Sin-like_protein_conserved_region_containing_prot ein_putative/Pfam:PF04801

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sin-like protein conserved region, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSL2_LEIDO

TriTrypDb:

LdBPK_131270.1 , LdCL_130018200 , LDHU3_13.1550

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0000428	DNA-directed RNA polymerase complex	4	2
GO:0005666	RNA polymerase III complex	4	1
GO:0005737	cytoplasm	2	1
GO:0030880	RNA polymerase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A0A3S7WSL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSL2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006351	DNA-templated transcription	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.335
CLV_NRD_NRD_1	284	286	PF00675	0.279
CLV_NRD_NRD_1	392	394	PF00675	0.271
CLV_NRD_NRD_1	40	42	PF00675	0.293
CLV_NRD_NRD_1	415	417	PF00675	0.365
CLV_NRD_NRD_1	453	455	PF00675	0.412
CLV_PCSK_KEX2_1	197	199	PF00082	0.335
CLV_PCSK_KEX2_1	39	41	PF00082	0.289
CLV_PCSK_KEX2_1	392	394	PF00082	0.271
CLV_PCSK_KEX2_1	414	416	PF00082	0.314
CLV_PCSK_KEX2_1	452	454	PF00082	0.360
CLV_PCSK_KEX2_1	635	637	PF00082	0.453
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.314
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.453
CLV_PCSK_SKI1_1	393	397	PF00082	0.271
CLV_PCSK_SKI1_1	551	555	PF00082	0.393
CLV_PCSK_SKI1_1	582	586	PF00082	0.511
CLV_PCSK_SKI1_1	644	648	PF00082	0.570
CLV_Separin_Metazoa	639	643	PF03568	0.452
DEG_APCC_DBOX_1	415	423	PF00400	0.382
DEG_Nend_UBRbox_3	1	3	PF02207	0.654
DEG_SCF_FBW7_1	143	150	PF00400	0.271
DEG_SCF_FBW7_1	478	485	PF00400	0.616
DEG_SPOP_SBC_1	161	165	PF00917	0.313
DOC_CKS1_1	137	142	PF01111	0.384
DOC_CKS1_1	153	158	PF01111	0.215
DOC_CYCLIN_RxL_1	547	556	PF00134	0.362
DOC_MAPK_FxFP_2	34	37	PF00069	0.271
DOC_MAPK_gen_1	562	570	PF00069	0.538
DOC_MAPK_JIP1_4	615	621	PF00069	0.452
DOC_MAPK_MEF2A_6	298	306	PF00069	0.371
DOC_MAPK_MEF2A_6	469	476	PF00069	0.517
DOC_MAPK_MEF2A_6	615	623	PF00069	0.452
DOC_PP2B_LxvP_1	158	161	PF13499	0.393
DOC_PP2B_LxvP_1	256	259	PF13499	0.289
DOC_PP4_FxxP_1	34	37	PF00568	0.271
DOC_PP4_FxxP_1	527	530	PF00568	0.670
DOC_PP4_FxxP_1	91	94	PF00568	0.267
DOC_USP7_MATH_1	161	165	PF00917	0.397
DOC_USP7_MATH_1	173	177	PF00917	0.255
DOC_USP7_MATH_1	226	230	PF00917	0.303
DOC_USP7_MATH_1	273	277	PF00917	0.404
DOC_USP7_MATH_1	313	317	PF00917	0.347
DOC_USP7_MATH_1	334	338	PF00917	0.335
DOC_USP7_MATH_1	391	395	PF00917	0.382
DOC_USP7_MATH_1	410	414	PF00917	0.189
DOC_USP7_MATH_1	507	511	PF00917	0.644
DOC_USP7_UBL2_3	562	566	PF12436	0.375
DOC_WW_Pin1_4	136	141	PF00397	0.298
DOC_WW_Pin1_4	143	148	PF00397	0.249
DOC_WW_Pin1_4	152	157	PF00397	0.229
DOC_WW_Pin1_4	21	26	PF00397	0.255
DOC_WW_Pin1_4	239	244	PF00397	0.363
DOC_WW_Pin1_4	478	483	PF00397	0.686
DOC_WW_Pin1_4	503	508	PF00397	0.746
DOC_WW_Pin1_4	522	527	PF00397	0.598
DOC_WW_Pin1_4	645	650	PF00397	0.578
DOC_WW_Pin1_4	90	95	PF00397	0.419
LIG_14-3-3_CanoR_1	114	119	PF00244	0.292
LIG_14-3-3_CanoR_1	230	240	PF00244	0.300
LIG_14-3-3_CanoR_1	285	289	PF00244	0.261
LIG_14-3-3_CanoR_1	368	377	PF00244	0.376
LIG_14-3-3_CanoR_1	644	649	PF00244	0.570
LIG_14-3-3_CanoR_1	81	85	PF00244	0.271
LIG_Actin_RPEL_3	386	405	PF02755	0.335
LIG_BRCT_BRCA1_1	123	127	PF00533	0.289
LIG_BRCT_BRCA1_1	92	96	PF00533	0.261
LIG_CaM_IQ_9	189	204	PF13499	0.335
LIG_EH1_1	627	635	PF00400	0.413
LIG_eIF4E_1	22	28	PF01652	0.335
LIG_FHA_1	153	159	PF00498	0.271
LIG_FHA_1	163	169	PF00498	0.271
LIG_FHA_1	290	296	PF00498	0.426
LIG_FHA_1	301	307	PF00498	0.460
LIG_FHA_1	399	405	PF00498	0.363
LIG_FHA_1	598	604	PF00498	0.354
LIG_FHA_2	185	191	PF00498	0.319
LIG_FHA_2	208	214	PF00498	0.293
LIG_FHA_2	313	319	PF00498	0.358
LIG_FHA_2	323	329	PF00498	0.384
LIG_FHA_2	56	62	PF00498	0.292
LIG_LIR_Apic_2	525	530	PF02991	0.673
LIG_LIR_Apic_2	612	616	PF02991	0.479
LIG_LIR_Apic_2	89	94	PF02991	0.263
LIG_LIR_Gen_1	381	390	PF02991	0.237
LIG_LIR_Nem_3	18	22	PF02991	0.271
LIG_LIR_Nem_3	381	385	PF02991	0.237
LIG_LIR_Nem_3	93	99	PF02991	0.313
LIG_PCNA_yPIPBox_3	626	634	PF02747	0.483
LIG_Pex14_1	346	350	PF04695	0.404
LIG_Pex14_1	417	421	PF04695	0.326
LIG_Pex14_2	436	440	PF04695	0.404
LIG_PTB_Apo_2	251	258	PF02174	0.404
LIG_REV1ctd_RIR_1	214	222	PF16727	0.335
LIG_SH2_CRK	22	26	PF00017	0.277
LIG_SH2_GRB2like	464	467	PF00017	0.433
LIG_SH2_NCK_1	22	26	PF00017	0.292
LIG_SH2_PTP2	137	140	PF00017	0.335
LIG_SH2_PTP2	620	623	PF00017	0.389
LIG_SH2_SRC	464	467	PF00017	0.433
LIG_SH2_STAT3	120	123	PF00017	0.271
LIG_SH2_STAT3	350	353	PF00017	0.335
LIG_SH2_STAT5	120	123	PF00017	0.404
LIG_SH2_STAT5	133	136	PF00017	0.404
LIG_SH2_STAT5	137	140	PF00017	0.404
LIG_SH2_STAT5	314	317	PF00017	0.493
LIG_SH2_STAT5	350	353	PF00017	0.335
LIG_SH2_STAT5	421	424	PF00017	0.326
LIG_SH2_STAT5	464	467	PF00017	0.482
LIG_SH2_STAT5	549	552	PF00017	0.394
LIG_SH2_STAT5	620	623	PF00017	0.399
LIG_SH3_3	123	129	PF00018	0.289
LIG_SH3_3	72	78	PF00018	0.384
LIG_SH3_5	609	613	PF00018	0.485
LIG_SUMO_SIM_anti_2	401	409	PF11976	0.351
LIG_TRAF2_1	210	213	PF00917	0.335
LIG_TRAF2_1	441	444	PF00917	0.404
LIG_TYR_ITIM	618	623	PF00017	0.382
LIG_WRC_WIRS_1	16	21	PF05994	0.404
LIG_WRC_WIRS_1	88	93	PF05994	0.271
MOD_CDK_SPxxK_3	90	97	PF00069	0.419
MOD_CK1_1	178	184	PF00069	0.295
MOD_CK1_1	221	227	PF00069	0.271
MOD_CK1_1	503	509	PF00069	0.757
MOD_CK1_1	510	516	PF00069	0.710
MOD_CK1_1	525	531	PF00069	0.680
MOD_CK1_1	80	86	PF00069	0.281
MOD_CK1_1	87	93	PF00069	0.287
MOD_CK2_1	156	162	PF00069	0.335
MOD_CK2_1	207	213	PF00069	0.271
MOD_CK2_1	231	237	PF00069	0.394
MOD_CK2_1	284	290	PF00069	0.404
MOD_CK2_1	312	318	PF00069	0.418
MOD_CK2_1	322	328	PF00069	0.292
MOD_CK2_1	391	397	PF00069	0.333
MOD_CK2_1	443	449	PF00069	0.464
MOD_CK2_1	55	61	PF00069	0.292
MOD_CK2_1	602	608	PF00069	0.405
MOD_CK2_1	645	651	PF00069	0.540
MOD_GlcNHglycan	101	104	PF01048	0.347
MOD_GlcNHglycan	223	227	PF01048	0.435
MOD_GlcNHglycan	263	266	PF01048	0.284
MOD_GlcNHglycan	267	270	PF01048	0.288
MOD_GlcNHglycan	388	391	PF01048	0.366
MOD_GlcNHglycan	489	492	PF01048	0.734
MOD_GlcNHglycan	512	515	PF01048	0.665
MOD_GlcNHglycan	517	520	PF01048	0.650
MOD_GlcNHglycan	522	525	PF01048	0.611
MOD_GlcNHglycan	531	534	PF01048	0.576
MOD_GlcNHglycan	55	58	PF01048	0.373
MOD_GlcNHglycan	604	607	PF01048	0.579
MOD_GlcNHglycan	651	654	PF01048	0.568
MOD_GlcNHglycan	662	665	PF01048	0.503
MOD_GSK3_1	114	121	PF00069	0.335
MOD_GSK3_1	143	150	PF00069	0.271
MOD_GSK3_1	152	159	PF00069	0.271
MOD_GSK3_1	173	180	PF00069	0.330
MOD_GSK3_1	218	225	PF00069	0.352
MOD_GSK3_1	226	233	PF00069	0.315
MOD_GSK3_1	261	268	PF00069	0.285
MOD_GSK3_1	369	376	PF00069	0.272
MOD_GSK3_1	478	485	PF00069	0.610
MOD_GSK3_1	503	510	PF00069	0.668
MOD_GSK3_1	51	58	PF00069	0.289
MOD_GSK3_1	522	529	PF00069	0.612
MOD_GSK3_1	645	652	PF00069	0.546
MOD_GSK3_1	656	663	PF00069	0.592
MOD_GSK3_1	80	87	PF00069	0.294
MOD_LATS_1	69	75	PF00433	0.237
MOD_N-GLC_1	118	123	PF02516	0.491
MOD_N-GLC_1	178	183	PF02516	0.404
MOD_N-GLC_2	432	434	PF02516	0.215
MOD_NEK2_1	118	123	PF00069	0.335
MOD_NEK2_1	231	236	PF00069	0.363
MOD_NEK2_1	306	311	PF00069	0.259
MOD_NEK2_1	354	359	PF00069	0.291
MOD_NEK2_1	385	390	PF00069	0.260
MOD_NEK2_1	52	57	PF00069	0.387
MOD_NEK2_1	584	589	PF00069	0.484
MOD_NEK2_2	391	396	PF00069	0.404
MOD_PIKK_1	121	127	PF00454	0.374
MOD_PIKK_1	173	179	PF00454	0.404
MOD_PIKK_1	290	296	PF00454	0.259
MOD_PIKK_1	443	449	PF00454	0.404
MOD_PK_1	218	224	PF00069	0.404
MOD_PK_1	71	77	PF00069	0.292
MOD_PKA_2	231	237	PF00069	0.297
MOD_PKA_2	284	290	PF00069	0.261
MOD_PKA_2	354	360	PF00069	0.384
MOD_PKA_2	391	397	PF00069	0.304
MOD_PKA_2	80	86	PF00069	0.274
MOD_PKB_1	228	236	PF00069	0.316
MOD_PKB_1	642	650	PF00069	0.520
MOD_Plk_1	118	124	PF00069	0.292
MOD_Plk_1	178	184	PF00069	0.411
MOD_Plk_1	218	224	PF00069	0.404
MOD_Plk_1	252	258	PF00069	0.267
MOD_Plk_1	597	603	PF00069	0.352
MOD_Plk_4	252	258	PF00069	0.289
MOD_Plk_4	273	279	PF00069	0.308
MOD_Plk_4	306	312	PF00069	0.322
MOD_Plk_4	597	603	PF00069	0.352
MOD_Plk_4	71	77	PF00069	0.326
MOD_ProDKin_1	136	142	PF00069	0.298
MOD_ProDKin_1	143	149	PF00069	0.249
MOD_ProDKin_1	152	158	PF00069	0.229
MOD_ProDKin_1	21	27	PF00069	0.255
MOD_ProDKin_1	239	245	PF00069	0.363
MOD_ProDKin_1	478	484	PF00069	0.685
MOD_ProDKin_1	503	509	PF00069	0.746
MOD_ProDKin_1	522	528	PF00069	0.597
MOD_ProDKin_1	645	651	PF00069	0.588
MOD_ProDKin_1	90	96	PF00069	0.419
MOD_SUMO_for_1	250	253	PF00179	0.237
MOD_SUMO_rev_2	430	438	PF00179	0.335
MOD_SUMO_rev_2	46	53	PF00179	0.404
MOD_SUMO_rev_2	676	682	PF00179	0.489
TRG_DiLeu_BaEn_1	62	67	PF01217	0.292
TRG_DiLeu_BaEn_1	629	634	PF01217	0.480
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.237
TRG_ENDOCYTIC_2	620	623	PF00928	0.432
TRG_ER_diArg_1	196	198	PF00400	0.293
TRG_ER_diArg_1	200	203	PF00400	0.284
TRG_ER_diArg_1	227	230	PF00400	0.271
TRG_ER_diArg_1	38	41	PF00400	0.271
TRG_ER_diArg_1	415	417	PF00400	0.295
TRG_ER_diArg_1	451	454	PF00400	0.360
TRG_ER_diArg_1	476	479	PF00400	0.623
TRG_ER_diArg_1	641	644	PF00400	0.473
TRG_ER_diArg_1	655	658	PF00400	0.476
TRG_NLS_MonoExtC_3	413	418	PF00514	0.404
TRG_NLS_MonoExtN_4	412	418	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	551	556	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	635	639	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P885	Leptomonas seymouri	69%	100%
A0A1X0NJG7	Trypanosomatidae	43%	98%
A0A3R7MBV2	Trypanosoma rangeli	43%	100%
A4H7C0	Leishmania braziliensis	88%	100%
A4HVR5	Leishmania infantum	100%	100%
D0A6H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9APG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QG17	Leishmania major	95%	100%
V5BM32	Trypanosoma cruzi	44%	100%