Leucine Rich repeats (2 copies), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSM9_LEIDO

TriTrypDb:

LdBPK_131470.1 , LdCL_130018900 , LDHU3_13.1630

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

A0A3S7WSM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.664
CLV_NRD_NRD_1	108	110	PF00675	0.560
CLV_NRD_NRD_1	320	322	PF00675	0.814
CLV_NRD_NRD_1	331	333	PF00675	0.530
CLV_NRD_NRD_1	401	403	PF00675	0.586
CLV_NRD_NRD_1	514	516	PF00675	0.517
CLV_NRD_NRD_1	553	555	PF00675	0.673
CLV_PCSK_FUR_1	512	516	PF00082	0.567
CLV_PCSK_KEX2_1	108	110	PF00082	0.560
CLV_PCSK_KEX2_1	320	322	PF00082	0.667
CLV_PCSK_KEX2_1	331	333	PF00082	0.523
CLV_PCSK_KEX2_1	401	403	PF00082	0.586
CLV_PCSK_KEX2_1	512	514	PF00082	0.509
CLV_PCSK_KEX2_1	553	555	PF00082	0.683
CLV_PCSK_SKI1_1	119	123	PF00082	0.727
CLV_PCSK_SKI1_1	162	166	PF00082	0.534
DEG_SPOP_SBC_1	597	601	PF00917	0.757
DOC_CKS1_1	573	578	PF01111	0.672
DOC_CKS1_1	63	68	PF01111	0.542
DOC_PP4_FxxP_1	115	118	PF00568	0.721
DOC_USP7_MATH_1	243	247	PF00917	0.429
DOC_USP7_MATH_1	342	346	PF00917	0.726
DOC_USP7_MATH_1	424	428	PF00917	0.685
DOC_USP7_MATH_1	452	456	PF00917	0.706
DOC_USP7_MATH_1	457	461	PF00917	0.622
DOC_USP7_MATH_1	562	566	PF00917	0.699
DOC_USP7_UBL2_3	609	613	PF12436	0.709
DOC_WW_Pin1_4	354	359	PF00397	0.692
DOC_WW_Pin1_4	407	412	PF00397	0.755
DOC_WW_Pin1_4	417	422	PF00397	0.709
DOC_WW_Pin1_4	572	577	PF00397	0.693
DOC_WW_Pin1_4	62	67	PF00397	0.585
LIG_14-3-3_CanoR_1	108	116	PF00244	0.605
LIG_14-3-3_CanoR_1	119	129	PF00244	0.649
LIG_14-3-3_CanoR_1	162	170	PF00244	0.502
LIG_14-3-3_CanoR_1	320	330	PF00244	0.682
LIG_14-3-3_CanoR_1	341	349	PF00244	0.698
LIG_14-3-3_CanoR_1	500	506	PF00244	0.531
LIG_14-3-3_CanoR_1	87	93	PF00244	0.721
LIG_14-3-3_CanoR_1	94	101	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BRCT_BRCA1_1	430	434	PF00533	0.683
LIG_BRCT_BRCA1_1	96	100	PF00533	0.640
LIG_CaM_IQ_9	505	521	PF13499	0.569
LIG_Clathr_ClatBox_1	531	535	PF01394	0.554
LIG_FHA_1	130	136	PF00498	0.506
LIG_FHA_1	152	158	PF00498	0.475
LIG_FHA_1	454	460	PF00498	0.582
LIG_FHA_1	467	473	PF00498	0.503
LIG_FHA_1	477	483	PF00498	0.481
LIG_FHA_1	526	532	PF00498	0.567
LIG_FHA_1	538	544	PF00498	0.600
LIG_FHA_2	404	410	PF00498	0.602
LIG_FHA_2	463	469	PF00498	0.550
LIG_FHA_2	5	11	PF00498	0.516
LIG_Integrin_RGD_1	466	468	PF01839	0.533
LIG_LIR_Gen_1	221	230	PF02991	0.468
LIG_LIR_Nem_3	221	225	PF02991	0.458
LIG_NRP_CendR_1	624	625	PF00754	0.773
LIG_PCNA_PIPBox_1	488	497	PF02747	0.518
LIG_PTB_Apo_2	472	479	PF02174	0.508
LIG_RPA_C_Fungi	336	348	PF08784	0.594
LIG_SH2_CRK	14	18	PF00017	0.668
LIG_SH2_CRK	473	477	PF00017	0.531
LIG_SH2_GRB2like	473	476	PF00017	0.446
LIG_SH2_SRC	222	225	PF00017	0.459
LIG_SH2_STAP1	527	531	PF00017	0.506
LIG_SH2_STAT3	277	280	PF00017	0.532
LIG_SH2_STAT5	180	183	PF00017	0.465
LIG_SH2_STAT5	222	225	PF00017	0.462
LIG_SH2_STAT5	277	280	PF00017	0.512
LIG_SH2_STAT5	527	530	PF00017	0.567
LIG_SH3_1	355	361	PF00018	0.585
LIG_SH3_1	613	619	PF00018	0.725
LIG_SH3_2	421	426	PF14604	0.589
LIG_SH3_2	619	624	PF14604	0.750
LIG_SH3_3	154	160	PF00018	0.611
LIG_SH3_3	355	361	PF00018	0.646
LIG_SH3_3	405	411	PF00018	0.610
LIG_SH3_3	418	424	PF00018	0.546
LIG_SH3_3	564	570	PF00018	0.741
LIG_SH3_3	602	608	PF00018	0.816
LIG_SH3_3	613	619	PF00018	0.670
LIG_SH3_CIN85_PxpxPR_1	619	624	PF14604	0.750
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.476
LIG_SUMO_SIM_anti_2	231	238	PF11976	0.600
LIG_SUMO_SIM_par_1	528	535	PF11976	0.555
LIG_TRAF2_1	604	607	PF00917	0.570
LIG_TRAF2_1	7	10	PF00917	0.567
LIG_TYR_ITIM	220	225	PF00017	0.461
LIG_UBA3_1	531	536	PF00899	0.523
LIG_WW_3	374	378	PF00397	0.667
LIG_WW_3	621	625	PF00397	0.752
MOD_CDK_SPK_2	407	412	PF00069	0.606
MOD_CK1_1	120	126	PF00069	0.745
MOD_CK1_1	246	252	PF00069	0.473
MOD_CK1_1	306	312	PF00069	0.757
MOD_CK1_1	363	369	PF00069	0.731
MOD_CK1_1	525	531	PF00069	0.618
MOD_CK1_1	549	555	PF00069	0.701
MOD_CK1_1	595	601	PF00069	0.748
MOD_CK2_1	305	311	PF00069	0.622
MOD_CK2_1	4	10	PF00069	0.519
MOD_CK2_1	403	409	PF00069	0.636
MOD_CK2_1	75	81	PF00069	0.743
MOD_GlcNHglycan	110	113	PF01048	0.713
MOD_GlcNHglycan	119	122	PF01048	0.654
MOD_GlcNHglycan	124	127	PF01048	0.716
MOD_GlcNHglycan	311	314	PF01048	0.603
MOD_GlcNHglycan	321	324	PF01048	0.590
MOD_GlcNHglycan	365	368	PF01048	0.826
MOD_GlcNHglycan	370	374	PF01048	0.717
MOD_GlcNHglycan	377	380	PF01048	0.589
MOD_GlcNHglycan	417	420	PF01048	0.753
MOD_GlcNHglycan	430	433	PF01048	0.629
MOD_GlcNHglycan	458	462	PF01048	0.600
MOD_GlcNHglycan	524	527	PF01048	0.550
MOD_GlcNHglycan	54	57	PF01048	0.746
MOD_GlcNHglycan	564	567	PF01048	0.695
MOD_GSK3_1	120	127	PF00069	0.678
MOD_GSK3_1	246	253	PF00069	0.523
MOD_GSK3_1	303	310	PF00069	0.752
MOD_GSK3_1	40	47	PF00069	0.770
MOD_GSK3_1	403	410	PF00069	0.712
MOD_GSK3_1	413	420	PF00069	0.767
MOD_GSK3_1	424	431	PF00069	0.658
MOD_GSK3_1	453	460	PF00069	0.586
MOD_GSK3_1	462	469	PF00069	0.559
MOD_GSK3_1	476	483	PF00069	0.622
MOD_GSK3_1	48	55	PF00069	0.685
MOD_GSK3_1	521	528	PF00069	0.650
MOD_GSK3_1	545	552	PF00069	0.525
MOD_GSK3_1	591	598	PF00069	0.745
MOD_GSK3_1	95	102	PF00069	0.611
MOD_N-GLC_1	174	179	PF02516	0.393
MOD_N-GLC_1	228	233	PF02516	0.573
MOD_N-GLC_1	250	255	PF02516	0.537
MOD_N-GLC_1	424	429	PF02516	0.736
MOD_N-GLC_1	591	596	PF02516	0.594
MOD_NEK2_1	100	105	PF00069	0.572
MOD_NEK2_1	174	179	PF00069	0.431
MOD_NEK2_1	250	255	PF00069	0.493
MOD_NEK2_1	462	467	PF00069	0.543
MOD_NEK2_2	13	18	PF00069	0.599
MOD_NEK2_2	326	331	PF00069	0.640
MOD_PIKK_1	129	135	PF00454	0.564
MOD_PIKK_1	193	199	PF00454	0.540
MOD_PIKK_1	476	482	PF00454	0.520
MOD_PK_1	614	620	PF00069	0.703
MOD_PKA_1	108	114	PF00069	0.564
MOD_PKA_2	108	114	PF00069	0.537
MOD_PKA_2	319	325	PF00069	0.702
MOD_PKA_2	546	552	PF00069	0.681
MOD_PKB_1	426	434	PF00069	0.603
MOD_Plk_1	174	180	PF00069	0.395
MOD_Plk_1	457	463	PF00069	0.633
MOD_Plk_1	496	502	PF00069	0.532
MOD_Plk_2-3	218	224	PF00069	0.476
MOD_Plk_4	136	142	PF00069	0.470
MOD_Plk_4	218	224	PF00069	0.439
MOD_Plk_4	527	533	PF00069	0.614
MOD_Plk_4	64	70	PF00069	0.639
MOD_Plk_4	96	102	PF00069	0.539
MOD_ProDKin_1	354	360	PF00069	0.688
MOD_ProDKin_1	407	413	PF00069	0.758
MOD_ProDKin_1	417	423	PF00069	0.708
MOD_ProDKin_1	572	578	PF00069	0.693
MOD_ProDKin_1	62	68	PF00069	0.588
MOD_SUMO_rev_2	442	449	PF00179	0.772
TRG_DiLeu_BaEn_1	136	141	PF01217	0.616
TRG_DiLeu_BaEn_1	190	195	PF01217	0.471
TRG_DiLeu_BaEn_1	390	395	PF01217	0.581
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.574
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.607
TRG_ENDOCYTIC_2	14	17	PF00928	0.604
TRG_ENDOCYTIC_2	222	225	PF00928	0.462
TRG_ENDOCYTIC_2	473	476	PF00928	0.471
TRG_ER_diArg_1	107	109	PF00400	0.559
TRG_ER_diArg_1	330	332	PF00400	0.613
TRG_ER_diArg_1	400	402	PF00400	0.620
TRG_ER_diArg_1	512	515	PF00400	0.514
TRG_ER_diArg_1	623	625	PF00400	0.762
TRG_NES_CRM1_1	193	207	PF08389	0.594
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P881	Leptomonas seymouri	41%	100%
A4H7C5	Leishmania braziliensis	65%	99%
A4HVS1	Leishmania infantum	100%	100%
D0A6G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9APG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QG11	Leishmania major	87%	100%