N-acetyltransferase_subunit_ARD1_putative/GeneDB: LmjF.13.0260

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetyltransferase subunit ARD1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSC5_LEIDO

TriTrypDb:

LdBPK_130260.1 , LdCL_130007600 , LDHU3_13.0320

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0031248	protein acetyltransferase complex	3	10
GO:0031414	N-terminal protein acetyltransferase complex	4	10
GO:0031415	NatA complex	5	10
GO:0032991	protein-containing complex	1	10
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	10
GO:1902493	acetyltransferase complex	4	10
GO:1902494	catalytic complex	2	10

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Expansion

Sequence features

A0A3S7WSC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSC5

Function

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Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	10
GO:0006474	N-terminal protein amino acid acetylation	5	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0031365	N-terminal protein amino acid modification	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043543	protein acylation	5	10

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004596	peptide alpha-N-acetyltransferase activity	8	10
GO:0008080	N-acetyltransferase activity	6	10
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	10
GO:1990189	peptide-serine-alpha-N-acetyltransferase activity	9	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.341
CLV_NRD_NRD_1	168	170	PF00675	0.630
CLV_NRD_NRD_1	4	6	PF00675	0.367
CLV_NRD_NRD_1	82	84	PF00675	0.319
CLV_PCSK_KEX2_1	165	167	PF00082	0.594
CLV_PCSK_KEX2_1	200	202	PF00082	0.739
CLV_PCSK_KEX2_1	253	255	PF00082	0.754
CLV_PCSK_KEX2_1	4	6	PF00082	0.367
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.594
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.739

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P642	Leptomonas seymouri	75%	98%
A0A0S4JB69	Bodo saltans	65%	92%
A0A1X0NPT1	Trypanosomatidae	63%	100%
A0A3R7M1B7	Trypanosoma rangeli	57%	100%
A4HDU9	Leishmania braziliensis	27%	100%
A4HHS3	Leishmania braziliensis	93%	100%
A4HVG9	Leishmania infantum	100%	100%
E9AP60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P07347	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P36416	Dictyostelium discoideum	42%	100%

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