Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WSC4_LEIDO

TriTrypDb:

LdBPK_130150.1 , LdCL_130006500 , LDHU3_13.0190

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S7WSC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.609
CLV_NRD_NRD_1	146	148	PF00675	0.590
CLV_NRD_NRD_1	154	156	PF00675	0.647
CLV_NRD_NRD_1	167	169	PF00675	0.633
CLV_NRD_NRD_1	218	220	PF00675	0.503
CLV_PCSK_FUR_1	144	148	PF00082	0.637
CLV_PCSK_KEX2_1	146	148	PF00082	0.655
CLV_PCSK_KEX2_1	154	156	PF00082	0.615
CLV_PCSK_KEX2_1	167	169	PF00082	0.676
CLV_PCSK_KEX2_1	218	220	PF00082	0.503
CLV_PCSK_KEX2_1	435	437	PF00082	0.561
CLV_PCSK_KEX2_1	452	454	PF00082	0.583
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.523
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.567
CLV_PCSK_SKI1_1	12	16	PF00082	0.482
CLV_PCSK_SKI1_1	154	158	PF00082	0.694
CLV_PCSK_SKI1_1	429	433	PF00082	0.432
CLV_PCSK_SKI1_1	79	83	PF00082	0.676
DEG_SCF_TRCP1_1	209	215	PF00400	0.592
DEG_SPOP_SBC_1	103	107	PF00917	0.773
DOC_CKS1_1	81	86	PF01111	0.777
DOC_CKS1_1	97	102	PF01111	0.485
DOC_MAPK_gen_1	135	143	PF00069	0.574
DOC_MAPK_MEF2A_6	135	143	PF00069	0.633
DOC_PP4_FxxP_1	303	306	PF00568	0.482
DOC_USP7_MATH_1	101	105	PF00917	0.755
DOC_USP7_MATH_1	366	370	PF00917	0.599
DOC_WW_Pin1_4	241	246	PF00397	0.441
DOC_WW_Pin1_4	289	294	PF00397	0.474
DOC_WW_Pin1_4	80	85	PF00397	0.752
DOC_WW_Pin1_4	96	101	PF00397	0.731
LIG_14-3-3_CanoR_1	339	343	PF00244	0.577
LIG_14-3-3_CanoR_1	436	440	PF00244	0.449
LIG_14-3-3_CanoR_1	67	73	PF00244	0.744
LIG_APCC_ABBA_1	275	280	PF00400	0.385
LIG_BRCT_BRCA1_1	106	110	PF00533	0.797
LIG_deltaCOP1_diTrp_1	232	239	PF00928	0.545
LIG_EH1_1	355	363	PF00400	0.634
LIG_eIF4E_1	451	457	PF01652	0.575
LIG_FHA_1	405	411	PF00498	0.687
LIG_FHA_1	97	103	PF00498	0.778
LIG_FHA_2	172	178	PF00498	0.668
LIG_FHA_2	194	200	PF00498	0.612
LIG_FHA_2	241	247	PF00498	0.539
LIG_HP1_1	372	376	PF01393	0.399
LIG_Integrin_RGD_1	54	56	PF01839	0.615
LIG_LIR_Apic_2	301	306	PF02991	0.516
LIG_LIR_Gen_1	196	204	PF02991	0.604
LIG_LIR_Gen_1	236	245	PF02991	0.418
LIG_LIR_Nem_3	13	18	PF02991	0.474
LIG_LIR_Nem_3	150	156	PF02991	0.628
LIG_LIR_Nem_3	196	200	PF02991	0.580
LIG_LIR_Nem_3	236	240	PF02991	0.410
LIG_LIR_Nem_3	460	466	PF02991	0.403
LIG_LIR_Nem_3	56	62	PF02991	0.626
LIG_MYND_1	377	381	PF01753	0.537
LIG_Pex14_2	11	15	PF04695	0.538
LIG_Pex14_2	229	233	PF04695	0.617
LIG_SH2_CRK	153	157	PF00017	0.622
LIG_SH2_CRK	26	30	PF00017	0.477
LIG_SH2_GRB2like	222	225	PF00017	0.486
LIG_SH2_STAP1	278	282	PF00017	0.504
LIG_SH2_STAP1	421	425	PF00017	0.372
LIG_SH2_STAT5	172	175	PF00017	0.640
LIG_SH2_STAT5	195	198	PF00017	0.716
LIG_SH2_STAT5	222	225	PF00017	0.712
LIG_SH2_STAT5	268	271	PF00017	0.475
LIG_SH2_STAT5	390	393	PF00017	0.381
LIG_SH3_2	114	119	PF14604	0.635
LIG_SH3_3	11	17	PF00018	0.544
LIG_SH3_3	111	117	PF00018	0.723
LIG_SH3_3	371	377	PF00018	0.450
LIG_SH3_3	91	97	PF00018	0.791
LIG_TRAF2_1	174	177	PF00917	0.617
MOD_CDK_SPxxK_3	241	248	PF00069	0.487
MOD_CK1_1	104	110	PF00069	0.749
MOD_CK1_1	193	199	PF00069	0.634
MOD_CK1_1	207	213	PF00069	0.579
MOD_CK1_1	289	295	PF00069	0.548
MOD_CK1_1	438	444	PF00069	0.477
MOD_CK2_1	171	177	PF00069	0.659
MOD_CK2_1	240	246	PF00069	0.490
MOD_CK2_1	278	284	PF00069	0.464
MOD_Cter_Amidation	433	436	PF01082	0.523
MOD_GlcNHglycan	209	212	PF01048	0.543
MOD_GlcNHglycan	252	255	PF01048	0.579
MOD_GlcNHglycan	280	283	PF01048	0.509
MOD_GlcNHglycan	309	312	PF01048	0.530
MOD_GlcNHglycan	319	322	PF01048	0.642
MOD_GSK3_1	200	207	PF00069	0.638
MOD_GSK3_1	276	283	PF00069	0.545
MOD_GSK3_1	417	424	PF00069	0.486
MOD_N-GLC_1	181	186	PF02516	0.660
MOD_N-GLC_1	289	294	PF02516	0.502
MOD_N-GLC_1	404	409	PF02516	0.695
MOD_NEK2_1	102	107	PF00069	0.789
MOD_NEK2_1	142	147	PF00069	0.642
MOD_NEK2_1	200	205	PF00069	0.713
MOD_NEK2_1	212	217	PF00069	0.510
MOD_NEK2_1	240	245	PF00069	0.496
MOD_NEK2_1	392	397	PF00069	0.466
MOD_NEK2_1	68	73	PF00069	0.714
MOD_PIKK_1	392	398	PF00454	0.509
MOD_PKA_1	154	160	PF00069	0.709
MOD_PKA_1	435	441	PF00069	0.537
MOD_PKA_2	154	160	PF00069	0.628
MOD_PKA_2	207	213	PF00069	0.573
MOD_PKA_2	338	344	PF00069	0.547
MOD_PKA_2	435	441	PF00069	0.468
MOD_Plk_1	283	289	PF00069	0.599
MOD_Plk_1	366	372	PF00069	0.596
MOD_Plk_4	225	231	PF00069	0.642
MOD_Plk_4	324	330	PF00069	0.541
MOD_Plk_4	357	363	PF00069	0.567
MOD_Plk_4	421	427	PF00069	0.364
MOD_ProDKin_1	241	247	PF00069	0.434
MOD_ProDKin_1	289	295	PF00069	0.466
MOD_ProDKin_1	80	86	PF00069	0.752
MOD_ProDKin_1	96	102	PF00069	0.732
MOD_SUMO_rev_2	244	250	PF00179	0.512
MOD_SUMO_rev_2	341	347	PF00179	0.546
TRG_ENDOCYTIC_2	153	156	PF00928	0.652
TRG_ENDOCYTIC_2	197	200	PF00928	0.591
TRG_ENDOCYTIC_2	26	29	PF00928	0.416
TRG_ENDOCYTIC_2	390	393	PF00928	0.497
TRG_ER_diArg_1	143	146	PF00400	0.680
TRG_ER_diArg_1	153	155	PF00400	0.714
TRG_ER_diArg_1	167	169	PF00400	0.661
TRG_ER_diArg_1	217	219	PF00400	0.536
TRG_ER_diArg_1	51	54	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I6	Leptomonas seymouri	54%	100%
A0A0S4JBB6	Bodo saltans	26%	96%
A0A1X0NPY5	Trypanosomatidae	38%	100%
A0A3R7KWR6	Trypanosoma rangeli	40%	100%
A4H722	Leishmania braziliensis	82%	100%
A4HVF1	Leishmania infantum	100%	100%
D0A6V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AP49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QGD9	Leishmania major	96%	100%
V5BDY2	Trypanosoma cruzi	39%	100%