Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSD9_LEIDO

TriTrypDb:

LdBPK_130310.1 , LdCL_130008400 , LDHU3_13.0420

Length:

1098

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WSD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1063	1067	PF00656	0.616
CLV_C14_Caspase3-7	135	139	PF00656	0.525
CLV_C14_Caspase3-7	441	445	PF00656	0.658
CLV_C14_Caspase3-7	70	74	PF00656	0.644
CLV_NRD_NRD_1	381	383	PF00675	0.486
CLV_NRD_NRD_1	401	403	PF00675	0.336
CLV_NRD_NRD_1	682	684	PF00675	0.490
CLV_NRD_NRD_1	771	773	PF00675	0.514
CLV_NRD_NRD_1	803	805	PF00675	0.638
CLV_NRD_NRD_1	864	866	PF00675	0.632
CLV_NRD_NRD_1	876	878	PF00675	0.687
CLV_NRD_NRD_1	883	885	PF00675	0.691
CLV_NRD_NRD_1	987	989	PF00675	0.509
CLV_PCSK_KEX2_1	401	403	PF00082	0.624
CLV_PCSK_KEX2_1	682	684	PF00082	0.490
CLV_PCSK_KEX2_1	771	773	PF00082	0.514
CLV_PCSK_KEX2_1	803	805	PF00082	0.638
CLV_PCSK_KEX2_1	866	868	PF00082	0.636
CLV_PCSK_KEX2_1	875	877	PF00082	0.696
CLV_PCSK_KEX2_1	883	885	PF00082	0.686
CLV_PCSK_KEX2_1	987	989	PF00082	0.501
CLV_PCSK_PC1ET2_1	866	868	PF00082	0.569
CLV_PCSK_SKI1_1	1050	1054	PF00082	0.520
CLV_PCSK_SKI1_1	216	220	PF00082	0.524
CLV_PCSK_SKI1_1	602	606	PF00082	0.506
CLV_PCSK_SKI1_1	772	776	PF00082	0.497
CLV_PCSK_SKI1_1	779	783	PF00082	0.496
CLV_PCSK_SKI1_1	846	850	PF00082	0.451
DEG_APCC_DBOX_1	1034	1042	PF00400	0.478
DEG_APCC_DBOX_1	152	160	PF00400	0.420
DEG_APCC_DBOX_1	673	681	PF00400	0.492
DEG_APCC_DBOX_1	771	779	PF00400	0.457
DEG_APCC_DBOX_1	947	955	PF00400	0.477
DEG_APCC_DBOX_1	986	994	PF00400	0.483
DEG_MDM2_SWIB_1	533	540	PF02201	0.376
DEG_Nend_UBRbox_3	1	3	PF02207	0.647
DEG_SCF_FBW7_1	253	260	PF00400	0.485
DEG_SCF_FBW7_1	910	917	PF00400	0.687
DEG_SCF_FBW7_2	1083	1090	PF00400	0.581
DEG_SPOP_SBC_1	65	69	PF00917	0.572
DOC_CKS1_1	1084	1089	PF01111	0.589
DOC_CKS1_1	254	259	PF01111	0.391
DOC_CKS1_1	915	920	PF01111	0.743
DOC_CYCLIN_RxL_1	569	579	PF00134	0.427
DOC_CYCLIN_RxL_1	809	821	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	965	971	PF00134	0.541
DOC_MAPK_DCC_7	1020	1030	PF00069	0.455
DOC_MAPK_gen_1	347	355	PF00069	0.582
DOC_MAPK_gen_1	771	777	PF00069	0.505
DOC_MAPK_gen_1	811	820	PF00069	0.564
DOC_MAPK_gen_1	987	995	PF00069	0.541
DOC_MAPK_MEF2A_6	216	225	PF00069	0.561
DOC_MAPK_MEF2A_6	238	246	PF00069	0.494
DOC_MAPK_MEF2A_6	370	378	PF00069	0.424
DOC_MAPK_MEF2A_6	602	610	PF00069	0.412
DOC_MAPK_MEF2A_6	811	819	PF00069	0.426
DOC_PP1_RVXF_1	481	488	PF00149	0.368
DOC_PP2B_LxvP_1	154	157	PF13499	0.418
DOC_PP2B_LxvP_1	353	356	PF13499	0.685
DOC_USP7_MATH_1	1085	1089	PF00917	0.641
DOC_USP7_MATH_1	214	218	PF00917	0.510
DOC_USP7_MATH_1	236	240	PF00917	0.464
DOC_USP7_MATH_1	257	261	PF00917	0.529
DOC_USP7_MATH_1	288	292	PF00917	0.662
DOC_USP7_MATH_1	516	520	PF00917	0.710
DOC_USP7_MATH_1	615	619	PF00917	0.592
DOC_USP7_MATH_1	65	69	PF00917	0.709
DOC_USP7_MATH_1	668	672	PF00917	0.561
DOC_USP7_MATH_1	938	942	PF00917	0.664
DOC_USP7_UBL2_3	174	178	PF12436	0.554
DOC_WW_Pin1_4	1083	1088	PF00397	0.640
DOC_WW_Pin1_4	253	258	PF00397	0.468
DOC_WW_Pin1_4	340	345	PF00397	0.368
DOC_WW_Pin1_4	38	43	PF00397	0.600
DOC_WW_Pin1_4	499	504	PF00397	0.675
DOC_WW_Pin1_4	910	915	PF00397	0.728
DOC_WW_Pin1_4	993	998	PF00397	0.483
LIG_14-3-3_CanoR_1	300	308	PF00244	0.629
LIG_14-3-3_CanoR_1	602	607	PF00244	0.536
LIG_14-3-3_CanoR_1	647	653	PF00244	0.459
LIG_14-3-3_CanoR_1	700	706	PF00244	0.696
LIG_14-3-3_CanoR_1	710	716	PF00244	0.657
LIG_14-3-3_CanoR_1	724	732	PF00244	0.564
LIG_14-3-3_CanoR_1	758	768	PF00244	0.518
LIG_14-3-3_CanoR_1	772	778	PF00244	0.429
LIG_14-3-3_CanoR_1	803	812	PF00244	0.566
LIG_14-3-3_CanoR_1	956	962	PF00244	0.502
LIG_AP2alpha_1	34	38	PF02296	0.523
LIG_APCC_Cbox_2	348	354	PF00515	0.660
LIG_BRCT_BRCA1_1	718	722	PF00533	0.608
LIG_Clathr_ClatBox_1	112	116	PF01394	0.513
LIG_Clathr_ClatBox_1	817	821	PF01394	0.476
LIG_deltaCOP1_diTrp_1	922	925	PF00928	0.647
LIG_eIF4E_1	479	485	PF01652	0.362
LIG_EVH1_1	915	919	PF00568	0.790
LIG_FHA_1	147	153	PF00498	0.538
LIG_FHA_1	210	216	PF00498	0.530
LIG_FHA_1	249	255	PF00498	0.400
LIG_FHA_1	287	293	PF00498	0.674
LIG_FHA_1	452	458	PF00498	0.526
LIG_FHA_1	504	510	PF00498	0.702
LIG_FHA_1	603	609	PF00498	0.496
LIG_FHA_1	704	710	PF00498	0.677
LIG_FHA_1	743	749	PF00498	0.412
LIG_FHA_1	750	756	PF00498	0.473
LIG_FHA_1	847	853	PF00498	0.438
LIG_FHA_2	1041	1047	PF00498	0.519
LIG_FHA_2	145	151	PF00498	0.473
LIG_FHA_2	388	394	PF00498	0.548
LIG_FHA_2	446	452	PF00498	0.598
LIG_FHA_2	547	553	PF00498	0.450
LIG_FHA_2	68	74	PF00498	0.595
LIG_FHA_2	829	835	PF00498	0.515
LIG_FHA_2	857	863	PF00498	0.553
LIG_GBD_Chelix_1	264	272	PF00786	0.519
LIG_GBD_Chelix_1	566	574	PF00786	0.372
LIG_HP1_1	1027	1031	PF01393	0.494
LIG_IRF3_LxIS_1	187	194	PF10401	0.473
LIG_LIR_Apic_2	1094	1098	PF02991	0.555
LIG_LIR_Apic_2	519	525	PF02991	0.580
LIG_LIR_Gen_1	314	324	PF02991	0.555
LIG_LIR_Gen_1	459	465	PF02991	0.560
LIG_LIR_Gen_1	534	545	PF02991	0.429
LIG_LIR_Gen_1	556	565	PF02991	0.546
LIG_LIR_Gen_1	607	617	PF02991	0.527
LIG_LIR_Gen_1	821	832	PF02991	0.531
LIG_LIR_Gen_1	859	868	PF02991	0.648
LIG_LIR_Gen_1	960	970	PF02991	0.440
LIG_LIR_LC3C_4	482	486	PF02991	0.429
LIG_LIR_Nem_3	314	319	PF02991	0.562
LIG_LIR_Nem_3	348	353	PF02991	0.586
LIG_LIR_Nem_3	459	464	PF02991	0.454
LIG_LIR_Nem_3	467	471	PF02991	0.404
LIG_LIR_Nem_3	534	540	PF02991	0.389
LIG_LIR_Nem_3	556	560	PF02991	0.500
LIG_LIR_Nem_3	607	612	PF02991	0.497
LIG_LIR_Nem_3	821	827	PF02991	0.456
LIG_LIR_Nem_3	859	863	PF02991	0.640
LIG_LIR_Nem_3	922	928	PF02991	0.649
LIG_LIR_Nem_3	953	958	PF02991	0.405
LIG_LIR_Nem_3	960	965	PF02991	0.394
LIG_NRBOX	641	647	PF00104	0.518
LIG_OCRL_FandH_1	643	655	PF00620	0.514
LIG_PALB2_WD40_1	124	132	PF16756	0.505
LIG_Pex14_2	34	38	PF04695	0.424
LIG_Pex14_2	533	537	PF04695	0.412
LIG_REV1ctd_RIR_1	98	107	PF16727	0.498
LIG_SH2_CRK	557	561	PF00017	0.491
LIG_SH2_CRK	790	794	PF00017	0.621
LIG_SH2_CRK	824	828	PF00017	0.471
LIG_SH2_GRB2like	787	790	PF00017	0.574
LIG_SH2_NCK_1	266	270	PF00017	0.519
LIG_SH2_SRC	266	269	PF00017	0.513
LIG_SH2_STAP1	461	465	PF00017	0.554
LIG_SH2_STAT5	166	169	PF00017	0.423
LIG_SH2_STAT5	327	330	PF00017	0.528
LIG_SH2_STAT5	398	401	PF00017	0.583
LIG_SH2_STAT5	479	482	PF00017	0.352
LIG_SH2_STAT5	609	612	PF00017	0.406
LIG_SH2_STAT5	747	750	PF00017	0.384
LIG_SH2_STAT5	787	790	PF00017	0.583
LIG_SH2_STAT5	958	961	PF00017	0.399
LIG_SH3_3	251	257	PF00018	0.375
LIG_SH3_3	506	512	PF00018	0.780
LIG_SH3_3	537	543	PF00018	0.380
LIG_SH3_3	6	12	PF00018	0.561
LIG_SH3_3	913	919	PF00018	0.680
LIG_SUMO_SIM_anti_2	676	681	PF11976	0.566
LIG_SUMO_SIM_par_1	142	147	PF11976	0.451
LIG_SUMO_SIM_par_1	317	323	PF11976	0.552
LIG_SUMO_SIM_par_1	816	821	PF11976	0.474
LIG_TRAF2_1	1087	1090	PF00917	0.663
LIG_TRAF2_1	731	734	PF00917	0.589
LIG_TRAF2_1	74	77	PF00917	0.490
LIG_TRFH_1	1081	1085	PF08558	0.584
LIG_TRFH_1	38	42	PF08558	0.671
LIG_TYR_ITIM	264	269	PF00017	0.429
LIG_UBA3_1	10	16	PF00899	0.548
LIG_UBA3_1	112	119	PF00899	0.483
LIG_WRC_WIRS_1	958	963	PF05994	0.335
MOD_CDK_SPxxK_3	340	347	PF00069	0.366
MOD_CK1_1	194	200	PF00069	0.466
MOD_CK1_1	248	254	PF00069	0.489
MOD_CK1_1	298	304	PF00069	0.670
MOD_CK1_1	41	47	PF00069	0.684
MOD_CK1_1	445	451	PF00069	0.590
MOD_CK1_1	66	72	PF00069	0.564
MOD_CK1_1	698	704	PF00069	0.680
MOD_CK1_1	807	813	PF00069	0.557
MOD_CK2_1	1040	1046	PF00069	0.550
MOD_CK2_1	144	150	PF00069	0.472
MOD_CK2_1	25	31	PF00069	0.483
MOD_CK2_1	359	365	PF00069	0.771
MOD_CK2_1	445	451	PF00069	0.654
MOD_CK2_1	456	462	PF00069	0.471
MOD_CK2_1	546	552	PF00069	0.442
MOD_CK2_1	589	595	PF00069	0.630
MOD_CK2_1	728	734	PF00069	0.613
MOD_CK2_1	891	897	PF00069	0.638
MOD_Cter_Amidation	769	772	PF01082	0.537
MOD_GlcNHglycan	15	19	PF01048	0.558
MOD_GlcNHglycan	212	215	PF01048	0.556
MOD_GlcNHglycan	226	229	PF01048	0.517
MOD_GlcNHglycan	247	250	PF01048	0.537
MOD_GlcNHglycan	43	46	PF01048	0.701
MOD_GlcNHglycan	576	579	PF01048	0.500
MOD_GlcNHglycan	59	62	PF01048	0.758
MOD_GlcNHglycan	6	9	PF01048	0.568
MOD_GlcNHglycan	617	620	PF01048	0.588
MOD_GlcNHglycan	632	635	PF01048	0.435
MOD_GlcNHglycan	648	651	PF01048	0.318
MOD_GlcNHglycan	697	700	PF01048	0.734
MOD_GlcNHglycan	718	721	PF01048	0.580
MOD_GlcNHglycan	725	728	PF01048	0.630
MOD_GlcNHglycan	806	809	PF01048	0.588
MOD_GSK3_1	1036	1043	PF00069	0.574
MOD_GSK3_1	210	217	PF00069	0.560
MOD_GSK3_1	236	243	PF00069	0.438
MOD_GSK3_1	244	251	PF00069	0.408
MOD_GSK3_1	253	260	PF00069	0.333
MOD_GSK3_1	288	295	PF00069	0.716
MOD_GSK3_1	299	306	PF00069	0.664
MOD_GSK3_1	307	314	PF00069	0.269
MOD_GSK3_1	336	343	PF00069	0.480
MOD_GSK3_1	356	363	PF00069	0.730
MOD_GSK3_1	41	48	PF00069	0.641
MOD_GSK3_1	499	506	PF00069	0.645
MOD_GSK3_1	585	592	PF00069	0.622
MOD_GSK3_1	59	66	PF00069	0.613
MOD_GSK3_1	716	723	PF00069	0.636
MOD_GSK3_1	754	761	PF00069	0.553
MOD_GSK3_1	803	810	PF00069	0.608
MOD_GSK3_1	836	843	PF00069	0.447
MOD_GSK3_1	846	853	PF00069	0.377
MOD_GSK3_1	875	882	PF00069	0.536
MOD_GSK3_1	910	917	PF00069	0.765
MOD_GSK3_1	946	953	PF00069	0.523
MOD_GSK3_1	96	103	PF00069	0.487
MOD_LATS_1	172	178	PF00433	0.545
MOD_N-GLC_1	45	50	PF02516	0.751
MOD_N-GLC_1	759	764	PF02516	0.665
MOD_N-GLC_2	789	791	PF02516	0.600
MOD_NEK2_1	1070	1075	PF00069	0.556
MOD_NEK2_1	117	122	PF00069	0.454
MOD_NEK2_1	144	149	PF00069	0.464
MOD_NEK2_1	186	191	PF00069	0.371
MOD_NEK2_1	204	209	PF00069	0.418
MOD_NEK2_1	224	229	PF00069	0.582
MOD_NEK2_1	240	245	PF00069	0.286
MOD_NEK2_1	293	298	PF00069	0.767
MOD_NEK2_1	311	316	PF00069	0.472
MOD_NEK2_1	336	341	PF00069	0.430
MOD_NEK2_1	604	609	PF00069	0.536
MOD_NEK2_1	63	68	PF00069	0.766
MOD_NEK2_1	646	651	PF00069	0.416
MOD_NEK2_1	673	678	PF00069	0.461
MOD_NEK2_1	713	718	PF00069	0.623
MOD_NEK2_1	741	746	PF00069	0.421
MOD_NEK2_1	851	856	PF00069	0.552
MOD_NEK2_1	89	94	PF00069	0.478
MOD_NEK2_1	999	1004	PF00069	0.553
MOD_PIKK_1	1050	1056	PF00454	0.543
MOD_PIKK_1	1085	1091	PF00454	0.703
MOD_PIKK_1	876	882	PF00454	0.635
MOD_PKA_1	803	809	PF00069	0.589
MOD_PKA_1	875	881	PF00069	0.632
MOD_PKA_2	299	305	PF00069	0.667
MOD_PKA_2	369	375	PF00069	0.558
MOD_PKA_2	451	457	PF00069	0.541
MOD_PKA_2	646	652	PF00069	0.554
MOD_PKA_2	673	679	PF00069	0.468
MOD_PKA_2	711	717	PF00069	0.629
MOD_PKA_2	723	729	PF00069	0.675
MOD_PKA_2	749	755	PF00069	0.421
MOD_PKA_2	802	808	PF00069	0.569
MOD_PKA_2	875	881	PF00069	0.691
MOD_Plk_1	445	451	PF00069	0.625
MOD_Plk_2-3	25	31	PF00069	0.483
MOD_Plk_4	1070	1076	PF00069	0.533
MOD_Plk_4	199	205	PF00069	0.506
MOD_Plk_4	219	225	PF00069	0.301
MOD_Plk_4	236	242	PF00069	0.356
MOD_Plk_4	25	31	PF00069	0.483
MOD_Plk_4	257	263	PF00069	0.441
MOD_Plk_4	288	294	PF00069	0.724
MOD_Plk_4	307	313	PF00069	0.385
MOD_Plk_4	369	375	PF00069	0.592
MOD_Plk_4	376	382	PF00069	0.498
MOD_Plk_4	566	572	PF00069	0.375
MOD_Plk_4	59	65	PF00069	0.761
MOD_Plk_4	604	610	PF00069	0.474
MOD_Plk_4	638	644	PF00069	0.465
MOD_Plk_4	668	674	PF00069	0.441
MOD_Plk_4	704	710	PF00069	0.703
MOD_Plk_4	742	748	PF00069	0.304
MOD_Plk_4	773	779	PF00069	0.439
MOD_Plk_4	950	956	PF00069	0.474
MOD_Plk_4	957	963	PF00069	0.396
MOD_Plk_4	96	102	PF00069	0.510
MOD_ProDKin_1	1083	1089	PF00069	0.650
MOD_ProDKin_1	253	259	PF00069	0.460
MOD_ProDKin_1	340	346	PF00069	0.367
MOD_ProDKin_1	38	44	PF00069	0.611
MOD_ProDKin_1	499	505	PF00069	0.680
MOD_ProDKin_1	910	916	PF00069	0.727
MOD_ProDKin_1	993	999	PF00069	0.475
MOD_SUMO_rev_2	1058	1067	PF00179	0.427
MOD_SUMO_rev_2	71	81	PF00179	0.488
TRG_DiLeu_BaEn_1	1007	1012	PF01217	0.527
TRG_DiLeu_BaEn_1	638	643	PF01217	0.553
TRG_DiLeu_BaEn_1	76	81	PF01217	0.445
TRG_DiLeu_BaEn_3	24	30	PF01217	0.516
TRG_DiLeu_BaEn_4	1046	1052	PF01217	0.559
TRG_DiLeu_BaEn_4	76	82	PF01217	0.463
TRG_DiLeu_BaLyEn_6	864	869	PF01217	0.586
TRG_DiLeu_LyEn_5	1007	1012	PF01217	0.527
TRG_ENDOCYTIC_2	266	269	PF00928	0.428
TRG_ENDOCYTIC_2	461	464	PF00928	0.522
TRG_ENDOCYTIC_2	557	560	PF00928	0.498
TRG_ENDOCYTIC_2	609	612	PF00928	0.406
TRG_ENDOCYTIC_2	824	827	PF00928	0.455
TRG_ENDOCYTIC_2	958	961	PF00928	0.399
TRG_ER_diArg_1	101	104	PF00400	0.591
TRG_ER_diArg_1	401	404	PF00400	0.569
TRG_ER_diArg_1	682	684	PF00400	0.514
TRG_ER_diArg_1	709	712	PF00400	0.596
TRG_ER_diArg_1	865	868	PF00400	0.642
TRG_ER_diArg_1	875	877	PF00400	0.662
TRG_NES_CRM1_1	133	145	PF08389	0.443
TRG_NES_CRM1_1	598	613	PF08389	0.518
TRG_NLS_MonoExtC_3	864	870	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	1010	1015	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	867	871	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	988	992	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI3	Leptomonas seymouri	58%	96%
A0A1X0NN90	Trypanosomatidae	37%	100%
A4H730	Leishmania braziliensis	84%	100%
A4HVG4	Leishmania infantum	99%	100%
D0A6U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AP65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QGB3	Leishmania major	95%	100%
V5ATV9	Trypanosoma cruzi	35%	100%