LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WSJ9_LEIDO
TriTrypDb:
LdBPK_130900.1 , LdCL_130014400 , LDHU3_13.1120
Length:
327

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A0A3S7WSJ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSJ9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 309 313 PF00656 0.642
CLV_NRD_NRD_1 130 132 PF00675 0.601
CLV_NRD_NRD_1 140 142 PF00675 0.625
CLV_NRD_NRD_1 181 183 PF00675 0.366
CLV_NRD_NRD_1 201 203 PF00675 0.604
CLV_NRD_NRD_1 225 227 PF00675 0.493
CLV_PCSK_KEX2_1 140 142 PF00082 0.602
CLV_PCSK_KEX2_1 181 183 PF00082 0.393
CLV_PCSK_KEX2_1 200 202 PF00082 0.614
CLV_PCSK_KEX2_1 224 226 PF00082 0.508
CLV_PCSK_PC7_1 196 202 PF00082 0.468
CLV_PCSK_PC7_1 221 227 PF00082 0.427
CLV_PCSK_SKI1_1 181 185 PF00082 0.387
CLV_PCSK_SKI1_1 217 221 PF00082 0.441
CLV_PCSK_SKI1_1 225 229 PF00082 0.472
CLV_PCSK_SKI1_1 305 309 PF00082 0.321
DEG_APCC_DBOX_1 216 224 PF00400 0.614
DEG_APCC_DBOX_1 310 318 PF00400 0.589
DEG_Nend_UBRbox_1 1 4 PF02207 0.656
DEG_SPOP_SBC_1 26 30 PF00917 0.553
DOC_MAPK_gen_1 140 148 PF00069 0.463
DOC_MAPK_gen_1 181 187 PF00069 0.567
DOC_MAPK_gen_1 224 235 PF00069 0.681
DOC_MAPK_HePTP_8 223 235 PF00069 0.611
DOC_MAPK_MEF2A_6 226 235 PF00069 0.594
DOC_PP2B_LxvP_1 108 111 PF13499 0.432
DOC_PP2B_LxvP_1 269 272 PF13499 0.426
DOC_USP7_MATH_1 240 244 PF00917 0.345
DOC_USP7_MATH_1 83 87 PF00917 0.430
DOC_USP7_MATH_2 203 209 PF00917 0.670
DOC_WW_Pin1_4 95 100 PF00397 0.451
LIG_14-3-3_CanoR_1 140 148 PF00244 0.428
LIG_14-3-3_CanoR_1 181 186 PF00244 0.596
LIG_14-3-3_CanoR_1 225 231 PF00244 0.667
LIG_14-3-3_CanoR_1 256 264 PF00244 0.365
LIG_Actin_WH2_2 36 53 PF00022 0.523
LIG_EH1_1 163 171 PF00400 0.312
LIG_EH1_1 247 255 PF00400 0.388
LIG_eIF4E_1 164 170 PF01652 0.312
LIG_FHA_1 101 107 PF00498 0.581
LIG_FHA_1 182 188 PF00498 0.582
LIG_FHA_1 63 69 PF00498 0.327
LIG_FHA_2 112 118 PF00498 0.391
LIG_FHA_2 189 195 PF00498 0.605
LIG_FHA_2 9 15 PF00498 0.606
LIG_GBD_Chelix_1 52 60 PF00786 0.255
LIG_LIR_LC3C_4 158 162 PF02991 0.315
LIG_PCNA_PIPBox_1 32 41 PF02747 0.522
LIG_PCNA_yPIPBox_3 32 44 PF02747 0.530
LIG_PDZ_Class_3 322 327 PF00595 0.555
LIG_Pex14_1 292 296 PF04695 0.312
LIG_SH2_CRK 64 68 PF00017 0.388
LIG_SH2_GRB2like 137 140 PF00017 0.439
LIG_SH2_NCK_1 236 240 PF00017 0.291
LIG_SH2_STAP1 164 168 PF00017 0.312
LIG_SH2_STAP1 174 178 PF00017 0.512
LIG_SH2_STAP1 236 240 PF00017 0.291
LIG_SH2_STAP1 64 68 PF00017 0.327
LIG_SH2_STAT5 133 136 PF00017 0.407
LIG_SH2_STAT5 177 180 PF00017 0.563
LIG_SH2_STAT5 287 290 PF00017 0.312
LIG_SH2_STAT5 38 41 PF00017 0.552
LIG_SH2_STAT5 64 67 PF00017 0.285
LIG_SH3_3 288 294 PF00018 0.388
LIG_SH3_CIN85_PxpxPR_1 212 217 PF14604 0.654
LIG_SUMO_SIM_anti_2 158 165 PF11976 0.362
LIG_SUMO_SIM_anti_2 65 70 PF11976 0.327
LIG_SUMO_SIM_par_1 158 165 PF11976 0.310
LIG_SUMO_SIM_par_1 273 279 PF11976 0.340
LIG_SUMO_SIM_par_1 312 318 PF11976 0.535
LIG_SUMO_SIM_par_1 64 70 PF11976 0.312
LIG_SUMO_SIM_par_1 72 78 PF11976 0.426
LIG_TRAF2_1 30 33 PF00917 0.582
LIG_TYR_ITIM 62 67 PF00017 0.312
MOD_CK1_1 243 249 PF00069 0.302
MOD_CK1_1 273 279 PF00069 0.430
MOD_CK2_1 111 117 PF00069 0.434
MOD_CK2_1 188 194 PF00069 0.606
MOD_CK2_1 25 31 PF00069 0.537
MOD_GlcNHglycan 149 152 PF01048 0.618
MOD_GlcNHglycan 157 160 PF01048 0.281
MOD_GlcNHglycan 207 210 PF01048 0.525
MOD_GlcNHglycan 45 48 PF01048 0.325
MOD_GlcNHglycan 69 72 PF01048 0.341
MOD_GSK3_1 303 310 PF00069 0.374
MOD_GSK3_1 39 46 PF00069 0.520
MOD_NEK2_1 106 111 PF00069 0.456
MOD_NEK2_1 303 308 PF00069 0.368
MOD_NEK2_1 39 44 PF00069 0.527
MOD_NEK2_1 62 67 PF00069 0.409
MOD_NEK2_1 69 74 PF00069 0.295
MOD_NEK2_2 172 177 PF00069 0.429
MOD_PIKK_1 109 115 PF00454 0.416
MOD_PIKK_1 257 263 PF00454 0.403
MOD_PKA_1 181 187 PF00069 0.535
MOD_PKA_2 139 145 PF00069 0.388
MOD_PKA_2 181 187 PF00069 0.546
MOD_PKA_2 257 263 PF00069 0.403
MOD_PKA_2 43 49 PF00069 0.609
MOD_PKB_1 224 232 PF00069 0.519
MOD_Plk_1 75 81 PF00069 0.421
MOD_Plk_4 111 117 PF00069 0.364
MOD_Plk_4 152 158 PF00069 0.372
MOD_Plk_4 243 249 PF00069 0.312
MOD_Plk_4 270 276 PF00069 0.382
MOD_Plk_4 62 68 PF00069 0.460
MOD_Plk_4 69 75 PF00069 0.253
MOD_Plk_4 83 89 PF00069 0.376
MOD_ProDKin_1 95 101 PF00069 0.453
TRG_ENDOCYTIC_2 264 267 PF00928 0.453
TRG_ENDOCYTIC_2 64 67 PF00928 0.312
TRG_ER_diArg_1 181 183 PF00400 0.560
TRG_ER_diArg_1 200 202 PF00400 0.812
TRG_ER_diArg_1 223 226 PF00400 0.628

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDT7 Leptomonas seymouri 52% 94%
A4H789 Leishmania braziliensis 76% 100%
A4HVM9 Leishmania infantum 100% 100%
E9APC5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QG53 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS