Glucosamine 6-phosphate N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actyltransferase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WSF7_LEIDO

TriTrypDb:

LdBPK_130500.1 , LdCL_130010400 , LDHU3_13.0670

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSF7

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	7
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	7
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009225	nucleotide-sugar metabolic process	4	7
GO:0009226	nucleotide-sugar biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0046349	amino sugar biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	7	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.554
CLV_NRD_NRD_1	177	179	PF00675	0.450
CLV_PCSK_FUR_1	175	179	PF00082	0.413
CLV_PCSK_KEX2_1	132	134	PF00082	0.595
CLV_PCSK_KEX2_1	177	179	PF00082	0.450
CLV_PCSK_SKI1_1	116	120	PF00082	0.457
CLV_PCSK_SKI1_1	164	168	PF00082	0.528
CLV_PCSK_SKI1_1	222	226	PF00082	0.457
CLV_PCSK_SKI1_1	228	232	PF00082	0.361
CLV_PCSK_SKI1_1	42	46	PF00082	0.412
CLV_PCSK_SKI1_1	59	63	PF00082	0.412
DOC_CKS1_1	258	263	PF01111	0.416
DOC_MAPK_gen_1	250	258	PF00069	0.595
DOC_PP4_FxxP_1	79	82	PF00568	0.556
DOC_USP7_UBL2_3	38	42	PF12436	0.408
DOC_WW_Pin1_4	245	250	PF00397	0.513
DOC_WW_Pin1_4	257	262	PF00397	0.429
LIG_14-3-3_CanoR_1	164	169	PF00244	0.509
LIG_14-3-3_CanoR_1	228	234	PF00244	0.446
LIG_Actin_WH2_2	104	121	PF00022	0.426
LIG_APCC_ABBA_1	70	75	PF00400	0.485
LIG_APCC_ABBAyCdc20_2	69	75	PF00400	0.401
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BRCT_BRCA1_1	237	241	PF00533	0.557
LIG_eIF4E_1	163	169	PF01652	0.446
LIG_eIF4E_1	98	104	PF01652	0.369
LIG_FHA_1	258	264	PF00498	0.403
LIG_FHA_1	61	67	PF00498	0.362
LIG_FHA_2	246	252	PF00498	0.566
LIG_GBD_Chelix_1	95	103	PF00786	0.418
LIG_LIR_Apic_2	76	82	PF02991	0.553
LIG_LIR_Gen_1	22	31	PF02991	0.460
LIG_LIR_Gen_1	232	241	PF02991	0.429
LIG_LIR_Gen_1	46	55	PF02991	0.588
LIG_LIR_Nem_3	22	28	PF02991	0.480
LIG_LIR_Nem_3	232	236	PF02991	0.412
LIG_LIR_Nem_3	43	48	PF02991	0.568
LIG_LIR_Nem_3	49	54	PF02991	0.500
LIG_LIR_Nem_3	86	91	PF02991	0.399
LIG_Pex14_1	229	233	PF04695	0.349
LIG_Pex14_2	225	229	PF04695	0.537
LIG_SH2_CRK	233	237	PF00017	0.481
LIG_SH2_GRB2like	98	101	PF00017	0.337
LIG_SH2_NCK_1	242	246	PF00017	0.549
LIG_SH2_STAP1	101	105	PF00017	0.353
LIG_SH2_STAT5	242	245	PF00017	0.455
LIG_SH2_STAT5	247	250	PF00017	0.502
LIG_SH2_STAT5	48	51	PF00017	0.395
LIG_SH2_STAT5	98	101	PF00017	0.360
LIG_SH3_4	151	158	PF00018	0.656
LIG_SH3_4	38	45	PF00018	0.394
LIG_SxIP_EBH_1	162	175	PF03271	0.491
LIG_TYR_ITIM	231	236	PF00017	0.364
MOD_CDK_SPK_2	245	250	PF00069	0.488
MOD_CK1_1	150	156	PF00069	0.662
MOD_CK1_1	180	186	PF00069	0.629
MOD_CK1_1	65	71	PF00069	0.508
MOD_GlcNHglycan	124	128	PF01048	0.517
MOD_GlcNHglycan	152	155	PF01048	0.671
MOD_GlcNHglycan	202	205	PF01048	0.382
MOD_GSK3_1	143	150	PF00069	0.683
MOD_GSK3_1	46	53	PF00069	0.414
MOD_N-GLC_1	99	104	PF02516	0.313
MOD_NEK2_1	1	6	PF00069	0.714
MOD_NEK2_1	117	122	PF00069	0.606
MOD_NEK2_1	123	128	PF00069	0.528
MOD_NEK2_1	62	67	PF00069	0.507
MOD_NEK2_1	99	104	PF00069	0.322
MOD_NEK2_2	154	159	PF00069	0.655
MOD_NEK2_2	170	175	PF00069	0.322
MOD_PKA_1	177	183	PF00069	0.581
MOD_PKA_2	177	183	PF00069	0.581
MOD_PKB_1	175	183	PF00069	0.563
MOD_Plk_1	99	105	PF00069	0.313
MOD_Plk_4	164	170	PF00069	0.511
MOD_Plk_4	46	52	PF00069	0.398
MOD_Plk_4	99	105	PF00069	0.325
MOD_ProDKin_1	245	251	PF00069	0.528
MOD_ProDKin_1	257	263	PF00069	0.413
MOD_SUMO_for_1	193	196	PF00179	0.456
MOD_SUMO_rev_2	53	61	PF00179	0.390
TRG_DiLeu_BaEn_1	107	112	PF01217	0.408
TRG_DiLeu_BaEn_1	30	35	PF01217	0.390
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.448
TRG_ENDOCYTIC_2	101	104	PF00928	0.384
TRG_ENDOCYTIC_2	233	236	PF00928	0.395
TRG_ENDOCYTIC_2	48	51	PF00928	0.413
TRG_ER_diArg_1	174	177	PF00400	0.404
TRG_ER_diArg_1	66	69	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B9	Leptomonas seymouri	58%	100%
A4H750	Leishmania braziliensis	67%	100%
A4HVJ0	Leishmania infantum	100%	100%
E9AP85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
Q4QG93	Leishmania major	92%	100%