RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-RING finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WSB0_LEIDO

TriTrypDb:

LdBPK_130230.1 , LdCL_130007300 , LDHU3_13.0280

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000795	synaptonemal complex	3	6
GO:0099086	synaptonemal structure	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WSB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSB0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	6
GO:0022414	reproductive process	1	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0140527	reciprocal homologous recombination	7	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	6
GO:0006996	organelle organization	4	1
GO:0007129	homologous chromosome pairing at meiosis	4	1
GO:0016043	cellular component organization	3	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0051276	chromosome organization	5	1
GO:0070192	chromosome organization involved in meiotic cell cycle	3	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	4
GO:0016740	transferase activity	2	6
GO:0019787	ubiquitin-like protein transferase activity	3	6
GO:0019789	SUMO transferase activity	4	6
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.636
CLV_NRD_NRD_1	149	151	PF00675	0.638
CLV_NRD_NRD_1	251	253	PF00675	0.740
CLV_NRD_NRD_1	305	307	PF00675	0.769
CLV_NRD_NRD_1	384	386	PF00675	0.749
CLV_NRD_NRD_1	88	90	PF00675	0.537
CLV_PCSK_KEX2_1	251	253	PF00082	0.740
CLV_PCSK_KEX2_1	292	294	PF00082	0.806
CLV_PCSK_KEX2_1	304	306	PF00082	0.646
CLV_PCSK_KEX2_1	384	386	PF00082	0.749
CLV_PCSK_KEX2_1	88	90	PF00082	0.537
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.806
CLV_PCSK_SKI1_1	326	330	PF00082	0.740
CLV_PCSK_SKI1_1	91	95	PF00082	0.625
DEG_APCC_DBOX_1	90	98	PF00400	0.628
DOC_CKS1_1	371	376	PF01111	0.796
DOC_CYCLIN_yCln2_LP_2	371	377	PF00134	0.777
DOC_PP4_FxxP_1	409	412	PF00568	0.805
DOC_USP7_MATH_1	105	109	PF00917	0.580
DOC_USP7_MATH_1	117	121	PF00917	0.622
DOC_USP7_MATH_1	220	224	PF00917	0.735
DOC_USP7_MATH_1	227	231	PF00917	0.677
DOC_USP7_MATH_1	232	236	PF00917	0.617
DOC_USP7_MATH_1	240	244	PF00917	0.538
DOC_USP7_MATH_1	265	269	PF00917	0.790
DOC_USP7_MATH_1	317	321	PF00917	0.763
DOC_USP7_MATH_1	344	348	PF00917	0.799
DOC_USP7_MATH_1	363	367	PF00917	0.630
DOC_USP7_MATH_1	392	396	PF00917	0.742
DOC_WW_Pin1_4	192	197	PF00397	0.794
DOC_WW_Pin1_4	223	228	PF00397	0.766
DOC_WW_Pin1_4	236	241	PF00397	0.680
DOC_WW_Pin1_4	327	332	PF00397	0.818
DOC_WW_Pin1_4	359	364	PF00397	0.794
DOC_WW_Pin1_4	370	375	PF00397	0.654
DOC_WW_Pin1_4	408	413	PF00397	0.816
LIG_14-3-3_CanoR_1	150	159	PF00244	0.738
LIG_14-3-3_CanoR_1	174	182	PF00244	0.770
LIG_14-3-3_CanoR_1	221	227	PF00244	0.706
LIG_14-3-3_CanoR_1	293	302	PF00244	0.739
LIG_14-3-3_CanoR_1	311	315	PF00244	0.761
LIG_14-3-3_CanoR_1	332	338	PF00244	0.727
LIG_14-3-3_CanoR_1	407	412	PF00244	0.779
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BRCT_BRCA1_1	347	351	PF00533	0.757
LIG_BRCT_BRCA1_1	365	369	PF00533	0.681
LIG_Clathr_ClatBox_1	50	54	PF01394	0.628
LIG_FHA_1	187	193	PF00498	0.799
LIG_FHA_1	370	376	PF00498	0.777
LIG_FHA_1	392	398	PF00498	0.621
LIG_LIR_Apic_2	230	234	PF02991	0.743
LIG_LIR_Nem_3	2	6	PF02991	0.619
LIG_SH2_CRK	48	52	PF00017	0.607
LIG_SH2_CRK	83	87	PF00017	0.606
LIG_SH2_STAT5	26	29	PF00017	0.542
LIG_SH2_STAT5	396	399	PF00017	0.608
LIG_SH3_1	208	214	PF00018	0.804
LIG_SH3_2	300	305	PF14604	0.707
LIG_SH3_3	156	162	PF00018	0.782
LIG_SH3_3	208	214	PF00018	0.804
LIG_SH3_3	297	303	PF00018	0.706
LIG_SH3_3	394	400	PF00018	0.625
LIG_TRAF2_1	124	127	PF00917	0.538
MOD_CDK_SPK_2	223	228	PF00069	0.742
MOD_CDK_SPK_2	327	332	PF00069	0.783
MOD_CDK_SPK_2	408	413	PF00069	0.805
MOD_CK1_1	19	25	PF00069	0.463
MOD_CK1_1	223	229	PF00069	0.777
MOD_CK1_1	235	241	PF00069	0.681
MOD_CK1_1	243	249	PF00069	0.567
MOD_CK1_1	268	274	PF00069	0.756
MOD_CK1_1	285	291	PF00069	0.606
MOD_CK1_1	298	304	PF00069	0.619
MOD_CK1_1	395	401	PF00069	0.610
MOD_GlcNHglycan	273	276	PF01048	0.784
MOD_GlcNHglycan	284	287	PF01048	0.631
MOD_GlcNHglycan	356	359	PF01048	0.799
MOD_GSK3_1	137	144	PF00069	0.630
MOD_GSK3_1	145	152	PF00069	0.554
MOD_GSK3_1	223	230	PF00069	0.799
MOD_GSK3_1	232	239	PF00069	0.698
MOD_GSK3_1	26	33	PF00069	0.517
MOD_GSK3_1	265	272	PF00069	0.740
MOD_GSK3_1	359	366	PF00069	0.720
MOD_GSK3_1	391	398	PF00069	0.610
MOD_LATS_1	250	256	PF00433	0.667
MOD_NEK2_1	282	287	PF00069	0.793
MOD_NEK2_1	369	374	PF00069	0.779
MOD_PIKK_1	105	111	PF00454	0.610
MOD_PIKK_1	117	123	PF00454	0.535
MOD_PIKK_1	145	151	PF00454	0.679
MOD_PIKK_1	154	160	PF00454	0.627
MOD_PIKK_1	75	81	PF00454	0.625
MOD_PK_1	16	22	PF00069	0.410
MOD_PKA_1	150	156	PF00069	0.635
MOD_PKA_2	105	111	PF00069	0.572
MOD_PKA_2	149	155	PF00069	0.640
MOD_PKA_2	173	179	PF00069	0.834
MOD_PKA_2	220	226	PF00069	0.782
MOD_PKA_2	227	233	PF00069	0.743
MOD_PKA_2	310	316	PF00069	0.759
MOD_PKA_2	398	404	PF00069	0.784
MOD_PKB_1	293	301	PF00069	0.811
MOD_Plk_4	285	291	PF00069	0.833
MOD_Plk_4	385	391	PF00069	0.774
MOD_Plk_4	392	398	PF00069	0.686
MOD_Plk_4	64	70	PF00069	0.585
MOD_ProDKin_1	192	198	PF00069	0.793
MOD_ProDKin_1	223	229	PF00069	0.766
MOD_ProDKin_1	236	242	PF00069	0.678
MOD_ProDKin_1	327	333	PF00069	0.819
MOD_ProDKin_1	359	365	PF00069	0.793
MOD_ProDKin_1	370	376	PF00069	0.653
MOD_ProDKin_1	408	414	PF00069	0.815
TRG_DiLeu_BaEn_4	127	133	PF01217	0.540
TRG_ENDOCYTIC_2	48	51	PF00928	0.601
TRG_ENDOCYTIC_2	83	86	PF00928	0.607
TRG_ER_diArg_1	303	306	PF00400	0.748
TRG_ER_diArg_1	384	386	PF00400	0.749
TRG_ER_diArg_1	87	89	PF00400	0.528
TRG_NLS_MonoExtC_3	291	297	PF00514	0.807

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHR7	Leishmania braziliensis	65%	100%
A4HVF8	Leishmania infantum	100%	100%
E9AP57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QGD1	Leishmania major	93%	100%