Dual specificity phosphatase, catalytic domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase, catalytic domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSG2_LEIDO

TriTrypDb:

LdBPK_130660.1 , LdCL_130012000 , LDHU3_13.0850

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSG2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.653
CLV_NRD_NRD_1	357	359	PF00675	0.472
CLV_NRD_NRD_1	536	538	PF00675	0.508
CLV_NRD_NRD_1	64	66	PF00675	0.524
CLV_PCSK_FUR_1	355	359	PF00082	0.464
CLV_PCSK_KEX2_1	357	359	PF00082	0.499
CLV_PCSK_KEX2_1	536	538	PF00082	0.508
CLV_PCSK_KEX2_1	66	68	PF00082	0.533
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.572
CLV_PCSK_PC7_1	62	68	PF00082	0.585
CLV_PCSK_SKI1_1	109	113	PF00082	0.504
CLV_PCSK_SKI1_1	121	125	PF00082	0.581
CLV_PCSK_SKI1_1	201	205	PF00082	0.483
CLV_PCSK_SKI1_1	294	298	PF00082	0.609
CLV_PCSK_SKI1_1	357	361	PF00082	0.503
CLV_PCSK_SKI1_1	416	420	PF00082	0.601
CLV_PCSK_SKI1_1	67	71	PF00082	0.537
CLV_PCSK_SKI1_1	72	76	PF00082	0.570
DEG_APCC_DBOX_1	108	116	PF00400	0.500
DEG_Nend_Nbox_1	1	3	PF02207	0.574
DOC_CKS1_1	359	364	PF01111	0.415
DOC_CKS1_1	541	546	PF01111	0.546
DOC_CYCLIN_RxL_1	62	73	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	461	467	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	541	547	PF00134	0.551
DOC_MAPK_gen_1	62	71	PF00069	0.539
DOC_MAPK_HePTP_8	515	527	PF00069	0.430
DOC_MAPK_MEF2A_6	518	527	PF00069	0.424
DOC_MAPK_RevD_3	52	67	PF00069	0.476
DOC_PP2B_LxvP_1	461	464	PF13499	0.469
DOC_USP7_MATH_1	147	151	PF00917	0.676
DOC_USP7_MATH_1	152	156	PF00917	0.724
DOC_USP7_MATH_1	194	198	PF00917	0.498
DOC_USP7_MATH_1	215	219	PF00917	0.485
DOC_USP7_MATH_1	243	247	PF00917	0.548
DOC_USP7_MATH_1	311	315	PF00917	0.614
DOC_USP7_MATH_1	495	499	PF00917	0.552
DOC_USP7_MATH_1	81	85	PF00917	0.604
DOC_WW_Pin1_4	187	192	PF00397	0.573
DOC_WW_Pin1_4	210	215	PF00397	0.587
DOC_WW_Pin1_4	25	30	PF00397	0.550
DOC_WW_Pin1_4	298	303	PF00397	0.521
DOC_WW_Pin1_4	324	329	PF00397	0.485
DOC_WW_Pin1_4	358	363	PF00397	0.427
DOC_WW_Pin1_4	402	407	PF00397	0.607
DOC_WW_Pin1_4	474	479	PF00397	0.384
DOC_WW_Pin1_4	540	545	PF00397	0.701
DOC_WW_Pin1_4	8	13	PF00397	0.462
DOC_WW_Pin1_4	83	88	PF00397	0.614
DOC_WW_Pin1_4	93	98	PF00397	0.650
LIG_14-3-3_CanoR_1	109	115	PF00244	0.503
LIG_14-3-3_CanoR_1	121	126	PF00244	0.583
LIG_14-3-3_CanoR_1	227	231	PF00244	0.560
LIG_14-3-3_CanoR_1	357	362	PF00244	0.495
LIG_14-3-3_CanoR_1	420	430	PF00244	0.461
LIG_14-3-3_CanoR_1	494	504	PF00244	0.513
LIG_14-3-3_CanoR_1	536	540	PF00244	0.435
LIG_14-3-3_CanoR_1	82	89	PF00244	0.601
LIG_Actin_WH2_2	263	281	PF00022	0.478
LIG_Actin_WH2_2	419	437	PF00022	0.412
LIG_Actin_WH2_2	479	496	PF00022	0.454
LIG_BRCT_BRCA1_1	306	310	PF00533	0.545
LIG_Clathr_ClatBox_1	483	487	PF01394	0.375
LIG_CSL_BTD_1	144	147	PF09270	0.641
LIG_FHA_1	103	109	PF00498	0.575
LIG_FHA_1	331	337	PF00498	0.435
LIG_FHA_1	358	364	PF00498	0.434
LIG_FHA_1	380	386	PF00498	0.411
LIG_FHA_1	9	15	PF00498	0.452
LIG_FHA_2	349	355	PF00498	0.454
LIG_FHA_2	4	10	PF00498	0.501
LIG_GBD_Chelix_1	284	292	PF00786	0.419
LIG_LIR_Gen_1	104	115	PF02991	0.565
LIG_LIR_Gen_1	407	415	PF02991	0.402
LIG_LIR_Nem_3	104	110	PF02991	0.570
LIG_LIR_Nem_3	407	412	PF02991	0.434
LIG_LIR_Nem_3	505	510	PF02991	0.408
LIG_NRBOX	287	293	PF00104	0.438
LIG_NRBOX	53	59	PF00104	0.513
LIG_SH2_CRK	339	343	PF00017	0.483
LIG_SH2_CRK	507	511	PF00017	0.334
LIG_SH2_STAT3	161	164	PF00017	0.536
LIG_SH3_2	544	549	PF14604	0.585
LIG_SH3_3	141	147	PF00018	0.602
LIG_SH3_3	296	302	PF00018	0.530
LIG_SH3_3	374	380	PF00018	0.451
LIG_SH3_3	444	450	PF00018	0.740
LIG_SH3_3	541	547	PF00018	0.723
LIG_SH3_3	91	97	PF00018	0.604
LIG_SUMO_SIM_par_1	206	213	PF11976	0.423
LIG_TYR_ITIM	483	488	PF00017	0.368
LIG_UBA3_1	70	75	PF00899	0.558
LIG_WW_3	79	83	PF00397	0.616
MOD_CDC14_SPxK_1	546	549	PF00782	0.591
MOD_CDK_SPxK_1	543	549	PF00069	0.578
MOD_CK1_1	150	156	PF00069	0.593
MOD_CK1_1	218	224	PF00069	0.464
MOD_CK1_1	229	235	PF00069	0.607
MOD_CK1_1	28	34	PF00069	0.639
MOD_CK1_1	399	405	PF00069	0.592
MOD_CK2_1	348	354	PF00069	0.462
MOD_CK2_1	495	501	PF00069	0.482
MOD_GlcNHglycan	149	152	PF01048	0.601
MOD_GlcNHglycan	154	157	PF01048	0.569
MOD_GlcNHglycan	254	257	PF01048	0.504
MOD_GlcNHglycan	30	33	PF01048	0.569
MOD_GlcNHglycan	313	316	PF01048	0.633
MOD_GlcNHglycan	402	405	PF01048	0.575
MOD_GlcNHglycan	497	500	PF01048	0.545
MOD_GlcNHglycan	527	530	PF01048	0.512
MOD_GlcNHglycan	76	79	PF01048	0.709
MOD_GlcNHglycan	83	86	PF01048	0.619
MOD_GlcNHglycan	97	100	PF01048	0.515
MOD_GSK3_1	146	153	PF00069	0.721
MOD_GSK3_1	19	26	PF00069	0.502
MOD_GSK3_1	190	197	PF00069	0.630
MOD_GSK3_1	225	232	PF00069	0.512
MOD_GSK3_1	294	301	PF00069	0.472
MOD_GSK3_1	3	10	PF00069	0.508
MOD_GSK3_1	305	312	PF00069	0.629
MOD_GSK3_1	379	386	PF00069	0.519
MOD_GSK3_1	392	399	PF00069	0.432
MOD_GSK3_1	472	479	PF00069	0.395
MOD_GSK3_1	70	77	PF00069	0.574
MOD_GSK3_1	81	88	PF00069	0.595
MOD_N-GLC_1	134	139	PF02516	0.578
MOD_N-GLC_2	524	526	PF02516	0.437
MOD_NEK2_1	110	115	PF00069	0.498
MOD_NEK2_1	192	197	PF00069	0.517
MOD_NEK2_1	305	310	PF00069	0.622
MOD_NEK2_1	400	405	PF00069	0.602
MOD_NEK2_1	429	434	PF00069	0.477
MOD_NEK2_1	472	477	PF00069	0.408
MOD_NEK2_1	53	58	PF00069	0.442
MOD_NEK2_1	7	12	PF00069	0.535
MOD_NEK2_1	70	75	PF00069	0.593
MOD_NEK2_2	102	107	PF00069	0.541
MOD_NEK2_2	194	199	PF00069	0.468
MOD_PIKK_1	379	385	PF00454	0.460
MOD_PIKK_1	434	440	PF00454	0.487
MOD_PIKK_1	455	461	PF00454	0.558
MOD_PIKK_1	488	494	PF00454	0.348
MOD_PK_1	476	482	PF00069	0.370
MOD_PKA_1	357	363	PF00069	0.451
MOD_PKA_2	226	232	PF00069	0.564
MOD_PKA_2	3	9	PF00069	0.537
MOD_PKA_2	357	363	PF00069	0.494
MOD_PKA_2	535	541	PF00069	0.433
MOD_PKA_2	81	87	PF00069	0.623
MOD_PKB_1	355	363	PF00069	0.452
MOD_Plk_1	134	140	PF00069	0.535
MOD_Plk_1	218	224	PF00069	0.409
MOD_Plk_1	317	323	PF00069	0.596
MOD_Plk_1	330	336	PF00069	0.383
MOD_Plk_4	102	108	PF00069	0.553
MOD_Plk_4	110	116	PF00069	0.465
MOD_Plk_4	476	482	PF00069	0.370
MOD_Plk_4	53	59	PF00069	0.458
MOD_Plk_4	530	536	PF00069	0.380
MOD_ProDKin_1	187	193	PF00069	0.570
MOD_ProDKin_1	210	216	PF00069	0.583
MOD_ProDKin_1	25	31	PF00069	0.554
MOD_ProDKin_1	298	304	PF00069	0.530
MOD_ProDKin_1	324	330	PF00069	0.474
MOD_ProDKin_1	358	364	PF00069	0.424
MOD_ProDKin_1	402	408	PF00069	0.607
MOD_ProDKin_1	474	480	PF00069	0.381
MOD_ProDKin_1	540	546	PF00069	0.709
MOD_ProDKin_1	8	14	PF00069	0.459
MOD_ProDKin_1	83	89	PF00069	0.614
MOD_ProDKin_1	93	99	PF00069	0.644
TRG_DiLeu_BaEn_1	425	430	PF01217	0.431
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.429
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.415
TRG_ENDOCYTIC_2	339	342	PF00928	0.483
TRG_ENDOCYTIC_2	485	488	PF00928	0.388
TRG_ENDOCYTIC_2	507	510	PF00928	0.335
TRG_ER_diArg_1	355	358	PF00400	0.470
TRG_ER_diArg_1	535	537	PF00400	0.448
TRG_NLS_MonoExtN_4	62	69	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI5	Leptomonas seymouri	29%	93%
A4H766	Leishmania braziliensis	69%	100%
A4HVK5	Leishmania infantum	99%	100%
E9APA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QG77	Leishmania major	90%	100%