Flagellar radial spoke protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellar radial spoke protein 4/6

Species:

Leishmania donovani

UniProt:

A0A3S7WSD6_LEIDO

TriTrypDb:

LdBPK_130290.1 , LdCL_130008600 , LDHU3_13.0440

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0001534	radial spoke	2	12
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005930	axoneme	2	1
GO:0097730	non-motile cilium	5	1

Expansion

Sequence features

A0A3S7WSD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSD6

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	11
GO:0030031	cell projection assembly	5	11
GO:0044782	cilium organization	5	11
GO:0060271	cilium assembly	6	11
GO:0060294	cilium movement involved in cell motility	5	12
GO:0070925	organelle assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	11
GO:0120036	plasma membrane bounded cell projection organization	5	11
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0035082	axoneme assembly	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.301
CLV_NRD_NRD_1	213	215	PF00675	0.278
CLV_NRD_NRD_1	327	329	PF00675	0.362
CLV_NRD_NRD_1	579	581	PF00675	0.596
CLV_NRD_NRD_1	91	93	PF00675	0.379
CLV_PCSK_FUR_1	191	195	PF00082	0.362
CLV_PCSK_KEX2_1	193	195	PF00082	0.288
CLV_PCSK_KEX2_1	263	265	PF00082	0.273
CLV_PCSK_KEX2_1	531	533	PF00082	0.337
CLV_PCSK_KEX2_1	579	581	PF00082	0.596
CLV_PCSK_KEX2_1	91	93	PF00082	0.347
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.278
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.331
CLV_PCSK_SKI1_1	160	164	PF00082	0.287
CLV_PCSK_SKI1_1	263	267	PF00082	0.286
CLV_PCSK_SKI1_1	331	335	PF00082	0.275
CLV_PCSK_SKI1_1	97	101	PF00082	0.337
DEG_APCC_DBOX_1	286	294	PF00400	0.468
DEG_SCF_SKP2-CKS1_1	470	477	PF00560	0.562
DOC_MAPK_gen_1	211	221	PF00069	0.473
DOC_MAPK_gen_1	331	340	PF00069	0.562
DOC_MAPK_gen_1	531	538	PF00069	0.537
DOC_PP2B_LxvP_1	102	105	PF13499	0.590
DOC_PP2B_LxvP_1	128	131	PF13499	0.562
DOC_PP2B_LxvP_1	338	341	PF13499	0.562
DOC_PP2B_LxvP_1	423	426	PF13499	0.531
DOC_PP4_FxxP_1	100	103	PF00568	0.517
DOC_PP4_FxxP_1	549	552	PF00568	0.498
DOC_USP7_MATH_1	239	243	PF00917	0.581
DOC_USP7_MATH_1	556	560	PF00917	0.581
DOC_USP7_UBL2_3	175	179	PF12436	0.551
DOC_USP7_UBL2_3	211	215	PF12436	0.537
DOC_USP7_UBL2_3	375	379	PF12436	0.487
DOC_WW_Pin1_4	237	242	PF00397	0.528
DOC_WW_Pin1_4	249	254	PF00397	0.421
DOC_WW_Pin1_4	339	344	PF00397	0.581
DOC_WW_Pin1_4	471	476	PF00397	0.562
DOC_WW_Pin1_4	547	552	PF00397	0.476
LIG_14-3-3_CanoR_1	232	236	PF00244	0.471
LIG_14-3-3_CanoR_1	292	301	PF00244	0.537
LIG_14-3-3_CanoR_1	532	538	PF00244	0.579
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BIR_III_4	403	407	PF00653	0.581
LIG_BRCT_BRCA1_1	184	188	PF00533	0.553
LIG_FHA_1	120	126	PF00498	0.476
LIG_FHA_1	199	205	PF00498	0.525
LIG_FHA_1	232	238	PF00498	0.544
LIG_FHA_1	265	271	PF00498	0.501
LIG_FHA_1	496	502	PF00498	0.501
LIG_FHA_1	569	575	PF00498	0.519
LIG_FHA_2	107	113	PF00498	0.476
LIG_FHA_2	181	187	PF00498	0.517
LIG_FHA_2	312	318	PF00498	0.581
LIG_FHA_2	563	569	PF00498	0.524
LIG_HCF-1_HBM_1	430	433	PF13415	0.622
LIG_Integrin_isoDGR_2	370	372	PF01839	0.287
LIG_KLC1_Yacidic_2	200	205	PF13176	0.562
LIG_LIR_Apic_2	546	552	PF02991	0.547
LIG_LIR_Gen_1	115	125	PF02991	0.466
LIG_LIR_Gen_1	132	138	PF02991	0.466
LIG_LIR_Gen_1	242	253	PF02991	0.503
LIG_LIR_Gen_1	31	40	PF02991	0.468
LIG_LIR_Nem_3	115	120	PF02991	0.466
LIG_LIR_Nem_3	132	136	PF02991	0.466
LIG_LIR_Nem_3	185	190	PF02991	0.509
LIG_LIR_Nem_3	224	230	PF02991	0.496
LIG_LIR_Nem_3	242	248	PF02991	0.485
LIG_LIR_Nem_3	31	36	PF02991	0.468
LIG_LIR_Nem_3	332	338	PF02991	0.480
LIG_LIR_Nem_3	422	427	PF02991	0.476
LIG_LIR_Nem_3	430	436	PF02991	0.600
LIG_MLH1_MIPbox_1	184	188	PF16413	0.553
LIG_NRBOX	38	44	PF00104	0.581
LIG_Pex14_1	533	537	PF04695	0.487
LIG_Pex14_2	177	181	PF04695	0.517
LIG_REV1ctd_RIR_1	174	183	PF16727	0.517
LIG_SH2_CRK	117	121	PF00017	0.476
LIG_SH2_CRK	33	37	PF00017	0.476
LIG_SH2_CRK	335	339	PF00017	0.487
LIG_SH2_NCK_1	117	121	PF00017	0.476
LIG_SH2_PTP2	227	230	PF00017	0.581
LIG_SH2_SRC	195	198	PF00017	0.532
LIG_SH2_STAP1	233	237	PF00017	0.562
LIG_SH2_STAT5	117	120	PF00017	0.487
LIG_SH2_STAT5	187	190	PF00017	0.482
LIG_SH2_STAT5	195	198	PF00017	0.467
LIG_SH2_STAT5	203	206	PF00017	0.452
LIG_SH2_STAT5	21	24	PF00017	0.476
LIG_SH2_STAT5	227	230	PF00017	0.574
LIG_SH2_STAT5	233	236	PF00017	0.544
LIG_SH2_STAT5	285	288	PF00017	0.476
LIG_SH2_STAT5	366	369	PF00017	0.481
LIG_SH2_STAT5	537	540	PF00017	0.470
LIG_SH3_2	475	480	PF14604	0.562
LIG_SH3_3	337	343	PF00018	0.545
LIG_SH3_3	374	380	PF00018	0.537
LIG_SH3_3	394	400	PF00018	0.345
LIG_SH3_3	433	439	PF00018	0.568
LIG_SH3_3	472	478	PF00018	0.479
LIG_SH3_3	549	555	PF00018	0.517
LIG_SH3_3	564	570	PF00018	0.425
LIG_SH3_4	211	218	PF00018	0.537
LIG_SH3_5	341	345	PF00018	0.525
LIG_SUMO_SIM_par_1	336	342	PF11976	0.593
LIG_TRAF2_1	151	154	PF00917	0.487
LIG_TRAF2_1	304	307	PF00917	0.487
LIG_TRAF2_1	310	313	PF00917	0.487
LIG_TRAF2_1	456	459	PF00917	0.527
LIG_TRAF2_1	460	463	PF00917	0.530
LIG_TRAF2_1	86	89	PF00917	0.562
LIG_WRC_WIRS_1	61	66	PF05994	0.562
LIG_WW_3	211	215	PF00397	0.553
MOD_CDK_SPxK_1	471	477	PF00069	0.562
MOD_CDK_SPxxK_3	237	244	PF00069	0.581
MOD_CK1_1	132	138	PF00069	0.537
MOD_CK1_1	295	301	PF00069	0.562
MOD_CK2_1	106	112	PF00069	0.476
MOD_CK2_1	4	10	PF00069	0.612
MOD_CK2_1	562	568	PF00069	0.592
MOD_CK2_1	586	592	PF00069	0.678
MOD_Cter_Amidation	529	532	PF01082	0.287
MOD_GlcNHglycan	269	273	PF01048	0.332
MOD_GlcNHglycan	30	33	PF01048	0.345
MOD_GlcNHglycan	6	9	PF01048	0.583
MOD_GlcNHglycan	76	79	PF01048	0.339
MOD_GSK3_1	115	122	PF00069	0.477
MOD_GSK3_1	231	238	PF00069	0.475
MOD_GSK3_1	264	271	PF00069	0.537
MOD_GSK3_1	291	298	PF00069	0.484
MOD_GSK3_1	60	67	PF00069	0.537
MOD_N-GLC_1	503	508	PF02516	0.288
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	158	163	PF00069	0.476
MOD_NEK2_1	235	240	PF00069	0.494
MOD_NEK2_1	270	275	PF00069	0.525
MOD_NEK2_1	64	69	PF00069	0.538
MOD_NEK2_2	198	203	PF00069	0.525
MOD_NEK2_2	495	500	PF00069	0.501
MOD_PIKK_1	80	86	PF00454	0.581
MOD_PKA_1	531	537	PF00069	0.581
MOD_PKA_2	231	237	PF00069	0.476
MOD_PKA_2	259	265	PF00069	0.581
MOD_PKA_2	291	297	PF00069	0.562
MOD_PKA_2	371	377	PF00069	0.476
MOD_PKA_2	531	537	PF00069	0.581
MOD_Plk_1	158	164	PF00069	0.476
MOD_Plk_1	80	86	PF00069	0.568
MOD_Plk_2-3	106	112	PF00069	0.551
MOD_Plk_2-3	311	317	PF00069	0.581
MOD_Plk_2-3	586	592	PF00069	0.659
MOD_Plk_4	121	127	PF00069	0.542
MOD_Plk_4	198	204	PF00069	0.525
MOD_Plk_4	231	237	PF00069	0.476
MOD_Plk_4	60	66	PF00069	0.490
MOD_ProDKin_1	237	243	PF00069	0.528
MOD_ProDKin_1	249	255	PF00069	0.421
MOD_ProDKin_1	339	345	PF00069	0.581
MOD_ProDKin_1	471	477	PF00069	0.562
MOD_ProDKin_1	547	553	PF00069	0.476
MOD_SUMO_rev_2	168	177	PF00179	0.562
MOD_SUMO_rev_2	89	99	PF00179	0.525
TRG_DiLeu_BaEn_1	153	158	PF01217	0.487
TRG_DiLeu_BaEn_2	59	65	PF01217	0.562
TRG_DiLeu_BaEn_4	153	159	PF01217	0.487
TRG_ENDOCYTIC_2	117	120	PF00928	0.476
TRG_ENDOCYTIC_2	187	190	PF00928	0.476
TRG_ENDOCYTIC_2	227	230	PF00928	0.574
TRG_ENDOCYTIC_2	33	36	PF00928	0.466
TRG_ENDOCYTIC_2	335	338	PF00928	0.487
TRG_ENDOCYTIC_2	433	436	PF00928	0.528
TRG_ER_diArg_1	190	193	PF00400	0.507
TRG_ER_diArg_1	578	580	PF00400	0.603
TRG_ER_diArg_1	90	92	PF00400	0.580
TRG_NES_CRM1_1	34	46	PF08389	0.581
TRG_NLS_MonoExtN_4	211	218	PF00514	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF4	Leptomonas seymouri	76%	100%
A0A0S4JGY1	Bodo saltans	50%	100%
A0A1X0NN98	Trypanosomatidae	57%	100%
A0A422NNZ6	Trypanosoma rangeli	58%	100%
A4H732	Leishmania braziliensis	87%	98%
A4HVG6	Leishmania infantum	99%	99%
D0A6U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AP67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
Q4QGB1	Leishmania major	93%	98%
V5BDZ5	Trypanosoma cruzi	58%	93%