LeishMANIAdb
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RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RING-type domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7WSB7_LEIDO
TriTrypDb:
LdBPK_120820.1 , LdCL_120020300 , LDHU3_12.1620
Length:
866

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSB7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSB7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 5
GO:0043167 ion binding 2 5
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 138 142 PF00656 0.674
CLV_C14_Caspase3-7 194 198 PF00656 0.618
CLV_C14_Caspase3-7 395 399 PF00656 0.568
CLV_NRD_NRD_1 126 128 PF00675 0.701
CLV_NRD_NRD_1 321 323 PF00675 0.505
CLV_NRD_NRD_1 332 334 PF00675 0.439
CLV_NRD_NRD_1 391 393 PF00675 0.696
CLV_NRD_NRD_1 437 439 PF00675 0.548
CLV_NRD_NRD_1 457 459 PF00675 0.377
CLV_NRD_NRD_1 475 477 PF00675 0.539
CLV_NRD_NRD_1 488 490 PF00675 0.619
CLV_NRD_NRD_1 5 7 PF00675 0.750
CLV_NRD_NRD_1 638 640 PF00675 0.593
CLV_NRD_NRD_1 67 69 PF00675 0.694
CLV_PCSK_FUR_1 329 333 PF00082 0.488
CLV_PCSK_KEX2_1 126 128 PF00082 0.701
CLV_PCSK_KEX2_1 321 323 PF00082 0.505
CLV_PCSK_KEX2_1 331 333 PF00082 0.454
CLV_PCSK_KEX2_1 391 393 PF00082 0.696
CLV_PCSK_KEX2_1 439 441 PF00082 0.556
CLV_PCSK_KEX2_1 457 459 PF00082 0.409
CLV_PCSK_KEX2_1 475 477 PF00082 0.539
CLV_PCSK_KEX2_1 488 490 PF00082 0.619
CLV_PCSK_KEX2_1 494 496 PF00082 0.532
CLV_PCSK_KEX2_1 5 7 PF00082 0.750
CLV_PCSK_KEX2_1 855 857 PF00082 0.644
CLV_PCSK_PC1ET2_1 439 441 PF00082 0.702
CLV_PCSK_PC1ET2_1 494 496 PF00082 0.476
CLV_PCSK_PC1ET2_1 855 857 PF00082 0.644
CLV_PCSK_PC7_1 317 323 PF00082 0.515
CLV_PCSK_SKI1_1 200 204 PF00082 0.709
CLV_PCSK_SKI1_1 306 310 PF00082 0.630
CLV_PCSK_SKI1_1 321 325 PF00082 0.530
CLV_PCSK_SKI1_1 332 336 PF00082 0.517
CLV_PCSK_SKI1_1 343 347 PF00082 0.649
CLV_PCSK_SKI1_1 365 369 PF00082 0.594
CLV_PCSK_SKI1_1 537 541 PF00082 0.645
CLV_PCSK_SKI1_1 576 580 PF00082 0.550
CLV_PCSK_SKI1_1 623 627 PF00082 0.722
CLV_Separin_Metazoa 279 283 PF03568 0.586
CLV_Separin_Metazoa 326 330 PF03568 0.572
DEG_APCC_DBOX_1 316 324 PF00400 0.558
DEG_APCC_DBOX_1 437 445 PF00400 0.701
DEG_APCC_DBOX_1 82 90 PF00400 0.613
DEG_SCF_FBW7_1 818 824 PF00400 0.472
DOC_CKS1_1 818 823 PF01111 0.477
DOC_MAPK_gen_1 548 557 PF00069 0.495
DOC_MAPK_gen_1 80 89 PF00069 0.616
DOC_MAPK_gen_1 854 862 PF00069 0.635
DOC_MAPK_JIP1_4 83 89 PF00069 0.458
DOC_MAPK_MEF2A_6 551 559 PF00069 0.647
DOC_MAPK_MEF2A_6 83 91 PF00069 0.616
DOC_MAPK_MEF2A_6 854 862 PF00069 0.635
DOC_PIKK_1 436 444 PF02985 0.587
DOC_PP1_RVXF_1 401 408 PF00149 0.637
DOC_USP7_MATH_1 270 274 PF00917 0.680
DOC_USP7_MATH_1 377 381 PF00917 0.568
DOC_USP7_MATH_1 741 745 PF00917 0.630
DOC_USP7_MATH_1 793 797 PF00917 0.686
DOC_USP7_MATH_1 821 825 PF00917 0.558
DOC_USP7_UBL2_3 65 69 PF12436 0.720
DOC_USP7_UBL2_3 850 854 PF12436 0.637
DOC_WW_Pin1_4 69 74 PF00397 0.719
DOC_WW_Pin1_4 78 83 PF00397 0.518
DOC_WW_Pin1_4 817 822 PF00397 0.659
LIG_14-3-3_CanoR_1 190 199 PF00244 0.620
LIG_14-3-3_CanoR_1 379 383 PF00244 0.633
LIG_14-3-3_CanoR_1 5 11 PF00244 0.734
LIG_14-3-3_CanoR_1 535 540 PF00244 0.611
LIG_14-3-3_CanoR_1 699 705 PF00244 0.579
LIG_14-3-3_CanoR_1 778 783 PF00244 0.654
LIG_14-3-3_CanoR_1 816 821 PF00244 0.617
LIG_Actin_WH2_2 273 288 PF00022 0.624
LIG_eIF4E_1 768 774 PF01652 0.568
LIG_FHA_1 145 151 PF00498 0.665
LIG_FHA_1 272 278 PF00498 0.729
LIG_FHA_1 342 348 PF00498 0.503
LIG_FHA_1 383 389 PF00498 0.693
LIG_FHA_1 494 500 PF00498 0.527
LIG_FHA_1 586 592 PF00498 0.781
LIG_FHA_1 603 609 PF00498 0.729
LIG_FHA_1 810 816 PF00498 0.593
LIG_FHA_1 99 105 PF00498 0.680
LIG_FHA_2 132 138 PF00498 0.671
LIG_FHA_2 274 280 PF00498 0.723
LIG_FHA_2 300 306 PF00498 0.587
LIG_FHA_2 307 313 PF00498 0.576
LIG_FHA_2 427 433 PF00498 0.547
LIG_FHA_2 536 542 PF00498 0.608
LIG_FHA_2 614 620 PF00498 0.554
LIG_FHA_2 715 721 PF00498 0.657
LIG_FHA_2 835 841 PF00498 0.613
LIG_LIR_Apic_2 753 758 PF02991 0.489
LIG_LIR_Gen_1 167 175 PF02991 0.609
LIG_LIR_Gen_1 633 642 PF02991 0.694
LIG_LIR_Nem_3 197 202 PF02991 0.664
LIG_LIR_Nem_3 633 637 PF02991 0.689
LIG_LIR_Nem_3 720 724 PF02991 0.509
LIG_NRBOX 323 329 PF00104 0.564
LIG_NRBOX 857 863 PF00104 0.555
LIG_PCNA_yPIPBox_3 806 815 PF02747 0.475
LIG_Rb_LxCxE_1 820 840 PF01857 0.629
LIG_SH2_CRK 755 759 PF00017 0.573
LIG_SH2_SRC 543 546 PF00017 0.575
LIG_SH2_STAP1 570 574 PF00017 0.638
LIG_SH2_STAT3 570 573 PF00017 0.639
LIG_SH2_STAT5 295 298 PF00017 0.702
LIG_SH2_STAT5 75 78 PF00017 0.638
LIG_SH2_STAT5 755 758 PF00017 0.553
LIG_SH2_STAT5 768 771 PF00017 0.373
LIG_SH3_3 25 31 PF00018 0.695
LIG_SH3_3 836 842 PF00018 0.545
LIG_SH3_4 65 72 PF00018 0.595
LIG_SUMO_SIM_anti_2 276 282 PF11976 0.522
LIG_SUMO_SIM_anti_2 85 91 PF11976 0.610
LIG_SUMO_SIM_anti_2 857 862 PF11976 0.629
LIG_TRAF2_1 302 305 PF00917 0.636
LIG_TRAF2_1 334 337 PF00917 0.697
LIG_TRAF2_1 429 432 PF00917 0.622
LIG_TRAF2_1 542 545 PF00917 0.520
LIG_TRAF2_1 689 692 PF00917 0.583
LIG_TRAF2_1 706 709 PF00917 0.483
LIG_UBA3_1 843 850 PF00899 0.552
LIG_WW_2 28 31 PF00397 0.728
MOD_CDK_SPK_2 78 83 PF00069 0.644
MOD_CK1_1 216 222 PF00069 0.606
MOD_CK1_1 22 28 PF00069 0.571
MOD_CK1_1 273 279 PF00069 0.722
MOD_CK1_1 781 787 PF00069 0.695
MOD_CK2_1 131 137 PF00069 0.661
MOD_CK2_1 223 229 PF00069 0.646
MOD_CK2_1 273 279 PF00069 0.722
MOD_CK2_1 299 305 PF00069 0.582
MOD_CK2_1 306 312 PF00069 0.578
MOD_CK2_1 377 383 PF00069 0.633
MOD_CK2_1 411 417 PF00069 0.731
MOD_CK2_1 426 432 PF00069 0.518
MOD_CK2_1 535 541 PF00069 0.597
MOD_CK2_1 613 619 PF00069 0.609
MOD_CK2_1 737 743 PF00069 0.609
MOD_CK2_1 793 799 PF00069 0.747
MOD_CK2_1 834 840 PF00069 0.527
MOD_GlcNHglycan 11 15 PF01048 0.698
MOD_GlcNHglycan 114 117 PF01048 0.681
MOD_GlcNHglycan 137 140 PF01048 0.625
MOD_GlcNHglycan 215 218 PF01048 0.635
MOD_GlcNHglycan 41 44 PF01048 0.720
MOD_GlcNHglycan 522 525 PF01048 0.677
MOD_GlcNHglycan 58 61 PF01048 0.572
MOD_GlcNHglycan 739 742 PF01048 0.566
MOD_GlcNHglycan 743 746 PF01048 0.499
MOD_GlcNHglycan 786 789 PF01048 0.671
MOD_GSK3_1 131 138 PF00069 0.566
MOD_GSK3_1 19 26 PF00069 0.545
MOD_GSK3_1 35 42 PF00069 0.527
MOD_GSK3_1 378 385 PF00069 0.687
MOD_GSK3_1 387 394 PF00069 0.523
MOD_GSK3_1 407 414 PF00069 0.375
MOD_GSK3_1 444 451 PF00069 0.607
MOD_GSK3_1 6 13 PF00069 0.706
MOD_GSK3_1 737 744 PF00069 0.561
MOD_GSK3_1 817 824 PF00069 0.557
MOD_GSK3_1 829 836 PF00069 0.574
MOD_LATS_1 363 369 PF00433 0.449
MOD_LATS_1 583 589 PF00433 0.769
MOD_LATS_1 776 782 PF00433 0.556
MOD_N-GLC_1 585 590 PF02516 0.735
MOD_N-GLC_1 778 783 PF02516 0.576
MOD_N-GLC_1 816 821 PF02516 0.481
MOD_NEK2_1 10 15 PF00069 0.697
MOD_NEK2_1 131 136 PF00069 0.652
MOD_NEK2_1 191 196 PF00069 0.620
MOD_NEK2_1 208 213 PF00069 0.413
MOD_NEK2_1 351 356 PF00069 0.477
MOD_NEK2_1 444 449 PF00069 0.693
MOD_NEK2_1 579 584 PF00069 0.509
MOD_NEK2_1 714 719 PF00069 0.657
MOD_NEK2_1 809 814 PF00069 0.602
MOD_NEK2_2 821 826 PF00069 0.475
MOD_PIKK_1 208 214 PF00454 0.707
MOD_PIKK_1 228 234 PF00454 0.381
MOD_PIKK_1 423 429 PF00454 0.672
MOD_PIKK_1 444 450 PF00454 0.695
MOD_PIKK_1 501 507 PF00454 0.484
MOD_PIKK_1 585 591 PF00454 0.772
MOD_PIKK_1 714 720 PF00454 0.658
MOD_PIKK_1 95 101 PF00454 0.670
MOD_PK_1 100 106 PF00069 0.680
MOD_PKA_1 332 338 PF00069 0.486
MOD_PKA_1 391 397 PF00069 0.628
MOD_PKA_1 5 11 PF00069 0.734
MOD_PKA_1 854 860 PF00069 0.639
MOD_PKA_2 112 118 PF00069 0.684
MOD_PKA_2 285 291 PF00069 0.607
MOD_PKA_2 332 338 PF00069 0.622
MOD_PKA_2 378 384 PF00069 0.558
MOD_PKA_2 391 397 PF00069 0.468
MOD_PKA_2 5 11 PF00069 0.734
MOD_PKA_2 698 704 PF00069 0.586
MOD_PKB_1 611 619 PF00069 0.561
MOD_Plk_1 10 16 PF00069 0.697
MOD_Plk_1 411 417 PF00069 0.731
MOD_Plk_1 778 784 PF00069 0.656
MOD_Plk_1 809 815 PF00069 0.589
MOD_Plk_4 149 155 PF00069 0.637
MOD_Plk_4 273 279 PF00069 0.625
MOD_Plk_4 821 827 PF00069 0.444
MOD_Plk_4 834 840 PF00069 0.531
MOD_ProDKin_1 69 75 PF00069 0.713
MOD_ProDKin_1 78 84 PF00069 0.515
MOD_ProDKin_1 817 823 PF00069 0.651
MOD_SUMO_rev_2 432 441 PF00179 0.683
TRG_DiLeu_BaLyEn_6 126 131 PF01217 0.710
TRG_DiLeu_BaLyEn_6 187 192 PF01217 0.611
TRG_DiLeu_BaLyEn_6 362 367 PF01217 0.567
TRG_ER_diArg_1 125 127 PF00400 0.694
TRG_ER_diArg_1 157 160 PF00400 0.480
TRG_ER_diArg_1 263 266 PF00400 0.660
TRG_ER_diArg_1 320 322 PF00400 0.650
TRG_ER_diArg_1 328 331 PF00400 0.585
TRG_ER_diArg_1 391 393 PF00400 0.696
TRG_ER_diArg_1 438 441 PF00400 0.559
TRG_ER_diArg_1 456 458 PF00400 0.408
TRG_ER_diArg_1 474 476 PF00400 0.534
TRG_ER_diArg_1 562 565 PF00400 0.516
TRG_ER_diArg_1 611 614 PF00400 0.548
TRG_Pf-PMV_PEXEL_1 306 310 PF00026 0.733
TRG_Pf-PMV_PEXEL_1 322 326 PF00026 0.408
TRG_Pf-PMV_PEXEL_1 391 395 PF00026 0.472
TRG_Pf-PMV_PEXEL_1 476 481 PF00026 0.464

Homologs

Protein Taxonomy Sequence identity Coverage
A4H704 Leishmania braziliensis 64% 99%
E9AGI6 Leishmania infantum 99% 100%
E9AP24 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4QGG5 Leishmania major 87% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS