Uncharacterized_ACR_YagE_family_COG1723_putative/ Pfam:PF02582

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR, YagE family COG1723, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSK6_LEIDO

TriTrypDb:

LdBPK_131030.1 , LdCL_130015600 , LDHU3_13.1250

Length:

592

Annotations

LeishMANIAdb annotations

Distantly homologous to the mammalian RMND1 mitochondrial protein (DUF155 domain protein).. Might have a mitochondrial transit sequence.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	9
GO:0016020	membrane	2	8
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7WSK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.484
CLV_C14_Caspase3-7	532	536	PF00656	0.467
CLV_NRD_NRD_1	154	156	PF00675	0.668
CLV_NRD_NRD_1	423	425	PF00675	0.392
CLV_NRD_NRD_1	479	481	PF00675	0.266
CLV_PCSK_KEX2_1	153	155	PF00082	0.666
CLV_PCSK_KEX2_1	423	425	PF00082	0.392
CLV_PCSK_KEX2_1	479	481	PF00082	0.266
CLV_PCSK_SKI1_1	356	360	PF00082	0.263
CLV_PCSK_SKI1_1	479	483	PF00082	0.283
CLV_PCSK_SKI1_1	492	496	PF00082	0.281
CLV_PCSK_SKI1_1	515	519	PF00082	0.263
CLV_PCSK_SKI1_1	68	72	PF00082	0.657
CLV_Separin_Metazoa	17	21	PF03568	0.433
DEG_Nend_UBRbox_2	1	3	PF02207	0.532
DEG_SCF_TRCP1_1	138	143	PF00400	0.528
DOC_CYCLIN_RxL_1	65	75	PF00134	0.450
DOC_MAPK_FxFP_2	341	344	PF00069	0.397
DOC_MAPK_gen_1	10	18	PF00069	0.448
DOC_MAPK_gen_1	466	476	PF00069	0.463
DOC_MAPK_MEF2A_6	446	454	PF00069	0.463
DOC_MAPK_MEF2A_6	559	567	PF00069	0.463
DOC_PP1_RVXF_1	410	416	PF00149	0.463
DOC_PP1_RVXF_1	557	563	PF00149	0.527
DOC_PP2B_LxvP_1	70	73	PF13499	0.435
DOC_PP4_FxxP_1	217	220	PF00568	0.434
DOC_PP4_FxxP_1	341	344	PF00568	0.397
DOC_PP4_FxxP_1	418	421	PF00568	0.463
DOC_USP7_MATH_1	130	134	PF00917	0.541
DOC_USP7_MATH_1	144	148	PF00917	0.372
DOC_USP7_MATH_1	218	222	PF00917	0.531
DOC_USP7_MATH_1	251	255	PF00917	0.525
DOC_USP7_MATH_1	299	303	PF00917	0.599
DOC_USP7_MATH_1	309	313	PF00917	0.501
DOC_USP7_MATH_1	328	332	PF00917	0.505
DOC_USP7_MATH_1	428	432	PF00917	0.542
DOC_WW_Pin1_4	103	108	PF00397	0.536
DOC_WW_Pin1_4	324	329	PF00397	0.570
DOC_WW_Pin1_4	459	464	PF00397	0.488
LIG_14-3-3_CanoR_1	120	124	PF00244	0.581
LIG_14-3-3_CanoR_1	24	29	PF00244	0.448
LIG_14-3-3_CanoR_1	379	385	PF00244	0.488
LIG_Actin_WH2_2	481	498	PF00022	0.463
LIG_APCC_ABBA_1	257	262	PF00400	0.494
LIG_Clathr_ClatBox_1	567	571	PF01394	0.338
LIG_deltaCOP1_diTrp_1	561	569	PF00928	0.338
LIG_FHA_1	104	110	PF00498	0.499
LIG_FHA_1	25	31	PF00498	0.421
LIG_FHA_1	262	268	PF00498	0.540
LIG_FHA_1	379	385	PF00498	0.479
LIG_FHA_1	392	398	PF00498	0.460
LIG_FHA_1	400	406	PF00498	0.530
LIG_FHA_1	427	433	PF00498	0.488
LIG_FHA_2	204	210	PF00498	0.328
LIG_FHA_2	519	525	PF00498	0.530
LIG_LIR_Apic_2	159	163	PF02991	0.534
LIG_LIR_Apic_2	173	177	PF02991	0.393
LIG_LIR_Apic_2	339	344	PF02991	0.397
LIG_LIR_Apic_2	362	368	PF02991	0.482
LIG_LIR_Apic_2	416	421	PF02991	0.463
LIG_LIR_Apic_2	510	516	PF02991	0.488
LIG_LIR_Gen_1	209	218	PF02991	0.320
LIG_LIR_Gen_1	221	229	PF02991	0.464
LIG_LIR_Gen_1	394	403	PF02991	0.530
LIG_LIR_Gen_1	42	53	PF02991	0.418
LIG_LIR_Gen_1	448	457	PF02991	0.463
LIG_LIR_Gen_1	561	570	PF02991	0.303
LIG_LIR_LC3C_4	254	259	PF02991	0.493
LIG_LIR_Nem_3	209	213	PF02991	0.338
LIG_LIR_Nem_3	221	225	PF02991	0.463
LIG_LIR_Nem_3	294	300	PF02991	0.508
LIG_LIR_Nem_3	354	360	PF02991	0.475
LIG_LIR_Nem_3	394	398	PF02991	0.531
LIG_LIR_Nem_3	42	48	PF02991	0.464
LIG_LIR_Nem_3	448	452	PF02991	0.463
LIG_LIR_Nem_3	55	60	PF02991	0.291
LIG_LIR_Nem_3	561	565	PF02991	0.303
LIG_NRBOX	14	20	PF00104	0.415
LIG_NRBOX	47	53	PF00104	0.404
LIG_OCRL_FandH_1	209	221	PF00620	0.370
LIG_PCNA_yPIPBox_3	10	19	PF02747	0.439
LIG_PCNA_yPIPBox_3	64	74	PF02747	0.387
LIG_Pex14_1	509	513	PF04695	0.463
LIG_PTB_Apo_2	383	390	PF02174	0.530
LIG_PTB_Phospho_1	383	389	PF10480	0.530
LIG_SH2_CRK	297	301	PF00017	0.511
LIG_SH2_CRK	345	349	PF00017	0.303
LIG_SH2_CRK	365	369	PF00017	0.362
LIG_SH2_PTP2	183	186	PF00017	0.285
LIG_SH2_PTP2	449	452	PF00017	0.530
LIG_SH2_SRC	525	528	PF00017	0.512
LIG_SH2_STAP1	380	384	PF00017	0.530
LIG_SH2_STAT3	199	202	PF00017	0.334
LIG_SH2_STAT3	380	383	PF00017	0.448
LIG_SH2_STAT5	183	186	PF00017	0.301
LIG_SH2_STAT5	205	208	PF00017	0.368
LIG_SH2_STAT5	337	340	PF00017	0.408
LIG_SH2_STAT5	357	360	PF00017	0.423
LIG_SH2_STAT5	380	383	PF00017	0.505
LIG_SH2_STAT5	449	452	PF00017	0.463
LIG_SH2_STAT5	513	516	PF00017	0.463
LIG_SH3_3	265	271	PF00018	0.530
LIG_SH3_4	515	522	PF00018	0.463
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.491
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.511
LIG_SUMO_SIM_par_1	401	407	PF11976	0.530
LIG_SUMO_SIM_par_1	84	90	PF11976	0.485
LIG_TRAF2_1	521	524	PF00917	0.530
LIG_TYR_ITIM	181	186	PF00017	0.303
LIG_TYR_ITIM	447	452	PF00017	0.463
MOD_CDK_SPxxK_3	459	466	PF00069	0.488
MOD_CK1_1	119	125	PF00069	0.606
MOD_CK1_1	291	297	PF00069	0.560
MOD_CK1_1	330	336	PF00069	0.449
MOD_CK2_1	472	478	PF00069	0.474
MOD_CK2_1	518	524	PF00069	0.530
MOD_GlcNHglycan	132	135	PF01048	0.689
MOD_GlcNHglycan	138	141	PF01048	0.668
MOD_GlcNHglycan	21	24	PF01048	0.613
MOD_GlcNHglycan	253	256	PF01048	0.797
MOD_GlcNHglycan	290	293	PF01048	0.731
MOD_GlcNHglycan	369	372	PF01048	0.288
MOD_GlcNHglycan	443	446	PF01048	0.274
MOD_GlcNHglycan	496	499	PF01048	0.263
MOD_GSK3_1	130	137	PF00069	0.541
MOD_GSK3_1	140	147	PF00069	0.442
MOD_GSK3_1	19	26	PF00069	0.462
MOD_GSK3_1	2	9	PF00069	0.498
MOD_GSK3_1	28	35	PF00069	0.436
MOD_GSK3_1	286	293	PF00069	0.584
MOD_GSK3_1	299	306	PF00069	0.426
MOD_GSK3_1	324	331	PF00069	0.494
MOD_GSK3_1	374	381	PF00069	0.495
MOD_N-GLC_1	310	315	PF02516	0.732
MOD_N-GLC_1	328	333	PF02516	0.695
MOD_NEK2_1	28	33	PF00069	0.414
MOD_NEK2_1	286	291	PF00069	0.544
MOD_NEK2_1	435	440	PF00069	0.499
MOD_NEK2_1	441	446	PF00069	0.509
MOD_NEK2_1	457	462	PF00069	0.478
MOD_NEK2_1	494	499	PF00069	0.463
MOD_NEK2_1	52	57	PF00069	0.362
MOD_PIKK_1	28	34	PF00454	0.405
MOD_PIKK_1	291	297	PF00454	0.488
MOD_PIKK_1	379	385	PF00454	0.448
MOD_PIKK_1	550	556	PF00454	0.560
MOD_PKA_2	119	125	PF00069	0.568
MOD_PKA_2	19	25	PF00069	0.456
MOD_PKA_2	28	34	PF00069	0.411
MOD_PKA_2	378	384	PF00069	0.530
MOD_PKA_2	399	405	PF00069	0.530
MOD_PKB_1	240	248	PF00069	0.561
MOD_Plk_1	310	316	PF00069	0.593
MOD_Plk_1	509	515	PF00069	0.532
MOD_Plk_4	218	224	PF00069	0.529
MOD_Plk_4	32	38	PF00069	0.417
MOD_Plk_4	330	336	PF00069	0.426
MOD_Plk_4	428	434	PF00069	0.491
MOD_Plk_4	509	515	PF00069	0.532
MOD_Plk_4	543	549	PF00069	0.521
MOD_ProDKin_1	103	109	PF00069	0.538
MOD_ProDKin_1	324	330	PF00069	0.566
MOD_ProDKin_1	459	465	PF00069	0.488
MOD_SUMO_rev_2	529	538	PF00179	0.463
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.466
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.518
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.463
TRG_ENDOCYTIC_2	183	186	PF00928	0.301
TRG_ENDOCYTIC_2	205	208	PF00928	0.360
TRG_ENDOCYTIC_2	297	300	PF00928	0.552
TRG_ENDOCYTIC_2	337	340	PF00928	0.348
TRG_ENDOCYTIC_2	345	348	PF00928	0.263
TRG_ENDOCYTIC_2	357	360	PF00928	0.362
TRG_ENDOCYTIC_2	449	452	PF00928	0.463
TRG_ENDOCYTIC_2	45	48	PF00928	0.413
TRG_ENDOCYTIC_2	491	494	PF00928	0.463
TRG_ER_diArg_1	153	155	PF00400	0.467
TRG_ER_diArg_1	412	415	PF00400	0.515
TRG_ER_diArg_1	422	424	PF00400	0.592
TRG_ER_diArg_1	479	481	PF00400	0.463
TRG_ER_diArg_1	54	57	PF00400	0.379
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7R5	Leptomonas seymouri	64%	98%
A0A0S4JBA8	Bodo saltans	55%	100%
A4H799	Leishmania braziliensis	84%	100%
A4HVP1	Leishmania infantum	100%	100%
E9APD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QG41	Leishmania major	97%	100%
V5B779	Trypanosoma cruzi	48%	100%