Serine peptidase, Clan SC, Family S9D

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3S7WSC7_LEIDO

TriTrypDb:

LdBPK_120920.1 , LdCL_120021300 , LDHU3_12.1720

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WSC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSC7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0008233	peptidase activity	3	3
GO:0008236	serine-type peptidase activity	4	3
GO:0017171	serine hydrolase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.450
CLV_C14_Caspase3-7	406	410	PF00656	0.601
CLV_C14_Caspase3-7	6	10	PF00656	0.606
CLV_NRD_NRD_1	126	128	PF00675	0.488
CLV_NRD_NRD_1	354	356	PF00675	0.477
CLV_NRD_NRD_1	513	515	PF00675	0.653
CLV_PCSK_FUR_1	511	515	PF00082	0.622
CLV_PCSK_KEX2_1	126	128	PF00082	0.488
CLV_PCSK_KEX2_1	443	445	PF00082	0.518
CLV_PCSK_KEX2_1	513	515	PF00082	0.653
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.504
CLV_PCSK_SKI1_1	135	139	PF00082	0.345
CLV_PCSK_SKI1_1	21	25	PF00082	0.585
CLV_PCSK_SKI1_1	266	270	PF00082	0.566
CLV_PCSK_SKI1_1	281	285	PF00082	0.457
CLV_PCSK_SKI1_1	369	373	PF00082	0.522
DEG_APCC_DBOX_1	159	167	PF00400	0.458
DEG_SCF_FBW7_2	104	111	PF00400	0.531
DEG_SPOP_SBC_1	536	540	PF00917	0.546
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.624
DOC_MAPK_JIP1_4	160	166	PF00069	0.419
DOC_MAPK_MEF2A_6	88	96	PF00069	0.438
DOC_PP1_RVXF_1	11	18	PF00149	0.538
DOC_PP1_RVXF_1	474	481	PF00149	0.405
DOC_PP2B_LxvP_1	275	278	PF13499	0.517
DOC_PP2B_LxvP_1	412	415	PF13499	0.594
DOC_PP4_FxxP_1	129	132	PF00568	0.442
DOC_PP4_FxxP_1	154	157	PF00568	0.547
DOC_PP4_FxxP_1	17	20	PF00568	0.462
DOC_USP7_MATH_1	308	312	PF00917	0.529
DOC_USP7_MATH_1	520	524	PF00917	0.655
DOC_USP7_MATH_1	536	540	PF00917	0.340
DOC_USP7_MATH_1	612	616	PF00917	0.541
DOC_WW_Pin1_4	104	109	PF00397	0.577
DOC_WW_Pin1_4	143	148	PF00397	0.447
DOC_WW_Pin1_4	379	384	PF00397	0.360
DOC_WW_Pin1_4	419	424	PF00397	0.584
DOC_WW_Pin1_4	432	437	PF00397	0.447
DOC_WW_Pin1_4	512	517	PF00397	0.645
LIG_14-3-3_CanoR_1	266	275	PF00244	0.517
LIG_14-3-3_CanoR_1	392	399	PF00244	0.589
LIG_14-3-3_CanoR_1	444	450	PF00244	0.523
LIG_14-3-3_CanoR_1	514	520	PF00244	0.705
LIG_14-3-3_CanoR_1	535	545	PF00244	0.605
LIG_14-3-3_CanoR_1	560	565	PF00244	0.518
LIG_Actin_WH2_2	497	515	PF00022	0.571
LIG_Actin_WH2_2	592	607	PF00022	0.517
LIG_Actin_WH2_2	71	86	PF00022	0.495
LIG_BRCT_BRCA1_1	13	17	PF00533	0.533
LIG_BRCT_BRCA1_1	476	480	PF00533	0.370
LIG_deltaCOP1_diTrp_1	532	537	PF00928	0.447
LIG_FHA_1	196	202	PF00498	0.457
LIG_FHA_1	217	223	PF00498	0.565
LIG_FHA_1	267	273	PF00498	0.578
LIG_FHA_1	331	337	PF00498	0.457
LIG_FHA_1	366	372	PF00498	0.420
LIG_FHA_1	394	400	PF00498	0.544
LIG_FHA_1	433	439	PF00498	0.368
LIG_FHA_1	61	67	PF00498	0.411
LIG_FHA_1	611	617	PF00498	0.681
LIG_FHA_2	302	308	PF00498	0.473
LIG_FHA_2	404	410	PF00498	0.574
LIG_FHA_2	426	432	PF00498	0.412
LIG_FHA_2	446	452	PF00498	0.399
LIG_FHA_2	480	486	PF00498	0.463
LIG_HCF-1_HBM_1	223	226	PF13415	0.521
LIG_LIR_Apic_2	14	20	PF02991	0.467
LIG_LIR_Apic_2	532	536	PF02991	0.449
LIG_LIR_Apic_2	600	606	PF02991	0.536
LIG_LIR_Gen_1	120	129	PF02991	0.414
LIG_LIR_Gen_1	326	336	PF02991	0.374
LIG_LIR_Gen_1	506	516	PF02991	0.575
LIG_LIR_Gen_1	525	534	PF02991	0.559
LIG_LIR_Gen_1	590	601	PF02991	0.494
LIG_LIR_Nem_3	120	125	PF02991	0.391
LIG_LIR_Nem_3	326	332	PF02991	0.389
LIG_LIR_Nem_3	506	512	PF02991	0.507
LIG_LIR_Nem_3	52	56	PF02991	0.396
LIG_LIR_Nem_3	525	530	PF02991	0.568
LIG_LIR_Nem_3	551	557	PF02991	0.413
LIG_LIR_Nem_3	590	596	PF02991	0.442
LIG_LIR_Nem_3	98	102	PF02991	0.355
LIG_MAD2	266	274	PF02301	0.571
LIG_MYND_1	274	278	PF01753	0.475
LIG_NRBOX	327	333	PF00104	0.375
LIG_NRBOX	488	494	PF00104	0.450
LIG_PCNA_PIPBox_1	116	125	PF02747	0.494
LIG_PCNA_yPIPBox_3	116	127	PF02747	0.470
LIG_PDZ_Class_1	615	620	PF00595	0.706
LIG_Pex14_2	150	154	PF04695	0.519
LIG_PTB_Apo_2	45	52	PF02174	0.521
LIG_SH2_CRK	290	294	PF00017	0.420
LIG_SH2_CRK	350	354	PF00017	0.517
LIG_SH2_CRK	53	57	PF00017	0.384
LIG_SH2_NCK_1	68	72	PF00017	0.475
LIG_SH2_PTP2	329	332	PF00017	0.384
LIG_SH2_SRC	68	71	PF00017	0.466
LIG_SH2_STAP1	290	294	PF00017	0.382
LIG_SH2_STAT3	226	229	PF00017	0.486
LIG_SH2_STAT5	122	125	PF00017	0.369
LIG_SH2_STAT5	128	131	PF00017	0.396
LIG_SH2_STAT5	226	229	PF00017	0.535
LIG_SH2_STAT5	242	245	PF00017	0.473
LIG_SH2_STAT5	329	332	PF00017	0.384
LIG_SH2_STAT5	350	353	PF00017	0.386
LIG_SH2_STAT5	55	58	PF00017	0.426
LIG_SH2_STAT5	557	560	PF00017	0.397
LIG_SH2_STAT5	593	596	PF00017	0.526
LIG_SH2_STAT5	603	606	PF00017	0.505
LIG_SH2_STAT5	85	88	PF00017	0.399
LIG_SH3_3	202	208	PF00018	0.379
LIG_SH3_3	32	38	PF00018	0.464
LIG_SH3_5	553	557	PF00018	0.539
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.381
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.400
LIG_SUMO_SIM_par_1	197	204	PF11976	0.525
LIG_SUMO_SIM_par_1	424	431	PF11976	0.508
LIG_TRAF2_1	526	529	PF00917	0.558
LIG_TRAF2_1	575	578	PF00917	0.573
LIG_TRAF2_1	582	585	PF00917	0.527
LIG_UBA3_1	272	281	PF00899	0.490
LIG_UBA3_1	438	443	PF00899	0.484
MOD_CK1_1	255	261	PF00069	0.536
MOD_CK1_1	515	521	PF00069	0.672
MOD_CK1_1	523	529	PF00069	0.607
MOD_CK2_1	392	398	PF00069	0.608
MOD_CK2_1	425	431	PF00069	0.400
MOD_CK2_1	523	529	PF00069	0.596
MOD_CK2_1	572	578	PF00069	0.536
MOD_GlcNHglycan	119	122	PF01048	0.357
MOD_GlcNHglycan	255	258	PF01048	0.478
MOD_GlcNHglycan	296	300	PF01048	0.524
MOD_GlcNHglycan	467	470	PF01048	0.500
MOD_GlcNHglycan	522	525	PF01048	0.631
MOD_GlcNHglycan	598	602	PF01048	0.546
MOD_GlcNHglycan	98	102	PF01048	0.442
MOD_GSK3_1	139	146	PF00069	0.461
MOD_GSK3_1	21	28	PF00069	0.489
MOD_GSK3_1	212	219	PF00069	0.544
MOD_GSK3_1	498	505	PF00069	0.439
MOD_GSK3_1	512	519	PF00069	0.554
MOD_GSK3_1	536	543	PF00069	0.610
MOD_GSK3_1	583	590	PF00069	0.487
MOD_GSK3_1	84	91	PF00069	0.379
MOD_N-GLC_1	215	220	PF02516	0.479
MOD_N-GLC_1	252	257	PF02516	0.478
MOD_N-GLC_1	502	507	PF02516	0.578
MOD_N-GLC_1	570	575	PF02516	0.536
MOD_N-GLC_2	357	359	PF02516	0.583
MOD_NEK2_1	11	16	PF00069	0.468
MOD_NEK2_1	332	337	PF00069	0.352
MOD_NEK2_1	558	563	PF00069	0.536
MOD_NEK2_1	570	575	PF00069	0.523
MOD_NEK2_1	97	102	PF00069	0.372
MOD_NEK2_2	314	319	PF00069	0.543
MOD_NEK2_2	403	408	PF00069	0.544
MOD_OFUCOSY	401	407	PF10250	0.547
MOD_PIKK_1	178	184	PF00454	0.595
MOD_PK_1	560	566	PF00069	0.472
MOD_PK_1	88	94	PF00069	0.464
MOD_PKA_2	231	237	PF00069	0.532
MOD_PKA_2	365	371	PF00069	0.520
MOD_PKA_2	540	546	PF00069	0.644
MOD_PKA_2	604	610	PF00069	0.564
MOD_PKB_1	264	272	PF00069	0.570
MOD_Plk_1	110	116	PF00069	0.395
MOD_Plk_1	215	221	PF00069	0.549
MOD_Plk_1	222	228	PF00069	0.494
MOD_Plk_1	474	480	PF00069	0.469
MOD_Plk_1	570	576	PF00069	0.458
MOD_Plk_1	88	94	PF00069	0.446
MOD_Plk_2-3	572	578	PF00069	0.573
MOD_Plk_4	11	17	PF00069	0.438
MOD_Plk_4	238	244	PF00069	0.524
MOD_Plk_4	255	261	PF00069	0.206
MOD_Plk_4	308	314	PF00069	0.525
MOD_Plk_4	425	431	PF00069	0.433
MOD_Plk_4	591	597	PF00069	0.540
MOD_ProDKin_1	104	110	PF00069	0.575
MOD_ProDKin_1	143	149	PF00069	0.447
MOD_ProDKin_1	379	385	PF00069	0.360
MOD_ProDKin_1	419	425	PF00069	0.573
MOD_ProDKin_1	432	438	PF00069	0.442
MOD_ProDKin_1	512	518	PF00069	0.654
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.484
TRG_ENDOCYTIC_2	122	125	PF00928	0.377
TRG_ENDOCYTIC_2	128	131	PF00928	0.385
TRG_ENDOCYTIC_2	193	196	PF00928	0.401
TRG_ENDOCYTIC_2	290	293	PF00928	0.398
TRG_ENDOCYTIC_2	329	332	PF00928	0.384
TRG_ENDOCYTIC_2	350	353	PF00928	0.484
TRG_ENDOCYTIC_2	509	512	PF00928	0.548
TRG_ENDOCYTIC_2	53	56	PF00928	0.385
TRG_ENDOCYTIC_2	593	596	PF00928	0.502
TRG_ENDOCYTIC_2	80	83	PF00928	0.474
TRG_ER_diArg_1	125	127	PF00400	0.481
TRG_ER_diArg_1	511	514	PF00400	0.608
TRG_ER_diArg_1	559	562	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4W3	Leptomonas seymouri	65%	100%
A0A1X0NMT5	Trypanosomatidae	39%	100%
A0A422NV23	Trypanosoma rangeli	40%	100%
C9ZI47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	83%
E9AGJ6	Leishmania infantum	99%	100%
E9AIN2	Leishmania braziliensis	82%	100%
E9AP33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QGF5	Leishmania major	95%	100%
V5BP52	Trypanosoma cruzi	39%	100%