RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WSN6_LEIDO

TriTrypDb:

LdBPK_131310.1 , LdCL_130018600 , LDHU3_13.1590

Length:

999

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.652
CLV_C14_Caspase3-7	312	316	PF00656	0.723
CLV_NRD_NRD_1	246	248	PF00675	0.709
CLV_NRD_NRD_1	856	858	PF00675	0.708
CLV_NRD_NRD_1	88	90	PF00675	0.639
CLV_PCSK_KEX2_1	245	247	PF00082	0.706
CLV_PCSK_KEX2_1	50	52	PF00082	0.695
CLV_PCSK_KEX2_1	858	860	PF00082	0.708
CLV_PCSK_KEX2_1	88	90	PF00082	0.676
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.695
CLV_PCSK_PC1ET2_1	858	860	PF00082	0.708
CLV_PCSK_PC7_1	84	90	PF00082	0.606
CLV_PCSK_SKI1_1	160	164	PF00082	0.659
DEG_Nend_UBRbox_3	1	3	PF02207	0.730
DEG_ODPH_VHL_1	427	440	PF01847	0.619
DEG_SCF_FBW7_1	209	215	PF00400	0.650
DEG_SCF_FBW7_1	486	493	PF00400	0.700
DEG_SPOP_SBC_1	114	118	PF00917	0.597
DEG_SPOP_SBC_1	496	500	PF00917	0.707
DEG_SPOP_SBC_1	590	594	PF00917	0.637
DEG_SPOP_SBC_1	624	628	PF00917	0.578
DOC_CKS1_1	190	195	PF01111	0.644
DOC_CKS1_1	209	214	PF01111	0.499
DOC_CKS1_1	487	492	PF01111	0.701
DOC_CKS1_1	952	957	PF01111	0.592
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.652
DOC_MAPK_gen_1	245	252	PF00069	0.665
DOC_PP2B_LxvP_1	42	45	PF13499	0.606
DOC_PP2B_PxIxI_1	44	50	PF00149	0.632
DOC_PP4_FxxP_1	300	303	PF00568	0.586
DOC_PP4_FxxP_1	426	429	PF00568	0.607
DOC_USP7_MATH_1	147	151	PF00917	0.647
DOC_USP7_MATH_1	184	188	PF00917	0.598
DOC_USP7_MATH_1	19	23	PF00917	0.634
DOC_USP7_MATH_1	264	268	PF00917	0.798
DOC_USP7_MATH_1	35	39	PF00917	0.589
DOC_USP7_MATH_1	361	365	PF00917	0.722
DOC_USP7_MATH_1	366	370	PF00917	0.652
DOC_USP7_MATH_1	374	378	PF00917	0.574
DOC_USP7_MATH_1	402	406	PF00917	0.702
DOC_USP7_MATH_1	469	473	PF00917	0.656
DOC_USP7_MATH_1	490	494	PF00917	0.694
DOC_USP7_MATH_1	530	534	PF00917	0.641
DOC_USP7_MATH_1	567	571	PF00917	0.576
DOC_USP7_MATH_1	590	594	PF00917	0.637
DOC_USP7_MATH_1	638	642	PF00917	0.608
DOC_USP7_MATH_1	725	729	PF00917	0.707
DOC_USP7_MATH_1	829	833	PF00917	0.608
DOC_USP7_MATH_1	912	916	PF00917	0.727
DOC_USP7_MATH_1	95	99	PF00917	0.683
DOC_USP7_MATH_1	950	954	PF00917	0.694
DOC_WW_Pin1_4	143	148	PF00397	0.673
DOC_WW_Pin1_4	15	20	PF00397	0.635
DOC_WW_Pin1_4	179	184	PF00397	0.675
DOC_WW_Pin1_4	189	194	PF00397	0.587
DOC_WW_Pin1_4	208	213	PF00397	0.565
DOC_WW_Pin1_4	220	225	PF00397	0.665
DOC_WW_Pin1_4	252	257	PF00397	0.670
DOC_WW_Pin1_4	29	34	PF00397	0.604
DOC_WW_Pin1_4	349	354	PF00397	0.686
DOC_WW_Pin1_4	381	386	PF00397	0.694
DOC_WW_Pin1_4	40	45	PF00397	0.814
DOC_WW_Pin1_4	429	434	PF00397	0.795
DOC_WW_Pin1_4	449	454	PF00397	0.533
DOC_WW_Pin1_4	465	470	PF00397	0.568
DOC_WW_Pin1_4	486	491	PF00397	0.656
DOC_WW_Pin1_4	503	508	PF00397	0.553
DOC_WW_Pin1_4	651	656	PF00397	0.677
DOC_WW_Pin1_4	762	767	PF00397	0.637
DOC_WW_Pin1_4	917	922	PF00397	0.647
DOC_WW_Pin1_4	942	947	PF00397	0.665
DOC_WW_Pin1_4	948	953	PF00397	0.617
DOC_WW_Pin1_4	972	977	PF00397	0.695
LIG_14-3-3_CanoR_1	12	20	PF00244	0.672
LIG_14-3-3_CanoR_1	21	27	PF00244	0.617
LIG_14-3-3_CanoR_1	247	253	PF00244	0.747
LIG_14-3-3_CanoR_1	348	353	PF00244	0.728
LIG_14-3-3_CanoR_1	406	410	PF00244	0.617
LIG_14-3-3_CanoR_1	422	426	PF00244	0.581
LIG_14-3-3_CanoR_1	497	502	PF00244	0.719
LIG_14-3-3_CanoR_1	522	529	PF00244	0.585
LIG_14-3-3_CanoR_1	966	971	PF00244	0.652
LIG_14-3-3_CanoR_1	987	994	PF00244	0.524
LIG_BRCT_BRCA1_1	471	475	PF00533	0.718
LIG_BRCT_BRCA1_1	764	768	PF00533	0.635
LIG_EVH1_1	794	798	PF00568	0.595
LIG_EVH1_2	166	170	PF00568	0.580
LIG_FHA_1	220	226	PF00498	0.588
LIG_FHA_1	308	314	PF00498	0.752
LIG_FHA_1	416	422	PF00498	0.574
LIG_FHA_1	481	487	PF00498	0.649
LIG_FHA_1	524	530	PF00498	0.602
LIG_FHA_1	557	563	PF00498	0.669
LIG_FHA_1	871	877	PF00498	0.696
LIG_FHA_1	878	884	PF00498	0.740
LIG_FHA_1	952	958	PF00498	0.592
LIG_FHA_1	97	103	PF00498	0.678
LIG_FHA_2	310	316	PF00498	0.795
LIG_FHA_2	652	658	PF00498	0.679
LIG_HCF-1_HBM_1	723	726	PF13415	0.591
LIG_Integrin_isoDGR_2	55	57	PF01839	0.650
LIG_LIR_Apic_2	424	429	PF02991	0.607
LIG_LIR_Gen_1	548	555	PF02991	0.654
LIG_LIR_Gen_1	592	602	PF02991	0.615
LIG_LIR_Gen_1	742	751	PF02991	0.592
LIG_LIR_Nem_3	237	241	PF02991	0.649
LIG_LIR_Nem_3	548	554	PF02991	0.657
LIG_LIR_Nem_3	592	598	PF02991	0.618
LIG_LIR_Nem_3	728	733	PF02991	0.660
LIG_LIR_Nem_3	742	747	PF02991	0.548
LIG_LYPXL_yS_3	730	733	PF13949	0.659
LIG_MYND_1	731	735	PF01753	0.651
LIG_SH2_CRK	551	555	PF00017	0.673
LIG_SH2_CRK	744	748	PF00017	0.591
LIG_SH2_CRK	779	783	PF00017	0.569
LIG_SH2_NCK_1	764	768	PF00017	0.635
LIG_SH2_SRC	684	687	PF00017	0.672
LIG_SH2_STAP1	774	778	PF00017	0.617
LIG_SH2_STAP1	924	928	PF00017	0.578
LIG_SH2_STAT3	600	603	PF00017	0.573
LIG_SH2_STAT3	660	663	PF00017	0.712
LIG_SH2_STAT3	666	669	PF00017	0.675
LIG_SH2_STAT3	746	749	PF00017	0.699
LIG_SH2_STAT3	774	777	PF00017	0.646
LIG_SH2_STAT3	803	806	PF00017	0.705
LIG_SH2_STAT3	821	824	PF00017	0.552
LIG_SH2_STAT3	833	836	PF00017	0.642
LIG_SH2_STAT5	238	241	PF00017	0.652
LIG_SH2_STAT5	551	554	PF00017	0.653
LIG_SH2_STAT5	746	749	PF00017	0.590
LIG_SH3_1	794	800	PF00018	0.650
LIG_SH3_2	193	198	PF14604	0.638
LIG_SH3_3	161	167	PF00018	0.689
LIG_SH3_3	188	194	PF00018	0.649
LIG_SH3_3	206	212	PF00018	0.562
LIG_SH3_3	221	227	PF00018	0.629
LIG_SH3_3	250	256	PF00018	0.671
LIG_SH3_3	351	357	PF00018	0.675
LIG_SH3_3	389	395	PF00018	0.712
LIG_SH3_3	484	490	PF00018	0.699
LIG_SH3_3	510	516	PF00018	0.658
LIG_SH3_3	599	605	PF00018	0.624
LIG_SH3_3	656	662	PF00018	0.704
LIG_SH3_3	707	713	PF00018	0.662
LIG_SH3_3	760	766	PF00018	0.681
LIG_SH3_3	792	798	PF00018	0.651
LIG_SH3_3	809	815	PF00018	0.562
LIG_SH3_3	887	893	PF00018	0.683
LIG_SH3_3	949	955	PF00018	0.650
LIG_SH3_5	662	666	PF00018	0.649
LIG_SUMO_SIM_par_1	436	441	PF11976	0.657
LIG_TRAF2_1	618	621	PF00917	0.670
LIG_TRAF2_2	713	718	PF00917	0.681
LIG_TRAF2_2	817	822	PF00917	0.690
LIG_TYR_ITIM	236	241	PF00017	0.648
LIG_WW_1	921	924	PF00397	0.559
LIG_WW_3	165	169	PF00397	0.580
MOD_CDC14_SPxK_1	18	21	PF00782	0.615
MOD_CDK_SPxK_1	15	21	PF00069	0.617
MOD_CDK_SPxK_1	972	978	PF00069	0.636
MOD_CDK_SPxxK_3	449	456	PF00069	0.675
MOD_CDK_SPxxK_3	467	474	PF00069	0.565
MOD_CK1_1	112	118	PF00069	0.626
MOD_CK1_1	129	135	PF00069	0.596
MOD_CK1_1	15	21	PF00069	0.597
MOD_CK1_1	179	185	PF00069	0.705
MOD_CK1_1	223	229	PF00069	0.710
MOD_CK1_1	251	257	PF00069	0.736
MOD_CK1_1	343	349	PF00069	0.704
MOD_CK1_1	352	358	PF00069	0.637
MOD_CK1_1	364	370	PF00069	0.579
MOD_CK1_1	377	383	PF00069	0.598
MOD_CK1_1	40	46	PF00069	0.678
MOD_CK1_1	405	411	PF00069	0.639
MOD_CK1_1	412	418	PF00069	0.644
MOD_CK1_1	500	506	PF00069	0.729
MOD_CK1_1	508	514	PF00069	0.632
MOD_CK1_1	545	551	PF00069	0.665
MOD_CK1_1	561	567	PF00069	0.566
MOD_CK1_1	570	576	PF00069	0.603
MOD_CK1_1	591	597	PF00069	0.643
MOD_CK1_1	6	12	PF00069	0.726
MOD_CK1_1	62	68	PF00069	0.723
MOD_CK1_1	627	633	PF00069	0.632
MOD_CK1_1	651	657	PF00069	0.679
MOD_CK1_1	802	808	PF00069	0.697
MOD_CK1_1	832	838	PF00069	0.613
MOD_CK1_1	870	876	PF00069	0.633
MOD_CK2_1	129	135	PF00069	0.698
MOD_CK2_1	20	26	PF00069	0.706
MOD_CK2_1	590	596	PF00069	0.639
MOD_CK2_1	651	657	PF00069	0.679
MOD_GlcNHglycan	137	140	PF01048	0.693
MOD_GlcNHglycan	178	181	PF01048	0.701
MOD_GlcNHglycan	184	187	PF01048	0.650
MOD_GlcNHglycan	22	25	PF01048	0.549
MOD_GlcNHglycan	342	345	PF01048	0.686
MOD_GlcNHglycan	363	366	PF01048	0.720
MOD_GlcNHglycan	369	372	PF01048	0.662
MOD_GlcNHglycan	37	40	PF01048	0.698
MOD_GlcNHglycan	376	379	PF01048	0.601
MOD_GlcNHglycan	483	486	PF01048	0.664
MOD_GlcNHglycan	492	495	PF01048	0.634
MOD_GlcNHglycan	5	8	PF01048	0.661
MOD_GlcNHglycan	507	510	PF01048	0.565
MOD_GlcNHglycan	526	529	PF01048	0.498
MOD_GlcNHglycan	532	535	PF01048	0.640
MOD_GlcNHglycan	544	547	PF01048	0.495
MOD_GlcNHglycan	585	588	PF01048	0.579
MOD_GlcNHglycan	61	64	PF01048	0.699
MOD_GlcNHglycan	727	730	PF01048	0.668
MOD_GlcNHglycan	79	83	PF01048	0.723
MOD_GlcNHglycan	844	847	PF01048	0.635
MOD_GlcNHglycan	853	856	PF01048	0.617
MOD_GlcNHglycan	912	915	PF01048	0.722
MOD_GlcNHglycan	99	102	PF01048	0.583
MOD_GlcNHglycan	996	999	PF01048	0.545
MOD_GSK3_1	109	116	PF00069	0.653
MOD_GSK3_1	131	138	PF00069	0.687
MOD_GSK3_1	143	150	PF00069	0.624
MOD_GSK3_1	15	22	PF00069	0.607
MOD_GSK3_1	175	182	PF00069	0.677
MOD_GSK3_1	2	9	PF00069	0.768
MOD_GSK3_1	208	215	PF00069	0.627
MOD_GSK3_1	219	226	PF00069	0.674
MOD_GSK3_1	237	244	PF00069	0.621
MOD_GSK3_1	248	255	PF00069	0.592
MOD_GSK3_1	287	294	PF00069	0.621
MOD_GSK3_1	309	316	PF00069	0.699
MOD_GSK3_1	318	325	PF00069	0.621
MOD_GSK3_1	336	343	PF00069	0.639
MOD_GSK3_1	344	351	PF00069	0.668
MOD_GSK3_1	353	360	PF00069	0.566
MOD_GSK3_1	377	384	PF00069	0.680
MOD_GSK3_1	405	412	PF00069	0.638
MOD_GSK3_1	429	436	PF00069	0.689
MOD_GSK3_1	459	466	PF00069	0.679
MOD_GSK3_1	486	493	PF00069	0.700
MOD_GSK3_1	495	502	PF00069	0.620
MOD_GSK3_1	503	510	PF00069	0.551
MOD_GSK3_1	541	548	PF00069	0.610
MOD_GSK3_1	554	561	PF00069	0.576
MOD_GSK3_1	623	630	PF00069	0.660
MOD_GSK3_1	680	687	PF00069	0.611
MOD_GSK3_1	877	884	PF00069	0.720
MOD_GSK3_1	923	930	PF00069	0.708
MOD_GSK3_1	93	100	PF00069	0.702
MOD_GSK3_1	942	949	PF00069	0.529
MOD_LATS_1	285	291	PF00433	0.607
MOD_LATS_1	520	526	PF00433	0.582
MOD_N-GLC_1	12	17	PF02516	0.707
MOD_N-GLC_1	307	312	PF02516	0.693
MOD_N-GLC_1	409	414	PF02516	0.707
MOD_N-GLC_1	481	486	PF02516	0.647
MOD_N-GLC_1	530	535	PF02516	0.615
MOD_N-GLC_1	851	856	PF02516	0.676
MOD_NEK2_1	128	133	PF00069	0.675
MOD_NEK2_1	158	163	PF00069	0.630
MOD_NEK2_1	409	414	PF00069	0.587
MOD_NEK2_1	523	528	PF00069	0.644
MOD_NEK2_1	910	915	PF00069	0.662
MOD_NEK2_1	964	969	PF00069	0.688
MOD_NEK2_2	45	50	PF00069	0.587
MOD_PIKK_1	463	469	PF00454	0.628
MOD_PIKK_1	750	756	PF00454	0.652
MOD_PIKK_1	786	792	PF00454	0.603
MOD_PIKK_1	802	808	PF00454	0.583
MOD_PIKK_1	832	838	PF00454	0.746
MOD_PK_1	246	252	PF00069	0.666
MOD_PK_1	966	972	PF00069	0.635
MOD_PKA_1	246	252	PF00069	0.714
MOD_PKA_1	88	94	PF00069	0.673
MOD_PKA_2	2	8	PF00069	0.755
MOD_PKA_2	20	26	PF00069	0.550
MOD_PKA_2	246	252	PF00069	0.714
MOD_PKA_2	301	307	PF00069	0.645
MOD_PKA_2	318	324	PF00069	0.575
MOD_PKA_2	347	353	PF00069	0.777
MOD_PKA_2	361	367	PF00069	0.626
MOD_PKA_2	405	411	PF00069	0.656
MOD_PKA_2	421	427	PF00069	0.537
MOD_PKA_2	496	502	PF00069	0.714
MOD_PKA_2	570	576	PF00069	0.623
MOD_PKA_2	87	93	PF00069	0.675
MOD_PKA_2	965	971	PF00069	0.646
MOD_PKA_2	986	992	PF00069	0.521
MOD_PKB_1	57	65	PF00069	0.612
MOD_Plk_1	264	270	PF00069	0.700
MOD_Plk_1	412	418	PF00069	0.654
MOD_Plk_1	481	487	PF00069	0.649
MOD_Plk_1	664	670	PF00069	0.648
MOD_Plk_1	877	883	PF00069	0.718
MOD_Plk_4	158	164	PF00069	0.668
MOD_Plk_4	214	220	PF00069	0.730
MOD_Plk_4	234	240	PF00069	0.737
MOD_Plk_4	264	270	PF00069	0.700
MOD_Plk_4	37	43	PF00069	0.619
MOD_Plk_4	421	427	PF00069	0.694
MOD_Plk_4	514	520	PF00069	0.617
MOD_Plk_4	545	551	PF00069	0.618
MOD_Plk_4	966	972	PF00069	0.671
MOD_ProDKin_1	143	149	PF00069	0.673
MOD_ProDKin_1	15	21	PF00069	0.642
MOD_ProDKin_1	179	185	PF00069	0.675
MOD_ProDKin_1	189	195	PF00069	0.584
MOD_ProDKin_1	208	214	PF00069	0.565
MOD_ProDKin_1	220	226	PF00069	0.694
MOD_ProDKin_1	252	258	PF00069	0.670
MOD_ProDKin_1	29	35	PF00069	0.604
MOD_ProDKin_1	349	355	PF00069	0.688
MOD_ProDKin_1	381	387	PF00069	0.695
MOD_ProDKin_1	40	46	PF00069	0.813
MOD_ProDKin_1	429	435	PF00069	0.796
MOD_ProDKin_1	449	455	PF00069	0.512
MOD_ProDKin_1	465	471	PF00069	0.569
MOD_ProDKin_1	486	492	PF00069	0.656
MOD_ProDKin_1	503	509	PF00069	0.552
MOD_ProDKin_1	651	657	PF00069	0.679
MOD_ProDKin_1	762	768	PF00069	0.636
MOD_ProDKin_1	917	923	PF00069	0.649
MOD_ProDKin_1	942	948	PF00069	0.662
MOD_ProDKin_1	951	957	PF00069	0.599
MOD_ProDKin_1	972	978	PF00069	0.697
TRG_ENDOCYTIC_2	238	241	PF00928	0.652
TRG_ENDOCYTIC_2	551	554	PF00928	0.678
TRG_ENDOCYTIC_2	730	733	PF00928	0.659
TRG_ENDOCYTIC_2	744	747	PF00928	0.548
TRG_ER_diArg_1	245	247	PF00400	0.706
TRG_ER_diArg_1	27	30	PF00400	0.698
TRG_ER_diArg_1	856	859	PF00400	0.708
TRG_ER_diArg_1	991	994	PF00400	0.536
TRG_NLS_MonoExtN_4	856	861	PF00514	0.702
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7C3	Leishmania braziliensis	50%	100%
A4HVR9	Leishmania infantum	99%	100%
E9APG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QG13	Leishmania major	83%	100%