Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSI8_LEIDO

TriTrypDb:

LdBPK_130780.1 , LdCL_130013200 , LDHU3_13.0990

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WSI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.581
CLV_NRD_NRD_1	103	105	PF00675	0.529
CLV_NRD_NRD_1	141	143	PF00675	0.537
CLV_NRD_NRD_1	236	238	PF00675	0.502
CLV_NRD_NRD_1	257	259	PF00675	0.456
CLV_NRD_NRD_1	51	53	PF00675	0.589
CLV_NRD_NRD_1	75	77	PF00675	0.551
CLV_PCSK_FUR_1	234	238	PF00082	0.495
CLV_PCSK_KEX2_1	140	142	PF00082	0.577
CLV_PCSK_KEX2_1	236	238	PF00082	0.482
CLV_PCSK_KEX2_1	257	259	PF00082	0.436
CLV_PCSK_KEX2_1	53	55	PF00082	0.543
CLV_PCSK_KEX2_1	75	77	PF00082	0.551
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.534
CLV_PCSK_SKI1_1	113	117	PF00082	0.668
CLV_PCSK_SKI1_1	148	152	PF00082	0.567
CLV_PCSK_SKI1_1	304	308	PF00082	0.567
CLV_Separin_Metazoa	155	159	PF03568	0.608
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.623
DOC_MAPK_MEF2A_6	276	284	PF00069	0.495
DOC_PP4_MxPP_1	88	91	PF00568	0.491
DOC_USP7_MATH_1	310	314	PF00917	0.465
DOC_USP7_MATH_1	48	52	PF00917	0.551
DOC_USP7_UBL2_3	286	290	PF12436	0.511
DOC_WW_Pin1_4	321	326	PF00397	0.731
DOC_WW_Pin1_4	36	41	PF00397	0.614
LIG_14-3-3_CanoR_1	148	157	PF00244	0.576
LIG_14-3-3_CanoR_1	158	168	PF00244	0.627
LIG_14-3-3_CanoR_1	63	68	PF00244	0.524
LIG_APCC_ABBAyCdc20_2	65	71	PF00400	0.426
LIG_BIR_III_2	146	150	PF00653	0.529
LIG_BRCT_BRCA1_1	312	316	PF00533	0.565
LIG_FHA_1	209	215	PF00498	0.425
LIG_FHA_2	149	155	PF00498	0.694
LIG_LIR_Apic_2	6	12	PF02991	0.656
LIG_LIR_Gen_1	131	139	PF02991	0.523
LIG_LIR_Gen_1	189	198	PF02991	0.418
LIG_LIR_Gen_1	202	208	PF02991	0.467
LIG_LIR_Gen_1	313	321	PF02991	0.663
LIG_LIR_Nem_3	131	137	PF02991	0.529
LIG_LIR_Nem_3	189	194	PF02991	0.404
LIG_LIR_Nem_3	202	206	PF02991	0.390
LIG_LIR_Nem_3	313	319	PF02991	0.661
LIG_LIR_Nem_3	62	67	PF02991	0.413
LIG_LIR_Nem_3	71	77	PF02991	0.418
LIG_SH2_CRK	9	13	PF00017	0.574
LIG_SH2_SRC	328	331	PF00017	0.498
LIG_SH2_STAP1	229	233	PF00017	0.499
LIG_SH2_STAT3	229	232	PF00017	0.540
LIG_SH2_STAT5	191	194	PF00017	0.453
LIG_SH2_STAT5	328	331	PF00017	0.517
LIG_SH3_3	154	160	PF00018	0.750
LIG_SH3_3	201	207	PF00018	0.445
LIG_SH3_3	34	40	PF00018	0.616
LIG_TRAF2_1	253	256	PF00917	0.494
LIG_TRAF2_1	324	327	PF00917	0.565
MOD_CK1_1	170	176	PF00069	0.608
MOD_CK1_1	36	42	PF00069	0.568
MOD_CK2_1	148	154	PF00069	0.690
MOD_CK2_1	295	301	PF00069	0.578
MOD_CK2_1	321	327	PF00069	0.573
MOD_GlcNHglycan	113	116	PF01048	0.634
MOD_GlcNHglycan	16	20	PF01048	0.619
MOD_GlcNHglycan	24	27	PF01048	0.587
MOD_GlcNHglycan	271	274	PF01048	0.430
MOD_GlcNHglycan	295	300	PF01048	0.669
MOD_GSK3_1	107	114	PF00069	0.590
MOD_GSK3_1	11	18	PF00069	0.644
MOD_GSK3_1	166	173	PF00069	0.674
MOD_GSK3_1	306	313	PF00069	0.672
MOD_NEK2_1	208	213	PF00069	0.441
MOD_PIKK_1	107	113	PF00454	0.476
MOD_PIKK_1	228	234	PF00454	0.540
MOD_PKA_1	236	242	PF00069	0.548
MOD_PKA_2	236	242	PF00069	0.460
MOD_PKB_1	140	148	PF00069	0.575
MOD_PKB_1	234	242	PF00069	0.546
MOD_Plk_1	208	214	PF00069	0.514
MOD_Plk_4	187	193	PF00069	0.405
MOD_Plk_4	199	205	PF00069	0.351
MOD_ProDKin_1	321	327	PF00069	0.731
MOD_ProDKin_1	36	42	PF00069	0.614
MOD_SUMO_for_1	289	292	PF00179	0.574
MOD_SUMO_rev_2	296	306	PF00179	0.743
TRG_AP2beta_CARGO_1	131	141	PF09066	0.588
TRG_DiLeu_BaEn_1	265	270	PF01217	0.517
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.445
TRG_ENDOCYTIC_2	191	194	PF00928	0.440
TRG_ER_diArg_1	140	142	PF00400	0.491
TRG_ER_diArg_1	233	236	PF00400	0.536
TRG_ER_diArg_1	257	259	PF00400	0.533
TRG_ER_diArg_1	74	76	PF00400	0.560
TRG_ER_diArg_1	98	101	PF00400	0.483
TRG_NLS_MonoExtC_3	51	56	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K8	Leptomonas seymouri	57%	90%
A0A0S4IK25	Bodo saltans	31%	83%
A0A1X0NN31	Trypanosomatidae	43%	100%
A4H777	Leishmania braziliensis	77%	100%
A4HVL7	Leishmania infantum	99%	100%
D0A6N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9APB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QG65	Leishmania major	91%	100%
V5BK51	Trypanosoma cruzi	42%	100%