FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WSN4_LEIDO

TriTrypDb:

LdBPK_131600.1 , LdCL_130020100 , LDHU3_13.1780

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.618
CLV_C14_Caspase3-7	145	149	PF00656	0.537
CLV_C14_Caspase3-7	380	384	PF00656	0.780
CLV_NRD_NRD_1	346	348	PF00675	0.566
CLV_NRD_NRD_1	356	358	PF00675	0.519
CLV_NRD_NRD_1	483	485	PF00675	0.576
CLV_NRD_NRD_1	51	53	PF00675	0.634
CLV_PCSK_FUR_1	481	485	PF00082	0.569
CLV_PCSK_KEX2_1	346	348	PF00082	0.566
CLV_PCSK_KEX2_1	483	485	PF00082	0.581
CLV_PCSK_KEX2_1	51	53	PF00082	0.591
CLV_PCSK_PC7_1	47	53	PF00082	0.588
CLV_PCSK_SKI1_1	257	261	PF00082	0.538
CLV_PCSK_SKI1_1	9	13	PF00082	0.511
DEG_APCC_DBOX_1	236	244	PF00400	0.410
DEG_APCC_DBOX_1	314	322	PF00400	0.423
DEG_APCC_DBOX_1	385	393	PF00400	0.614
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DOC_CKS1_1	394	399	PF01111	0.622
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.619
DOC_PP2B_LxvP_1	112	115	PF13499	0.573
DOC_PP2B_LxvP_1	175	178	PF13499	0.630
DOC_PP2B_LxvP_1	414	417	PF13499	0.502
DOC_PP2B_LxvP_1	467	470	PF13499	0.488
DOC_PP4_FxxP_1	170	173	PF00568	0.621
DOC_USP7_MATH_1	239	243	PF00917	0.418
DOC_USP7_MATH_1	281	285	PF00917	0.405
DOC_USP7_MATH_1	381	385	PF00917	0.679
DOC_WW_Pin1_4	135	140	PF00397	0.722
DOC_WW_Pin1_4	164	169	PF00397	0.566
DOC_WW_Pin1_4	235	240	PF00397	0.456
DOC_WW_Pin1_4	387	392	PF00397	0.626
DOC_WW_Pin1_4	393	398	PF00397	0.617
DOC_WW_Pin1_4	442	447	PF00397	0.521
DOC_WW_Pin1_4	70	75	PF00397	0.658
LIG_14-3-3_CanoR_1	117	127	PF00244	0.622
LIG_14-3-3_CanoR_1	237	245	PF00244	0.408
LIG_14-3-3_CanoR_1	51	55	PF00244	0.567
LIG_14-3-3_CterR_2	483	487	PF00244	0.677
LIG_APCC_ABBA_1	157	162	PF00400	0.570
LIG_APCC_ABBA_1	204	209	PF00400	0.548
LIG_BRCT_BRCA1_1	166	170	PF00533	0.580
LIG_Clathr_ClatBox_1	226	230	PF01394	0.363
LIG_Clathr_ClatBox_1	424	428	PF01394	0.337
LIG_FHA_1	102	108	PF00498	0.704
LIG_FHA_1	251	257	PF00498	0.488
LIG_FHA_1	394	400	PF00498	0.631
LIG_FHA_1	411	417	PF00498	0.499
LIG_FHA_1	420	426	PF00498	0.397
LIG_FHA_2	104	110	PF00498	0.513
LIG_FHA_2	250	256	PF00498	0.500
LIG_FHA_2	371	377	PF00498	0.628
LIG_FHA_2	5	11	PF00498	0.633
LIG_FHA_2	90	96	PF00498	0.573
LIG_GBD_Chelix_1	227	235	PF00786	0.449
LIG_GBD_Chelix_1	303	311	PF00786	0.401
LIG_KLC1_Yacidic_2	158	162	PF13176	0.577
LIG_LIR_Apic_2	167	173	PF02991	0.623
LIG_LIR_Gen_1	151	161	PF02991	0.581
LIG_LIR_Nem_3	151	157	PF02991	0.574
LIG_LIR_Nem_3	19	24	PF02991	0.470
LIG_NRBOX	462	468	PF00104	0.496
LIG_PDZ_Class_1	482	487	PF00595	0.677
LIG_Pex14_2	265	269	PF04695	0.352
LIG_Rb_pABgroove_1	148	156	PF01858	0.580
LIG_SH2_CRK	21	25	PF00017	0.492
LIG_SH2_CRK	218	222	PF00017	0.564
LIG_SH2_CRK	40	44	PF00017	0.578
LIG_SH2_GRB2like	317	320	PF00017	0.408
LIG_SH2_SRC	160	163	PF00017	0.578
LIG_SH2_SRC	317	320	PF00017	0.456
LIG_SH2_STAP1	218	222	PF00017	0.564
LIG_SH2_STAT3	338	341	PF00017	0.486
LIG_SH2_STAT5	160	163	PF00017	0.656
LIG_SH2_STAT5	317	320	PF00017	0.498
LIG_SH3_3	218	224	PF00018	0.550
LIG_SH3_3	307	313	PF00018	0.532
LIG_SH3_3	322	328	PF00018	0.364
LIG_SH3_3	388	394	PF00018	0.812
LIG_SUMO_SIM_anti_2	421	430	PF11976	0.428
LIG_SUMO_SIM_par_1	103	110	PF11976	0.562
LIG_SUMO_SIM_par_1	224	230	PF11976	0.381
LIG_SUMO_SIM_par_1	421	430	PF11976	0.428
LIG_WW_3	114	118	PF00397	0.602
MOD_CK1_1	118	124	PF00069	0.650
MOD_CK1_1	130	136	PF00069	0.579
MOD_CK1_1	238	244	PF00069	0.403
MOD_CK1_1	384	390	PF00069	0.604
MOD_CK2_1	185	191	PF00069	0.591
MOD_CK2_1	249	255	PF00069	0.509
MOD_CK2_1	281	287	PF00069	0.417
MOD_CK2_1	295	301	PF00069	0.420
MOD_CK2_1	370	376	PF00069	0.630
MOD_CK2_1	4	10	PF00069	0.643
MOD_CK2_1	70	76	PF00069	0.784
MOD_CK2_1	89	95	PF00069	0.566
MOD_GlcNHglycan	109	112	PF01048	0.657
MOD_GlcNHglycan	120	123	PF01048	0.625
MOD_GlcNHglycan	144	147	PF01048	0.563
MOD_GlcNHglycan	213	216	PF01048	0.695
MOD_GlcNHglycan	452	455	PF01048	0.424
MOD_GSK3_1	1	8	PF00069	0.569
MOD_GSK3_1	103	110	PF00069	0.660
MOD_GSK3_1	160	167	PF00069	0.584
MOD_GSK3_1	231	238	PF00069	0.444
MOD_GSK3_1	479	486	PF00069	0.658
MOD_GSK3_1	55	62	PF00069	0.599
MOD_N-GLC_1	118	123	PF02516	0.641
MOD_N-GLC_2	372	374	PF02516	0.583
MOD_NEK2_1	1	6	PF00069	0.592
MOD_NEK2_1	107	112	PF00069	0.584
MOD_NEK2_1	231	236	PF00069	0.365
MOD_NEK2_1	356	361	PF00069	0.606
MOD_NEK2_1	436	441	PF00069	0.481
MOD_NEK2_1	452	457	PF00069	0.493
MOD_NEK2_1	88	93	PF00069	0.562
MOD_NEK2_2	381	386	PF00069	0.672
MOD_PIKK_1	185	191	PF00454	0.591
MOD_PIKK_1	436	442	PF00454	0.495
MOD_PIKK_1	77	83	PF00454	0.532
MOD_PKA_2	1	7	PF00069	0.537
MOD_PKA_2	356	362	PF00069	0.567
MOD_PKA_2	367	373	PF00069	0.551
MOD_PKA_2	50	56	PF00069	0.569
MOD_Plk_1	161	167	PF00069	0.613
MOD_Plk_1	195	201	PF00069	0.587
MOD_Plk_1	9	15	PF00069	0.505
MOD_Plk_4	217	223	PF00069	0.563
MOD_Plk_4	231	237	PF00069	0.373
MOD_Plk_4	410	416	PF00069	0.601
MOD_Plk_4	452	458	PF00069	0.417
MOD_ProDKin_1	135	141	PF00069	0.716
MOD_ProDKin_1	164	170	PF00069	0.570
MOD_ProDKin_1	235	241	PF00069	0.464
MOD_ProDKin_1	387	393	PF00069	0.623
MOD_ProDKin_1	442	448	PF00069	0.518
MOD_ProDKin_1	70	76	PF00069	0.654
TRG_DiLeu_BaEn_1	462	467	PF01217	0.492
TRG_DiLeu_BaEn_2	18	24	PF01217	0.514
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.594
TRG_ENDOCYTIC_2	21	24	PF00928	0.491
TRG_ENDOCYTIC_2	218	221	PF00928	0.565
TRG_ENDOCYTIC_2	40	43	PF00928	0.580
TRG_ER_diArg_1	210	213	PF00400	0.603
TRG_ER_diArg_1	481	484	PF00400	0.612
TRG_NES_CRM1_1	148	162	PF08389	0.531
TRG_NLS_Bipartite_1	346	361	PF00514	0.473
TRG_NLS_MonoExtN_4	355	361	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.453
TRG_PTS1	484	487	PF00515	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K4	Leptomonas seymouri	48%	83%
A4H7E3	Leishmania braziliensis	75%	100%
A4HVT3	Leishmania infantum	100%	100%
E9APH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QG00	Leishmania major	92%	100%