Zinc-binding dehydrogenase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WSH2_LEIDO

TriTrypDb:

LdBPK_130610.1 , LdCL_130011500 , LDHU3_13.0800

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSH2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016491	oxidoreductase activity	2	13
GO:0003960	NADPH:quinone reductase activity	5	4
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	3
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	4
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	4
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046914	transition metal ion binding	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.425
CLV_NRD_NRD_1	264	266	PF00675	0.347
CLV_PCSK_KEX2_1	111	113	PF00082	0.464
CLV_PCSK_SKI1_1	112	116	PF00082	0.346
CLV_PCSK_SKI1_1	184	188	PF00082	0.331
CLV_PCSK_SKI1_1	38	42	PF00082	0.464
CLV_PCSK_SKI1_1	87	91	PF00082	0.310
DOC_CYCLIN_RxL_1	240	251	PF00134	0.228
DOC_MAPK_gen_1	119	129	PF00069	0.352
DOC_MAPK_gen_1	265	272	PF00069	0.294
DOC_MAPK_MEF2A_6	122	129	PF00069	0.347
DOC_MAPK_MEF2A_6	265	272	PF00069	0.347
DOC_MAPK_MEF2A_6	333	342	PF00069	0.306
DOC_MAPK_NFAT4_5	122	130	PF00069	0.320
DOC_PP4_FxxP_1	282	285	PF00568	0.280
DOC_USP7_MATH_1	22	26	PF00917	0.482
DOC_USP7_MATH_1	222	226	PF00917	0.251
DOC_USP7_UBL2_3	333	337	PF12436	0.309
DOC_WW_Pin1_4	178	183	PF00397	0.352
LIG_14-3-3_CanoR_1	243	248	PF00244	0.364
LIG_Actin_WH2_2	75	92	PF00022	0.368
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_BIR_III_3	1	5	PF00653	0.484
LIG_BRCT_BRCA1_1	16	20	PF00533	0.387
LIG_BRCT_BRCA1_1	279	283	PF00533	0.344
LIG_CtBP_PxDLS_1	126	130	PF00389	0.265
LIG_deltaCOP1_diTrp_1	327	330	PF00928	0.409
LIG_FHA_1	131	137	PF00498	0.338
LIG_FHA_1	187	193	PF00498	0.421
LIG_FHA_1	279	285	PF00498	0.301
LIG_FHA_1	55	61	PF00498	0.368
LIG_LIR_Apic_2	280	285	PF02991	0.254
LIG_LIR_Gen_1	104	114	PF02991	0.302
LIG_LIR_Gen_1	220	231	PF02991	0.406
LIG_LIR_Gen_1	320	330	PF02991	0.402
LIG_LIR_Nem_3	104	109	PF02991	0.281
LIG_LIR_Nem_3	123	127	PF02991	0.454
LIG_LIR_Nem_3	17	23	PF02991	0.402
LIG_LIR_Nem_3	220	226	PF02991	0.406
LIG_LIR_Nem_3	315	319	PF02991	0.398
LIG_LIR_Nem_3	320	326	PF02991	0.399
LIG_LIR_Nem_3	7	11	PF02991	0.439
LIG_LIR_Nem_3	97	103	PF02991	0.282
LIG_LYPXL_SIV_4	222	230	PF13949	0.368
LIG_MLH1_MIPbox_1	279	283	PF16413	0.368
LIG_PDZ_Class_2	337	342	PF00595	0.282
LIG_Pex14_2	283	287	PF04695	0.389
LIG_Pex14_2	69	73	PF04695	0.280
LIG_SH2_CRK	106	110	PF00017	0.292
LIG_SH2_CRK	290	294	PF00017	0.411
LIG_SH2_NCK_1	223	227	PF00017	0.280
LIG_SH2_NCK_1	323	327	PF00017	0.403
LIG_SH2_STAT5	124	127	PF00017	0.389
LIG_SH2_STAT5	46	49	PF00017	0.368
LIG_SH3_3	138	144	PF00018	0.343
LIG_SH3_3	24	30	PF00018	0.480
LIG_SH3_3	62	68	PF00018	0.331
LIG_SUMO_SIM_par_1	125	130	PF11976	0.266
LIG_SUMO_SIM_par_1	78	84	PF11976	0.310
LIG_TYR_ITIM	221	226	PF00017	0.299
LIG_TYR_ITSM	102	109	PF00017	0.223
LIG_WRC_WIRS_1	279	284	PF05994	0.251
MOD_CDC14_SPxK_1	181	184	PF00782	0.275
MOD_CDK_SPxK_1	178	184	PF00069	0.275
MOD_CK1_1	130	136	PF00069	0.330
MOD_CK1_1	180	186	PF00069	0.368
MOD_CK1_1	278	284	PF00069	0.313
MOD_CK2_1	22	28	PF00069	0.478
MOD_GlcNHglycan	128	132	PF01048	0.349
MOD_GlcNHglycan	275	278	PF01048	0.269
MOD_GlcNHglycan	83	86	PF01048	0.373
MOD_GSK3_1	171	178	PF00069	0.332
MOD_GSK3_1	273	280	PF00069	0.338
MOD_N-GLC_1	49	54	PF02516	0.280
MOD_NEK2_1	127	132	PF00069	0.267
MOD_NEK2_1	188	193	PF00069	0.453
MOD_NEK2_1	273	278	PF00069	0.314
MOD_OFUCOSY	173	179	PF10250	0.359
MOD_PIKK_1	94	100	PF00454	0.312
MOD_PK_1	217	223	PF00069	0.181
MOD_PKA_2	254	260	PF00069	0.370
MOD_PKB_1	241	249	PF00069	0.234
MOD_Plk_4	171	177	PF00069	0.313
MOD_Plk_4	22	28	PF00069	0.448
MOD_Plk_4	278	284	PF00069	0.289
MOD_ProDKin_1	178	184	PF00069	0.352
MOD_SUMO_rev_2	84	91	PF00179	0.368
TRG_ENDOCYTIC_2	100	103	PF00928	0.332
TRG_ENDOCYTIC_2	106	109	PF00928	0.320
TRG_ENDOCYTIC_2	124	127	PF00928	0.441
TRG_ENDOCYTIC_2	223	226	PF00928	0.303
TRG_ENDOCYTIC_2	290	293	PF00928	0.440
TRG_ENDOCYTIC_2	323	326	PF00928	0.398
TRG_ENDOCYTIC_2	46	49	PF00928	0.408
TRG_ENDOCYTIC_2	8	11	PF00928	0.346
TRG_ER_diArg_1	240	243	PF00400	0.234

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I0	Leptomonas seymouri	40%	100%
A0A0N0P5I8	Leptomonas seymouri	28%	92%
A0A0N0P7C5	Leptomonas seymouri	75%	100%
A0A0N1I913	Leptomonas seymouri	38%	99%
A0A0N1PB21	Leptomonas seymouri	28%	99%
A0A0S4ILS9	Bodo saltans	29%	100%
A0A0S4IUY2	Bodo saltans	30%	100%
A0A0S4JMB1	Bodo saltans	52%	98%
A0A0S4KHW9	Bodo saltans	29%	100%
A0A1W5SKT4	Aspergillus terreus	28%	96%
A0A1X0P0B2	Trypanosomatidae	51%	100%
A0A1X0P8R2	Trypanosomatidae	28%	100%
A0A3Q8IRG0	Leishmania donovani	43%	100%
A0A3R7L374	Trypanosoma rangeli	32%	100%
A0A422NF38	Trypanosoma rangeli	24%	100%
A0A422NKE0	Trypanosoma rangeli	55%	100%
A0A451EJQ8	Leishmania donovani	31%	100%
A4H3L9	Leishmania braziliensis	31%	100%
A4H761	Leishmania braziliensis	89%	100%
A4HPT6	Leishmania braziliensis	42%	99%
A4HVK0	Leishmania infantum	100%	100%
A4IE56	Leishmania infantum	42%	100%
A6QQF5	Bos taurus	28%	98%
A7RK30	Nematostella vectensis	28%	94%
B0BNC9	Rattus norvegicus	28%	98%
D0A480	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ACK2	Leishmania major	31%	100%
E9AG46	Leishmania infantum	31%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AP96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
O23939	Fragaria vesca	24%	100%
O34812	Bacillus subtilis (strain 168)	29%	100%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	99%
O97764	Bos taurus	28%	100%
P11415	Cavia porcellus	27%	100%
P19333	Tetronarce californica	27%	90%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	30%	100%
P42865	Leishmania amazonensis	42%	100%
P47199	Mus musculus	26%	100%
P76113	Escherichia coli (strain K12)	27%	99%
P97584	Rattus norvegicus	26%	100%
Q0CJC5	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	28%	96%
Q24K16	Bos taurus	42%	91%
Q39173	Arabidopsis thaliana	29%	100%
Q3MIE4	Rattus norvegicus	29%	85%
Q3UNZ8	Mus musculus	28%	98%
Q4Q0Z7	Leishmania major	43%	100%
Q4QG82	Leishmania major	96%	100%
Q53FA7	Homo sapiens	28%	100%
Q54YT4	Dictyostelium discoideum	26%	98%
Q59I44	Burkholderia sp.	31%	100%
Q62465	Mus musculus	29%	84%
Q6AYT0	Rattus norvegicus	26%	100%
Q6WAU0	Mentha piperita	32%	100%
Q7T3C7	Danio rerio	25%	88%
Q7YS70	Bos taurus	26%	92%
Q80TB8	Mus musculus	23%	82%
Q8BGC4	Mus musculus	42%	91%
Q8JFV8	Danio rerio	28%	71%
Q8LCU7	Arabidopsis thaliana	24%	91%
Q8N4Q0	Homo sapiens	40%	91%
Q8WZM3	Candida tropicalis	24%	89%
Q8WZM4	Candida tropicalis	25%	89%
Q91YR9	Mus musculus	27%	100%
Q99536	Homo sapiens	30%	87%
Q9C0Y6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	98%
Q9HCJ6	Homo sapiens	24%	82%
Q9SLN8	Nicotiana tabacum	29%	100%
Q9SV68	Arabidopsis thaliana	26%	100%
Q9V6U9	Drosophila melanogaster	24%	96%
Q9Z311	Rattus norvegicus	26%	92%
Q9ZUC1	Arabidopsis thaliana	24%	89%
V5BXF0	Trypanosoma cruzi	32%	100%