LeishMANIAdb
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Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine Rich repeat, putative
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WSJ0_LEIDO
TriTrypDb:
LdBPK_130800.1 , LdCL_130013400 , LDHU3_13.1010
Length:
821

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7

Expansion

Sequence features

A0A3S7WSJ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSJ0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 692 696 PF00656 0.548
CLV_NRD_NRD_1 262 264 PF00675 0.635
CLV_NRD_NRD_1 303 305 PF00675 0.699
CLV_NRD_NRD_1 330 332 PF00675 0.765
CLV_NRD_NRD_1 44 46 PF00675 0.612
CLV_NRD_NRD_1 818 820 PF00675 0.832
CLV_PCSK_KEX2_1 183 185 PF00082 0.681
CLV_PCSK_KEX2_1 262 264 PF00082 0.635
CLV_PCSK_KEX2_1 303 305 PF00082 0.699
CLV_PCSK_KEX2_1 329 331 PF00082 0.804
CLV_PCSK_KEX2_1 36 38 PF00082 0.567
CLV_PCSK_KEX2_1 427 429 PF00082 0.742
CLV_PCSK_KEX2_1 43 45 PF00082 0.605
CLV_PCSK_KEX2_1 792 794 PF00082 0.738
CLV_PCSK_KEX2_1 818 820 PF00082 0.832
CLV_PCSK_PC1ET2_1 183 185 PF00082 0.583
CLV_PCSK_PC1ET2_1 36 38 PF00082 0.567
CLV_PCSK_PC1ET2_1 427 429 PF00082 0.742
CLV_PCSK_PC1ET2_1 792 794 PF00082 0.738
CLV_PCSK_SKI1_1 169 173 PF00082 0.691
CLV_PCSK_SKI1_1 176 180 PF00082 0.545
CLV_PCSK_SKI1_1 183 187 PF00082 0.454
CLV_PCSK_SKI1_1 236 240 PF00082 0.714
CLV_PCSK_SKI1_1 477 481 PF00082 0.722
CLV_PCSK_SKI1_1 588 592 PF00082 0.636
CLV_PCSK_SKI1_1 750 754 PF00082 0.561
CLV_PCSK_SKI1_1 792 796 PF00082 0.695
DEG_SCF_FBW7_1 443 448 PF00400 0.686
DEG_SCF_FBW7_1 48 53 PF00400 0.673
DEG_SPOP_SBC_1 231 235 PF00917 0.709
DEG_SPOP_SBC_1 371 375 PF00917 0.761
DEG_SPOP_SBC_1 385 389 PF00917 0.552
DEG_SPOP_SBC_1 512 516 PF00917 0.711
DOC_ANK_TNKS_1 404 411 PF00023 0.670
DOC_CKS1_1 275 280 PF01111 0.728
DOC_CKS1_1 453 458 PF01111 0.689
DOC_CKS1_1 487 492 PF01111 0.745
DOC_CYCLIN_RxL_1 173 182 PF00134 0.665
DOC_CYCLIN_RxL_1 679 692 PF00134 0.464
DOC_CYCLIN_yCln2_LP_2 60 63 PF00134 0.671
DOC_MAPK_DCC_7 731 741 PF00069 0.516
DOC_MAPK_gen_1 650 659 PF00069 0.481
DOC_MAPK_gen_1 679 688 PF00069 0.472
DOC_MAPK_MEF2A_6 139 147 PF00069 0.572
DOC_MAPK_MEF2A_6 149 156 PF00069 0.579
DOC_MAPK_MEF2A_6 783 791 PF00069 0.733
DOC_MAPK_NFAT4_5 149 157 PF00069 0.607
DOC_PP1_RVXF_1 680 686 PF00149 0.501
DOC_PP2B_LxvP_1 60 63 PF13499 0.710
DOC_PP2B_LxvP_1 811 814 PF13499 0.787
DOC_PP4_FxxP_1 275 278 PF00568 0.732
DOC_PP4_FxxP_1 51 54 PF00568 0.690
DOC_PP4_FxxP_1 538 541 PF00568 0.712
DOC_PP4_MxPP_1 334 337 PF00568 0.714
DOC_USP7_MATH_1 230 234 PF00917 0.840
DOC_USP7_MATH_1 242 246 PF00917 0.612
DOC_USP7_MATH_1 257 261 PF00917 0.626
DOC_USP7_MATH_1 282 286 PF00917 0.770
DOC_USP7_MATH_1 370 374 PF00917 0.837
DOC_USP7_MATH_1 621 625 PF00917 0.489
DOC_USP7_MATH_1 64 68 PF00917 0.643
DOC_USP7_MATH_1 73 77 PF00917 0.566
DOC_USP7_MATH_1 781 785 PF00917 0.655
DOC_USP7_MATH_1 84 88 PF00917 0.693
DOC_USP7_MATH_1 93 97 PF00917 0.649
DOC_USP7_UBL2_3 446 450 PF12436 0.642
DOC_USP7_UBL2_3 646 650 PF12436 0.481
DOC_WW_Pin1_4 191 196 PF00397 0.695
DOC_WW_Pin1_4 237 242 PF00397 0.703
DOC_WW_Pin1_4 250 255 PF00397 0.613
DOC_WW_Pin1_4 274 279 PF00397 0.731
DOC_WW_Pin1_4 341 346 PF00397 0.748
DOC_WW_Pin1_4 386 391 PF00397 0.796
DOC_WW_Pin1_4 441 446 PF00397 0.741
DOC_WW_Pin1_4 449 454 PF00397 0.696
DOC_WW_Pin1_4 46 51 PF00397 0.652
DOC_WW_Pin1_4 481 486 PF00397 0.718
DOC_WW_Pin1_4 89 94 PF00397 0.802
LIG_14-3-3_CanoR_1 153 163 PF00244 0.601
LIG_14-3-3_CanoR_1 236 241 PF00244 0.718
LIG_14-3-3_CanoR_1 43 51 PF00244 0.640
LIG_14-3-3_CanoR_1 477 486 PF00244 0.719
LIG_14-3-3_CanoR_1 623 627 PF00244 0.492
LIG_14-3-3_CanoR_1 636 642 PF00244 0.496
LIG_14-3-3_CanoR_1 718 728 PF00244 0.488
LIG_14-3-3_CanoR_1 731 737 PF00244 0.517
LIG_14-3-3_CanoR_1 738 742 PF00244 0.311
LIG_14-3-3_CanoR_1 775 781 PF00244 0.716
LIG_14-3-3_CanoR_1 783 788 PF00244 0.645
LIG_14-3-3_CanoR_1 793 801 PF00244 0.630
LIG_Actin_WH2_2 609 625 PF00022 0.527
LIG_APCC_ABBA_1 1 6 PF00400 0.689
LIG_BIR_II_1 1 5 PF00653 0.726
LIG_BIR_III_4 569 573 PF00653 0.594
LIG_BRCT_BRCA1_1 244 248 PF00533 0.728
LIG_BRCT_BRCA1_1 373 377 PF00533 0.832
LIG_BRCT_BRCA1_1 95 99 PF00533 0.725
LIG_EVH1_1 801 805 PF00568 0.734
LIG_FHA_1 387 393 PF00498 0.709
LIG_FHA_1 442 448 PF00498 0.661
LIG_FHA_1 481 487 PF00498 0.832
LIG_FHA_1 563 569 PF00498 0.559
LIG_FHA_1 654 660 PF00498 0.520
LIG_FHA_2 476 482 PF00498 0.720
LIG_FHA_2 638 644 PF00498 0.535
LIG_GBD_Chelix_1 116 124 PF00786 0.535
LIG_LIR_Apic_2 272 278 PF02991 0.734
LIG_LIR_Apic_2 295 300 PF02991 0.607
LIG_LIR_Apic_2 49 54 PF02991 0.682
LIG_LIR_Apic_2 536 541 PF02991 0.703
LIG_LIR_Gen_1 346 355 PF02991 0.830
LIG_LIR_Gen_1 589 598 PF02991 0.546
LIG_LIR_Nem_3 295 299 PF02991 0.690
LIG_LIR_Nem_3 346 352 PF02991 0.835
LIG_LIR_Nem_3 374 380 PF02991 0.827
LIG_LIR_Nem_3 552 558 PF02991 0.650
LIG_LIR_Nem_3 589 594 PF02991 0.554
LIG_MYND_1 467 471 PF01753 0.736
LIG_MYND_1 809 813 PF01753 0.719
LIG_NRBOX 140 146 PF00104 0.671
LIG_NRBOX 174 180 PF00104 0.565
LIG_NRBOX 738 744 PF00104 0.591
LIG_NRP_CendR_1 818 821 PF00754 0.760
LIG_PTB_Apo_2 432 439 PF02174 0.579
LIG_SH2_CRK 130 134 PF00017 0.580
LIG_SH2_CRK 297 301 PF00017 0.703
LIG_SH2_GRB2like 433 436 PF00017 0.579
LIG_SH2_NCK_1 297 301 PF00017 0.601
LIG_SH2_NCK_1 502 506 PF00017 0.586
LIG_SH2_SRC 433 436 PF00017 0.579
LIG_SH2_STAP1 292 296 PF00017 0.702
LIG_SH2_STAP1 502 506 PF00017 0.722
LIG_SH2_STAT5 114 117 PF00017 0.537
LIG_SH2_STAT5 349 352 PF00017 0.811
LIG_SH2_STAT5 433 436 PF00017 0.579
LIG_SH2_STAT5 615 618 PF00017 0.609
LIG_SH2_STAT5 626 629 PF00017 0.480
LIG_SH3_1 330 336 PF00018 0.832
LIG_SH3_1 450 456 PF00018 0.709
LIG_SH3_3 251 257 PF00018 0.609
LIG_SH3_3 330 336 PF00018 0.733
LIG_SH3_3 393 399 PF00018 0.702
LIG_SH3_3 450 456 PF00018 0.702
LIG_SH3_3 484 490 PF00018 0.838
LIG_SH3_3 51 57 PF00018 0.791
LIG_SH3_3 799 805 PF00018 0.707
LIG_SUMO_SIM_anti_2 740 746 PF11976 0.531
LIG_SUMO_SIM_par_1 564 569 PF11976 0.482
LIG_SUMO_SIM_par_1 740 746 PF11976 0.531
LIG_TYR_ITIM 128 133 PF00017 0.567
LIG_UBA3_1 30 36 PF00899 0.554
LIG_WW_3 812 816 PF00397 0.710
MOD_CDK_SPK_2 191 196 PF00069 0.631
MOD_CDK_SPK_2 441 446 PF00069 0.679
MOD_CDK_SPK_2 89 94 PF00069 0.802
MOD_CDK_SPxxK_3 452 459 PF00069 0.710
MOD_CK1_1 208 214 PF00069 0.759
MOD_CK1_1 218 224 PF00069 0.761
MOD_CK1_1 26 32 PF00069 0.647
MOD_CK1_1 312 318 PF00069 0.708
MOD_CK1_1 373 379 PF00069 0.753
MOD_CK1_1 436 442 PF00069 0.703
MOD_CK1_1 452 458 PF00069 0.574
MOD_CK1_1 608 614 PF00069 0.691
MOD_CK1_1 653 659 PF00069 0.618
MOD_CK1_1 76 82 PF00069 0.758
MOD_CK1_1 785 791 PF00069 0.696
MOD_CK2_1 155 161 PF00069 0.608
MOD_CK2_1 415 421 PF00069 0.767
MOD_CK2_1 475 481 PF00069 0.721
MOD_CK2_1 693 699 PF00069 0.595
MOD_CK2_1 89 95 PF00069 0.804
MOD_GlcNHglycan 15 18 PF01048 0.799
MOD_GlcNHglycan 205 208 PF01048 0.724
MOD_GlcNHglycan 213 216 PF01048 0.718
MOD_GlcNHglycan 267 270 PF01048 0.785
MOD_GlcNHglycan 306 309 PF01048 0.701
MOD_GlcNHglycan 381 384 PF01048 0.794
MOD_GlcNHglycan 428 431 PF01048 0.717
MOD_GlcNHglycan 438 441 PF01048 0.679
MOD_GlcNHglycan 447 450 PF01048 0.553
MOD_GlcNHglycan 515 518 PF01048 0.705
MOD_GlcNHglycan 588 591 PF01048 0.503
MOD_GlcNHglycan 71 74 PF01048 0.698
MOD_GlcNHglycan 723 726 PF01048 0.432
MOD_GlcNHglycan 75 78 PF01048 0.687
MOD_GlcNHglycan 763 766 PF01048 0.692
MOD_GlcNHglycan 805 808 PF01048 0.770
MOD_GSK3_1 19 26 PF00069 0.733
MOD_GSK3_1 205 212 PF00069 0.732
MOD_GSK3_1 232 239 PF00069 0.835
MOD_GSK3_1 253 260 PF00069 0.694
MOD_GSK3_1 270 277 PF00069 0.632
MOD_GSK3_1 422 429 PF00069 0.672
MOD_GSK3_1 441 448 PF00069 0.735
MOD_GSK3_1 46 53 PF00069 0.662
MOD_GSK3_1 475 482 PF00069 0.800
MOD_GSK3_1 622 629 PF00069 0.511
MOD_GSK3_1 69 76 PF00069 0.751
MOD_GSK3_1 775 782 PF00069 0.658
MOD_GSK3_1 89 96 PF00069 0.776
MOD_LATS_1 302 308 PF00433 0.622
MOD_LATS_1 634 640 PF00433 0.444
MOD_N-GLC_1 191 196 PF02516 0.631
MOD_N-GLC_1 208 213 PF02516 0.508
MOD_N-GLC_1 282 287 PF02516 0.781
MOD_N-GLC_1 534 539 PF02516 0.712
MOD_N-GLC_1 637 642 PF02516 0.476
MOD_N-GLC_1 693 698 PF02516 0.512
MOD_N-GLC_1 714 719 PF02516 0.589
MOD_NEK2_1 167 172 PF00069 0.640
MOD_NEK2_1 179 184 PF00069 0.518
MOD_NEK2_1 622 627 PF00069 0.583
MOD_NEK2_1 672 677 PF00069 0.561
MOD_NEK2_1 686 691 PF00069 0.471
MOD_NEK2_1 69 74 PF00069 0.716
MOD_NEK2_1 701 706 PF00069 0.451
MOD_NEK2_1 714 719 PF00069 0.487
MOD_NEK2_1 721 726 PF00069 0.264
MOD_NEK2_1 743 748 PF00069 0.571
MOD_NEK2_2 270 275 PF00069 0.816
MOD_PIKK_1 84 90 PF00454 0.686
MOD_PK_1 650 656 PF00069 0.473
MOD_PK_1 783 789 PF00069 0.732
MOD_PKA_1 262 268 PF00069 0.634
MOD_PKA_1 43 49 PF00069 0.622
MOD_PKA_1 792 798 PF00069 0.695
MOD_PKA_2 262 268 PF00069 0.802
MOD_PKA_2 416 422 PF00069 0.786
MOD_PKA_2 43 49 PF00069 0.622
MOD_PKA_2 622 628 PF00069 0.489
MOD_PKA_2 737 743 PF00069 0.500
MOD_PKA_2 774 780 PF00069 0.724
MOD_PKA_2 782 788 PF00069 0.649
MOD_PKA_2 792 798 PF00069 0.704
MOD_Plk_1 534 540 PF00069 0.627
MOD_Plk_1 637 643 PF00069 0.492
MOD_Plk_1 650 656 PF00069 0.573
MOD_Plk_1 693 699 PF00069 0.458
MOD_Plk_2-3 644 650 PF00069 0.485
MOD_Plk_4 143 149 PF00069 0.664
MOD_Plk_4 167 173 PF00069 0.604
MOD_Plk_4 26 32 PF00069 0.573
MOD_Plk_4 270 276 PF00069 0.677
MOD_Plk_4 287 293 PF00069 0.700
MOD_Plk_4 433 439 PF00069 0.772
MOD_Plk_4 55 61 PF00069 0.695
MOD_Plk_4 562 568 PF00069 0.582
MOD_Plk_4 622 628 PF00069 0.570
MOD_Plk_4 637 643 PF00069 0.389
MOD_Plk_4 64 70 PF00069 0.584
MOD_Plk_4 672 678 PF00069 0.446
MOD_Plk_4 737 743 PF00069 0.482
MOD_Plk_4 93 99 PF00069 0.701
MOD_ProDKin_1 191 197 PF00069 0.690
MOD_ProDKin_1 237 243 PF00069 0.703
MOD_ProDKin_1 250 256 PF00069 0.614
MOD_ProDKin_1 274 280 PF00069 0.730
MOD_ProDKin_1 341 347 PF00069 0.751
MOD_ProDKin_1 386 392 PF00069 0.800
MOD_ProDKin_1 441 447 PF00069 0.744
MOD_ProDKin_1 449 455 PF00069 0.698
MOD_ProDKin_1 46 52 PF00069 0.658
MOD_ProDKin_1 481 487 PF00069 0.714
MOD_ProDKin_1 89 95 PF00069 0.804
MOD_SUMO_rev_2 639 648 PF00179 0.548
TRG_DiLeu_BaLyEn_6 128 133 PF01217 0.567
TRG_DiLeu_BaLyEn_6 697 702 PF01217 0.588
TRG_DiLeu_BaLyEn_6 724 729 PF01217 0.462
TRG_ENDOCYTIC_2 130 133 PF00928 0.577
TRG_ENDOCYTIC_2 296 299 PF00928 0.693
TRG_ENDOCYTIC_2 349 352 PF00928 0.839
TRG_ENDOCYTIC_2 555 558 PF00928 0.629
TRG_ER_diArg_1 100 103 PF00400 0.564
TRG_ER_diArg_1 262 264 PF00400 0.635
TRG_ER_diArg_1 303 305 PF00400 0.738
TRG_ER_diArg_1 329 331 PF00400 0.793
TRG_ER_diArg_1 43 45 PF00400 0.706
TRG_ER_diArg_1 681 684 PF00400 0.490
TRG_ER_diArg_1 818 821 PF00400 0.838
TRG_Pf-PMV_PEXEL_1 131 135 PF00026 0.573
TRG_Pf-PMV_PEXEL_1 184 188 PF00026 0.692
TRG_Pf-PMV_PEXEL_1 459 464 PF00026 0.615

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IB03 Leptomonas seymouri 40% 100%
A4H779 Leishmania braziliensis 64% 100%
A4HVL9 Leishmania infantum 100% 100%
E9APB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%
Q4QG63 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS