EF-hand domain pair, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

programmed cell death 6 protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WSM4_LEIDO

TriTrypDb:

LdBPK_131500.1 , LdCL_130019100 , LDHU3_13.1650

Length:

110

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSM4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.199
CLV_NRD_NRD_1	54	56	PF00675	0.199
CLV_PCSK_SKI1_1	81	85	PF00082	0.281
DEG_Nend_UBRbox_2	1	3	PF02207	0.367
DOC_MAPK_gen_1	59	67	PF00069	0.199
DOC_MAPK_gen_1	89	97	PF00069	0.297
LIG_BRCT_BRCA1_1	63	67	PF00533	0.199
LIG_Clathr_ClatBox_1	96	100	PF01394	0.292
LIG_FHA_2	21	27	PF00498	0.199
LIG_LIR_Gen_1	2	12	PF02991	0.328
LIG_LIR_Gen_1	68	78	PF02991	0.199
LIG_LIR_Nem_3	2	7	PF02991	0.338
LIG_LIR_Nem_3	64	70	PF02991	0.199
LIG_SH2_PTP2	70	73	PF00017	0.199
LIG_SH2_STAT5	70	73	PF00017	0.199
LIG_SH2_STAT5	86	89	PF00017	0.283
LIG_WRC_WIRS_1	99	104	PF05994	0.280
MOD_CK1_1	31	37	PF00069	0.199
MOD_CK1_1	46	52	PF00069	0.199
MOD_GlcNHglycan	22	26	PF01048	0.199
MOD_GlcNHglycan	40	43	PF01048	0.199
MOD_GlcNHglycan	90	94	PF01048	0.303
MOD_GSK3_1	98	105	PF00069	0.275
MOD_NEK2_1	102	107	PF00069	0.270
MOD_NEK2_1	38	43	PF00069	0.199
MOD_PKA_2	20	26	PF00069	0.199
MOD_PKA_2	31	37	PF00069	0.199
MOD_PKA_2	38	44	PF00069	0.199
MOD_PKA_2	61	67	PF00069	0.199
MOD_PKB_1	19	27	PF00069	0.199
MOD_Plk_1	46	52	PF00069	0.199
MOD_Plk_1	71	77	PF00069	0.251
MOD_Plk_4	71	77	PF00069	0.251
MOD_Plk_4	98	104	PF00069	0.280
TRG_DiLeu_BaEn_2	71	77	PF01217	0.251
TRG_DiLeu_BaEn_4	2	8	PF01217	0.336
TRG_ENDOCYTIC_2	70	73	PF00928	0.199
TRG_ER_diArg_1	18	21	PF00400	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
G3V7W1	RAT	34%	58%
O75340	HUMAN	34%	58%
O88456	MOUSE	28%	41%
P04574	PIG	29%	41%
P04632	HUMAN	30%	41%
P05044	CRIGR	29%	56%
P06813	RABIT	30%	41%
P12815	MOUSE	34%	58%
P13135	BOVIN	29%	42%
P28676	HUMAN	30%	51%
P30626	HUMAN	29%	56%
Q5R4U9	PONAB	29%	56%
Q5RAI6	PONAB	30%	50%
Q6P069	MOUSE	31%	56%
Q8VC88	MOUSE	31%	50%
Q94743	SCHJA	33%	64%
Q96L46	HUMAN	29%	44%