Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TATA element modulatory factor 1 TATA binding, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSC1_LEIDO

TriTrypDb:

LdBPK_130370.1 , LdCL_130009100 , LDHU3_13.0530

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WSC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.609
CLV_MEL_PAP_1	295	301	PF00089	0.529
CLV_NRD_NRD_1	563	565	PF00675	0.491
CLV_NRD_NRD_1	591	593	PF00675	0.592
CLV_NRD_NRD_1	673	675	PF00675	0.531
CLV_NRD_NRD_1	732	734	PF00675	0.574
CLV_PCSK_KEX2_1	539	541	PF00082	0.602
CLV_PCSK_KEX2_1	664	666	PF00082	0.576
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.602
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.559
CLV_PCSK_SKI1_1	126	130	PF00082	0.516
CLV_Separin_Metazoa	683	687	PF03568	0.458
DEG_APCC_DBOX_1	453	461	PF00400	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.485
DEG_SCF_FBW7_1	136	141	PF00400	0.542
DEG_SCF_FBW7_2	181	187	PF00400	0.597
DEG_SIAH_1	97	105	PF03145	0.666
DEG_SPOP_SBC_1	235	239	PF00917	0.797
DOC_CDC14_PxL_1	651	659	PF14671	0.611
DOC_CKS1_1	181	186	PF01111	0.583
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.591
DOC_MAPK_gen_1	592	598	PF00069	0.596
DOC_PP2B_LxvP_1	188	191	PF13499	0.610
DOC_PP2B_LxvP_1	82	85	PF13499	0.661
DOC_PP4_FxxP_1	121	124	PF00568	0.524
DOC_USP7_MATH_1	110	114	PF00917	0.598
DOC_USP7_MATH_1	160	164	PF00917	0.626
DOC_USP7_MATH_1	221	225	PF00917	0.680
DOC_USP7_MATH_1	235	239	PF00917	0.549
DOC_USP7_MATH_1	243	247	PF00917	0.610
DOC_USP7_MATH_1	309	313	PF00917	0.626
DOC_USP7_MATH_1	42	46	PF00917	0.525
DOC_USP7_MATH_1	493	497	PF00917	0.531
DOC_USP7_MATH_1	62	66	PF00917	0.644
DOC_USP7_MATH_1	659	663	PF00917	0.550
DOC_USP7_MATH_1	745	749	PF00917	0.670
DOC_USP7_MATH_1	750	754	PF00917	0.617
DOC_WW_Pin1_4	112	117	PF00397	0.589
DOC_WW_Pin1_4	134	139	PF00397	0.552
DOC_WW_Pin1_4	169	174	PF00397	0.738
DOC_WW_Pin1_4	180	185	PF00397	0.567
DOC_WW_Pin1_4	198	203	PF00397	0.739
DOC_WW_Pin1_4	241	246	PF00397	0.650
DOC_WW_Pin1_4	251	256	PF00397	0.607
DOC_WW_Pin1_4	37	42	PF00397	0.552
DOC_WW_Pin1_4	638	643	PF00397	0.677
LIG_14-3-3_CanoR_1	290	296	PF00244	0.579
LIG_14-3-3_CanoR_1	298	303	PF00244	0.485
LIG_14-3-3_CanoR_1	404	413	PF00244	0.378
LIG_14-3-3_CanoR_1	454	458	PF00244	0.536
LIG_14-3-3_CanoR_1	488	494	PF00244	0.504
LIG_14-3-3_CanoR_1	512	518	PF00244	0.548
LIG_14-3-3_CanoR_1	552	556	PF00244	0.551
LIG_14-3-3_CanoR_1	650	655	PF00244	0.599
LIG_14-3-3_CanoR_1	686	694	PF00244	0.539
LIG_Actin_WH2_2	409	427	PF00022	0.528
LIG_Actin_WH2_2	439	456	PF00022	0.540
LIG_Actin_WH2_2	591	608	PF00022	0.594
LIG_APCC_Cbox_2	572	578	PF00515	0.552
LIG_BRCT_BRCA1_1	237	241	PF00533	0.638
LIG_CtBP_PxDLS_1	185	189	PF00389	0.572
LIG_EH_1	657	661	PF12763	0.664
LIG_FHA_1	163	169	PF00498	0.544
LIG_FHA_1	217	223	PF00498	0.581
LIG_FHA_1	308	314	PF00498	0.624
LIG_FHA_1	466	472	PF00498	0.552
LIG_FHA_1	527	533	PF00498	0.534
LIG_FHA_2	127	133	PF00498	0.590
LIG_FHA_2	181	187	PF00498	0.571
LIG_FHA_2	299	305	PF00498	0.431
LIG_FHA_2	432	438	PF00498	0.539
LIG_FHA_2	460	466	PF00498	0.539
LIG_FHA_2	497	503	PF00498	0.505
LIG_FHA_2	522	528	PF00498	0.517
LIG_FHA_2	582	588	PF00498	0.579
LIG_GBD_Chelix_1	399	407	PF00786	0.527
LIG_LIR_Apic_2	119	124	PF02991	0.526
LIG_LIR_Gen_1	115	125	PF02991	0.507
LIG_LIR_Gen_1	264	272	PF02991	0.585
LIG_LIR_Gen_1	527	536	PF02991	0.447
LIG_LIR_Gen_1	571	581	PF02991	0.554
LIG_LIR_Nem_3	115	121	PF02991	0.514
LIG_LIR_Nem_3	264	268	PF02991	0.605
LIG_LIR_Nem_3	527	531	PF02991	0.532
LIG_LIR_Nem_3	533	538	PF02991	0.467
LIG_LIR_Nem_3	571	577	PF02991	0.548
LIG_MYND_1	655	659	PF01753	0.600
LIG_Pex14_1	570	574	PF04695	0.545
LIG_Pex14_1	704	708	PF04695	0.478
LIG_PTAP_UEV_1	84	89	PF05743	0.584
LIG_SH2_CRK	528	532	PF00017	0.514
LIG_SH2_CRK	535	539	PF00017	0.473
LIG_SH2_CRK	708	712	PF00017	0.508
LIG_SH2_SRC	215	218	PF00017	0.526
LIG_SH2_STAP1	428	432	PF00017	0.547
LIG_SH2_STAP1	528	532	PF00017	0.578
LIG_SH2_STAT3	428	431	PF00017	0.535
LIG_SH2_STAT5	528	531	PF00017	0.626
LIG_SH2_STAT5	574	577	PF00017	0.554
LIG_SH3_3	100	106	PF00018	0.573
LIG_SH3_3	121	127	PF00018	0.569
LIG_SH3_3	170	176	PF00018	0.587
LIG_SH3_3	178	184	PF00018	0.558
LIG_SH3_3	239	245	PF00018	0.651
LIG_SH3_3	250	256	PF00018	0.606
LIG_SH3_3	35	41	PF00018	0.553
LIG_SH3_3	653	659	PF00018	0.559
LIG_SH3_3	82	88	PF00018	0.597
LIG_SUMO_SIM_anti_2	14	24	PF11976	0.548
LIG_TRAF2_1	184	187	PF00917	0.580
LIG_TRAF2_1	301	304	PF00917	0.560
LIG_TRAF2_1	370	373	PF00917	0.459
LIG_TRAF2_1	576	579	PF00917	0.565
LIG_TRFH_1	121	125	PF08558	0.500
LIG_UBA3_1	326	332	PF00899	0.559
MOD_CDC14_SPxK_1	172	175	PF00782	0.648
MOD_CDK_SPxK_1	169	175	PF00069	0.649
MOD_CK1_1	112	118	PF00069	0.640
MOD_CK1_1	131	137	PF00069	0.502
MOD_CK1_1	150	156	PF00069	0.550
MOD_CK1_1	195	201	PF00069	0.667
MOD_CK1_1	224	230	PF00069	0.599
MOD_CK1_1	237	243	PF00069	0.530
MOD_CK1_1	439	445	PF00069	0.544
MOD_CK1_1	45	51	PF00069	0.513
MOD_CK1_1	496	502	PF00069	0.538
MOD_CK1_1	510	516	PF00069	0.386
MOD_CK1_1	554	560	PF00069	0.522
MOD_CK1_1	634	640	PF00069	0.731
MOD_CK1_1	748	754	PF00069	0.679
MOD_CK2_1	180	186	PF00069	0.791
MOD_CK2_1	297	303	PF00069	0.585
MOD_CK2_1	367	373	PF00069	0.460
MOD_CK2_1	431	437	PF00069	0.497
MOD_CK2_1	502	508	PF00069	0.551
MOD_CK2_1	521	527	PF00069	0.381
MOD_CK2_1	581	587	PF00069	0.676
MOD_CK2_1	613	619	PF00069	0.684
MOD_CK2_1	629	635	PF00069	0.543
MOD_GlcNHglycan	112	115	PF01048	0.569
MOD_GlcNHglycan	138	141	PF01048	0.664
MOD_GlcNHglycan	147	150	PF01048	0.758
MOD_GlcNHglycan	158	161	PF01048	0.574
MOD_GlcNHglycan	197	200	PF01048	0.616
MOD_GlcNHglycan	210	213	PF01048	0.521
MOD_GlcNHglycan	227	230	PF01048	0.506
MOD_GlcNHglycan	369	372	PF01048	0.606
MOD_GlcNHglycan	428	431	PF01048	0.535
MOD_GlcNHglycan	513	516	PF01048	0.542
MOD_GlcNHglycan	560	563	PF01048	0.536
MOD_GlcNHglycan	60	63	PF01048	0.610
MOD_GlcNHglycan	607	610	PF01048	0.603
MOD_GlcNHglycan	638	641	PF01048	0.618
MOD_GlcNHglycan	652	655	PF01048	0.729
MOD_GlcNHglycan	687	690	PF01048	0.537
MOD_GlcNHglycan	748	751	PF01048	0.633
MOD_GlcNHglycan	754	757	PF01048	0.582
MOD_GlcNHglycan	85	88	PF01048	0.658
MOD_GSK3_1	105	112	PF00069	0.660
MOD_GSK3_1	134	141	PF00069	0.646
MOD_GSK3_1	156	163	PF00069	0.612
MOD_GSK3_1	216	223	PF00069	0.617
MOD_GSK3_1	224	231	PF00069	0.698
MOD_GSK3_1	237	244	PF00069	0.534
MOD_GSK3_1	309	316	PF00069	0.626
MOD_GSK3_1	431	438	PF00069	0.496
MOD_GSK3_1	459	466	PF00069	0.540
MOD_GSK3_1	507	514	PF00069	0.538
MOD_GSK3_1	534	541	PF00069	0.534
MOD_GSK3_1	554	561	PF00069	0.314
MOD_GSK3_1	577	584	PF00069	0.594
MOD_GSK3_1	58	65	PF00069	0.620
MOD_GSK3_1	611	618	PF00069	0.555
MOD_GSK3_1	634	641	PF00069	0.686
MOD_GSK3_1	746	753	PF00069	0.657
MOD_N-GLC_1	291	296	PF02516	0.585
MOD_N-GLC_1	458	463	PF02516	0.538
MOD_N-GLC_1	668	673	PF02516	0.510
MOD_NEK2_1	1	6	PF00069	0.456
MOD_NEK2_1	424	429	PF00069	0.606
MOD_NEK2_1	453	458	PF00069	0.518
MOD_NEK2_1	507	512	PF00069	0.541
MOD_NEK2_1	538	543	PF00069	0.492
MOD_NEK2_1	577	582	PF00069	0.494
MOD_NEK2_1	598	603	PF00069	0.613
MOD_NEK2_1	605	610	PF00069	0.603
MOD_NEK2_1	613	618	PF00069	0.544
MOD_NEK2_1	621	626	PF00069	0.456
MOD_NEK2_2	116	121	PF00069	0.514
MOD_NEK2_2	659	664	PF00069	0.552
MOD_PIKK_1	402	408	PF00454	0.527
MOD_PIKK_1	507	513	PF00454	0.539
MOD_PIKK_1	581	587	PF00454	0.516
MOD_PIKK_1	611	617	PF00454	0.669
MOD_PKA_2	150	156	PF00069	0.670
MOD_PKA_2	297	303	PF00069	0.529
MOD_PKA_2	453	459	PF00069	0.538
MOD_PKA_2	487	493	PF00069	0.503
MOD_PKA_2	511	517	PF00069	0.547
MOD_PKA_2	551	557	PF00069	0.524
MOD_PKA_2	591	597	PF00069	0.515
MOD_PKA_2	673	679	PF00069	0.552
MOD_PKA_2	685	691	PF00069	0.456
MOD_Plk_1	291	297	PF00069	0.550
MOD_Plk_1	526	532	PF00069	0.423
MOD_Plk_1	598	604	PF00069	0.591
MOD_Plk_2-3	200	206	PF00069	0.572
MOD_Plk_2-3	502	508	PF00069	0.487
MOD_Plk_2-3	527	533	PF00069	0.478
MOD_Plk_2-3	551	557	PF00069	0.481
MOD_Plk_4	1	7	PF00069	0.451
MOD_Plk_4	45	51	PF00069	0.611
MOD_Plk_4	527	533	PF00069	0.478
MOD_Plk_4	591	597	PF00069	0.594
MOD_ProDKin_1	112	118	PF00069	0.590
MOD_ProDKin_1	134	140	PF00069	0.552
MOD_ProDKin_1	169	175	PF00069	0.738
MOD_ProDKin_1	180	186	PF00069	0.550
MOD_ProDKin_1	198	204	PF00069	0.638
MOD_ProDKin_1	241	247	PF00069	0.653
MOD_ProDKin_1	251	257	PF00069	0.599
MOD_ProDKin_1	37	43	PF00069	0.550
MOD_ProDKin_1	638	644	PF00069	0.680
MOD_SUMO_rev_2	40	48	PF00179	0.524
MOD_SUMO_rev_2	422	427	PF00179	0.421
MOD_SUMO_rev_2	670	676	PF00179	0.619
TRG_DiLeu_BaEn_1	527	532	PF01217	0.533
TRG_DiLeu_BaEn_1	713	718	PF01217	0.518
TRG_DiLeu_BaEn_1	78	83	PF01217	0.648
TRG_DiLeu_BaEn_4	342	348	PF01217	0.503
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.547
TRG_ENDOCYTIC_2	528	531	PF00928	0.597
TRG_ENDOCYTIC_2	535	538	PF00928	0.549
TRG_ENDOCYTIC_2	574	577	PF00928	0.554
TRG_ENDOCYTIC_2	708	711	PF00928	0.521
TRG_ENDOCYTIC_2	722	725	PF00928	0.380
TRG_ER_diArg_1	361	364	PF00400	0.526
TRG_NES_CRM1_1	7	23	PF08389	0.512
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	573	578	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7L520	Trypanosoma rangeli	27%	100%
A4H737	Leishmania braziliensis	74%	100%
E9AP72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QGA6	Leishmania major	94%	100%