Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSJ6_LEIDO

TriTrypDb:

LdBPK_130880.1 , LdCL_130014200 , LDHU3_13.1100

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.685
CLV_C14_Caspase3-7	309	313	PF00656	0.751
CLV_C14_Caspase3-7	440	444	PF00656	0.648
CLV_NRD_NRD_1	128	130	PF00675	0.700
CLV_NRD_NRD_1	183	185	PF00675	0.473
CLV_NRD_NRD_1	187	189	PF00675	0.478
CLV_NRD_NRD_1	191	193	PF00675	0.475
CLV_NRD_NRD_1	197	199	PF00675	0.478
CLV_NRD_NRD_1	226	228	PF00675	0.624
CLV_NRD_NRD_1	253	255	PF00675	0.514
CLV_NRD_NRD_1	269	271	PF00675	0.459
CLV_NRD_NRD_1	281	283	PF00675	0.748
CLV_NRD_NRD_1	289	291	PF00675	0.692
CLV_NRD_NRD_1	293	295	PF00675	0.782
CLV_NRD_NRD_1	3	5	PF00675	0.592
CLV_NRD_NRD_1	324	326	PF00675	0.580
CLV_NRD_NRD_1	353	355	PF00675	0.722
CLV_NRD_NRD_1	400	402	PF00675	0.657
CLV_NRD_NRD_1	470	472	PF00675	0.525
CLV_NRD_NRD_1	476	478	PF00675	0.587
CLV_NRD_NRD_1	72	74	PF00675	0.556
CLV_PCSK_FUR_1	290	294	PF00082	0.693
CLV_PCSK_FUR_1	468	472	PF00082	0.496
CLV_PCSK_KEX2_1	16	18	PF00082	0.566
CLV_PCSK_KEX2_1	191	193	PF00082	0.502
CLV_PCSK_KEX2_1	197	199	PF00082	0.444
CLV_PCSK_KEX2_1	224	226	PF00082	0.584
CLV_PCSK_KEX2_1	260	262	PF00082	0.609
CLV_PCSK_KEX2_1	281	283	PF00082	0.612
CLV_PCSK_KEX2_1	291	293	PF00082	0.683
CLV_PCSK_KEX2_1	3	5	PF00082	0.592
CLV_PCSK_KEX2_1	31	33	PF00082	0.518
CLV_PCSK_KEX2_1	326	328	PF00082	0.553
CLV_PCSK_KEX2_1	348	350	PF00082	0.767
CLV_PCSK_KEX2_1	353	355	PF00082	0.674
CLV_PCSK_KEX2_1	400	402	PF00082	0.614
CLV_PCSK_KEX2_1	425	427	PF00082	0.450
CLV_PCSK_KEX2_1	470	472	PF00082	0.548
CLV_PCSK_KEX2_1	65	67	PF00082	0.483
CLV_PCSK_KEX2_1	72	74	PF00082	0.474
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.616
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.505
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.565
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.614
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.705
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.473
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.553
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.684
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.565
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.502
CLV_PCSK_PC7_1	349	355	PF00082	0.510
CLV_PCSK_PC7_1	396	402	PF00082	0.575
CLV_PCSK_PC7_1	68	74	PF00082	0.512
CLV_PCSK_SKI1_1	19	23	PF00082	0.659
CLV_PCSK_SKI1_1	214	218	PF00082	0.606
CLV_PCSK_SKI1_1	257	261	PF00082	0.479
CLV_PCSK_SKI1_1	31	35	PF00082	0.625
CLV_PCSK_SKI1_1	56	60	PF00082	0.581
CLV_PCSK_SKI1_1	73	77	PF00082	0.605
DEG_SCF_FBW7_1	120	126	PF00400	0.633
DOC_ANK_TNKS_1	309	316	PF00023	0.628
DOC_CKS1_1	120	125	PF01111	0.782
DOC_MAPK_gen_1	245	252	PF00069	0.497
DOC_MAPK_gen_1	323	330	PF00069	0.583
DOC_MAPK_gen_1	425	432	PF00069	0.460
DOC_MAPK_MEF2A_6	245	252	PF00069	0.497
DOC_PP1_RVXF_1	324	331	PF00149	0.576
DOC_PP2B_LxvP_1	152	155	PF13499	0.788
DOC_USP7_MATH_1	123	127	PF00917	0.722
DOC_USP7_MATH_1	341	345	PF00917	0.712
DOC_USP7_MATH_1	385	389	PF00917	0.595
DOC_USP7_MATH_1	447	451	PF00917	0.565
DOC_USP7_MATH_1	91	95	PF00917	0.636
DOC_USP7_UBL2_3	185	189	PF12436	0.475
DOC_USP7_UBL2_3	224	228	PF12436	0.613
DOC_WW_Pin1_4	119	124	PF00397	0.795
DOC_WW_Pin1_4	21	26	PF00397	0.519
LIG_14-3-3_CanoR_1	254	260	PF00244	0.633
LIG_14-3-3_CanoR_1	325	331	PF00244	0.575
LIG_14-3-3_CanoR_1	461	467	PF00244	0.516
LIG_14-3-3_CanoR_1	80	87	PF00244	0.529
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_FHA_2	164	170	PF00498	0.653
LIG_FHA_2	238	244	PF00498	0.641
LIG_FHA_2	438	444	PF00498	0.645
LIG_Integrin_RGD_1	310	312	PF01839	0.628
LIG_LIR_Gen_1	136	144	PF02991	0.572
LIG_LIR_Gen_1	357	367	PF02991	0.520
LIG_LIR_Gen_1	452	463	PF02991	0.381
LIG_LIR_Nem_3	136	140	PF02991	0.592
LIG_LIR_Nem_3	357	362	PF02991	0.522
LIG_LIR_Nem_3	452	458	PF02991	0.574
LIG_LIR_Nem_3	485	489	PF02991	0.594
LIG_PDZ_Class_2	485	490	PF00595	0.535
LIG_SH2_NCK_1	359	363	PF00017	0.616
LIG_SH2_STAP1	215	219	PF00017	0.573
LIG_SH2_STAT5	61	64	PF00017	0.499
LIG_SH3_2	128	133	PF14604	0.636
LIG_SH3_3	117	123	PF00018	0.685
LIG_SH3_3	125	131	PF00018	0.704
LIG_SH3_3	148	154	PF00018	0.751
LIG_SH3_3	368	374	PF00018	0.519
LIG_SH3_4	130	137	PF00018	0.543
LIG_SUMO_SIM_anti_2	360	366	PF11976	0.514
LIG_TRAF2_1	177	180	PF00917	0.602
LIG_TRAF2_1	207	210	PF00917	0.469
LIG_UBA3_1	58	65	PF00899	0.555
MOD_CDK_SPxxK_3	21	28	PF00069	0.509
MOD_CK1_1	100	106	PF00069	0.672
MOD_CK1_1	316	322	PF00069	0.660
MOD_CK1_1	47	53	PF00069	0.597
MOD_CK1_1	90	96	PF00069	0.807
MOD_CK2_1	136	142	PF00069	0.648
MOD_CK2_1	174	180	PF00069	0.655
MOD_CK2_1	341	347	PF00069	0.717
MOD_CK2_1	389	395	PF00069	0.603
MOD_Cter_Amidation	222	225	PF01082	0.582
MOD_GlcNHglycan	142	147	PF01048	0.716
MOD_GlcNHglycan	297	300	PF01048	0.639
MOD_GlcNHglycan	391	394	PF01048	0.533
MOD_GlcNHglycan	89	92	PF01048	0.708
MOD_GlcNHglycan	93	96	PF01048	0.715
MOD_GSK3_1	111	118	PF00069	0.656
MOD_GSK3_1	119	126	PF00069	0.678
MOD_GSK3_1	159	166	PF00069	0.681
MOD_GSK3_1	385	392	PF00069	0.545
MOD_GSK3_1	47	54	PF00069	0.608
MOD_GSK3_1	87	94	PF00069	0.650
MOD_N-GLC_1	265	270	PF02516	0.665
MOD_NEK2_1	144	149	PF00069	0.594
MOD_PIKK_1	265	271	PF00454	0.516
MOD_PIKK_1	51	57	PF00454	0.478
MOD_PKA_1	293	299	PF00069	0.628
MOD_PKA_1	326	332	PF00069	0.550
MOD_PKA_2	160	166	PF00069	0.726
MOD_PKA_2	293	299	PF00069	0.597
MOD_PKA_2	326	332	PF00069	0.567
MOD_PKA_2	447	453	PF00069	0.567
MOD_PKA_2	79	85	PF00069	0.586
MOD_PKA_2	87	93	PF00069	0.577
MOD_PKB_1	292	300	PF00069	0.715
MOD_Plk_2-3	136	142	PF00069	0.581
MOD_ProDKin_1	119	125	PF00069	0.796
MOD_ProDKin_1	21	27	PF00069	0.515
MOD_SUMO_for_1	259	262	PF00179	0.466
MOD_SUMO_for_1	482	485	PF00179	0.540
MOD_SUMO_rev_2	24	33	PF00179	0.614
MOD_SUMO_rev_2	473	480	PF00179	0.578
TRG_DiLeu_BaEn_1	410	415	PF01217	0.542
TRG_DiLeu_LyEn_5	410	415	PF01217	0.578
TRG_ENDOCYTIC_2	359	362	PF00928	0.610
TRG_ER_diArg_1	197	200	PF00400	0.588
TRG_ER_diArg_1	281	283	PF00400	0.601
TRG_ER_diArg_1	290	293	PF00400	0.644
TRG_ER_diArg_1	325	328	PF00400	0.574
TRG_ER_diArg_1	353	355	PF00400	0.488
TRG_ER_diArg_1	400	402	PF00400	0.613
TRG_ER_diArg_1	411	414	PF00400	0.529
TRG_ER_diArg_1	468	471	PF00400	0.566
TRG_NLS_Bipartite_1	3	20	PF00514	0.621
TRG_NLS_MonoCore_2	128	133	PF00514	0.636
TRG_NLS_MonoCore_2	289	294	PF00514	0.690
TRG_NLS_MonoExtC_3	128	133	PF00514	0.706
TRG_NLS_MonoExtC_3	223	228	PF00514	0.568
TRG_NLS_MonoExtC_3	289	294	PF00514	0.698
TRG_NLS_MonoExtN_4	128	133	PF00514	0.698
TRG_NLS_MonoExtN_4	224	231	PF00514	0.589
TRG_NLS_MonoExtN_4	28	35	PF00514	0.555
TRG_NLS_MonoExtN_4	323	329	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE43	Leptomonas seymouri	55%	97%
A0A422NGB0	Trypanosoma rangeli	36%	100%
A4H787	Leishmania braziliensis	71%	99%
A4HVM7	Leishmania infantum	99%	100%
D0A6M7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9APC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QG55	Leishmania major	90%	100%
V5AVQ1	Trypanosoma cruzi	35%	100%