Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSC2_LEIDO

TriTrypDb:

LdBPK_120910.1 , LdCL_120021200 , LDHU3_12.1710

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WSC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSC2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0016192	vesicle-mediated transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0006906	vesicle fusion	6	1
GO:0006914	autophagy	3	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0034058	endosomal vesicle fusion	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0061919	process utilizing autophagic mechanism	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	554	558	PF00656	0.223
CLV_C14_Caspase3-7	607	611	PF00656	0.596
CLV_C14_Caspase3-7	68	72	PF00656	0.432
CLV_C14_Caspase3-7	848	852	PF00656	0.406
CLV_MEL_PAP_1	49	55	PF00089	0.313
CLV_NRD_NRD_1	144	146	PF00675	0.371
CLV_NRD_NRD_1	186	188	PF00675	0.404
CLV_NRD_NRD_1	526	528	PF00675	0.334
CLV_NRD_NRD_1	630	632	PF00675	0.459
CLV_NRD_NRD_1	73	75	PF00675	0.492
CLV_NRD_NRD_1	782	784	PF00675	0.471
CLV_NRD_NRD_1	86	88	PF00675	0.424
CLV_NRD_NRD_1	925	927	PF00675	0.395
CLV_PCSK_FUR_1	524	528	PF00082	0.334
CLV_PCSK_KEX2_1	146	148	PF00082	0.463
CLV_PCSK_KEX2_1	526	528	PF00082	0.334
CLV_PCSK_KEX2_1	629	631	PF00082	0.439
CLV_PCSK_KEX2_1	73	75	PF00082	0.492
CLV_PCSK_KEX2_1	782	784	PF00082	0.450
CLV_PCSK_KEX2_1	86	88	PF00082	0.424
CLV_PCSK_KEX2_1	925	927	PF00082	0.382
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.463
CLV_PCSK_SKI1_1	115	119	PF00082	0.462
CLV_PCSK_SKI1_1	146	150	PF00082	0.392
CLV_PCSK_SKI1_1	234	238	PF00082	0.496
CLV_PCSK_SKI1_1	306	310	PF00082	0.483
CLV_PCSK_SKI1_1	465	469	PF00082	0.500
CLV_PCSK_SKI1_1	571	575	PF00082	0.483
CLV_PCSK_SKI1_1	658	662	PF00082	0.488
CLV_PCSK_SKI1_1	688	692	PF00082	0.491
CLV_PCSK_SKI1_1	730	734	PF00082	0.526
CLV_PCSK_SKI1_1	746	750	PF00082	0.433
CLV_PCSK_SKI1_1	78	82	PF00082	0.381
CLV_PCSK_SKI1_1	792	796	PF00082	0.352
CLV_PCSK_SKI1_1	86	90	PF00082	0.304
CLV_Separin_Metazoa	506	510	PF03568	0.334
DEG_APCC_DBOX_1	464	472	PF00400	0.389
DEG_APCC_DBOX_1	85	93	PF00400	0.428
DEG_Nend_UBRbox_3	1	3	PF02207	0.686
DEG_SCF_FBW7_2	216	223	PF00400	0.411
DEG_SCF_FBW7_2	250	257	PF00400	0.522
DOC_CKS1_1	204	209	PF01111	0.549
DOC_CKS1_1	217	222	PF01111	0.504
DOC_CKS1_1	251	256	PF01111	0.522
DOC_CYCLIN_RxL_1	33	44	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.486
DOC_MAPK_gen_1	132	142	PF00069	0.374
DOC_MAPK_gen_1	524	534	PF00069	0.398
DOC_MAPK_gen_1	715	725	PF00069	0.465
DOC_MAPK_gen_1	86	92	PF00069	0.458
DOC_MAPK_gen_1	925	935	PF00069	0.382
DOC_MAPK_MEF2A_6	526	534	PF00069	0.395
DOC_PP1_RVXF_1	144	151	PF00149	0.399
DOC_PP1_RVXF_1	171	178	PF00149	0.338
DOC_PP1_RVXF_1	246	252	PF00149	0.552
DOC_PP1_RVXF_1	34	41	PF00149	0.413
DOC_PP1_RVXF_1	343	349	PF00149	0.294
DOC_PP1_RVXF_1	656	662	PF00149	0.522
DOC_PP2B_LxvP_1	214	217	PF13499	0.492
DOC_PP2B_LxvP_1	443	446	PF13499	0.516
DOC_PP4_FxxP_1	428	431	PF00568	0.523
DOC_PP4_FxxP_1	725	728	PF00568	0.539
DOC_USP7_MATH_1	105	109	PF00917	0.499
DOC_USP7_MATH_1	244	248	PF00917	0.553
DOC_USP7_MATH_1	321	325	PF00917	0.492
DOC_USP7_MATH_1	350	354	PF00917	0.435
DOC_USP7_MATH_1	434	438	PF00917	0.549
DOC_USP7_MATH_1	476	480	PF00917	0.509
DOC_USP7_MATH_1	608	612	PF00917	0.559
DOC_USP7_MATH_1	813	817	PF00917	0.551
DOC_USP7_MATH_1	866	870	PF00917	0.398
DOC_WW_Pin1_4	203	208	PF00397	0.517
DOC_WW_Pin1_4	216	221	PF00397	0.423
DOC_WW_Pin1_4	250	255	PF00397	0.480
DOC_WW_Pin1_4	332	337	PF00397	0.485
DOC_WW_Pin1_4	432	437	PF00397	0.609
DOC_WW_Pin1_4	683	688	PF00397	0.541
DOC_WW_Pin1_4	724	729	PF00397	0.549
DOC_WW_Pin1_4	749	754	PF00397	0.522
DOC_WW_Pin1_4	831	836	PF00397	0.536
LIG_14-3-3_CanoR_1	135	141	PF00244	0.369
LIG_14-3-3_CanoR_1	145	151	PF00244	0.371
LIG_14-3-3_CanoR_1	17	22	PF00244	0.486
LIG_14-3-3_CanoR_1	351	355	PF00244	0.500
LIG_14-3-3_CanoR_1	576	584	PF00244	0.557
LIG_14-3-3_CanoR_1	600	606	PF00244	0.664
LIG_14-3-3_CanoR_1	658	667	PF00244	0.451
LIG_14-3-3_CanoR_1	704	710	PF00244	0.527
LIG_14-3-3_CanoR_1	78	83	PF00244	0.454
LIG_14-3-3_CanoR_1	782	791	PF00244	0.342
LIG_14-3-3_CanoR_1	836	844	PF00244	0.513
LIG_14-3-3_CanoR_1	884	892	PF00244	0.349
LIG_14-3-3_CanoR_1	904	914	PF00244	0.384
LIG_APCC_ABBA_1	697	702	PF00400	0.410
LIG_APCC_ABBA_1	933	938	PF00400	0.223
LIG_FHA_1	163	169	PF00498	0.489
LIG_FHA_1	198	204	PF00498	0.495
LIG_FHA_1	299	305	PF00498	0.461
LIG_FHA_1	531	537	PF00498	0.452
LIG_FHA_1	558	564	PF00498	0.419
LIG_FHA_1	668	674	PF00498	0.452
LIG_FHA_1	684	690	PF00498	0.543
LIG_FHA_1	819	825	PF00498	0.490
LIG_FHA_1	832	838	PF00498	0.604
LIG_FHA_2	147	153	PF00498	0.414
LIG_FHA_2	154	160	PF00498	0.472
LIG_FHA_2	283	289	PF00498	0.524
LIG_FHA_2	496	502	PF00498	0.329
LIG_FHA_2	590	596	PF00498	0.538
LIG_FHA_2	676	682	PF00498	0.477
LIG_FHA_2	731	737	PF00498	0.555
LIG_FHA_2	954	960	PF00498	0.370
LIG_HCF-1_HBM_1	261	264	PF13415	0.476
LIG_LIR_Apic_2	257	263	PF02991	0.362
LIG_LIR_Apic_2	722	728	PF02991	0.511
LIG_LIR_Gen_1	296	307	PF02991	0.443
LIG_LIR_Gen_1	694	705	PF02991	0.367
LIG_LIR_Gen_1	817	828	PF02991	0.376
LIG_LIR_Gen_1	862	873	PF02991	0.287
LIG_LIR_Gen_1	886	895	PF02991	0.319
LIG_LIR_Gen_1	963	971	PF02991	0.592
LIG_LIR_Nem_3	14	19	PF02991	0.440
LIG_LIR_Nem_3	296	302	PF02991	0.442
LIG_LIR_Nem_3	33	38	PF02991	0.474
LIG_LIR_Nem_3	694	700	PF02991	0.342
LIG_LIR_Nem_3	714	720	PF02991	0.246
LIG_LIR_Nem_3	817	823	PF02991	0.388
LIG_LIR_Nem_3	862	868	PF02991	0.287
LIG_LIR_Nem_3	886	892	PF02991	0.319
LIG_LIR_Nem_3	963	968	PF02991	0.524
LIG_NRBOX	157	163	PF00104	0.503
LIG_NRBOX	232	238	PF00104	0.484
LIG_NRBOX	503	509	PF00104	0.398
LIG_NRBOX	531	537	PF00104	0.398
LIG_NRBOX	719	725	PF00104	0.390
LIG_NRBOX	823	829	PF00104	0.384
LIG_PCNA_yPIPBox_3	583	597	PF02747	0.512
LIG_PDZ_Class_3	966	971	PF00595	0.525
LIG_Pex14_2	636	640	PF04695	0.420
LIG_PTAP_UEV_1	269	274	PF05743	0.543
LIG_REV1ctd_RIR_1	625	631	PF16727	0.468
LIG_RPA_C_Fungi	130	142	PF08784	0.378
LIG_RPA_C_Fungi	777	789	PF08784	0.512
LIG_SH2_CRK	16	20	PF00017	0.478
LIG_SH2_CRK	35	39	PF00017	0.478
LIG_SH2_CRK	820	824	PF00017	0.411
LIG_SH2_CRK	889	893	PF00017	0.358
LIG_SH2_NCK_1	260	264	PF00017	0.475
LIG_SH2_NCK_1	542	546	PF00017	0.334
LIG_SH2_SRC	260	263	PF00017	0.350
LIG_SH2_SRC	542	545	PF00017	0.398
LIG_SH2_SRC	812	815	PF00017	0.559
LIG_SH2_STAP1	318	322	PF00017	0.510
LIG_SH2_STAP1	542	546	PF00017	0.406
LIG_SH2_STAP1	669	673	PF00017	0.394
LIG_SH2_STAP1	713	717	PF00017	0.478
LIG_SH2_STAP1	807	811	PF00017	0.384
LIG_SH2_STAP1	820	824	PF00017	0.357
LIG_SH2_STAP1	889	893	PF00017	0.336
LIG_SH2_STAT3	587	590	PF00017	0.485
LIG_SH2_STAT3	695	698	PF00017	0.450
LIG_SH2_STAT5	190	193	PF00017	0.356
LIG_SH2_STAT5	264	267	PF00017	0.362
LIG_SH2_STAT5	347	350	PF00017	0.338
LIG_SH2_STAT5	404	407	PF00017	0.404
LIG_SH2_STAT5	460	463	PF00017	0.417
LIG_SH2_STAT5	669	672	PF00017	0.477
LIG_SH2_STAT5	679	682	PF00017	0.535
LIG_SH2_STAT5	695	698	PF00017	0.390
LIG_SH2_STAT5	763	766	PF00017	0.430
LIG_SH2_STAT5	820	823	PF00017	0.411
LIG_SH3_3	163	169	PF00018	0.467
LIG_SH3_3	214	220	PF00018	0.455
LIG_SH3_3	267	273	PF00018	0.495
LIG_SH3_3	276	282	PF00018	0.320
LIG_SH3_3	433	439	PF00018	0.596
LIG_SH3_3	704	710	PF00018	0.527
LIG_SH3_3	854	860	PF00018	0.300
LIG_SUMO_SIM_anti_2	62	68	PF11976	0.457
LIG_SUMO_SIM_anti_2	838	846	PF11976	0.315
LIG_SUMO_SIM_par_1	163	170	PF11976	0.470
LIG_SUMO_SIM_par_1	335	341	PF11976	0.375
LIG_SUMO_SIM_par_1	467	472	PF11976	0.399
LIG_SUMO_SIM_par_1	532	537	PF11976	0.398
LIG_SUMO_SIM_par_1	689	694	PF11976	0.474
LIG_SUMO_SIM_par_1	88	94	PF11976	0.332
LIG_TRAF2_1	734	737	PF00917	0.637
LIG_Vh1_VBS_1	605	623	PF01044	0.450
LIG_WRC_WIRS_1	492	497	PF05994	0.403
LIG_WRC_WIRS_1	868	873	PF05994	0.287
MOD_CDC14_SPxK_1	727	730	PF00782	0.591
MOD_CDK_SPK_2	203	208	PF00069	0.539
MOD_CDK_SPK_2	683	688	PF00069	0.541
MOD_CDK_SPK_2	831	836	PF00069	0.545
MOD_CDK_SPxK_1	724	730	PF00069	0.551
MOD_CK1_1	196	202	PF00069	0.479
MOD_CK1_1	31	37	PF00069	0.361
MOD_CK1_1	413	419	PF00069	0.546
MOD_CK1_1	479	485	PF00069	0.301
MOD_CK1_1	59	65	PF00069	0.381
MOD_CK1_1	599	605	PF00069	0.622
MOD_CK2_1	146	152	PF00069	0.400
MOD_CK2_1	282	288	PF00069	0.465
MOD_CK2_1	409	415	PF00069	0.505
MOD_CK2_1	469	475	PF00069	0.406
MOD_CK2_1	495	501	PF00069	0.341
MOD_CK2_1	589	595	PF00069	0.568
MOD_CK2_1	635	641	PF00069	0.479
MOD_CK2_1	675	681	PF00069	0.467
MOD_CK2_1	730	736	PF00069	0.531
MOD_Cter_Amidation	185	188	PF01082	0.468
MOD_Cter_Amidation	84	87	PF01082	0.469
MOD_GlcNHglycan	107	110	PF01048	0.568
MOD_GlcNHglycan	162	165	PF01048	0.400
MOD_GlcNHglycan	208	211	PF01048	0.505
MOD_GlcNHglycan	270	273	PF01048	0.515
MOD_GlcNHglycan	319	322	PF01048	0.390
MOD_GlcNHglycan	391	394	PF01048	0.362
MOD_GlcNHglycan	471	474	PF01048	0.578
MOD_GlcNHglycan	566	569	PF01048	0.611
MOD_GlcNHglycan	57	61	PF01048	0.541
MOD_GlcNHglycan	579	582	PF01048	0.492
MOD_GlcNHglycan	601	604	PF01048	0.621
MOD_GlcNHglycan	606	609	PF01048	0.496
MOD_GlcNHglycan	758	761	PF01048	0.532
MOD_GlcNHglycan	770	773	PF01048	0.517
MOD_GlcNHglycan	885	888	PF01048	0.313
MOD_GlcNHglycan	889	892	PF01048	0.329
MOD_GlcNHglycan	953	956	PF01048	0.314
MOD_GSK3_1	193	200	PF00069	0.518
MOD_GSK3_1	264	271	PF00069	0.469
MOD_GSK3_1	289	296	PF00069	0.438
MOD_GSK3_1	30	37	PF00069	0.452
MOD_GSK3_1	317	324	PF00069	0.389
MOD_GSK3_1	409	416	PF00069	0.539
MOD_GSK3_1	491	498	PF00069	0.423
MOD_GSK3_1	595	602	PF00069	0.582
MOD_GSK3_1	604	611	PF00069	0.550
MOD_GSK3_1	616	623	PF00069	0.365
MOD_GSK3_1	677	684	PF00069	0.516
MOD_GSK3_1	724	731	PF00069	0.572
MOD_GSK3_1	814	821	PF00069	0.572
MOD_GSK3_1	831	838	PF00069	0.392
MOD_GSK3_1	883	890	PF00069	0.354
MOD_LATS_1	781	787	PF00433	0.508
MOD_N-GLC_1	795	800	PF02516	0.427
MOD_N-GLC_1	878	883	PF02516	0.390
MOD_N-GLC_2	512	514	PF02516	0.276
MOD_N-GLC_2	845	847	PF02516	0.358
MOD_NEK2_1	123	128	PF00069	0.442
MOD_NEK2_1	151	156	PF00069	0.538
MOD_NEK2_1	160	165	PF00069	0.495
MOD_NEK2_1	178	183	PF00069	0.404
MOD_NEK2_1	349	354	PF00069	0.496
MOD_NEK2_1	491	496	PF00069	0.473
MOD_NEK2_2	589	594	PF00069	0.396
MOD_NEK2_2	7	12	PF00069	0.395
MOD_NEK2_2	807	812	PF00069	0.392
MOD_NEK2_2	953	958	PF00069	0.392
MOD_PIKK_1	460	466	PF00454	0.486
MOD_PIKK_1	479	485	PF00454	0.444
MOD_PIKK_1	544	550	PF00454	0.398
MOD_PK_1	28	34	PF00069	0.379
MOD_PKA_1	146	152	PF00069	0.365
MOD_PKA_1	782	788	PF00069	0.441
MOD_PKA_2	146	152	PF00069	0.461
MOD_PKA_2	350	356	PF00069	0.502
MOD_PKA_2	599	605	PF00069	0.516
MOD_PKA_2	782	788	PF00069	0.317
MOD_PKA_2	835	841	PF00069	0.477
MOD_PKA_2	883	889	PF00069	0.336
MOD_PKB_1	926	934	PF00069	0.398
MOD_Plk_1	115	121	PF00069	0.441
MOD_Plk_1	288	294	PF00069	0.600
MOD_Plk_1	409	415	PF00069	0.543
MOD_Plk_1	609	615	PF00069	0.460
MOD_Plk_1	802	808	PF00069	0.520
MOD_Plk_1	878	884	PF00069	0.389
MOD_Plk_2-3	410	416	PF00069	0.490
MOD_Plk_4	146	152	PF00069	0.438
MOD_Plk_4	162	168	PF00069	0.499
MOD_Plk_4	173	179	PF00069	0.458
MOD_Plk_4	530	536	PF00069	0.406
MOD_Plk_4	61	67	PF00069	0.509
MOD_Plk_4	623	629	PF00069	0.338
MOD_Plk_4	635	641	PF00069	0.523
MOD_Plk_4	642	648	PF00069	0.442
MOD_Plk_4	78	84	PF00069	0.526
MOD_Plk_4	867	873	PF00069	0.445
MOD_Plk_4	928	934	PF00069	0.358
MOD_ProDKin_1	203	209	PF00069	0.524
MOD_ProDKin_1	216	222	PF00069	0.430
MOD_ProDKin_1	250	256	PF00069	0.478
MOD_ProDKin_1	332	338	PF00069	0.474
MOD_ProDKin_1	432	438	PF00069	0.606
MOD_ProDKin_1	683	689	PF00069	0.537
MOD_ProDKin_1	724	730	PF00069	0.561
MOD_ProDKin_1	749	755	PF00069	0.516
MOD_ProDKin_1	831	837	PF00069	0.529
MOD_SUMO_rev_2	44	49	PF00179	0.434
TRG_AP2beta_CARGO_1	694	704	PF09066	0.476
TRG_DiLeu_BaEn_4	736	742	PF01217	0.536
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.469
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.449
TRG_ENDOCYTIC_2	16	19	PF00928	0.433
TRG_ENDOCYTIC_2	299	302	PF00928	0.534
TRG_ENDOCYTIC_2	35	38	PF00928	0.489
TRG_ENDOCYTIC_2	637	640	PF00928	0.404
TRG_ENDOCYTIC_2	820	823	PF00928	0.527
TRG_ENDOCYTIC_2	889	892	PF00928	0.358
TRG_ENDOCYTIC_2	965	968	PF00928	0.528
TRG_ER_diArg_1	145	148	PF00400	0.496
TRG_ER_diArg_1	628	631	PF00400	0.433
TRG_ER_diArg_1	738	741	PF00400	0.446
TRG_ER_diArg_1	86	88	PF00400	0.446
TRG_ER_diArg_1	925	928	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	896	901	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	925	930	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT4	Leptomonas seymouri	52%	99%
A0A1X0NP42	Trypanosomatidae	29%	97%
A0A3R7M5A4	Trypanosoma rangeli	31%	99%
C9ZI46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
E9AGJ5	Leishmania infantum	100%	100%
E9AIN3	Leishmania braziliensis	79%	100%
E9AP32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QGF6	Leishmania major	91%	100%
Q8L5Y0	Arabidopsis thaliana	22%	97%
V5BF34	Trypanosoma cruzi	31%	98%