Putative ACR, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized ACR, COG1678, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSH5_LEIDO

TriTrypDb:

LdBPK_130440.1 , LdCL_130009800 , LDHU3_13.0610

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WSH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.443
CLV_NRD_NRD_1	17	19	PF00675	0.450
CLV_NRD_NRD_1	252	254	PF00675	0.648
CLV_NRD_NRD_1	325	327	PF00675	0.759
CLV_NRD_NRD_1	371	373	PF00675	0.453
CLV_NRD_NRD_1	418	420	PF00675	0.453
CLV_NRD_NRD_1	620	622	PF00675	0.612
CLV_NRD_NRD_1	66	68	PF00675	0.445
CLV_NRD_NRD_1	9	11	PF00675	0.432
CLV_PCSK_FUR_1	617	621	PF00082	0.598
CLV_PCSK_KEX2_1	17	19	PF00082	0.440
CLV_PCSK_KEX2_1	252	254	PF00082	0.640
CLV_PCSK_KEX2_1	325	327	PF00082	0.759
CLV_PCSK_KEX2_1	371	373	PF00082	0.453
CLV_PCSK_KEX2_1	418	420	PF00082	0.453
CLV_PCSK_KEX2_1	616	618	PF00082	0.604
CLV_PCSK_KEX2_1	619	621	PF00082	0.594
CLV_PCSK_KEX2_1	66	68	PF00082	0.445
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.708
CLV_PCSK_PC7_1	367	373	PF00082	0.453
CLV_PCSK_SKI1_1	200	204	PF00082	0.746
CLV_PCSK_SKI1_1	3	7	PF00082	0.452
CLV_PCSK_SKI1_1	367	371	PF00082	0.335
CLV_PCSK_SKI1_1	372	376	PF00082	0.335
CLV_PCSK_SKI1_1	379	383	PF00082	0.335
CLV_PCSK_SKI1_1	58	62	PF00082	0.552
DEG_APCC_DBOX_1	371	379	PF00400	0.453
DEG_APCC_DBOX_1	57	65	PF00400	0.437
DEG_Nend_UBRbox_2	1	3	PF02207	0.489
DEG_SPOP_SBC_1	116	120	PF00917	0.670
DEG_SPOP_SBC_1	206	210	PF00917	0.756
DOC_MAPK_gen_1	352	361	PF00069	0.555
DOC_MAPK_gen_1	371	378	PF00069	0.257
DOC_MAPK_MEF2A_6	145	153	PF00069	0.490
DOC_MAPK_MEF2A_6	262	271	PF00069	0.691
DOC_MAPK_MEF2A_6	352	361	PF00069	0.668
DOC_MAPK_MEF2A_6	371	378	PF00069	0.244
DOC_USP7_MATH_1	108	112	PF00917	0.727
DOC_USP7_MATH_1	117	121	PF00917	0.643
DOC_USP7_MATH_1	131	135	PF00917	0.500
DOC_USP7_MATH_1	206	210	PF00917	0.756
DOC_USP7_MATH_1	277	281	PF00917	0.700
DOC_USP7_MATH_1	317	321	PF00917	0.847
DOC_USP7_MATH_1	329	333	PF00917	0.522
DOC_USP7_MATH_1	431	435	PF00917	0.335
DOC_USP7_MATH_1	456	460	PF00917	0.335
DOC_USP7_MATH_1	516	520	PF00917	0.515
DOC_USP7_MATH_1	550	554	PF00917	0.738
DOC_USP7_MATH_1	641	645	PF00917	0.447
DOC_WW_Pin1_4	167	172	PF00397	0.485
DOC_WW_Pin1_4	572	577	PF00397	0.587
DOC_WW_Pin1_4	606	611	PF00397	0.623
DOC_WW_Pin1_4	69	74	PF00397	0.483
LIG_14-3-3_CanoR_1	145	150	PF00244	0.521
LIG_14-3-3_CanoR_1	244	248	PF00244	0.757
LIG_14-3-3_CanoR_1	325	329	PF00244	0.648
LIG_14-3-3_CanoR_1	371	375	PF00244	0.335
LIG_14-3-3_CanoR_1	379	388	PF00244	0.335
LIG_14-3-3_CanoR_1	640	646	PF00244	0.454
LIG_BRCT_BRCA1_1	56	60	PF00533	0.577
LIG_deltaCOP1_diTrp_1	43	47	PF00928	0.496
LIG_deltaCOP1_diTrp_1	51	60	PF00928	0.479
LIG_FAT_LD_1	467	475	PF03623	0.335
LIG_FHA_1	136	142	PF00498	0.748
LIG_FHA_1	146	152	PF00498	0.503
LIG_FHA_1	156	162	PF00498	0.271
LIG_FHA_1	197	203	PF00498	0.613
LIG_FHA_1	223	229	PF00498	0.596
LIG_FHA_1	371	377	PF00498	0.335
LIG_FHA_1	405	411	PF00498	0.337
LIG_FHA_1	423	429	PF00498	0.466
LIG_FHA_1	82	88	PF00498	0.581
LIG_FHA_2	289	295	PF00498	0.705
LIG_FHA_2	57	63	PF00498	0.558
LIG_LIR_Apic_2	72	78	PF02991	0.499
LIG_LIR_Gen_1	178	189	PF02991	0.578
LIG_LIR_Nem_3	178	184	PF02991	0.576
LIG_LIR_Nem_3	43	47	PF02991	0.511
LIG_LIR_Nem_3	624	628	PF02991	0.642
LIG_LIR_Nem_3	7	12	PF02991	0.432
LIG_Pex14_1	638	642	PF04695	0.431
LIG_REV1ctd_RIR_1	367	376	PF16727	0.335
LIG_SH2_CRK	156	160	PF00017	0.541
LIG_SH2_CRK	642	646	PF00017	0.460
LIG_SH2_CRK	9	13	PF00017	0.411
LIG_SH2_NCK_1	642	646	PF00017	0.578
LIG_SH2_PTP2	75	78	PF00017	0.507
LIG_SH2_SRC	75	78	PF00017	0.619
LIG_SH2_STAP1	37	41	PF00017	0.511
LIG_SH2_STAP1	649	653	PF00017	0.465
LIG_SH2_STAT3	90	93	PF00017	0.465
LIG_SH2_STAT5	189	192	PF00017	0.447
LIG_SH2_STAT5	75	78	PF00017	0.630
LIG_SH3_3	446	452	PF00018	0.453
LIG_SH3_3	642	648	PF00018	0.590
LIG_SH3_3	74	80	PF00018	0.534
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.560
LIG_SUMO_SIM_anti_2	373	378	PF11976	0.335
LIG_SUMO_SIM_anti_2	466	471	PF11976	0.493
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.234
LIG_TRAF2_1	121	124	PF00917	0.710
LIG_TRAF2_1	328	331	PF00917	0.793
LIG_TRAF2_1	336	339	PF00917	0.650
LIG_TRAF2_1	480	483	PF00917	0.453
LIG_TRAF2_2	33	38	PF00917	0.487
LIG_TYR_ITIM	154	159	PF00017	0.544
LIG_WW_2	77	80	PF00397	0.531
MOD_CK1_1	134	140	PF00069	0.621
MOD_CK1_1	157	163	PF00069	0.420
MOD_CK1_1	175	181	PF00069	0.465
MOD_CK1_1	208	214	PF00069	0.737
MOD_CK1_1	258	264	PF00069	0.681
MOD_CK1_1	362	368	PF00069	0.441
MOD_CK1_1	434	440	PF00069	0.335
MOD_CK1_1	512	518	PF00069	0.335
MOD_CK1_1	96	102	PF00069	0.594
MOD_CK2_1	117	123	PF00069	0.793
MOD_CK2_1	209	215	PF00069	0.675
MOD_CK2_1	288	294	PF00069	0.701
MOD_CK2_1	324	330	PF00069	0.750
MOD_CK2_1	333	339	PF00069	0.643
MOD_CK2_1	477	483	PF00069	0.453
MOD_GlcNHglycan	119	122	PF01048	0.668
MOD_GlcNHglycan	133	136	PF01048	0.512
MOD_GlcNHglycan	212	215	PF01048	0.677
MOD_GlcNHglycan	258	261	PF01048	0.656
MOD_GlcNHglycan	291	294	PF01048	0.723
MOD_GlcNHglycan	326	329	PF01048	0.677
MOD_GlcNHglycan	335	338	PF01048	0.755
MOD_GlcNHglycan	384	387	PF01048	0.348
MOD_GlcNHglycan	433	436	PF01048	0.335
MOD_GlcNHglycan	477	482	PF01048	0.339
MOD_GlcNHglycan	511	514	PF01048	0.346
MOD_GlcNHglycan	559	562	PF01048	0.640
MOD_GlcNHglycan	567	570	PF01048	0.660
MOD_GlcNHglycan	572	575	PF01048	0.657
MOD_GlcNHglycan	629	632	PF01048	0.603
MOD_GSK3_1	131	138	PF00069	0.661
MOD_GSK3_1	196	203	PF00069	0.704
MOD_GSK3_1	205	212	PF00069	0.607
MOD_GSK3_1	329	336	PF00069	0.731
MOD_GSK3_1	400	407	PF00069	0.335
MOD_GSK3_1	434	441	PF00069	0.335
MOD_GSK3_1	512	519	PF00069	0.465
MOD_GSK3_1	523	530	PF00069	0.522
MOD_GSK3_1	606	613	PF00069	0.538
MOD_N-GLC_1	175	180	PF02516	0.580
MOD_N-GLC_1	47	52	PF02516	0.526
MOD_N-GLC_1	69	74	PF02516	0.483
MOD_NEK2_1	172	177	PF00069	0.608
MOD_NEK2_1	231	236	PF00069	0.685
MOD_NEK2_1	359	364	PF00069	0.422
MOD_NEK2_1	370	375	PF00069	0.335
MOD_NEK2_1	433	438	PF00069	0.346
MOD_NEK2_1	523	528	PF00069	0.422
MOD_NEK2_1	586	591	PF00069	0.634
MOD_PIKK_1	24	30	PF00454	0.440
MOD_PIKK_1	532	538	PF00454	0.716
MOD_PKA_1	255	261	PF00069	0.660
MOD_PKA_2	144	150	PF00069	0.526
MOD_PKA_2	243	249	PF00069	0.581
MOD_PKA_2	324	330	PF00069	0.645
MOD_PKA_2	370	376	PF00069	0.335
MOD_PKA_2	528	534	PF00069	0.675
MOD_PKB_1	253	261	PF00069	0.654
MOD_Plk_1	19	25	PF00069	0.434
MOD_Plk_1	329	335	PF00069	0.811
MOD_Plk_1	400	406	PF00069	0.335
MOD_Plk_1	438	444	PF00069	0.335
MOD_Plk_1	516	522	PF00069	0.571
MOD_Plk_1	586	592	PF00069	0.635
MOD_Plk_2-3	56	62	PF00069	0.448
MOD_Plk_4	231	237	PF00069	0.559
MOD_Plk_4	422	428	PF00069	0.463
MOD_Plk_4	438	444	PF00069	0.271
MOD_Plk_4	610	616	PF00069	0.535
MOD_Plk_4	634	640	PF00069	0.447
MOD_Plk_4	93	99	PF00069	0.563
MOD_ProDKin_1	167	173	PF00069	0.483
MOD_ProDKin_1	572	578	PF00069	0.589
MOD_ProDKin_1	606	612	PF00069	0.624
MOD_ProDKin_1	69	75	PF00069	0.485
MOD_SUMO_for_1	499	502	PF00179	0.389
MOD_SUMO_for_1	590	593	PF00179	0.623
MOD_SUMO_rev_2	349	357	PF00179	0.671
MOD_SUMO_rev_2	50	55	PF00179	0.611
TRG_DiLeu_BaEn_1	356	361	PF01217	0.574
TRG_DiLeu_BaEn_1	384	389	PF01217	0.453
TRG_DiLeu_BaEn_2	55	61	PF01217	0.571
TRG_DiLeu_BaEn_3	338	344	PF01217	0.672
TRG_ENDOCYTIC_2	156	159	PF00928	0.544
TRG_ENDOCYTIC_2	507	510	PF00928	0.336
TRG_ENDOCYTIC_2	642	645	PF00928	0.462
TRG_ENDOCYTIC_2	649	652	PF00928	0.481
TRG_ENDOCYTIC_2	9	12	PF00928	0.428
TRG_ER_diArg_1	17	19	PF00400	0.440
TRG_ER_diArg_1	252	255	PF00400	0.593
TRG_ER_diArg_1	370	372	PF00400	0.453
TRG_ER_diArg_1	417	419	PF00400	0.453
TRG_ER_diArg_1	617	620	PF00400	0.605
TRG_ER_diArg_1	65	67	PF00400	0.444
TRG_NLS_MonoCore_2	615	620	PF00514	0.705
TRG_NLS_MonoExtC_3	615	620	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM6	Leptomonas seymouri	58%	100%
A4H744	Leishmania braziliensis	80%	98%
A4HVI4	Leishmania infantum	100%	100%
E9AP79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QG99	Leishmania major	93%	100%