR_Nem_3	311	316	PF02991	0.393
LIG_LIR_Nem_3	33	39	PF02991	0.299
LIG_LIR_Nem_3	416	420	PF02991	0.252
LIG_LIR_Nem_3	430	436	PF02991	0.240
LIG_LIR_Nem_3	504	508	PF02991	0.284
LIG_LIR_Nem_3	532	537	PF02991	0.349
LIG_MAD2	74	82	PF02301	0.295
LIG_MYND_3	287	291	PF01753	0.300
LIG_NBox_RRM_1	363	373	PF00076	0.386
LIG_PDZ_Class_2	564	569	PF00595	0.403
LIG_Pex14_1	223	227	PF04695	0.386
LIG_Pex14_2	501	505	PF04695	0.385
LIG_Pex14_2	530	534	PF04695	0.334
LIG_PTB_Apo_2	456	463	PF02174	0.185
LIG_SH2_CRK	282	286	PF00017	0.256
LIG_SH2_CRK	36	40	PF00017	0.256
LIG_SH2_CRK	420	424	PF00017	0.185
LIG_SH2_CRK	464	468	PF00017	0.410
LIG_SH2_NCK_1	177	181	PF00017	0.402
LIG_SH2_NCK_1	183	187	PF00017	0.461
LIG_SH2_NCK_1	230	234	PF00017	0.297
LIG_SH2_NCK_1	282	286	PF00017	0.222
LIG_SH2_PTP2	107	110	PF00017	0.320
LIG_SH2_PTP2	341	344	PF00017	0.256
LIG_SH2_SRC	234	237	PF00017	0.399
LIG_SH2_STAP1	34	38	PF00017	0.269
LIG_SH2_STAP1	555	559	PF00017	0.444
LIG_SH2_STAT3	555	558	PF00017	0.441
LIG_SH2_STAT5	107	110	PF00017	0.299
LIG_SH2_STAT5	177	180	PF00017	0.355
LIG_SH2_STAT5	230	233	PF00017	0.330
LIG_SH2_STAT5	3	6	PF00017	0.468
LIG_SH2_STAT5	341	344	PF00017	0.256
LIG_SH2_STAT5	406	409	PF00017	0.285
LIG_SH2_STAT5	435	438	PF00017	0.240
LIG_SH2_STAT5	464	467	PF00017	0.260
LIG_SH2_STAT5	513	516	PF00017	0.362
LIG_SH2_STAT5	555	558	PF00017	0.503
LIG_SH3_1	183	189	PF00018	0.379
LIG_SH3_1	282	288	PF00018	0.256
LIG_SH3_1	330	336	PF00018	0.312
LIG_SH3_2	186	191	PF14604	0.462
LIG_SH3_3	114	120	PF00018	0.408
LIG_SH3_3	183	189	PF00018	0.382
LIG_SH3_3	245	251	PF00018	0.300
LIG_SH3_3	282	288	PF00018	0.271
LIG_SH3_3	300	306	PF00018	0.330
LIG_SH3_3	330	336	PF00018	0.346
LIG_SH3_3	440	446	PF00018	0.240
LIG_SH3_3	536	542	PF00018	0.396
LIG_SH3_5	232	236	PF00018	0.269
LIG_Sin3_3	14	21	PF02671	0.270
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.427
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.313
LIG_SUMO_SIM_par_1	60	65	PF11976	0.279
LIG_WRC_WIRS_1	498	503	PF05994	0.377
MOD_CDC14_SPxK_1	28	31	PF00782	0.457
MOD_CDK_SPxK_1	25	31	PF00069	0.468
MOD_CDK_SPxxK_3	422	429	PF00069	0.324
MOD_CK1_1	126	132	PF00069	0.423
MOD_CK1_1	138	144	PF00069	0.365
MOD_CK1_1	317	323	PF00069	0.305
MOD_CK1_1	378	384	PF00069	0.371
MOD_CK1_1	421	427	PF00069	0.407
MOD_CK1_1	549	555	PF00069	0.379
MOD_CK2_1	149	155	PF00069	0.303
MOD_CK2_1	164	170	PF00069	0.361
MOD_CK2_1	175	181	PF00069	0.302
MOD_CK2_1	487	493	PF00069	0.525
MOD_Cter_Amidation	57	60	PF01082	0.393
MOD_GlcNHglycan	12	15	PF01048	0.358
MOD_GlcNHglycan	125	128	PF01048	0.431
MOD_GSK3_1	160	167	PF00069	0.417
MOD_GSK3_1	218	225	PF00069	0.352
MOD_GSK3_1	25	32	PF00069	0.467
MOD_GSK3_1	418	425	PF00069	0.386
MOD_GSK3_1	476	483	PF00069	0.237
MOD_GSK3_1	489	496	PF00069	0.301
MOD_GSK3_1	549	556	PF00069	0.491
MOD_N-GLC_1	149	154	PF02516	0.344
MOD_N-GLC_1	544	549	PF02516	0.382
MOD_N-GLC_2	463	465	PF02516	0.141
MOD_NEK2_1	135	140	PF00069	0.460
MOD_NEK2_1	260	265	PF00069	0.256
MOD_NEK2_1	369	374	PF00069	0.312
MOD_NEK2_1	476	481	PF00069	0.256
MOD_NEK2_1	515	520	PF00069	0.362
MOD_NEK2_1	553	558	PF00069	0.502
MOD_NEK2_2	375	380	PF00069	0.239
MOD_PKA_2	30	36	PF00069	0.359
MOD_PKA_2	314	320	PF00069	0.386
MOD_PKA_2	404	410	PF00069	0.371
MOD_Plk_1	149	155	PF00069	0.326
MOD_Plk_1	175	181	PF00069	0.359
MOD_Plk_1	64	70	PF00069	0.312
MOD_Plk_2-3	164	170	PF00069	0.492
MOD_Plk_4	149	155	PF00069	0.306
MOD_Plk_4	418	424	PF00069	0.386
MOD_Plk_4	497	503	PF00069	0.338
MOD_Plk_4	529	535	PF00069	0.333
MOD_Plk_4	549	555	PF00069	0.226
MOD_ProDKin_1	228	234	PF00069	0.303
MOD_ProDKin_1	25	31	PF00069	0.468
MOD_ProDKin_1	422	428	PF00069	0.324
MOD_ProDKin_1	538	544	PF00069	0.425
MOD_SUMO_for_1	526	529	PF00179	0.457
MOD_SUMO_rev_2	317	323	PF00179	0.305
MOD_SUMO_rev_2	385	394	PF00179	0.301
TRG_DiLeu_BaEn_1	275	280	PF01217	0.240
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.239
TRG_ENDOCYTIC_2	107	110	PF00928	0.284
TRG_ENDOCYTIC_2	341	344	PF00928	0.247
TRG_ENDOCYTIC_2	36	39	PF00928	0.258
TRG_ENDOCYTIC_2	420	423	PF00928	0.223
TRG_ENDOCYTIC_2	464	467	PF00928	0.287
TRG_ER_diArg_1	24	27	PF00400	0.402
TRG_NES_CRM1_1	493	506	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.207

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K9	Leptomonas seymouri	78%	100%
A0A0S4IT90	Bodo saltans	54%	87%
A0A1X0NLC9	Trypanosomatidae	61%	100%
A0A422P4A3	Trypanosoma rangeli	60%	100%
A4H7F2	Leishmania braziliensis	84%	100%
A4HVU0	Leishmania infantum	99%	100%
B7TWW5	Panax ginseng	34%	100%
D0A6E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
E9API6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9R5G2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%
I1RQ76	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
O13306	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
O48651	Panax ginseng	33%	100%
O65402	Arabidopsis thaliana	27%	100%
O65403	Arabidopsis thaliana	26%	100%
O65404	Arabidopsis thaliana	26%	100%
O65726	Brassica napus	26%	100%
O65727	Brassica napus	26%	100%
O81000	Arabidopsis thaliana	35%	97%
P32476	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P52019	Mus musculus	35%	99%
P52020	Rattus norvegicus	34%	99%
Q14534	Homo sapiens	34%	99%
Q4QFZ2	Leishmania major	94%	100%
Q75F69	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	100%
Q8VYH2	Arabidopsis thaliana	34%	100%
Q92206	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	100%
Q9C1W3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q9SM02	Arabidopsis thaliana	33%	100%
V5BRL1	Trypanosoma cruzi	58%	99%