Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSI1_LEIDO

TriTrypDb:

LdBPK_130860.1 , LdCL_130014000 , LDHU3_13.1080

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.623
CLV_C14_Caspase3-7	439	443	PF00656	0.661
CLV_NRD_NRD_1	3	5	PF00675	0.598
CLV_NRD_NRD_1	336	338	PF00675	0.472
CLV_NRD_NRD_1	58	60	PF00675	0.629
CLV_NRD_NRD_1	610	612	PF00675	0.390
CLV_PCSK_KEX2_1	3	5	PF00082	0.598
CLV_PCSK_KEX2_1	543	545	PF00082	0.380
CLV_PCSK_KEX2_1	58	60	PF00082	0.629
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.380
CLV_PCSK_SKI1_1	215	219	PF00082	0.574
CLV_PCSK_SKI1_1	3	7	PF00082	0.531
CLV_PCSK_SKI1_1	399	403	PF00082	0.564
CLV_PCSK_SKI1_1	578	582	PF00082	0.447
CLV_PCSK_SKI1_1	623	627	PF00082	0.388
CLV_PCSK_SKI1_1	88	92	PF00082	0.531
CLV_Separin_Metazoa	148	152	PF03568	0.413
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DEG_SCF_FBW7_1	401	406	PF00400	0.529
DEG_SCF_FBW7_1	603	610	PF00400	0.429
DEG_SPOP_SBC_1	82	86	PF00917	0.742
DOC_CYCLIN_yCln2_LP_2	46	49	PF00134	0.580
DOC_MAPK_gen_1	310	318	PF00069	0.413
DOC_PP1_RVXF_1	302	309	PF00149	0.366
DOC_PP1_RVXF_1	581	588	PF00149	0.412
DOC_PP2B_LxvP_1	46	49	PF13499	0.605
DOC_PP4_MxPP_1	509	512	PF00568	0.496
DOC_USP7_MATH_1	111	115	PF00917	0.649
DOC_USP7_MATH_1	131	135	PF00917	0.601
DOC_USP7_MATH_1	15	19	PF00917	0.531
DOC_USP7_MATH_1	349	353	PF00917	0.693
DOC_USP7_MATH_1	38	42	PF00917	0.710
DOC_USP7_MATH_1	403	407	PF00917	0.622
DOC_USP7_MATH_1	416	420	PF00917	0.655
DOC_USP7_MATH_1	423	427	PF00917	0.635
DOC_USP7_MATH_1	488	492	PF00917	0.687
DOC_USP7_MATH_1	568	572	PF00917	0.471
DOC_USP7_MATH_1	62	66	PF00917	0.641
DOC_USP7_MATH_1	81	85	PF00917	0.688
DOC_USP7_UBL2_3	211	215	PF12436	0.538
DOC_USP7_UBL2_3	461	465	PF12436	0.533
DOC_WW_Pin1_4	19	24	PF00397	0.784
DOC_WW_Pin1_4	292	297	PF00397	0.428
DOC_WW_Pin1_4	399	404	PF00397	0.518
DOC_WW_Pin1_4	443	448	PF00397	0.613
DOC_WW_Pin1_4	562	567	PF00397	0.437
DOC_WW_Pin1_4	603	608	PF00397	0.441
DOC_WW_Pin1_4	83	88	PF00397	0.748
LIG_14-3-3_CanoR_1	14	20	PF00244	0.584
LIG_14-3-3_CanoR_1	256	266	PF00244	0.425
LIG_14-3-3_CanoR_1	3	12	PF00244	0.530
LIG_14-3-3_CanoR_1	384	392	PF00244	0.583
LIG_14-3-3_CanoR_1	452	460	PF00244	0.508
LIG_14-3-3_CanoR_1	88	97	PF00244	0.537
LIG_AP2alpha_1	572	576	PF02296	0.438
LIG_APCC_ABBA_1	372	377	PF00400	0.579
LIG_APCC_ABBA_1	614	619	PF00400	0.355
LIG_BIR_III_4	357	361	PF00653	0.656
LIG_Clathr_ClatBox_1	522	526	PF01394	0.360
LIG_EVH1_1	510	514	PF00568	0.397
LIG_EVH1_2	530	534	PF00568	0.367
LIG_FHA_1	131	137	PF00498	0.587
LIG_FHA_1	198	204	PF00498	0.621
LIG_FHA_1	367	373	PF00498	0.631
LIG_FHA_1	38	44	PF00498	0.569
LIG_FHA_1	389	395	PF00498	0.551
LIG_FHA_1	396	402	PF00498	0.569
LIG_FHA_1	467	473	PF00498	0.646
LIG_FHA_1	522	528	PF00498	0.559
LIG_FHA_1	608	614	PF00498	0.385
LIG_FHA_2	142	148	PF00498	0.531
LIG_FHA_2	162	168	PF00498	0.272
LIG_FHA_2	374	380	PF00498	0.633
LIG_FHA_2	383	389	PF00498	0.511
LIG_FHA_2	469	475	PF00498	0.589
LIG_GBD_Chelix_1	179	187	PF00786	0.372
LIG_GBD_Chelix_1	569	577	PF00786	0.486
LIG_LIR_Gen_1	500	510	PF02991	0.476
LIG_LIR_Gen_1	549	560	PF02991	0.404
LIG_LIR_Gen_1	571	580	PF02991	0.436
LIG_LIR_Nem_3	500	505	PF02991	0.438
LIG_LIR_Nem_3	539	545	PF02991	0.378
LIG_LIR_Nem_3	549	555	PF02991	0.408
LIG_LIR_Nem_3	571	575	PF02991	0.427
LIG_Pex14_2	534	538	PF04695	0.364
LIG_Pex14_2	572	576	PF04695	0.541
LIG_REV1ctd_RIR_1	573	582	PF16727	0.440
LIG_SH2_CRK	542	546	PF00017	0.381
LIG_SH2_GRB2like	317	320	PF00017	0.418
LIG_SH2_GRB2like	548	551	PF00017	0.417
LIG_SH2_NCK_1	552	556	PF00017	0.394
LIG_SH2_PTP2	502	505	PF00017	0.513
LIG_SH2_STAP1	177	181	PF00017	0.373
LIG_SH2_STAP1	548	552	PF00017	0.417
LIG_SH2_STAT3	617	620	PF00017	0.449
LIG_SH2_STAT5	299	302	PF00017	0.398
LIG_SH2_STAT5	317	320	PF00017	0.418
LIG_SH2_STAT5	335	338	PF00017	0.502
LIG_SH2_STAT5	502	505	PF00017	0.634
LIG_SH2_STAT5	97	100	PF00017	0.673
LIG_SH3_3	508	514	PF00018	0.420
LIG_SH3_3	524	530	PF00018	0.373
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.363
LIG_SUMO_SIM_anti_2	260	267	PF11976	0.473
LIG_SUMO_SIM_anti_2	524	529	PF11976	0.366
LIG_SUMO_SIM_par_1	521	526	PF11976	0.359
LIG_SxIP_EBH_1	259	270	PF03271	0.387
LIG_TRAF2_1	164	167	PF00917	0.409
LIG_TRAF2_1	386	389	PF00917	0.585
LIG_TRAF2_1	491	494	PF00917	0.726
LIG_TRAF2_1	65	68	PF00917	0.686
LIG_TYR_ITAM	539	555	PF00017	0.396
LIG_UBA3_1	276	284	PF00899	0.369
LIG_UBA3_1	307	313	PF00899	0.391
LIG_WRC_WIRS_1	569	574	PF05994	0.373
MOD_CDK_SPK_2	562	567	PF00069	0.437
MOD_CDK_SPK_2	83	88	PF00069	0.544
MOD_CK1_1	242	248	PF00069	0.522
MOD_CK1_1	257	263	PF00069	0.339
MOD_CK1_1	292	298	PF00069	0.410
MOD_CK1_1	36	42	PF00069	0.689
MOD_CK1_1	443	449	PF00069	0.701
MOD_CK1_1	466	472	PF00069	0.637
MOD_CK2_1	161	167	PF00069	0.417
MOD_CK2_1	229	235	PF00069	0.642
MOD_CK2_1	382	388	PF00069	0.643
MOD_CK2_1	468	474	PF00069	0.595
MOD_CK2_1	488	494	PF00069	0.683
MOD_CK2_1	62	68	PF00069	0.611
MOD_GlcNHglycan	121	124	PF01048	0.703
MOD_GlcNHglycan	133	136	PF01048	0.531
MOD_GlcNHglycan	183	186	PF01048	0.363
MOD_GlcNHglycan	29	32	PF01048	0.642
MOD_GlcNHglycan	346	349	PF01048	0.641
MOD_GlcNHglycan	351	354	PF01048	0.608
MOD_GlcNHglycan	40	43	PF01048	0.648
MOD_GlcNHglycan	418	421	PF01048	0.709
MOD_GlcNHglycan	425	428	PF01048	0.635
MOD_GlcNHglycan	429	432	PF01048	0.648
MOD_GlcNHglycan	442	445	PF01048	0.752
MOD_GlcNHglycan	465	468	PF01048	0.609
MOD_GlcNHglycan	515	518	PF01048	0.522
MOD_GlcNHglycan	64	67	PF01048	0.727
MOD_GlcNHglycan	70	73	PF01048	0.716
MOD_GSK3_1	131	138	PF00069	0.576
MOD_GSK3_1	15	22	PF00069	0.542
MOD_GSK3_1	239	246	PF00069	0.555
MOD_GSK3_1	250	257	PF00069	0.624
MOD_GSK3_1	288	295	PF00069	0.430
MOD_GSK3_1	33	40	PF00069	0.614
MOD_GSK3_1	395	402	PF00069	0.557
MOD_GSK3_1	403	410	PF00069	0.610
MOD_GSK3_1	423	430	PF00069	0.732
MOD_GSK3_1	436	443	PF00069	0.592
MOD_GSK3_1	461	468	PF00069	0.578
MOD_GSK3_1	603	610	PF00069	0.429
MOD_GSK3_1	82	89	PF00069	0.660
MOD_N-GLC_1	154	159	PF02516	0.382
MOD_N-GLC_1	288	293	PF02516	0.408
MOD_N-GLC_2	161	163	PF02516	0.429
MOD_NEK2_1	156	161	PF00069	0.397
MOD_NEK2_1	229	234	PF00069	0.518
MOD_NEK2_1	250	255	PF00069	0.451
MOD_NEK2_1	272	277	PF00069	0.392
MOD_NEK2_1	463	468	PF00069	0.660
MOD_NEK2_1	587	592	PF00069	0.430
MOD_NEK2_1	618	623	PF00069	0.390
MOD_NEK2_1	8	13	PF00069	0.564
MOD_PIKK_1	161	167	PF00454	0.396
MOD_PIKK_1	601	607	PF00454	0.539
MOD_PKA_1	3	9	PF00069	0.578
MOD_PKA_2	3	9	PF00069	0.594
MOD_PKA_2	383	389	PF00069	0.614
MOD_PKA_2	423	429	PF00069	0.687
MOD_Plk_1	288	294	PF00069	0.403
MOD_Plk_1	327	333	PF00069	0.426
MOD_Plk_1	388	394	PF00069	0.526
MOD_Plk_4	250	256	PF00069	0.458
MOD_Plk_4	258	264	PF00069	0.389
MOD_Plk_4	272	278	PF00069	0.334
MOD_Plk_4	388	394	PF00069	0.529
MOD_Plk_4	42	48	PF00069	0.600
MOD_Plk_4	497	503	PF00069	0.471
MOD_Plk_4	568	574	PF00069	0.402
MOD_ProDKin_1	19	25	PF00069	0.782
MOD_ProDKin_1	292	298	PF00069	0.421
MOD_ProDKin_1	399	405	PF00069	0.524
MOD_ProDKin_1	443	449	PF00069	0.613
MOD_ProDKin_1	562	568	PF00069	0.439
MOD_ProDKin_1	603	609	PF00069	0.434
MOD_ProDKin_1	83	89	PF00069	0.747
MOD_SUMO_for_1	217	220	PF00179	0.514
MOD_SUMO_rev_2	214	219	PF00179	0.470
MOD_SUMO_rev_2	298	306	PF00179	0.378
MOD_SUMO_rev_2	63	71	PF00179	0.604
TRG_DiLeu_BaEn_1	145	150	PF01217	0.440
TRG_DiLeu_BaEn_1	208	213	PF01217	0.441
TRG_DiLeu_BaEn_2	387	393	PF01217	0.531
TRG_ENDOCYTIC_2	176	179	PF00928	0.357
TRG_ENDOCYTIC_2	502	505	PF00928	0.634
TRG_ENDOCYTIC_2	542	545	PF00928	0.378
TRG_ENDOCYTIC_2	552	555	PF00928	0.394
TRG_ER_diArg_1	2	4	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM83	Leptomonas seymouri	56%	100%
A4H785	Leishmania braziliensis	77%	99%
A4HVM5	Leishmania infantum	100%	100%
E9APC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	97%
Q4QG57	Leishmania major	92%	100%