LeishMANIAdb
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Mitogen-activated protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitogen-activated protein kinase
Gene product:
mitogen-activated protein kinase 7, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WSP5_LEIDO
TriTrypDb:
LdBPK_131380.1 * , LdCL_130021100 , LDHU3_13.1890
Length:
573

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3S7WSP5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSP5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016310 phosphorylation 5 16
GO:0019538 protein metabolic process 3 16
GO:0036211 protein modification process 4 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043412 macromolecule modification 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:0007165 signal transduction 2 2
GO:0035556 intracellular signal transduction 3 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 16
GO:0003824 catalytic activity 1 16
GO:0004672 protein kinase activity 3 16
GO:0004674 protein serine/threonine kinase activity 4 15
GO:0004707 MAP kinase activity 5 10
GO:0005488 binding 1 16
GO:0005524 ATP binding 5 16
GO:0016301 kinase activity 4 16
GO:0016740 transferase activity 2 16
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 16
GO:0017076 purine nucleotide binding 4 16
GO:0030554 adenyl nucleotide binding 5 16
GO:0032553 ribonucleotide binding 3 16
GO:0032555 purine ribonucleotide binding 4 16
GO:0032559 adenyl ribonucleotide binding 5 16
GO:0035639 purine ribonucleoside triphosphate binding 4 16
GO:0036094 small molecule binding 2 16
GO:0043167 ion binding 2 16
GO:0043168 anion binding 3 16
GO:0097159 organic cyclic compound binding 2 16
GO:0097367 carbohydrate derivative binding 2 16
GO:0140096 catalytic activity, acting on a protein 2 16
GO:1901265 nucleoside phosphate binding 3 16
GO:1901363 heterocyclic compound binding 2 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 12 16 PF00656 0.425
CLV_C14_Caspase3-7 158 162 PF00656 0.273
CLV_NRD_NRD_1 135 137 PF00675 0.473
CLV_NRD_NRD_1 163 165 PF00675 0.332
CLV_NRD_NRD_1 35 37 PF00675 0.398
CLV_NRD_NRD_1 373 375 PF00675 0.280
CLV_NRD_NRD_1 424 426 PF00675 0.204
CLV_NRD_NRD_1 473 475 PF00675 0.306
CLV_NRD_NRD_1 99 101 PF00675 0.495
CLV_PCSK_FUR_1 97 101 PF00082 0.482
CLV_PCSK_KEX2_1 134 136 PF00082 0.476
CLV_PCSK_KEX2_1 163 165 PF00082 0.251
CLV_PCSK_KEX2_1 373 375 PF00082 0.337
CLV_PCSK_KEX2_1 475 477 PF00082 0.318
CLV_PCSK_KEX2_1 99 101 PF00082 0.492
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.476
CLV_PCSK_PC1ET2_1 475 477 PF00082 0.315
CLV_PCSK_SKI1_1 111 115 PF00082 0.367
CLV_PCSK_SKI1_1 135 139 PF00082 0.479
CLV_PCSK_SKI1_1 150 154 PF00082 0.391
CLV_PCSK_SKI1_1 163 167 PF00082 0.242
CLV_PCSK_SKI1_1 253 257 PF00082 0.313
CLV_PCSK_SKI1_1 374 378 PF00082 0.298
CLV_PCSK_SKI1_1 549 553 PF00082 0.331
CLV_PCSK_SKI1_1 93 97 PF00082 0.683
CLV_Separin_Metazoa 497 501 PF03568 0.428
DEG_APCC_DBOX_1 162 170 PF00400 0.285
DEG_Nend_Nbox_1 1 3 PF02207 0.323
DOC_CDC14_PxL_1 342 350 PF14671 0.251
DOC_CKS1_1 390 395 PF01111 0.337
DOC_CKS1_1 399 404 PF01111 0.299
DOC_CYCLIN_RxL_1 371 378 PF00134 0.314
DOC_CYCLIN_RxL_1 464 472 PF00134 0.320
DOC_CYCLIN_RxL_1 546 555 PF00134 0.298
DOC_MAPK_gen_1 163 171 PF00069 0.298
DOC_MAPK_gen_1 253 262 PF00069 0.273
DOC_MAPK_gen_1 341 350 PF00069 0.297
DOC_MAPK_gen_1 425 436 PF00069 0.222
DOC_MAPK_HePTP_8 338 350 PF00069 0.298
DOC_MAPK_MEF2A_6 341 350 PF00069 0.298
DOC_MAPK_MEF2A_6 521 528 PF00069 0.400
DOC_PP1_RVXF_1 465 472 PF00149 0.299
DOC_PP4_FxxP_1 487 490 PF00568 0.425
DOC_USP7_MATH_1 196 200 PF00917 0.359
DOC_USP7_MATH_1 284 288 PF00917 0.592
DOC_USP7_MATH_1 295 299 PF00917 0.686
DOC_USP7_MATH_1 547 551 PF00917 0.357
DOC_USP7_UBL2_3 150 154 PF12436 0.291
DOC_WW_Pin1_4 141 146 PF00397 0.363
DOC_WW_Pin1_4 389 394 PF00397 0.318
DOC_WW_Pin1_4 398 403 PF00397 0.332
DOC_WW_Pin1_4 528 533 PF00397 0.362
LIG_14-3-3_CanoR_1 317 323 PF00244 0.586
LIG_14-3-3_CanoR_1 36 40 PF00244 0.352
LIG_14-3-3_CanoR_1 500 506 PF00244 0.440
LIG_14-3-3_CanoR_1 541 548 PF00244 0.437
LIG_14-3-3_CanoR_1 73 81 PF00244 0.344
LIG_Actin_WH2_2 152 169 PF00022 0.284
LIG_Actin_WH2_2 205 223 PF00022 0.372
LIG_Actin_WH2_2 382 398 PF00022 0.337
LIG_AP2alpha_2 485 487 PF02296 0.337
LIG_APCC_ABBA_1 48 53 PF00400 0.294
LIG_BRCT_BRCA1_1 129 133 PF00533 0.506
LIG_BRCT_BRCA1_1 198 202 PF00533 0.337
LIG_BRCT_BRCA1_1 447 451 PF00533 0.314
LIG_BRCT_BRCA1_1 530 534 PF00533 0.358
LIG_Clathr_ClatBox_1 468 472 PF01394 0.337
LIG_CtBP_PxDLS_1 458 462 PF00389 0.348
LIG_deltaCOP1_diTrp_1 304 311 PF00928 0.474
LIG_EH1_1 205 213 PF00400 0.285
LIG_EH1_1 416 424 PF00400 0.337
LIG_eIF4E_1 206 212 PF01652 0.227
LIG_eIF4E_1 343 349 PF01652 0.298
LIG_FHA_1 108 114 PF00498 0.529
LIG_FHA_1 333 339 PF00498 0.308
LIG_FHA_1 390 396 PF00498 0.258
LIG_FHA_2 10 16 PF00498 0.419
LIG_FHA_2 292 298 PF00498 0.486
LIG_FHA_2 476 482 PF00498 0.332
LIG_GBD_Chelix_1 234 242 PF00786 0.337
LIG_LIR_Apic_2 340 346 PF02991 0.273
LIG_LIR_Apic_2 485 490 PF02991 0.337
LIG_LIR_Gen_1 144 152 PF02991 0.344
LIG_LIR_Gen_1 153 160 PF02991 0.459
LIG_LIR_Gen_1 199 208 PF02991 0.377
LIG_LIR_Nem_3 144 149 PF02991 0.344
LIG_LIR_Nem_3 153 159 PF02991 0.459
LIG_LIR_Nem_3 199 205 PF02991 0.314
LIG_LIR_Nem_3 229 234 PF02991 0.362
LIG_LIR_Nem_3 304 309 PF02991 0.599
LIG_LIR_Nem_3 485 491 PF02991 0.371
LIG_NRBOX 215 221 PF00104 0.337
LIG_NRP_CendR_1 571 573 PF00754 0.483
LIG_Pex14_2 534 538 PF04695 0.382
LIG_REV1ctd_RIR_1 485 489 PF16727 0.283
LIG_SH2_CRK 63 67 PF00017 0.350
LIG_SH2_GRB2like 80 83 PF00017 0.320
LIG_SH2_NCK_1 129 133 PF00017 0.531
LIG_SH2_SRC 244 247 PF00017 0.278
LIG_SH2_STAT3 382 385 PF00017 0.248
LIG_SH2_STAT5 107 110 PF00017 0.521
LIG_SH2_STAT5 174 177 PF00017 0.337
LIG_SH2_STAT5 206 209 PF00017 0.309
LIG_SH2_STAT5 244 247 PF00017 0.314
LIG_SH2_STAT5 31 34 PF00017 0.490
LIG_SH2_STAT5 337 340 PF00017 0.298
LIG_SH2_STAT5 382 385 PF00017 0.288
LIG_SH3_1 396 402 PF00018 0.342
LIG_SH3_3 120 126 PF00018 0.487
LIG_SH3_3 184 190 PF00018 0.354
LIG_SH3_3 278 284 PF00018 0.405
LIG_SH3_3 396 402 PF00018 0.288
LIG_SH3_3 452 458 PF00018 0.286
LIG_SUMO_SIM_anti_2 347 352 PF11976 0.332
LIG_SUMO_SIM_anti_2 384 392 PF11976 0.337
LIG_TRAF2_1 222 225 PF00917 0.391
LIG_TRAF2_1 509 512 PF00917 0.496
LIG_UBA3_1 165 170 PF00899 0.384
LIG_WRC_WIRS_1 468 473 PF05994 0.351
LIG_WW_1 329 332 PF00397 0.251
MOD_CDK_SPxxK_3 389 396 PF00069 0.337
MOD_CK1_1 287 293 PF00069 0.587
MOD_CK1_1 504 510 PF00069 0.596
MOD_CK2_1 219 225 PF00069 0.319
MOD_CK2_1 291 297 PF00069 0.662
MOD_CK2_1 41 47 PF00069 0.464
MOD_CK2_1 475 481 PF00069 0.297
MOD_CK2_1 491 497 PF00069 0.309
MOD_CK2_1 547 553 PF00069 0.435
MOD_Cter_Amidation 161 164 PF01082 0.273
MOD_GlcNHglycan 198 201 PF01048 0.297
MOD_GlcNHglycan 247 250 PF01048 0.334
MOD_GlcNHglycan 297 301 PF01048 0.670
MOD_GlcNHglycan 313 316 PF01048 0.583
MOD_GlcNHglycan 320 323 PF01048 0.555
MOD_GlcNHglycan 361 364 PF01048 0.452
MOD_GlcNHglycan 543 546 PF01048 0.326
MOD_GSK3_1 191 198 PF00069 0.251
MOD_GSK3_1 287 294 PF00069 0.545
MOD_GSK3_1 430 437 PF00069 0.301
MOD_GSK3_1 528 535 PF00069 0.491
MOD_NEK2_1 20 25 PF00069 0.620
MOD_NEK2_1 219 224 PF00069 0.337
MOD_NEK2_1 273 278 PF00069 0.337
MOD_NEK2_1 309 314 PF00069 0.572
MOD_NEK2_1 424 429 PF00069 0.251
MOD_NEK2_1 434 439 PF00069 0.228
MOD_NEK2_1 445 450 PF00069 0.337
MOD_NEK2_1 74 79 PF00069 0.424
MOD_NEK2_1 9 14 PF00069 0.338
MOD_NEK2_2 547 552 PF00069 0.275
MOD_PIKK_1 220 226 PF00454 0.289
MOD_PIKK_1 381 387 PF00454 0.246
MOD_PIKK_1 439 445 PF00454 0.284
MOD_PKA_1 150 156 PF00069 0.379
MOD_PKA_1 475 481 PF00069 0.316
MOD_PKA_2 35 41 PF00069 0.382
MOD_PKA_2 424 430 PF00069 0.204
MOD_PKA_2 475 481 PF00069 0.298
MOD_PKA_2 540 546 PF00069 0.455
MOD_Plk_1 285 291 PF00069 0.521
MOD_Plk_4 41 47 PF00069 0.402
MOD_Plk_4 446 452 PF00069 0.361
MOD_Plk_4 75 81 PF00069 0.341
MOD_ProDKin_1 141 147 PF00069 0.354
MOD_ProDKin_1 389 395 PF00069 0.318
MOD_ProDKin_1 398 404 PF00069 0.332
MOD_ProDKin_1 528 534 PF00069 0.355
MOD_SUMO_rev_2 248 257 PF00179 0.274
MOD_SUMO_rev_2 410 418 PF00179 0.337
TRG_DiLeu_BaEn_3 413 419 PF01217 0.337
TRG_DiLeu_BaEn_3 89 95 PF01217 0.413
TRG_ENDOCYTIC_2 236 239 PF00928 0.316
TRG_ENDOCYTIC_2 63 66 PF00928 0.370
TRG_ER_diArg_1 108 111 PF00400 0.464
TRG_ER_diArg_1 135 137 PF00400 0.427
TRG_ER_diArg_1 163 165 PF00400 0.332
TRG_ER_diArg_1 372 374 PF00400 0.337
TRG_ER_diArg_1 473 476 PF00400 0.305
TRG_ER_diArg_1 97 100 PF00400 0.647
TRG_NLS_MonoExtN_4 132 138 PF00514 0.492
TRG_NLS_MonoExtN_4 473 478 PF00514 0.370
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.283
TRG_Pf-PMV_PEXEL_1 489 493 PF00026 0.385
TRG_Pf-PMV_PEXEL_1 549 553 PF00026 0.467
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.448

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2E2 Leptomonas seymouri 30% 100%
A0A0N1I304 Leptomonas seymouri 68% 99%
A0A0N1II59 Leptomonas seymouri 28% 100%
A0A0S4ILC2 Bodo saltans 33% 100%
A0A0S4IUF2 Bodo saltans 25% 100%
A0A0S4IXW3 Bodo saltans 30% 100%
A0A0S4J343 Bodo saltans 24% 100%
A0A0S4J8M8 Bodo saltans 23% 71%
A0A0S4JCX8 Bodo saltans 26% 100%
A0A0S4JXW9 Bodo saltans 35% 100%
A0A0S4KIN4 Bodo saltans 37% 84%
A0A1X0NQM7 Trypanosomatidae 29% 100%
A0A1X0P018 Trypanosomatidae 28% 100%
A0A1X0P3B9 Trypanosomatidae 32% 100%
A0A3Q8IH39 Leishmania donovani 29% 100%
A0A3Q8ITZ9 Leishmania donovani 33% 100%
A0A3Q8IVR8 Leishmania donovani 31% 100%
A0A3R7KBU3 Trypanosoma rangeli 26% 100%
A0A3R7M0A0 Trypanosoma rangeli 31% 100%
A0A3R7NAU1 Trypanosoma rangeli 25% 100%
A0A3S5H528 Leishmania donovani 30% 100%
A0A3S5H7N7 Leishmania donovani 34% 100%
A0A3S7WR45 Leishmania donovani 32% 100%
A0A3S7XA45 Leishmania donovani 30% 100%
A0A422N878 Trypanosoma rangeli 25% 100%
A0A451EJH2 Leishmania donovani 27% 99%
A4H601 Leishmania braziliensis 30% 100%
A4H641 Leishmania braziliensis 31% 96%
A4H7F4 Leishmania braziliensis 82% 100%
A4HFF3 Leishmania braziliensis 25% 100%
A4HIM5 Leishmania braziliensis 36% 100%
A4HLJ9 Leishmania braziliensis 33% 100%
A4HNG3 Leishmania braziliensis 32% 100%
A4HNT2 Leishmania braziliensis 31% 100%
A4HRN3 Leishmania infantum 27% 99%
A4HRT2 Leishmania infantum 30% 100%
A4HUC8 Leishmania infantum 29% 100%
A4HUG1 Leishmania infantum 32% 100%
A4HVU2 Leishmania infantum 100% 100%
A4I5X0 Leishmania infantum 34% 100%
A4I910 Leishmania infantum 33% 100%
A4IC54 Leishmania infantum 30% 100%
A4ICR2 Leishmania infantum 31% 100%
B5X564 Arabidopsis thaliana 31% 89%
B6DTC0 Bodo saltans 33% 100%
C9ZJF3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 74%
D0A105 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E9ACB1 Leishmania major 27% 95%
E9ACG8 Leishmania major 29% 100%
E9AFX4 Leishmania major 30% 100%
E9AJJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 99%
E9AN28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AN59 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9API8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B164 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B3X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9B727 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
F4ICB6 Arabidopsis thaliana 30% 81%
G4N374 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 33% 100%
O13352 Magnaporthe oryzae 33% 100%
O23145 Arabidopsis thaliana 27% 100%
O60145 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
P27704 Rattus norvegicus 29% 80%
P43068 Candida albicans 28% 100%
P46551 Caenorhabditis elegans 29% 78%
P49185 Rattus norvegicus 27% 100%
Q00536 Homo sapiens 26% 100%
Q04735 Mus musculus 26% 100%
Q16659 Homo sapiens 29% 79%
Q336M2 Oryza sativa subsp. japonica 28% 100%
Q4Q204 Leishmania major 31% 100%
Q4Q449 Leishmania major 33% 100%
Q4Q701 Leishmania major 34% 100%
Q4Q7S2 Leishmania major 31% 100%
Q4QFZ0 Leishmania major 94% 100%
Q4QHG6 Leishmania major 32% 100%
Q4QHJ8 Leishmania major 31% 100%
Q5AAG6 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 100%
Q5F3W3 Gallus gallus 30% 79%
Q5R7U1 Pongo abelii 29% 79%
Q60EZ2 Oryza sativa subsp. japonica 28% 100%
Q61532 Mus musculus 29% 80%
Q6Z8C8 Oryza sativa subsp. japonica 26% 100%
Q80Y86 Mus musculus 33% 100%
Q8I7M8 Caenorhabditis elegans 27% 86%
Q8QHK8 Xenopus laevis 27% 100%
Q9DGD9 Danio rerio 27% 100%
Q9LWN0 Oryza sativa subsp. japonica 28% 100%
Q9SJG9 Arabidopsis thaliana 32% 95%
Q9TVL3 Caenorhabditis elegans 31% 100%
V5BCX5 Trypanosoma cruzi 26% 100%
V5BI43 Trypanosoma cruzi 25% 100%
V5BSG8 Trypanosoma cruzi 32% 100%
V5DCN7 Trypanosoma cruzi 27% 96%
V5DIC3 Trypanosoma cruzi 24% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS