LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WSM6_LEIDO
TriTrypDb:
LdBPK_131220.1 , LdCL_130017700 , LDHU3_13.1500
Length:
465

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Extensively duplicated gene family.. Localization: ER (experimental)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 12, no: 4
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

A0A3S7WSM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSM6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 300 306 PF00089 0.441
CLV_NRD_NRD_1 157 159 PF00675 0.438
CLV_NRD_NRD_1 343 345 PF00675 0.544
CLV_NRD_NRD_1 375 377 PF00675 0.573
CLV_NRD_NRD_1 393 395 PF00675 0.538
CLV_NRD_NRD_1 432 434 PF00675 0.588
CLV_NRD_NRD_1 436 438 PF00675 0.582
CLV_PCSK_KEX2_1 157 159 PF00082 0.438
CLV_PCSK_KEX2_1 342 344 PF00082 0.540
CLV_PCSK_KEX2_1 375 377 PF00082 0.567
CLV_PCSK_KEX2_1 432 434 PF00082 0.588
CLV_PCSK_KEX2_1 436 438 PF00082 0.581
CLV_PCSK_PC7_1 432 438 PF00082 0.582
CLV_PCSK_SKI1_1 251 255 PF00082 0.707
DEG_Nend_UBRbox_1 1 4 PF02207 0.629
DOC_ANK_TNKS_1 375 382 PF00023 0.629
DOC_CYCLIN_yClb3_PxF_3 232 240 PF00134 0.391
DOC_MAPK_gen_1 288 295 PF00069 0.729
DOC_MAPK_MEF2A_6 2 9 PF00069 0.480
DOC_PP1_RVXF_1 249 256 PF00149 0.512
DOC_USP7_MATH_1 105 109 PF00917 0.388
DOC_WW_Pin1_4 332 337 PF00397 0.768
DOC_WW_Pin1_4 401 406 PF00397 0.646
LIG_14-3-3_CanoR_1 234 244 PF00244 0.444
LIG_14-3-3_CanoR_1 441 450 PF00244 0.820
LIG_BIR_III_4 67 71 PF00653 0.280
LIG_BRCT_BRCA1_1 443 447 PF00533 0.769
LIG_Clathr_ClatBox_1 202 206 PF01394 0.310
LIG_FHA_1 197 203 PF00498 0.459
LIG_FHA_1 59 65 PF00498 0.293
LIG_FHA_2 419 425 PF00498 0.661
LIG_FHA_2 58 64 PF00498 0.274
LIG_LIR_Apic_2 419 425 PF02991 0.696
LIG_LIR_Gen_1 194 203 PF02991 0.362
LIG_LIR_Gen_1 219 230 PF02991 0.352
LIG_LIR_Gen_1 258 269 PF02991 0.378
LIG_LIR_Gen_1 444 455 PF02991 0.736
LIG_LIR_Nem_3 149 155 PF02991 0.291
LIG_LIR_Nem_3 194 198 PF02991 0.352
LIG_LIR_Nem_3 219 225 PF02991 0.379
LIG_LIR_Nem_3 227 231 PF02991 0.410
LIG_LIR_Nem_3 258 264 PF02991 0.352
LIG_LIR_Nem_3 444 450 PF02991 0.766
LIG_MYND_1 325 329 PF01753 0.655
LIG_NRBOX 11 17 PF00104 0.483
LIG_PDZ_Class_2 460 465 PF00595 0.767
LIG_Pex14_1 133 137 PF04695 0.354
LIG_Pex14_1 152 156 PF04695 0.354
LIG_Pex14_1 260 264 PF04695 0.379
LIG_Pex14_2 246 250 PF04695 0.495
LIG_RPA_C_Fungi 371 383 PF08784 0.516
LIG_SH2_CRK 195 199 PF00017 0.552
LIG_SH2_CRK 222 226 PF00017 0.373
LIG_SH2_CRK 322 326 PF00017 0.620
LIG_SH2_NCK_1 195 199 PF00017 0.400
LIG_SH2_NCK_1 322 326 PF00017 0.620
LIG_SH2_SRC 378 381 PF00017 0.559
LIG_SH2_SRC 422 425 PF00017 0.626
LIG_SH2_STAT5 100 103 PF00017 0.463
LIG_SH2_STAT5 188 191 PF00017 0.559
LIG_SH2_STAT5 281 284 PF00017 0.413
LIG_SH2_STAT5 308 311 PF00017 0.683
LIG_SH2_STAT5 58 61 PF00017 0.446
LIG_SH3_3 104 110 PF00018 0.361
LIG_SH3_3 173 179 PF00018 0.369
LIG_SH3_3 2 8 PF00018 0.403
LIG_SH3_3 205 211 PF00018 0.425
LIG_SH3_3 229 235 PF00018 0.648
LIG_SH3_3 350 356 PF00018 0.630
LIG_SH3_3 402 408 PF00018 0.639
LIG_SH3_3 447 453 PF00018 0.725
LIG_SUMO_SIM_par_1 11 17 PF11976 0.584
LIG_TRAF2_1 289 292 PF00917 0.643
LIG_TRAF2_1 336 339 PF00917 0.730
LIG_TRAF2_1 421 424 PF00917 0.666
LIG_TRAF2_1 60 63 PF00917 0.288
LIG_TRAF2_2 353 358 PF00917 0.640
LIG_TRFH_1 228 232 PF08558 0.398
LIG_UBA3_1 33 39 PF00899 0.514
MOD_CK1_1 194 200 PF00069 0.524
MOD_CK1_1 384 390 PF00069 0.517
MOD_CK1_1 401 407 PF00069 0.722
MOD_CK1_1 435 441 PF00069 0.774
MOD_CK1_1 47 53 PF00069 0.485
MOD_CK2_1 368 374 PF00069 0.649
MOD_CK2_1 407 413 PF00069 0.639
MOD_CK2_1 418 424 PF00069 0.560
MOD_CK2_1 445 451 PF00069 0.522
MOD_CK2_1 49 55 PF00069 0.563
MOD_CK2_1 57 63 PF00069 0.389
MOD_GlcNHglycan 103 106 PF01048 0.434
MOD_GlcNHglycan 18 21 PF01048 0.603
MOD_GlcNHglycan 409 412 PF01048 0.836
MOD_GlcNHglycan 424 428 PF01048 0.804
MOD_GlcNHglycan 51 54 PF01048 0.455
MOD_GSK3_1 105 112 PF00069 0.340
MOD_GSK3_1 119 126 PF00069 0.429
MOD_GSK3_1 251 258 PF00069 0.561
MOD_GSK3_1 360 367 PF00069 0.628
MOD_GSK3_1 40 47 PF00069 0.356
MOD_GSK3_1 428 435 PF00069 0.783
MOD_GSK3_1 441 448 PF00069 0.702
MOD_GSK3_1 54 61 PF00069 0.234
MOD_GSK3_1 71 78 PF00069 0.259
MOD_GSK3_1 94 101 PF00069 0.401
MOD_NEK2_1 16 21 PF00069 0.549
MOD_NEK2_1 364 369 PF00069 0.584
MOD_NEK2_1 398 403 PF00069 0.572
MOD_NEK2_1 49 54 PF00069 0.444
MOD_NEK2_2 283 288 PF00069 0.572
MOD_PIKK_1 160 166 PF00454 0.430
MOD_PIKK_1 315 321 PF00454 0.688
MOD_PIKK_1 441 447 PF00454 0.736
MOD_PK_1 439 445 PF00069 0.798
MOD_PKA_1 157 163 PF00069 0.269
MOD_PKA_1 432 438 PF00069 0.753
MOD_PKA_2 157 163 PF00069 0.289
MOD_PKA_2 431 437 PF00069 0.783
MOD_PKB_1 437 445 PF00069 0.748
MOD_Plk_1 359 365 PF00069 0.653
MOD_Plk_1 384 390 PF00069 0.728
MOD_Plk_1 399 405 PF00069 0.809
MOD_Plk_1 54 60 PF00069 0.425
MOD_Plk_1 95 101 PF00069 0.413
MOD_Plk_4 54 60 PF00069 0.442
MOD_Plk_4 75 81 PF00069 0.391
MOD_Plk_4 95 101 PF00069 0.219
MOD_ProDKin_1 332 338 PF00069 0.727
MOD_ProDKin_1 401 407 PF00069 0.561
MOD_SUMO_for_1 289 292 PF00179 0.643
TRG_DiLeu_BaLyEn_6 205 210 PF01217 0.356
TRG_ENDOCYTIC_2 195 198 PF00928 0.469
TRG_ENDOCYTIC_2 222 225 PF00928 0.419
TRG_ER_diArg_1 156 158 PF00400 0.269
TRG_ER_diArg_1 342 344 PF00400 0.615
TRG_ER_diArg_1 436 439 PF00400 0.744
TRG_Pf-PMV_PEXEL_1 441 445 PF00026 0.744

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2I6 Leptomonas seymouri 47% 99%
A0A1X0NJM3 Trypanosomatidae 27% 100%
A0A1X0NK39 Trypanosomatidae 23% 100%
A0A1X0NN75 Trypanosomatidae 24% 100%
A0A1X0NVE8 Trypanosomatidae 24% 100%
A0A3S7X9E7 Leishmania donovani 35% 100%
A0A422MPN3 Trypanosoma rangeli 25% 100%
A4H7B5 Leishmania braziliensis 67% 100%
A4HMU5 Leishmania braziliensis 34% 100%
A4HVR0 Leishmania infantum 100% 100%
E9AFA3 Leishmania major 35% 100%
E9AHW4 Leishmania infantum 36% 100%
E9APF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B6F8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
Q4QG22 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS