Lipase (Class 3), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSB8_LEIDO

TriTrypDb:

LdBPK_130200.1 , LdCL_130007000 , LDHU3_13.0250

Length:

747

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSB8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	579	583	PF00656	0.611
CLV_NRD_NRD_1	163	165	PF00675	0.602
CLV_NRD_NRD_1	194	196	PF00675	0.521
CLV_NRD_NRD_1	302	304	PF00675	0.417
CLV_NRD_NRD_1	367	369	PF00675	0.492
CLV_NRD_NRD_1	551	553	PF00675	0.537
CLV_NRD_NRD_1	608	610	PF00675	0.633
CLV_PCSK_KEX2_1	194	196	PF00082	0.542
CLV_PCSK_KEX2_1	289	291	PF00082	0.441
CLV_PCSK_KEX2_1	31	33	PF00082	0.623
CLV_PCSK_KEX2_1	367	369	PF00082	0.492
CLV_PCSK_KEX2_1	614	616	PF00082	0.620
CLV_PCSK_KEX2_1	674	676	PF00082	0.725
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.412
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.607
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.612
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.720
CLV_PCSK_SKI1_1	227	231	PF00082	0.487
CLV_PCSK_SKI1_1	237	241	PF00082	0.631
CLV_PCSK_SKI1_1	289	293	PF00082	0.493
CLV_PCSK_SKI1_1	303	307	PF00082	0.370
CLV_PCSK_SKI1_1	443	447	PF00082	0.381
CLV_PCSK_SKI1_1	49	53	PF00082	0.564
CLV_PCSK_SKI1_1	723	727	PF00082	0.511
DEG_APCC_DBOX_1	179	187	PF00400	0.520
DEG_APCC_DBOX_1	302	310	PF00400	0.364
DEG_APCC_DBOX_1	478	486	PF00400	0.346
DEG_SCF_TRCP1_1	243	249	PF00400	0.459
DEG_SPOP_SBC_1	18	22	PF00917	0.605
DOC_CYCLIN_RxL_1	109	118	PF00134	0.503
DOC_CYCLIN_RxL_1	286	294	PF00134	0.424
DOC_MAPK_gen_1	213	221	PF00069	0.473
DOC_MAPK_gen_1	303	309	PF00069	0.403
DOC_MAPK_gen_1	443	453	PF00069	0.378
DOC_MAPK_gen_1	479	487	PF00069	0.289
DOC_MAPK_gen_1	552	560	PF00069	0.446
DOC_MAPK_MEF2A_6	213	221	PF00069	0.496
DOC_MAPK_MEF2A_6	436	444	PF00069	0.430
DOC_MAPK_MEF2A_6	479	487	PF00069	0.383
DOC_MAPK_MEF2A_6	719	726	PF00069	0.503
DOC_MAPK_NFAT4_5	719	727	PF00069	0.389
DOC_PP1_RVXF_1	110	117	PF00149	0.540
DOC_PP1_RVXF_1	355	362	PF00149	0.424
DOC_PP1_RVXF_1	75	81	PF00149	0.385
DOC_PP2B_LxvP_1	634	637	PF13499	0.507
DOC_PP2B_PxIxI_1	621	627	PF00149	0.591
DOC_PP4_FxxP_1	350	353	PF00568	0.355
DOC_PP4_FxxP_1	487	490	PF00568	0.318
DOC_USP7_MATH_1	128	132	PF00917	0.563
DOC_USP7_MATH_1	199	203	PF00917	0.494
DOC_USP7_MATH_1	246	250	PF00917	0.663
DOC_USP7_MATH_1	360	364	PF00917	0.422
DOC_USP7_MATH_1	389	393	PF00917	0.414
DOC_USP7_MATH_1	461	465	PF00917	0.356
DOC_USP7_MATH_1	493	497	PF00917	0.332
DOC_USP7_MATH_1	547	551	PF00917	0.498
DOC_USP7_MATH_1	585	589	PF00917	0.633
DOC_USP7_MATH_1	602	606	PF00917	0.539
DOC_USP7_MATH_1	85	89	PF00917	0.421
DOC_USP7_UBL2_3	236	240	PF12436	0.676
DOC_USP7_UBL2_3	610	614	PF12436	0.661
DOC_WW_Pin1_4	200	205	PF00397	0.513
DOC_WW_Pin1_4	213	218	PF00397	0.598
DOC_WW_Pin1_4	472	477	PF00397	0.293
DOC_WW_Pin1_4	615	620	PF00397	0.602
DOC_WW_Pin1_4	66	71	PF00397	0.502
LIG_14-3-3_CanoR_1	100	110	PF00244	0.512
LIG_14-3-3_CanoR_1	121	125	PF00244	0.598
LIG_14-3-3_CanoR_1	227	233	PF00244	0.565
LIG_14-3-3_CanoR_1	290	296	PF00244	0.479
LIG_14-3-3_CanoR_1	436	441	PF00244	0.373
LIG_14-3-3_CanoR_1	595	600	PF00244	0.652
LIG_14-3-3_CanoR_1	648	652	PF00244	0.510
LIG_Actin_WH2_2	430	445	PF00022	0.346
LIG_BIR_III_4	160	164	PF00653	0.574
LIG_BRCT_BRCA1_1	201	205	PF00533	0.408
LIG_eIF4E_1	8	14	PF01652	0.592
LIG_FHA_1	105	111	PF00498	0.435
LIG_FHA_1	216	222	PF00498	0.485
LIG_FHA_1	250	256	PF00498	0.507
LIG_FHA_1	300	306	PF00498	0.413
LIG_FHA_1	375	381	PF00498	0.515
LIG_FHA_1	415	421	PF00498	0.408
LIG_FHA_1	466	472	PF00498	0.355
LIG_FHA_1	708	714	PF00498	0.314
LIG_FHA_2	263	269	PF00498	0.456
LIG_FHA_2	647	653	PF00498	0.506
LIG_FHA_2	665	671	PF00498	0.473
LIG_FHA_2	81	87	PF00498	0.422
LIG_GBD_Chelix_1	462	470	PF00786	0.296
LIG_LIR_Apic_2	348	353	PF02991	0.354
LIG_LIR_Apic_2	486	490	PF02991	0.285
LIG_LIR_Apic_2	740	746	PF02991	0.503
LIG_LIR_Gen_1	202	212	PF02991	0.515
LIG_LIR_Gen_1	261	267	PF02991	0.469
LIG_LIR_Gen_1	344	353	PF02991	0.431
LIG_LIR_Nem_3	178	184	PF02991	0.504
LIG_LIR_Nem_3	202	208	PF02991	0.516
LIG_LIR_Nem_3	261	266	PF02991	0.432
LIG_LIR_Nem_3	329	334	PF02991	0.373
LIG_LIR_Nem_3	344	350	PF02991	0.466
LIG_NRBOX	496	502	PF00104	0.289
LIG_PCNA_yPIPBox_3	436	445	PF02747	0.251
LIG_SH2_CRK	334	338	PF00017	0.344
LIG_SH2_CRK	743	747	PF00017	0.545
LIG_SH2_CRK	8	12	PF00017	0.516
LIG_SH2_GRB2like	510	513	PF00017	0.283
LIG_SH2_NCK_1	125	129	PF00017	0.589
LIG_SH2_NCK_1	743	747	PF00017	0.545
LIG_SH2_NCK_1	8	12	PF00017	0.516
LIG_SH2_SRC	525	528	PF00017	0.507
LIG_SH2_SRC	741	744	PF00017	0.510
LIG_SH2_STAP1	263	267	PF00017	0.456
LIG_SH2_STAP1	334	338	PF00017	0.377
LIG_SH2_STAT5	184	187	PF00017	0.535
LIG_SH2_STAT5	207	210	PF00017	0.459
LIG_SH2_STAT5	427	430	PF00017	0.445
LIG_SH2_STAT5	525	528	PF00017	0.507
LIG_SH2_STAT5	703	706	PF00017	0.395
LIG_SH2_STAT5	741	744	PF00017	0.506
LIG_SH3_3	166	172	PF00018	0.568
LIG_SH3_3	316	322	PF00018	0.410
LIG_SH3_3	334	340	PF00018	0.340
LIG_SH3_3	613	619	PF00018	0.644
LIG_SUMO_SIM_anti_2	218	223	PF11976	0.360
LIG_TRAF2_1	564	567	PF00917	0.468
MOD_CDK_SPxxK_3	472	479	PF00069	0.293
MOD_CK1_1	131	137	PF00069	0.595
MOD_CK1_1	139	145	PF00069	0.524
MOD_CK1_1	147	153	PF00069	0.571
MOD_CK1_1	249	255	PF00069	0.616
MOD_CK1_1	363	369	PF00069	0.533
MOD_CK1_1	464	470	PF00069	0.336
MOD_CK1_1	537	543	PF00069	0.511
MOD_CK1_1	69	75	PF00069	0.506
MOD_CK1_1	717	723	PF00069	0.536
MOD_CK2_1	262	268	PF00069	0.452
MOD_CK2_1	32	38	PF00069	0.654
MOD_CK2_1	561	567	PF00069	0.599
MOD_CK2_1	80	86	PF00069	0.442
MOD_Cter_Amidation	162	165	PF01082	0.598
MOD_DYRK1A_RPxSP_1	615	619	PF00069	0.602
MOD_GlcNHglycan	126	129	PF01048	0.706
MOD_GlcNHglycan	21	24	PF01048	0.716
MOD_GlcNHglycan	243	246	PF01048	0.626
MOD_GlcNHglycan	248	251	PF01048	0.659
MOD_GlcNHglycan	270	273	PF01048	0.454
MOD_GlcNHglycan	350	353	PF01048	0.437
MOD_GlcNHglycan	362	365	PF01048	0.450
MOD_GlcNHglycan	531	534	PF01048	0.550
MOD_GlcNHglycan	585	588	PF01048	0.764
MOD_GlcNHglycan	731	734	PF01048	0.388
MOD_GlcNHglycan	743	746	PF01048	0.455
MOD_GSK3_1	120	127	PF00069	0.520
MOD_GSK3_1	19	26	PF00069	0.718
MOD_GSK3_1	213	220	PF00069	0.536
MOD_GSK3_1	227	234	PF00069	0.458
MOD_GSK3_1	262	269	PF00069	0.475
MOD_GSK3_1	322	329	PF00069	0.434
MOD_GSK3_1	341	348	PF00069	0.424
MOD_GSK3_1	359	366	PF00069	0.455
MOD_GSK3_1	374	381	PF00069	0.379
MOD_GSK3_1	410	417	PF00069	0.493
MOD_GSK3_1	461	468	PF00069	0.346
MOD_GSK3_1	491	498	PF00069	0.358
MOD_GSK3_1	525	532	PF00069	0.535
MOD_GSK3_1	664	671	PF00069	0.462
MOD_GSK3_1	703	710	PF00069	0.387
MOD_N-GLC_1	232	237	PF02516	0.570
MOD_N-GLC_1	514	519	PF02516	0.348
MOD_N-GLC_1	602	607	PF02516	0.540
MOD_N-GLC_1	626	631	PF02516	0.584
MOD_NEK2_1	120	125	PF00069	0.533
MOD_NEK2_1	232	237	PF00069	0.610
MOD_NEK2_1	241	246	PF00069	0.527
MOD_NEK2_1	266	271	PF00069	0.463
MOD_NEK2_1	291	296	PF00069	0.452
MOD_NEK2_1	384	389	PF00069	0.367
MOD_NEK2_1	483	488	PF00069	0.375
MOD_NEK2_1	491	496	PF00069	0.364
MOD_NEK2_1	529	534	PF00069	0.512
MOD_NEK2_2	547	552	PF00069	0.458
MOD_OFUCOSY	55	60	PF10250	0.483
MOD_OFUCOSY	79	84	PF10250	0.437
MOD_PIKK_1	115	121	PF00454	0.598
MOD_PIKK_1	384	390	PF00454	0.367
MOD_PIKK_1	602	608	PF00454	0.590
MOD_PIKK_1	676	682	PF00454	0.405
MOD_PK_1	595	601	PF00069	0.601
MOD_PKA_1	610	616	PF00069	0.616
MOD_PKA_1	674	680	PF00069	0.700
MOD_PKA_2	120	126	PF00069	0.672
MOD_PKA_2	647	653	PF00069	0.501
MOD_PKA_2	674	680	PF00069	0.569
MOD_PKA_2	80	86	PF00069	0.438
MOD_PKA_2	99	105	PF00069	0.352
MOD_Plk_1	664	670	PF00069	0.459
MOD_Plk_4	120	126	PF00069	0.531
MOD_Plk_4	217	223	PF00069	0.461
MOD_Plk_4	262	268	PF00069	0.371
MOD_Plk_4	436	442	PF00069	0.446
MOD_Plk_4	461	467	PF00069	0.379
MOD_Plk_4	525	531	PF00069	0.522
MOD_Plk_4	537	543	PF00069	0.508
MOD_ProDKin_1	200	206	PF00069	0.509
MOD_ProDKin_1	213	219	PF00069	0.595
MOD_ProDKin_1	472	478	PF00069	0.293
MOD_ProDKin_1	615	621	PF00069	0.602
MOD_ProDKin_1	66	72	PF00069	0.500
MOD_SUMO_for_1	502	505	PF00179	0.230
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.370
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.308
TRG_ENDOCYTIC_2	263	266	PF00928	0.459
TRG_ENDOCYTIC_2	334	337	PF00928	0.357
TRG_ENDOCYTIC_2	510	513	PF00928	0.304
TRG_ENDOCYTIC_2	596	599	PF00928	0.598
TRG_ENDOCYTIC_2	693	696	PF00928	0.347
TRG_ENDOCYTIC_2	8	11	PF00928	0.516
TRG_ER_diArg_1	193	195	PF00400	0.563
TRG_ER_diArg_1	367	369	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R6	Leptomonas seymouri	47%	95%
A0A0N1I7D8	Leptomonas seymouri	27%	89%
A0A1X0P712	Trypanosomatidae	25%	100%
A4HHR9	Leishmania braziliensis	28%	93%
A4HHS0	Leishmania braziliensis	54%	100%
A4HVG0	Leishmania infantum	99%	100%
E9AP54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QGD4	Leishmania major	86%	100%