LeishMANIAdb
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Coiled-coil domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Coiled-coil domain-containing protein
Gene product:
Protein of unknown function (DUF1014), putative
Species:
Leishmania donovani
UniProt:
A0A3S7WSF4_LEIDO
TriTrypDb:
LdBPK_130410.1 , LdCL_130009500 , LDHU3_13.0570
Length:
278

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 161

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7WSF4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSF4

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006351 DNA-templated transcription 7 1
GO:0006366 transcription by RNA polymerase II 8 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0018130 heterocycle biosynthetic process 4 1
GO:0019438 aromatic compound biosynthetic process 4 1
GO:0032774 RNA biosynthetic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034654 nucleobase-containing compound biosynthetic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:0097659 nucleic acid-templated transcription 6 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901362 organic cyclic compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 1
GO:0003713 transcription coactivator activity 3 1
GO:0140110 transcription regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 182 186 PF00656 0.561
CLV_NRD_NRD_1 216 218 PF00675 0.286
CLV_NRD_NRD_1 25 27 PF00675 0.644
CLV_NRD_NRD_1 252 254 PF00675 0.540
CLV_PCSK_KEX2_1 191 193 PF00082 0.275
CLV_PCSK_KEX2_1 216 218 PF00082 0.275
CLV_PCSK_KEX2_1 25 27 PF00082 0.637
CLV_PCSK_KEX2_1 252 254 PF00082 0.542
CLV_PCSK_KEX2_1 56 58 PF00082 0.554
CLV_PCSK_KEX2_1 73 75 PF00082 0.529
CLV_PCSK_PC1ET2_1 191 193 PF00082 0.287
CLV_PCSK_PC1ET2_1 56 58 PF00082 0.600
CLV_PCSK_PC1ET2_1 73 75 PF00082 0.451
CLV_PCSK_PC7_1 187 193 PF00082 0.275
CLV_PCSK_PC7_1 21 27 PF00082 0.642
CLV_PCSK_PC7_1 69 75 PF00082 0.661
CLV_PCSK_SKI1_1 112 116 PF00082 0.651
CLV_PCSK_SKI1_1 143 147 PF00082 0.662
CLV_PCSK_SKI1_1 191 195 PF00082 0.380
CLV_PCSK_SKI1_1 48 52 PF00082 0.535
DOC_USP7_MATH_1 133 137 PF00917 0.699
DOC_USP7_UBL2_3 194 198 PF12436 0.582
DOC_USP7_UBL2_3 274 278 PF12436 0.729
DOC_USP7_UBL2_3 48 52 PF12436 0.538
DOC_USP7_UBL2_3 62 66 PF12436 0.533
DOC_USP7_UBL2_3 87 91 PF12436 0.601
DOC_USP7_UBL2_3 99 103 PF12436 0.492
DOC_WW_Pin1_4 228 233 PF00397 0.500
LIG_14-3-3_CanoR_1 13 20 PF00244 0.623
LIG_14-3-3_CanoR_1 143 148 PF00244 0.589
LIG_14-3-3_CanoR_1 216 224 PF00244 0.501
LIG_14-3-3_CanoR_1 41 49 PF00244 0.575
LIG_Actin_WH2_2 201 218 PF00022 0.573
LIG_deltaCOP1_diTrp_1 222 228 PF00928 0.476
LIG_EH_1 233 237 PF12763 0.487
LIG_FHA_1 238 244 PF00498 0.461
LIG_FHA_2 161 167 PF00498 0.497
LIG_LIR_Gen_1 218 227 PF02991 0.512
LIG_LIR_Nem_3 218 223 PF02991 0.512
LIG_PCNA_yPIPBox_3 216 228 PF02747 0.487
LIG_PCNA_yPIPBox_3 91 105 PF02747 0.515
LIG_SH2_GRB2like 10 13 PF00017 0.633
LIG_SH2_STAP1 201 205 PF00017 0.541
LIG_SH2_STAT5 10 13 PF00017 0.633
LIG_SH3_3 120 126 PF00018 0.652
LIG_SH3_3 229 235 PF00018 0.500
LIG_SH3_3 83 89 PF00018 0.598
LIG_TRAF2_1 151 154 PF00917 0.630
LIG_TYR_ITSM 216 223 PF00017 0.580
LIG_UBA3_1 223 230 PF00899 0.500
MOD_CK2_1 256 262 PF00069 0.739
MOD_CMANNOS 225 228 PF00535 0.275
MOD_Cter_Amidation 189 192 PF01082 0.275
MOD_GlcNHglycan 135 138 PF01048 0.637
MOD_GlcNHglycan 160 163 PF01048 0.307
MOD_GlcNHglycan 177 180 PF01048 0.242
MOD_GlcNHglycan 2 5 PF01048 0.590
MOD_GSK3_1 154 161 PF00069 0.379
MOD_N-GLC_1 175 180 PF02516 0.383
MOD_NEK2_1 215 220 PF00069 0.487
MOD_PIKK_1 215 221 PF00454 0.477
MOD_PKA_2 12 18 PF00069 0.614
MOD_PKA_2 215 221 PF00069 0.500
MOD_PKA_2 40 46 PF00069 0.658
MOD_PKB_1 141 149 PF00069 0.525
MOD_Plk_1 110 116 PF00069 0.568
MOD_Plk_2-3 256 262 PF00069 0.667
MOD_ProDKin_1 228 234 PF00069 0.500
MOD_SUMO_for_1 124 127 PF00179 0.749
MOD_SUMO_for_1 208 211 PF00179 0.536
MOD_SUMO_rev_2 43 50 PF00179 0.529
MOD_SUMO_rev_2 58 68 PF00179 0.446
TRG_ENDOCYTIC_2 197 200 PF00928 0.468
TRG_ENDOCYTIC_2 220 223 PF00928 0.496
TRG_ER_diArg_1 215 217 PF00400 0.500
TRG_ER_diArg_1 25 27 PF00400 0.644
TRG_ER_diArg_1 252 254 PF00400 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1R4 Leptomonas seymouri 69% 100%
A0A0S4JL95 Bodo saltans 45% 100%
A0A1X0NNI4 Trypanosomatidae 54% 100%
A0A3R7NKC3 Trypanosoma rangeli 53% 100%
A4H741 Leishmania braziliensis 83% 100%
A4HVI1 Leishmania infantum 100% 100%
D0A6T0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AP76 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q28HN4 Xenopus tropicalis 29% 100%
Q4QGA2 Leishmania major 94% 100%
Q54GW3 Dictyostelium discoideum 30% 100%
Q68EY7 Xenopus laevis 29% 100%
Q6DD17 Xenopus laevis 30% 100%
Q6PHE8 Danio rerio 28% 100%
V5BAV6 Trypanosoma cruzi 54% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS