Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSK1_LEIDO

TriTrypDb:

LdBPK_131070.1 , LdCL_130016000 , LDHU3_13.1300

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S7WSK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.489
CLV_C14_Caspase3-7	191	195	PF00656	0.687
CLV_NRD_NRD_1	118	120	PF00675	0.555
CLV_NRD_NRD_1	15	17	PF00675	0.621
CLV_NRD_NRD_1	187	189	PF00675	0.732
CLV_NRD_NRD_1	238	240	PF00675	0.613
CLV_NRD_NRD_1	272	274	PF00675	0.695
CLV_NRD_NRD_1	28	30	PF00675	0.686
CLV_NRD_NRD_1	315	317	PF00675	0.400
CLV_NRD_NRD_1	397	399	PF00675	0.451
CLV_NRD_NRD_1	411	413	PF00675	0.564
CLV_NRD_NRD_1	418	420	PF00675	0.693
CLV_PCSK_KEX2_1	117	119	PF00082	0.534
CLV_PCSK_KEX2_1	15	17	PF00082	0.621
CLV_PCSK_KEX2_1	187	189	PF00082	0.729
CLV_PCSK_KEX2_1	224	226	PF00082	0.669
CLV_PCSK_KEX2_1	238	240	PF00082	0.546
CLV_PCSK_KEX2_1	271	273	PF00082	0.673
CLV_PCSK_KEX2_1	28	30	PF00082	0.686
CLV_PCSK_KEX2_1	397	399	PF00082	0.445
CLV_PCSK_KEX2_1	411	413	PF00082	0.575
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.678
CLV_PCSK_PC7_1	183	189	PF00082	0.653
CLV_PCSK_SKI1_1	111	115	PF00082	0.568
CLV_PCSK_SKI1_1	118	122	PF00082	0.491
CLV_PCSK_SKI1_1	141	145	PF00082	0.468
CLV_PCSK_SKI1_1	221	225	PF00082	0.702
CLV_PCSK_SKI1_1	350	354	PF00082	0.466
CLV_PCSK_SKI1_1	460	464	PF00082	0.476
CLV_PCSK_SKI1_1	491	495	PF00082	0.342
CLV_Separin_Metazoa	394	398	PF03568	0.417
DEG_Nend_UBRbox_3	1	3	PF02207	0.531
DEG_SPOP_SBC_1	83	87	PF00917	0.693
DOC_CKS1_1	442	447	PF01111	0.654
DOC_CYCLIN_RxL_1	115	125	PF00134	0.542
DOC_CYCLIN_RxL_1	289	297	PF00134	0.488
DOC_CYCLIN_RxL_1	363	372	PF00134	0.451
DOC_MAPK_gen_1	277	287	PF00069	0.428
DOC_MAPK_gen_1	397	405	PF00069	0.618
DOC_MAPK_MEF2A_6	280	287	PF00069	0.388
DOC_MAPK_MEF2A_6	387	395	PF00069	0.499
DOC_MAPK_MEF2A_6	397	405	PF00069	0.618
DOC_PP1_RVXF_1	364	371	PF00149	0.414
DOC_PP2B_LxvP_1	287	290	PF13499	0.458
DOC_PP4_FxxP_1	405	408	PF00568	0.753
DOC_PP4_FxxP_1	435	438	PF00568	0.690
DOC_SPAK_OSR1_1	310	314	PF12202	0.437
DOC_USP7_MATH_1	290	294	PF00917	0.534
DOC_USP7_MATH_1	326	330	PF00917	0.642
DOC_USP7_MATH_1	421	425	PF00917	0.708
DOC_USP7_MATH_1	66	70	PF00917	0.622
DOC_USP7_MATH_1	84	88	PF00917	0.638
DOC_USP7_UBL2_3	317	321	PF12436	0.507
DOC_WW_Pin1_4	192	197	PF00397	0.743
DOC_WW_Pin1_4	253	258	PF00397	0.781
DOC_WW_Pin1_4	329	334	PF00397	0.683
DOC_WW_Pin1_4	427	432	PF00397	0.641
DOC_WW_Pin1_4	438	443	PF00397	0.581
DOC_WW_Pin1_4	92	97	PF00397	0.681
LIG_14-3-3_CanoR_1	159	169	PF00244	0.500
LIG_14-3-3_CanoR_1	205	210	PF00244	0.494
LIG_14-3-3_CanoR_1	277	287	PF00244	0.494
LIG_14-3-3_CanoR_1	364	369	PF00244	0.422
LIG_14-3-3_CanoR_1	412	418	PF00244	0.656
LIG_14-3-3_CanoR_1	451	457	PF00244	0.604
LIG_Actin_WH2_2	525	541	PF00022	0.471
LIG_APCC_ABBA_1	72	77	PF00400	0.718
LIG_BIR_III_2	81	85	PF00653	0.650
LIG_BRCT_BRCA1_1	165	169	PF00533	0.381
LIG_BRCT_BRCA1_1	366	370	PF00533	0.488
LIG_BRCT_BRCA1_1	68	72	PF00533	0.640
LIG_BRCT_BRCA1_1	86	90	PF00533	0.774
LIG_CaM_IQ_9	128	143	PF13499	0.508
LIG_deltaCOP1_diTrp_1	307	311	PF00928	0.331
LIG_deltaCOP1_diTrp_1	344	353	PF00928	0.497
LIG_FHA_1	503	509	PF00498	0.511
LIG_FHA_2	307	313	PF00498	0.429
LIG_FHA_2	335	341	PF00498	0.610
LIG_GBD_Chelix_1	534	542	PF00786	0.496
LIG_IRF3_LxIS_1	3	8	PF10401	0.628
LIG_KLC1_Yacidic_2	389	394	PF13176	0.466
LIG_LIR_Apic_2	402	408	PF02991	0.674
LIG_LIR_Apic_2	475	481	PF02991	0.459
LIG_LIR_Apic_2	77	83	PF02991	0.656
LIG_LIR_Gen_1	307	315	PF02991	0.330
LIG_LIR_Gen_1	389	400	PF02991	0.415
LIG_LIR_Gen_1	495	504	PF02991	0.545
LIG_LIR_Nem_3	156	161	PF02991	0.505
LIG_LIR_Nem_3	286	291	PF02991	0.345
LIG_LIR_Nem_3	307	311	PF02991	0.331
LIG_LIR_Nem_3	69	75	PF02991	0.679
LIG_MLH1_MIPbox_1	165	169	PF16413	0.381
LIG_MYND_1	151	155	PF01753	0.432
LIG_SH2_CRK	206	210	PF00017	0.489
LIG_SH2_CRK	478	482	PF00017	0.455
LIG_SH2_GRB2like	358	361	PF00017	0.445
LIG_SH2_NCK_1	242	246	PF00017	0.687
LIG_SH2_SRC	179	182	PF00017	0.567
LIG_SH2_SRC	358	361	PF00017	0.445
LIG_SH2_STAP1	472	476	PF00017	0.464
LIG_SH2_STAT3	511	514	PF00017	0.455
LIG_SH2_STAT5	168	171	PF00017	0.358
LIG_SH2_STAT5	179	182	PF00017	0.461
LIG_SH2_STAT5	242	245	PF00017	0.686
LIG_SH2_STAT5	358	361	PF00017	0.488
LIG_SH2_STAT5	392	395	PF00017	0.455
LIG_SH2_STAT5	482	485	PF00017	0.441
LIG_SH2_STAT5	497	500	PF00017	0.458
LIG_SH2_STAT5	511	514	PF00017	0.488
LIG_SH2_STAT5	524	527	PF00017	0.430
LIG_SH3_3	149	155	PF00018	0.420
LIG_SH3_3	439	445	PF00018	0.728
LIG_SH3_3	95	101	PF00018	0.655
LIG_TRAF2_1	378	381	PF00917	0.396
LIG_TRAF2_1	58	61	PF00917	0.763
LIG_WRC_WIRS_1	453	458	PF05994	0.406
LIG_WW_3	218	222	PF00397	0.676
MOD_CK1_1	103	109	PF00069	0.568
MOD_CK1_1	167	173	PF00069	0.512
MOD_CK1_1	329	335	PF00069	0.656
MOD_CK1_1	424	430	PF00069	0.745
MOD_CK1_1	455	461	PF00069	0.478
MOD_CK1_1	8	14	PF00069	0.675
MOD_CK1_1	85	91	PF00069	0.687
MOD_CK2_1	334	340	PF00069	0.492
MOD_CK2_1	412	418	PF00069	0.753
MOD_Cter_Amidation	185	188	PF01082	0.627
MOD_GlcNHglycan	155	158	PF01048	0.503
MOD_GlcNHglycan	18	21	PF01048	0.545
MOD_GlcNHglycan	221	224	PF01048	0.773
MOD_GlcNHglycan	30	33	PF01048	0.709
MOD_GlcNHglycan	34	37	PF01048	0.564
MOD_GlcNHglycan	426	429	PF01048	0.774
MOD_GlcNHglycan	457	460	PF01048	0.455
MOD_GlcNHglycan	467	471	PF01048	0.304
MOD_GlcNHglycan	7	10	PF01048	0.667
MOD_GlcNHglycan	87	90	PF01048	0.648
MOD_GSK3_1	11	18	PF00069	0.718
MOD_GSK3_1	160	167	PF00069	0.546
MOD_GSK3_1	28	35	PF00069	0.680
MOD_GSK3_1	290	297	PF00069	0.444
MOD_GSK3_1	451	458	PF00069	0.567
MOD_GSK3_1	534	541	PF00069	0.498
MOD_GSK3_1	84	91	PF00069	0.640
MOD_NEK2_1	161	166	PF00069	0.474
MOD_NEK2_1	169	174	PF00069	0.324
MOD_NEK2_1	283	288	PF00069	0.500
MOD_NEK2_1	294	299	PF00069	0.436
MOD_NEK2_1	3	8	PF00069	0.530
MOD_NEK2_1	334	339	PF00069	0.471
MOD_NEK2_1	401	406	PF00069	0.682
MOD_NEK2_1	534	539	PF00069	0.488
MOD_NEK2_1	90	95	PF00069	0.742
MOD_NEK2_2	66	71	PF00069	0.563
MOD_PIKK_1	406	412	PF00454	0.676
MOD_PIKK_1	461	467	PF00454	0.490
MOD_PK_1	205	211	PF00069	0.493
MOD_PKA_1	15	21	PF00069	0.596
MOD_PKA_1	28	34	PF00069	0.631
MOD_PKA_1	411	417	PF00069	0.549
MOD_PKA_2	15	21	PF00069	0.625
MOD_PKA_2	240	246	PF00069	0.710
MOD_PKA_2	28	34	PF00069	0.697
MOD_PKA_2	411	417	PF00069	0.662
MOD_PKA_2	47	53	PF00069	0.732
MOD_Plk_1	294	300	PF00069	0.417
MOD_Plk_1	306	312	PF00069	0.281
MOD_Plk_1	401	407	PF00069	0.607
MOD_Plk_4	164	170	PF00069	0.550
MOD_Plk_4	294	300	PF00069	0.438
MOD_ProDKin_1	192	198	PF00069	0.741
MOD_ProDKin_1	253	259	PF00069	0.781
MOD_ProDKin_1	329	335	PF00069	0.683
MOD_ProDKin_1	427	433	PF00069	0.640
MOD_ProDKin_1	438	444	PF00069	0.579
MOD_ProDKin_1	92	98	PF00069	0.678
MOD_SUMO_rev_2	414	421	PF00179	0.752
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.630
TRG_ENDOCYTIC_2	168	171	PF00928	0.358
TRG_ENDOCYTIC_2	206	209	PF00928	0.484
TRG_ENDOCYTIC_2	392	395	PF00928	0.486
TRG_ENDOCYTIC_2	497	500	PF00928	0.424
TRG_ER_diArg_1	117	119	PF00400	0.561
TRG_ER_diArg_1	15	17	PF00400	0.620
TRG_ER_diArg_1	237	239	PF00400	0.658
TRG_ER_diArg_1	27	29	PF00400	0.691
TRG_ER_diArg_1	271	273	PF00400	0.696
TRG_ER_diArg_1	363	366	PF00400	0.349
TRG_ER_diArg_1	396	398	PF00400	0.434
TRG_NES_CRM1_1	389	402	PF08389	0.463
TRG_NES_CRM1_1	492	507	PF08389	0.346
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	460	465	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J1	Leptomonas seymouri	53%	100%
A0A0S4J8B7	Bodo saltans	28%	100%
A0A1X0NMY2	Trypanosomatidae	33%	100%
A0A3R7KEA8	Trypanosoma rangeli	33%	100%
A4HVP5	Leishmania infantum	100%	100%
D0A6K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9APE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QG37	Leishmania major	92%	100%
V5D7N8	Trypanosoma cruzi	33%	100%